{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:06:44Z","timestamp":1779196004379,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602122"],"award-info":[{"award-number":["31602122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M600233"],"award-info":[{"award-number":["2016M600233"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.micpath.2019.103792","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T11:24:15Z","timestamp":1570620255000},"page":"103792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Sodium butyrate alleviates lipopolysaccharide-induced endometritis in mice through inhibiting inflammatory response"],"prefix":"10.1016","volume":"137","author":[{"given":"Jian","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naisheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhe","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2019.103792_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12782","article-title":"Chronic endometritis in patients with unexplained infertility: prevalence and effects of antibiotic treatment on spontaneous conception","volume":"79","author":"Cicinelli","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2019.103792_bib2","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1186\/cc11666","article-title":"Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis","volume":"16","author":"Alfieri","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.micpath.2019.103792_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.intimp.2014.07.015","article-title":"Liver X receptor agonist prevents LPS-induced mastitis in mice","volume":"22","author":"Fu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.micpath.2019.103792_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-014-1965-y","article-title":"3,4,5-trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo","volume":"390","author":"Lee","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.micpath.2019.103792_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1210\/en.2005-1113","article-title":"Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus","volume":"147","author":"Herath","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.micpath.2019.103792_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.fertnstert.2007.03.074","article-title":"Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies","volume":"89","author":"Cicinelli","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2019.103792_bib7","doi-asserted-by":"crossref","first-page":"27583","DOI":"10.1038\/srep27583","article-title":"Abrogating ClC-3 inhibits LPS-induced inflammation via blocking the TLR4\/NF-kappaB pathway","volume":"6","author":"Xiang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2019.103792_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vetmic.2018.10.031","article-title":"PI3K\/Akt\/mTOR signaling pathway participates in Streptococcus uberis-induced inflammation in mammary epithelial cells in concert with the classical TLRs\/NF-kB pathway","volume":"227","author":"Li","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2019.103792_bib9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.theriogenology.2006.04.006","article-title":"Pathogenesis and treatment of endometritis in the mare: a review","volume":"66","author":"Hurtgen","year":"2006","journal-title":"Theriogenology"},{"key":"10.1016\/j.micpath.2019.103792_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12976","article-title":"Amelioration of Escherichia coli-induced endometritis with ascorbic acid in non-pregnant mouse models","volume":"80","author":"Bafor","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2019.103792_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/aji.12438","article-title":"Chronic endometritis: potential cause of infertility and obstetric and neonatal complications","volume":"75","author":"Kitaya","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2019.103792_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment Pharmacol. Ther."},{"key":"10.1016\/j.micpath.2019.103792_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood","volume":"28","author":"Cummings","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.micpath.2019.103792_bib14","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.micpath.2019.103792_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jnutbio.2011.01.007","article-title":"Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis","volume":"23","author":"Vieira","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.micpath.2019.103792_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2018.05.006","article-title":"Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness","volume":"350","author":"Seth","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.micpath.2019.103792_bib17","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1111\/bph.13976","article-title":"Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide","volume":"174","author":"Wang","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.micpath.2019.103792_bib18","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/acs.jafc.6b02304","article-title":"Engeletin alleviates lipopolysaccharide-induced endometritis in mice by inhibiting TLR4-mediated NF-kappaB activation","volume":"64","author":"Wu","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.micpath.2019.103792_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3082805","article-title":"Indirubin treatment of lipopolysaccharide-induced mastitis in a mouse model and activity in mouse mammary epithelial cells","volume":"2017","author":"Lai","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.micpath.2019.103792_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2014.11.002","article-title":"Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-kappaB signal pathway","volume":"24","author":"Fu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.micpath.2019.103792_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000478-199002000-00008","article-title":"Endometrial histopathology in patients with culture-proved upper genital tract infection and laparoscopically diagnosed acute salpingitis","volume":"14","author":"Kiviat","year":"1990","journal-title":"Am. J. Surg. Pathol."