{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:42:06Z","timestamp":1774618926157,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC1309703"],"award-info":[{"award-number":["2017YFC1309703"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.micpath.2019.04.023","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T12:16:21Z","timestamp":1555330581000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review"],"prefix":"10.1016","volume":"132","author":[{"given":"Xiang","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunfang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2019.04.023_bib1","series-title":"Global Tuberculosis Report 2018","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.micpath.2019.04.023_bib2","series-title":"The Natural History of Mycobacterium tuberculosis Infection in Adults","first-page":"129","author":"Maher","year":"2009"},{"key":"10.1016\/j.micpath.2019.04.023_bib3","first-page":"2013","article-title":"Risk factors for tuberculosis","author":"Narasimhan","year":"2013","journal-title":"Pulmonary medicine"},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/sj.gene.6363915","article-title":"Susceptibility to mycobacterial infections: the importance of host genetics","volume":"4","author":"Bellamy","year":"2003","journal-title":"Genes Immun."},{"issue":"2","key":"10.1016\/j.micpath.2019.04.023_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1183\/09031936.03.00061703","article-title":"The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease","volume":"23","author":"Ogus","year":"2004","journal-title":"Eur. Respir. J."},{"issue":"12","key":"10.1016\/j.micpath.2019.04.023_bib6","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1086\/345920","article-title":"Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis","volume":"186","author":"Awomoyi","year":"2002","journal-title":"J. Infect. Dis."},{"issue":"9204","key":"10.1016\/j.micpath.2019.04.023_bib7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0140-6736(99)02301-6","article-title":"Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study","volume":"355","author":"Wilkinson","year":"2000","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.micpath.2019.04.023_bib8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1084\/jem.170.4.1175","article-title":"The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10","volume":"170","author":"Sastry","year":"1989","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.micpath.2019.04.023_bib9","first-page":"305","article-title":"Mannose-binding lectin: structure, function, genetics and disease associations","volume":"2","author":"Turner","year":"2000","journal-title":"Rev. Immunogenet."},{"issue":"11","key":"10.1016\/j.micpath.2019.04.023_bib10","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0167-5699(96)10062-1","article-title":"Mannose-binding lectin: the pluripotent molecule of the innate immune system","volume":"17","author":"Turner","year":"1996","journal-title":"Immunol. today"},{"issue":"2","key":"10.1016\/j.micpath.2019.04.023_bib11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.68.2.688-693.2000","article-title":"Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition","volume":"68","author":"Neth","year":"2000","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.micpath.2019.04.023_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1086\/377183","article-title":"Mannose-binding lectin polymorphisms in clinical tuberculosis","volume":"188","author":"Soborg","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.micpath.2019.04.023_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0161-5890(03)00155-X","article-title":"The role of mannose-binding lectin in health and disease","volume":"40","author":"Turner","year":"2003","journal-title":"Mol. Immunol."},{"issue":"9","key":"10.1016\/j.micpath.2019.04.023_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/hmg\/1.9.709","article-title":"High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene","volume":"1","author":"Lipscombe","year":"1992","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-065X.2009.00789.x","article-title":"Mannose\u2010binding lectin and innate immunity","volume":"230","author":"Eddie Ip","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2019.04.023_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12879-015-0879-y","article-title":"Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2019.04.023_bib17","first-page":"323","article-title":"MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population","volume":"19","author":"da Cruz","year":"2013","journal-title":"Infect. Genet. Evol. J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"10.1016\/j.micpath.2019.04.023_bib18","first-page":"129","article-title":"An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population","volume":"38","author":"Wu","year":"2015","journal-title":"Int. J. Infect. Dis. IJID. Official Publ. Int. Soc. Infect. Dis."