{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:37:06Z","timestamp":1772087826835,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Defence"},{"name":"National Science Foundation"},{"DOI":"10.13039\/501100004488","name":"HRZZ","doi-asserted-by":"publisher","award":["IP-2016-06-9003"],"award-info":[{"award-number":["IP-2016-06-9003"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.micpath.2019.103937","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T19:43:55Z","timestamp":1576611835000},"page":"103937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The role of B cells in an early immune response to Mycobacterium bovis"],"prefix":"10.1016","volume":"140","author":[{"given":"Zuzana","family":"Krocova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Plzakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Pavkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Kubelkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ales","family":"Macela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Ozanic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Marecic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirna","family":"Mihelcic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Santic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2019.103937_bib1","first-page":"1","article-title":"Research progress on immune response of B lymphocytes and anti-Mycobacterium tuberculosis infection","volume":"5","author":"You","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.micpath.2019.103937_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/imr.12276","article-title":"B cells and antibodies in the defense against Mycobacterium tuberculosis infection","volume":"264","author":"Achkar","year":"2015","journal-title":"Immunol. Rev."},{"issue":"Suppl 3","key":"10.1016\/j.micpath.2019.103937_bib3","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1093\/cid\/civ614","article-title":"B in TB: B cells as mediators of clinically relevant immune responses in tuberculosis","volume":"61","author":"Rao","year":"2015","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"issue":"4","key":"10.1016\/j.micpath.2019.103937_bib4","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.imbio.2015.12.003","article-title":"Human B cells have an active phagocytic capability and undergo immune activation upon phagocytosis of Mycobacterium tuberculosis","volume":"221","author":"Zhu","year":"2016","journal-title":"Immunobiology"},{"issue":"6","key":"10.1016\/j.micpath.2019.103937_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/rccm.201707-1475OC","article-title":"B cells producing type I IFN modulate macrophage polarization in tuberculosis","volume":"197","author":"B\u00e9nard","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.micpath.2019.103937_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/imm.12909","article-title":"Both B-1a and B-1b cells exposed to Mycobacterium tuberculosis lipids differentiate into IgM antibody-secreting cells","volume":"154","author":"Ordo\u00f1ez","year":"2018","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.micpath.2019.103937_bib7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.imbio.2010.01.003","article-title":"B-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection","volume":"215","author":"Russo","year":"2010","journal-title":"Immunobiology. prosinec"},{"issue":"3","key":"10.1016\/j.micpath.2019.103937_bib8","first-page":"1227","article-title":"B cells delay neutrophil migration toward the site of stimulus: tardiness critical for effective bacillus Calmette-Gu\u00e9rin vaccination against tuberculosis infection in mice","volume":"1","author":"Kondratieva","year":"1950","journal-title":"J Immunol Baltim Md"},{"key":"10.1016\/j.micpath.2019.103937_bib9","author":"Lerm"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.191.2.287","article-title":"Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages","volume":"191","author":"Malik","year":"2000","journal-title":"J Exp Med. 17. leden"},{"issue":"47","key":"10.1016\/j.micpath.2019.103937_bib11","doi-asserted-by":"crossref","first-page":"20441","DOI":"10.1073\/pnas.1013827107","article-title":"Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting","volume":"107","author":"Joller","year":"2010","journal-title":"Proc Natl Acad Sci U S A. 23. listopad"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1440-1843.1996.tb00021.x","article-title":"Effect of antibacterial antibody on bactericidal activities of superoxide and lysosomal enzyme from alveolar macrophages in rabbits","volume":"1","author":"Suga","year":"1996","journal-title":"Respirol Carlton Vic. \u010derven"},{"issue":"10","key":"10.1016\/j.micpath.2019.103937_bib13","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1128\/IAI.73.10.6711-6720.2005","article-title":"Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies","volume":"73","author":"de Valli\u00e8re","year":"2005","journal-title":"Infect Immun. \u0159\u00edjen"},{"issue":"1","key":"10.1016\/j.micpath.2019.103937_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1128\/IAI.68.1.335-341.2000","article-title":"Clearance and organ distribution of Mycobacterium tuberculosis lipoarabinomannan (LAM) in the presence and absence of LAM-binding immunoglobulin M","volume":"68","author":"Glatman-Freedman","year":"2000","journal-title":"Infect Immun. leden"},{"issue":"1","key":"10.1016\/j.micpath.2019.103937_bib15","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1038\/s41598-018-22307-8","article-title":"A highly potent and broadly neutralizing H1 influenza-specific human monoclonal antibody","volume":"8","author":"Nogales","year":"2018","journal-title":"Sci Rep. 12. b\u0159ezen"},{"issue":"3","key":"10.1016\/j.micpath.2019.103937_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0147-9571(02)00039-5","article-title":"In vitro study of Listeria monocytogenes infection to murine primary and human transformed B cells","volume":"26","author":"Menon","year":"2003","journal-title":"Comp Immunol Microbiol Infect Dis. kv\u011bten"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micpath.2008.01.010","article-title":"Interaction of B cells with intracellular pathogen Francisella tularensis","volume":"45","author":"Krocova","year":"2008","journal-title":"Microb Pathog. srpen"},{"key":"10.1016\/j.micpath.2019.103937_bib18","article-title":"Antigen phagocytosis by B cells is required for a potent humoral response","volume":"9","author":"Mart\u00ednez-Ria\u00f1o","year":"2018","journal-title":"EMBO Rep."