},{"issue":"Suppl 2","key":"10.1016\/j.micpath.2019.103792_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2527\/1999.77suppl_2101x","article-title":"Inflammation in the bovine female reproductive tract","volume":"77","author":"Bondurant","year":"1999","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.micpath.2019.103792_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.fertnstert.2018.04.012","article-title":"Endometritis: new time, new concepts","volume":"110","author":"Kitaya","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2019.103792_bib24","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2460\/javma.1984.185.10.1194","article-title":"Therapeutic strategies involving antimicrobial treatment of the uterus in large animals","volume":"185","author":"Gustafsson","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.micpath.2019.103792_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0749-0720(15)30759-3","article-title":"Pharmacologic considerations in the management of peripartum conditions in the cow","volume":"8","author":"Gilbert","year":"1992","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"10.1016\/j.micpath.2019.103792_bib26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0749-0720(15)31132-4","article-title":"Rationale for treatment of endometritis in the dairy cow","volume":"3","author":"Bretzlaff","year":"1987","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"10.1016\/j.micpath.2019.103792_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0022-1759(92)90200-D","article-title":"cDNA clones of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) from human blood mononuclear cells differentiated into granulocyte precursors in liquid cultures","volume":"154","author":"Romano","year":"1992","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.micpath.2019.103792_bib28","doi-asserted-by":"crossref","first-page":"16542","DOI":"10.1074\/jbc.270.28.16542","article-title":"Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils","volume":"270","author":"Domigan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2019.103792_bib29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/34923","article-title":"Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils","volume":"391","author":"Eiserich","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2019.103792_bib30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/modpathol.2010.98","article-title":"Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis","volume":"23","author":"Kitaya","year":"2010","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.micpath.2019.103792_bib31","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1071\/RD09120","article-title":"Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis","volume":"22","author":"Fischer","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.micpath.2019.103792_bib32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.freeradbiomed.2016.04.022","article-title":"Variant innate immune responses of mammary epithelial cells to challenge by Staphylococcus aureus, Escherichia coli and the regulating effect of taurine on these bioprocesses","volume":"96","author":"Zheng","year":"2016","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.micpath.2019.103792_bib33","first-page":"91","article-title":"Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings","volume":"11","author":"Dinarello","year":"1997","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.micpath.2019.103792_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0753-3322(94)90005-1","article-title":"Cytokines and macrophages","volume":"48","author":"Cavaillon","year":"1994","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.micpath.2019.103792_bib35","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0024-3205(03)00490-9","article-title":"Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes","volume":"73","author":"Cavaglieri","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2019.103792_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1465-9921-11-33","article-title":"Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"11","author":"Ni","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.micpath.2019.103792_bib37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nutres.2008.02.012","article-title":"Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells","volume":"28","author":"Usami","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.micpath.2019.103792_bib38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jnutbio.2010.07.009","article-title":"Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils","volume":"22","author":"Vinolo","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.micpath.2019.103792_bib39","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3390\/biom5031266","article-title":"NF-kappaB signaling in chronic inflammatory airway disease","volume":"5","author":"Schuliga","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.micpath.2019.103792_bib40","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1073\/pnas.92.21.9618","article-title":"Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons","volume":"92","author":"Kaltschmidt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.micpath.2019.103792_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature12143","article-title":"Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH","volume":"497","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2019.103792_bib42","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1349-7006.2011.01904.x","article-title":"Histone deacetylase inhibitors block nuclear factor-kappaB-dependent transcription by interfering with RNA polymerase II recruitment","volume":"102","author":"Furumai","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.micpath.2019.103792_bib43","doi-asserted-by":"crossref","first-page":"15383","DOI":"10.1074\/jbc.M609166200","article-title":"Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha","volume":"282","author":"Horion","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019314111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019314111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:27:35Z","timestamp":1760110055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401019314111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":43,"alternative-id":["S0882401019314111"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103792","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium butyrate alleviates lipopolysaccharide-induced endometritis in mice through inhibiting inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103792","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103792"}}