},{"issue":"6","key":"10.1016\/j.micpath.2019.04.023_bib19","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jiph.2016.11.003","article-title":"Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis","volume":"10","author":"Ceylan","year":"2017","journal-title":"Journal of infection and public health"},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.humimm.2012.09.001","article-title":"No evidence of association between MBL2A\/O polymorphisms and Mycobacterium tuberculosis infection in populations from the Brazilian Amazon region","volume":"74","author":"Araujo","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.micpath.2019.04.023_bib21","doi-asserted-by":"crossref","first-page":"469128","DOI":"10.1155\/2012\/469128","article-title":"Mannose-binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from cantabria (northern Spain)","volume":"2012","author":"Ocejo-Vinyals","year":"2012","journal-title":"Pulm Med"},{"issue":"4","key":"10.1016\/j.micpath.2019.04.023_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/iji.12126","article-title":"Mannose-binding lectin exon 1 and promoter polymorphisms in tuberculosis disease in a Mediterranean area","volume":"41","author":"Garcia-Gasalla","year":"2014","journal-title":"Int. J. Immunogenet."},{"issue":"4","key":"10.1016\/j.micpath.2019.04.023_bib23","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s10753-015-0150-0","article-title":"No strong relationship between components of the lectin pathway of complement and susceptibility to pulmonary Tuberculosis","volume":"38","author":"Chalmers","year":"2015","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.micpath.2019.04.023_bib24","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.humimm.2014.06.006","article-title":"Age-dependent association of mannose-binding lectin polymorphisms with the development of pulmonary tuberculosis in Viet Nam","volume":"75","author":"Hijikata","year":"2014","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.micpath.2019.04.023_bib25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2147\/COPD.S152655","article-title":"The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review","volume":"13","author":"Tong","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.micpath.2019.04.023_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"6","key":"10.1016\/j.micpath.2019.04.023_bib27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/sim.650","article-title":"A comparison of statistical methods for meta\u2010analysis","volume":"20","author":"Brockwell","year":"2001","journal-title":"Stat. Med."},{"key":"10.1016\/j.micpath.2019.04.023_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.gdata.2017.05.005","article-title":"Mannose-Binding Lectin (MBL) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran","volume":"12","author":"Amiri","year":"2017","journal-title":"Genomics data"},{"key":"10.1016\/j.micpath.2019.04.023_bib29","doi-asserted-by":"crossref","first-page":"36488","DOI":"10.1038\/srep36488","article-title":"Association of mannose-binding lectin polymorphisms with tuberculosis susceptibility among Chinese","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.micpath.2019.04.023_bib30","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.molimm.2006.11.002","article-title":"Influence of candidate susceptibility genes on tuberculosis in a high endemic region","volume":"44","author":"Soborg","year":"2007","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.micpath.2019.04.023_bib31","first-page":"1098","article-title":"Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population","volume":"10","author":"Liu","year":"2006","journal-title":"Int. J. Tuberc. Lung Dis. Official J. Int. Union against Tuberc. Lung Dis."},{"issue":"3","key":"10.1016\/j.micpath.2019.04.023_bib32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1574-695X.2006.00053.x","article-title":"Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis","volume":"46","author":"Selvaraj","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2019.04.023_bib33","first-page":"95","article-title":"The effect of mannose-binding protein gene polymorphisms in recurrent respiratory system infections in children and lung tuberculosis","volume":"45","author":"Ozbas-Gerceker","year":"2003","journal-title":"Turk. J. Pediatr."},{"issue":"4","key":"10.1016\/j.micpath.2019.04.023_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1054\/tuld.1999.0204","article-title":"Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India","volume":"79","author":"Selvaraj","year":"1999","journal-title":"Tuber. Lung Dis. Official J. Int. Union against Tuber. .Lung Dis."},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1744-313X.2011.01047.x","article-title":"Association of mannose-binding lectin gene polymorphism with tuberculosis susceptibility and sputum conversion time","volume":"39","author":"Singla","year":"2012","journal-title":"Int. J. Immunogenet."