{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:28:00Z","timestamp":1778084880412,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.micpath.2019.103637","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T22:05:17Z","timestamp":1563487517000},"page":"103637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Dietary supplementation with caffeine increases survival rate, reduces microbial load and protects the liver against Aeromonas hydrophila-induced hepatic damage in the grass carp Ctenopharyngodon idella"],"prefix":"10.1016","volume":"135","author":[{"given":"Matheus D.","family":"Baldissera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine F.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo B.","family":"Abbad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila M.","family":"Verdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto CV.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandro S.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Baldisserotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2019.103637_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.fsi.2019.04.036","article-title":"Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila","volume":"89","author":"Devi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.prevetmed.2018.03.004","article-title":"The role of infectious disease impact in informing decision-making for animal health management in aquaculture systems in Bangladesh","volume":"167","author":"Garza","year":"2019","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.micpath.2019.103637_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.fsi.2019.01.044","article-title":"Hematological and immune changes in Piaractus mesopotamicus in the sepsis induced by Aeromonas hydrophila","volume":"88","author":"Claudiano","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2014.04.017","article-title":"Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicemia outbreaks in pond-cultured cyprinid fish in an epidemic area in central China","volume":"432","author":"Zhang","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2019.103637_bib5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.aquaculture.2018.10.045","article-title":"Immunoglobulin Y in the diagnosis of Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus)","volume":"500","author":"Fernandes","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2019.103637_bib6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.fsi.2018.11.076","article-title":"Immunostimulation of Cyprinus carpio using phage lysate of Aeromonas hydrophila","volume":"86","author":"Yun","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.fsi.2016.02.035","article-title":"Transcriptome profiling of grass carp (Ctenopharyngodon idellus) infected with Aeromonas hydrophila","volume":"51","author":"Yang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.dci.2018.09.018","article-title":"RNase1 alleviates the Aeromonas hydrophila-induced oxidative stress in blunt snout bream","volume":"91","author":"Geng","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.micpath.2019.05.017","article-title":"Aeromonas hydrophila infection in silver catfish causes hyperlocomotion related to stress","volume":"132","author":"Bandeira Junior","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2019.103637_bib10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/lam.13138","article-title":"Multidrug resistant Aeromonas spp. isolated from zebrafish (Danio rerio): antibiogram, antimicrobial resistance genes and class 1 integron gene cassettes","volume":"68","author":"Hossain","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2019.103637_bib11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s10695-019-00616-7","article-title":"A caffeine-supplemented diet modulates oxidative stress markers and prevents oxidative damage in the livers of Nile tilapia (Oreochromis niloticus) exposed to hypoxia","volume":"45","author":"Baldissera","year":"2019","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.micpath.2019.103637_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.clim.2018.04.008","article-title":"Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity","volume":"192","author":"Iris","year":"2018","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3923\/jm.2008.457.465","article-title":"Inhibitory effect of caffeine on growth of various bacterial strains","volume":"3","author":"Dash","year":"2008","journal-title":"Res. J. Microbiol."},{"key":"10.1016\/j.micpath.2019.103637_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.foodres.2012.07.026","article-title":"Influence of natural coffee compounds, coffee extracts and increased levels of caffeine on the inhibition of Streptococcus mutans","volume":"49","author":"Almeida","year":"2012","journal-title":"Food Res. Int."},{"key":"10.1016\/j.micpath.2019.103637_bib15","first-page":"20","article-title":"Effect of certain phytochemicals on Aeromonas hydrophila","volume":"2","author":"Kothar","year":"2011","journal-title":"Res. Biotechnol."},{"key":"10.1016\/j.micpath.2019.103637_bib16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0043-1354(78)90107-0","article-title":"Ammonia determinations based on indophenol formation with sodium salicylate","volume":"12","author":"Verdouw","year":"1978","journal-title":"Water Res."},{"key":"10.1016\/j.micpath.2019.103637_bib17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.micpath.2016.07.002","article-title":"In vivo bactericidal effect of Melaleuca alternifolia essential oil against Aeromonas hydrophila: silver catfish (Rhamdia quelen) as an experimental model","volume":"98","author":"Souza","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2019.103637_bib18","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1186\/s12917-017-1273-3","article-title":"Elimination kinetics of eugenol in grass carp in a simulated transportation setting","volume":"13","author":"Zhao","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.micpath.2019.103637_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.micpath.2019.103637_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00244-003-0073-x","article-title":"Determination of lipid peroxides in invertebrates using the Fe (III) xylenol orange complex