{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:17:05Z","timestamp":1776395825820,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Research and Development Program","award":["2016YFD0501607"],"award-info":[{"award-number":["2016YFD0501607"]}]},{"DOI":"10.13039\/501100010042","name":"Special Fund for Agro-scientific Research in the Public Interest","doi-asserted-by":"publisher","award":["201403054"],"award-info":[{"award-number":["201403054"]}],"id":[{"id":"10.13039\/501100010042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province of China","doi-asserted-by":"publisher","award":["BK20151306"],"award-info":[{"award-number":["BK20151306"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yangzhou University Science and Technology Innovation Team"},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.micpath.2019.01.035","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T17:27:05Z","timestamp":1548782825000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The SseL protein inhibits the intracellular NF-\u03baB pathway to enhance the virulence of Salmonella Pullorum in a chicken model"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-2513","authenticated-orcid":false,"given":"Shizhong","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaonan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"391","key":"10.1016\/j.micpath.2019.01.035_bib1","first-page":"1","article-title":"Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ","volume":"5","author":"Mor","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2019.01.035_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.rvsc.2016.05.007","article-title":"Safety and Protective efficacy of a sPiC and crP deletion mutant of Salmonella Gallinarum as a live attenuated vaccine for fowl tyPhoid","volume":"107","author":"Cheng","year":"2016","journal-title":"Res. Vet. Sci."},{"issue":"8","key":"10.1016\/j.micpath.2019.01.035_bib3","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1073\/pnas.1000041107","article-title":"Dynamics of intracellular bacterial replication at the single cell level","volume":"107","author":"Helaine","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"15","key":"10.1016\/j.micpath.2019.01.035_bib4","doi-asserted-by":"crossref","first-page":"7800","DOI":"10.1073\/pnas.93.15.7800","article-title":"Identification of a pathogenicity island required for Salmonella survival in host cells","volume":"93","author":"Ochman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.micpath.2019.01.035_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1462-5822.2011.01719.x","article-title":"Subversion of innate immune responses by bacterial hindrance of NF-kappaB pathway","volume":"14","author":"Le","year":"2012","journal-title":"Cell Microbiol."},{"issue":"4","key":"10.1016\/j.micpath.2019.01.035_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nrmicro2539","article-title":"Modulation of NF-kappaB signaling by microbial pathogens","volume":"9","author":"Rahman","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.micpath.2019.01.035_bib7","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.4049\/jimmunol.169.6.2846","article-title":"Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway","volume":"169","author":"Collier-Hyams","year":"2002","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.micpath.2019.01.035_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.chom.2008.02.016","article-title":"Salmonella AvrA coordinates suppression of host immune and apoptotic defenses via JNK pathway blockade","volume":"3","author":"Jones","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.micpath.2019.01.035_bib9","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2353\/ajpath.2007.070220","article-title":"Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination","volume":"171","author":"Ye","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.micpath.2019.01.035_bib10","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1073\/pnas.0610095104","article-title":"SseL, a Salmonella deubiquitinase required for macrophage killing and virulence","volume":"104","author":"Rytk\u00f6nen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.micpath.2019.01.035_bib11","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.4049\/jimmunol.180.7.5045","article-title":"Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses","volume":"180","author":"Negrate","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2019.01.035_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053064","article-title":"Lack of Effect of the Salmonella Deubiquitinase SseL on the NF-\u03baB pathway","volume":"8","author":"Mesquita","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.micpath.2019.01.035_bib13","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"19","key":"10.1016\/j.micpath.2019.01.035_bib14","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1128\/JB.184.19.5234-5239.2002","article-title":"Identification of GtgE, a novel virulence factor encoded on the Gifsy-2 bacteriophage of Salmonella enterica serovar Typhimurium","volume":"184","author":"Ho","year":"2002","journal-title":"J. Bacteriol."