},{"issue":"6","key":"10.1016\/j.micpath.2019.04.023_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tube.2007.07.007","article-title":"Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India","volume":"87","author":"Alagarasu","year":"2007","journal-title":"Tuberculosis"},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/qjmed\/91.1.13","article-title":"Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans","volume":"91","author":"Bellamy","year":"1998","journal-title":"QJM : monthly journal of the Association of Physicians"},{"issue":"6","key":"10.1016\/j.micpath.2019.04.023_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020908","article-title":"Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis","volume":"6","author":"Thye","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2019.04.023_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micpath.2017.08.054","article-title":"Association of IFNG gene polymorphisms with pulmonary tuberculosis but not with spinal tuberculosis in a Chinese Han population","volume":"111","author":"Li","year":"2017","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.micpath.2019.04.023_bib40","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1086\/596658","article-title":"Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis","volume":"199","author":"Capparelli","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib41","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12879-017-2310-3","article-title":"Association of mannose-binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China","volume":"17","author":"Guo","year":"2017","journal-title":"BMC Infect. Dis."},{"issue":"3","key":"10.1016\/j.micpath.2019.04.023_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcdt.2016.12.012","article-title":"Mannose binding lectin in patients with pulmonary tuberculosis: active and inactive","volume":"66","author":"Alsalahy","year":"2017","journal-title":"Egypt. J. Chest Dis. Tuberc."},{"issue":"4 Pt 1","key":"10.1016\/j.micpath.2019.04.023_bib43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1203\/00006450-199904010-00002","article-title":"Mannose-binding protein B allele confers protection against tuberculous meningitis","volume":"45","author":"Hoal-Van Helden","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.micpath.2019.04.023_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14196\/mjiri.31.66","article-title":"Serum mannan-binding lectin in patients with pulmonary tuberculosis: its lack of a relationship to the disease and response to treatment","volume":"31","author":"Ahmadi","year":"2017","journal-title":"Med. J. Islam. Repub. Iran"},{"issue":"8","key":"10.1016\/j.micpath.2019.04.023_bib45","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.humimm.2014.06.006","article-title":"Age-dependent association of mannose-binding lectin polymorphisms with the development of pulmonary tuberculosis in Viet Nam","volume":"75","author":"Hijikata","year":"2014","journal-title":"Hum. Immunol."},{"issue":"6","key":"10.1016\/j.micpath.2019.04.023_bib46","first-page":"428","article-title":"Research on relationship of polymorphism of mannose-binding lectin gene with susceptibility to tuberculosis in Zhuang population","volume":"31","author":"Fang","year":"2011","journal-title":"Int J Respir (Chinese)"},{"issue":"8","key":"10.1016\/j.micpath.2019.04.023_bib47","first-page":"889","article-title":"Study on the susceptibility of MBL gene rs1800450 to tuberculosis in Ningxia","volume":"36","author":"Zhao","year":"2014","journal-title":"Journal of Ningxia Medical University"},{"key":"10.1016\/j.micpath.2019.04.023_bib48","series-title":"Correlation Analysis and Mechanism of Mannose-Binding Lectin Gene Polymorphism and Susceptibility to Tuberculosis in Chinese Han Population","author":"Wang","year":"2009"},{"issue":"2","key":"10.1016\/j.micpath.2019.04.023_bib49","first-page":"135","article-title":"A study on the Association of polymorphisms of the MBL gene with the susceptibility to tuberculosis of Xinjiang Hazakhs","volume":"33","author":"Zhang","year":"2011","journal-title":"Journal of Nongken Medicine (Chinese)"},{"issue":"13","key":"10.1016\/j.micpath.2019.04.023_bib50","first-page":"1767","article-title":"Study on relation between regulation of MBL level and pulmonary tuberculosis susceptibility","volume":"37","author":"Liu","year":"2016","journal-title":"Internet J. Lab. Med."},{"issue":"7","key":"10.1016\/j.micpath.2019.04.023_bib51","first-page":"445","article-title":"Correlation between MBL-A\/B gene with the susceptibility of tuberculosis in Xingjiang Uighur population","volume":"34","author":"Zhou","year":"2012","journal-title":"Chin J Antituberc (Chinese)"},{"issue":"1","key":"10.1016\/j.micpath.2019.04.023_bib52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41598-017-00299-1","article-title":"Association between the MIF-173G\/C polymorphism and serum MIF levels with pulmonary tuberculosis: a meta-analysis","volume":"7","author":"Tong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2019.04.023_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/IDR.S188980","article-title":"Association of MBL2 gene polymorphisms with pulmonary tuberculosis susceptibility: trial sequence meta-analysis as evidence","volume":"12","author":"Mandal","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.micpath.2019.04.023_bib54","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2147\/IDR.S168465","article-title":"Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies","volume":"11","author":"Wu","year":"2018","journal-title":"Infect. Drug Resist."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101930395X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240101930395X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T07:12:43Z","timestamp":1560323563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240101930395X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":54,"alternative-id":["S088240101930395X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2019.04.023","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2019.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}