formation","volume":"45","author":"Monserrat","year":"2003","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.micpath.2019.103637_bib21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0076-6879(94)33041-7","article-title":"Oxidative damage of proteins: spectrophotometer for carbonyl assay","volume":"233","author":"Reznick","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.micpath.2019.103637_bib22","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.scitotenv.2008.11.038","article-title":"A method to measure total antioxidant capacity against peroxyl radicals in aquatic organisms: application to evaluate microcystins toxicity","volume":"407","author":"Amado","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.micpath.2019.103637_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.micpath.2019.103637_bib24","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase","volume":"70","author":"Pagli","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.micpath.2019.103637_bib25","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2019.103637_bib26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.micpath.2019.103637_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0003-2697(81)90321-3","article-title":"Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein","volume":"116","author":"Read","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.micpath.2019.103637_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.micpath.2018.11.035","article-title":"Determination of lethal dose of Aeromonas hydrophila Ah17 strain in snake head fish Channa striata","volume":"127","author":"Samayanpaulraj","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2019.103637_bib29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.aquaculture.2016.08.001","article-title":"Seaweeds as an alternative therapeutic source for aquatic disease management","volume":"464","author":"Thanigaivel","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2019.103637_bib30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.micpath.2019.103637_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/aem.34.2.189-193.1977","article-title":"Increased spore yields of Clostridium perfringens in the presence of methylxanthines","volume":"34","author":"Sacks","year":"1977","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2019.103637_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0027-5107(80)90133-5","article-title":"The effect of caffeine on cell growth and metabolism of thymidine in Escherichia coli","volume":"83","author":"Sandlie","year":"1980","journal-title":"Mutat. Res."},{"key":"10.1016\/j.micpath.2019.103637_bib33","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1073\/pnas.87.9.3522","article-title":"Molecular mechanisms of DNA repair inhibition by caffeine","volume":"87","author":"Selb","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micpath.2019.103637_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2016.12.016","article-title":"Melaleuca alternifolia essential oil enhances the non-specific immune system and prevents oxidative damage in Rhamdia quelen experimentally infected by Aeromonas hydrophila: effects on cholinergic and purinergic systems in liver tissue","volume":"61","author":"Baldissera","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10695-015-0171-5","article-title":"Contaminant-induced oxidative stress in fish: a mechanistic approach","volume":"42","author":"Lushchak","year":"2016","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.micpath.2019.103637_bib36","first-page":"79","article-title":"Growth, blood health, antioxidant status, immune response and resistance to Aeromonas hydrophila of juvenile yellow catfish exposed to di-2-ethylhexylphthalate (DEHP)","volume":"202","author":"Yuan","year":"2017","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.micpath.2019.103637_bib37","first-page":"164","article-title":"Oxidative stress and antioxidant responses in Nile tilapia Oreochromis niloticus experimentally infected by Providencia rettgeri, Microb","volume":"131","author":"Souza","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2019.103637_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.fsi.2019.03.006","article-title":"Dietary chitosan oligosaccharides modulate the growth, intestine digestive enzymes, body composition and nonspecific immunity of loach Paramisgurnus dabryanus","volume":"88","author":"Zhang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2019.103637_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.aquaculture.2018.12.011","article-title":"Dietary flavonoids from Allium mongolicum Regel promotes growth, improves immune, antioxidant status, immune-related signaling molecules and disease resistance in juvenile northern snakehead fish (Channa argus)","volume":"501","author":"Li","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.micpath.2019.103637_bib40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.lfs.2013.12.002","article-title":"Caffeine supplementation modulates oxidative stress markers in the liver of trained rats","volume":"96","author":"Barcelos","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2019.103637_bib41","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.lfs.2017.10.039","article-title":"Caffeine and acetaminophen association: effects on mitochondrial bioenergetics","volume":"193","author":"Gon\u00e7alves","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2019.103637_bib42","first-page":"92","article-title":"Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes","volume":"16","author":"Roth","year":"2011","journal-title":"Exp. Clin. Cardiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019310708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019310708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:23:43Z","timestamp":1760109823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401019310708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":42,"alternative-id":["S0882401019310708"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103637","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary supplementation with caffeine increases survival rate, reduces microbial load and protects the liver against Aeromonas hydrophila-induced hepatic damage in the grass carp Ctenopharyngodon idella","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103637"}}