},{"issue":"12","key":"10.1016\/j.micpath.2019.01.035_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052043","article-title":"Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient Fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice","volume":"7","author":"Vishwakarma","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.micpath.2019.01.035_bib16","first-page":"345","article-title":"Construction of a Salmonella pullorum S06004\u0394sifA strain and study on its biological characteristics","volume":"45","author":"Yin","year":"2015","journal-title":"Chin. Vet. Sci."},{"issue":"20","key":"10.1016\/j.micpath.2019.01.035_bib17","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1128\/AEM.01696-14","article-title":"Stress response of Salmonella enterica serovar typhimurium to acidified nitrite","volume":"80","author":"M\u00fchlig","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"issue":"9","key":"10.1016\/j.micpath.2019.01.035_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000595","article-title":"Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA","volume":"5","author":"Du","year":"2009","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.micpath.2019.01.035_bib19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00284-014-0521-z","article-title":"Role of the flagellar basal-body protein, FlgC, in the binding of Salmonella enterica serovar Enteritidis to host cells","volume":"68","author":"Shippy","year":"2014","journal-title":"Curr. Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2019.01.035_bib20","first-page":"77","article-title":"Calculation of the index of acute toxicity by the method of linear regression. Comparison with the method of \u201cKarber and Behrens\u201d","volume":"7","author":"Gilles","year":"1974","journal-title":"Eur. J. Toxicol. Environ. Hyg."},{"issue":"22","key":"10.1016\/j.micpath.2019.01.035_bib21","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1128\/JB.00628-13","article-title":"The transfer-messenger RNA-small protein B system plays a role in avian pathogenic Escherichia coli pathogenicity","volume":"195","author":"Mu","year":"2013","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.micpath.2019.01.035_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ygcen.2008.09.013","article-title":"Prospects for understanding immune-endocrine interactions in the chickens","volume":"163","author":"Kaiser","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"issue":"1\u20133","key":"10.1016\/j.micpath.2019.01.035_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetimm.2008.10.295","article-title":"The immunobiology of avian systemic salmonellosis","volume":"128","author":"Chappell","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3\u20134","key":"10.1016\/j.micpath.2019.01.035_bib24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.vetimm.2012.03.008","volume":"146","author":"Settaa","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.micpath.2019.01.035_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetimm.2008.06.005","article-title":"Profiling pro-inflammatory cytokine and chemokine mRNA expression levels as a novel method for selection of increased innate immune responsiveness","volume":"126","author":"Swaggerty","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"5","key":"10.1016\/j.micpath.2019.01.035_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/03079457.2012.718071","article-title":"The long view: Salmonella\u2013the last forty years","volume":"41","author":"Barrow","year":"2012","journal-title":"Avian Pathol."},{"issue":"9","key":"10.1016\/j.micpath.2019.01.035_bib27","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1128\/IAI.00145-13","article-title":"Identification of Salmonella enterica serovar Pullorum antigenic determinants expressed in vivo","volume":"81","author":"Li","year":"2013","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.micpath.2019.01.035_bib28","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/CVI.00130-15","article-title":"Evaluation of the Salmonella enterica serovar Pullorum pathogenicity island 2 mutant as a candidate live attenuated oral vaccine","volume":"22","author":"Yin","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"issue":"9","key":"10.1016\/j.micpath.2019.01.035_bib29","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1021\/acs.jproteome.5b00574","article-title":"Identification of Salmonella Typhimurium deubiquitinase SseL substrates by immunoaffinity enrichment and quantitative proteomic analysis","volume":"14","author":"Nakayasu","year":"2015","journal-title":"J. Proteome Res."},{"issue":"12","key":"10.1016\/j.micpath.2019.01.035_bib30","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tim.2011.08.004","article-title":"Microbial-induced immunomodulation by targeting the NF-kB system","volume":"19","author":"Neish","year":"2011","journal-title":"Trends Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018315122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401018315122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:44:38Z","timestamp":1565203478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401018315122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":30,"alternative-id":["S0882401018315122"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2019.01.035","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The SseL protein inhibits the intracellular NF-\u03baB pathway to enhance the virulence of Salmonella Pullorum in a chicken model","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2019.01.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}