},{"issue":"1 Spec No","key":"10.1016\/j.micpath.2019.103937_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0378-1119(95)00706-7","article-title":"Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions","volume":"173","author":"Valdivia","year":"1996","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cellimm.2008.07.002","article-title":"Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection","volume":"254","author":"Pecora","year":"2009","journal-title":"Cell. Immunol."},{"issue":"16","key":"10.1016\/j.micpath.2019.103937_bib22","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1016\/j.molimm.2009.07.015","article-title":"Multiple routes of complement activation by Mycobacterium bovis BCG","volume":"46","author":"Carroll","year":"2009","journal-title":"Mol Immunol. 1. \u0159\u00edjen"},{"issue":"5","key":"10.1016\/j.micpath.2019.103937_bib23","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1084\/jem.140.5.1336","article-title":"Receptor for the fourth component of complement on human B lymphocytes and cultured human lymphoblastoid cells","volume":"140","author":"Bokisch","year":"1974","journal-title":"J Exp Med. 31. \u0159\u00edjen"},{"issue":"3","key":"10.1016\/j.micpath.2019.103937_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0882-4010(03)00099-8","article-title":"Macrophage\u2014Mycobacterium tuberculosis interactions: role of complement receptor 3","volume":"35","author":"Velasco-Vel\u00e1zquez","year":"2003","journal-title":"Microb Pathog. 1. z\u00e1\u0159\u00ed"},{"issue":"7","key":"10.1016\/j.micpath.2019.103937_bib25","first-page":"2771","article-title":"Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3","volume":"1","author":"Schlesinger","year":"1950","journal-title":"J Immunol Baltim Md"},{"issue":"11","key":"10.1016\/j.micpath.2019.103937_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050667","article-title":"Selective infection of antigen-specific B lymphocytes by Salmonella mediates bacterial survival and systemic spreading of infection","volume":"7","author":"Souwer","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.micpath.2019.103937_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132571","article-title":"Entry of Francisella tularensis into murine B cells: the role of B cell receptors and complement receptors","volume":"10","author":"Plzakova","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.micpath.2019.103937_bib28","first-page":"5379","article-title":"A critical role for complement C3d and the B cell coreceptor (CD19\/CD21) complex in the initiation of inflammatory arthritis","volume":"15","author":"Del Nagro","year":"1950","journal-title":"J Immunol Baltim Md"},{"key":"10.1016\/j.micpath.2019.103937_bib29","author":"Borhis"},{"key":"10.1016\/j.micpath.2019.103937_bib30","author":"Sindhava"},{"key":"10.1016\/j.micpath.2019.103937_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2162-3619-1-36","article-title":"CD19: a biomarker for B cell development, lymphoma diagnosis and therapy","volume":"1","author":"Wang","year":"2012","journal-title":"Exp. Hematol. Oncol."},{"issue":"14","key":"10.1016\/j.micpath.2019.103937_bib32","doi-asserted-by":"crossref","first-page":"9108","DOI":"10.1074\/jbc.272.14.9108","article-title":"Signaling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line the activation OF lyn tyrosine kinase and the MITOGEN-ACTIVATED protein kinase pathway","volume":"272","author":"Holland","year":"1997","journal-title":"J Biol Chem. 4. duben"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib33","first-page":"77","article-title":"The role of B lymphocytes as antigen-presenting cells. Arch Immunol Ther Exp (Warsz)","volume":"56","author":"Chen","year":"2008","journal-title":"duben"},{"key":"10.1016\/j.micpath.2019.103937_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.micpath.2014.08.009","article-title":"B cell subsets are activated and produce cytokines during early phases of Francisella tularensis LVS infection","volume":"75","author":"Plzakova","year":"2014","journal-title":"Microb Pathog. \u0159\u00edjen"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib35","first-page":"115","article-title":"Presentation of antigen by B cells subsets. I. Lyb-5+ and Lyb-5- B cells differ in ability to stimulate antigen specific T cells","volume":"42","author":"Zimecki","year":"1994","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"3","key":"10.1016\/j.micpath.2019.103937_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.coi.2008.03.003","article-title":"Cytokine-producing B lymphocytes\u2014key regulators of immunity","volume":"20","author":"Lund","year":"2008","journal-title":"Curr Opin Immunol. \u010derven"},{"issue":"3","key":"10.1016\/j.micpath.2019.103937_bib37","first-page":"421","article-title":"Cytokine-producing effector B cells regulate type 2 immunity to H. Polygyrus. Immunity. 20","volume":"30","author":"Wojciechowski","year":"2009","journal-title":"b\u0159ezen"},{"issue":"8","key":"10.1016\/j.micpath.2019.103937_bib38","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/infdis\/jit037","article-title":"Role of interleukin 6 in innate immunity to Mycobacterium tuberculosis infection","volume":"207","author":"Martinez","year":"2013","journal-title":"J Infect Dis. 15. duben"},{"issue":"1","key":"10.1016\/j.micpath.2019.103937_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.186.1.39","article-title":"Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis","volume":"186","author":"Cooper","year":"1997","journal-title":"J Exp Med. 7. \u010dervenec"},{"issue":"2","key":"10.1016\/j.micpath.2019.103937_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cyto.2007.11.022","article-title":"IL-23 and IL-17 in tuberculosis","volume":"41","author":"Khader","year":"2008","journal-title":"Cytokine. \u00fanor"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019313099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019313099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:25:41Z","timestamp":1760109941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401019313099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":39,"alternative-id":["S0882401019313099"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103937","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of B cells in an early immune response to Mycobacterium bovis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2019.103937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103937"}}