{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:24Z","timestamp":1760145564733,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.micpath.2020.104038","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:42:11Z","timestamp":1580730131000},"page":"104038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Degeneration of the intestinal microbial community in PI3K\u03b3-knockout mice"],"prefix":"10.1016","volume":"142","author":[{"given":"Yi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104038_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3892\/ijmm.2014.1981","article-title":"PI3K\/AKT\/PTEN pathway as a target for Crohn's disease therapy (Review)","volume":"35","author":"Tokuhira","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.micpath.2020.104038_bib2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/lam.13067","article-title":"Enterococcus faecium HDRsEf1 elevates the intestinal barrier defense against enterotoxigenic Escherichia coli and regulates occludin expression via activation of TLR-2 and PI3K signalling pathways","volume":"67","author":"Yan","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2020.104038_bib3","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1097\/MIB.0b013e318281f5a3","article-title":"Induced and natural regulatory T cells in the development of inflammatory bowel disease","volume":"19","author":"Mayne","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.micpath.2020.104038_bib4","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.3390\/ijms17111858","article-title":"The multifaceted roles of PI3K\u03b3 in hypertension, vascular biology, and inflammation","volume":"17","author":"Perrotta","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2020.104038_bib5","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bmcl.2018.02.032","article-title":"Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3K\u03b3 isoform selective activity","volume":"28","author":"Srinivas","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.micpath.2020.104038_bib6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood-2017-05-786566","article-title":"Duvelisib, a novel oral dual inhibitor of PI3K-\u03b4,\u03b3, is clinically active in advanced hematologic malignancies","volume":"131","author":"Flinn","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.micpath.2020.104038_bib7","series-title":"Management of Animal Care and Use Programs in Research, Education, and Testing","first-page":"11","article-title":"Culture of care: organizational responsibilities","author":"Brown","year":"2018"},{"key":"10.1016\/j.micpath.2020.104038_bib8","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1111\/jgh.14281","article-title":"Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation","volume":"33","author":"Chen","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2020.104038_bib9","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1038\/emi.2016.25","article-title":"Fecal bacterial microbiome diversity in chronic HIV-infected patients in China","volume":"5","author":"Sun","year":"2016","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.micpath.2020.104038_bib10","series-title":"Egu General Assembly Conference","article-title":"Changes in landscape diversity induced by climate over a Mediterranean region","author":"Acampora","year":"2010"},{"key":"10.1016\/j.micpath.2020.104038_bib11","first-page":"663","article-title":"[Correlation between gut microbiota and behavior symptoms in children with autism spectrum disorder]","volume":"21","author":"Zhao","year":"2019","journal-title":"Zhong Guo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.micpath.2020.104038_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.fm.2018.06.010","article-title":"Viral community predicts the geographical origin of fermented vegetable foods more precisely than bacterial community","volume":"76","author":"Jung","year":"2018","journal-title":"Food Microbiol."},{"key":"10.1016\/j.micpath.2020.104038_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12917-018-1690-y","article-title":"Modulation of intestinal microbiota, morphology and mucin composition by dietary insect meal inclusion in free-range chickens","volume":"14","author":"Biasato","year":"2018","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.micpath.2020.104038_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189021","article-title":"On the calculation of betweenness centrality in marine connectivity studies using transfer probabilities","volume":"12","author":"Costa","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104038_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-4939-8728-3_11","article-title":"Predicting the functional potential of the microbiome from marker genes using PICRUSt","volume":"1849","author":"Douglas","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micpath.2020.104038_bib16","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1182\/blood-2007-04-086751","article-title":"Inactivation of PI3K\u03b3 and PI3K\u03b4 distorts T-cell development and causes multiple organ inflammation","volume":"110","author":"Ji","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.micpath.2020.104038_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00171-16","article-title":"Lifestyle and horizontal gene transfer-mediated evolution of Mucispirillum schaedleri, a core member of the murine gut microbiota","volume":"2","author":"Loy","year":"2017","journal-title":"mSystems"},{"key":"10.1016\/j.micpath.2020.104038_bib18","first-page":"1","article-title":"[Experimental study of the effect of succinate of 1-phenylpropanol on biliary function; its importance as a choleretic]","volume":"9","author":"Bouhairi","year":"1957","journal-title":"Rev. Bras. Gastroenterol."},{"key":"10.1016\/j.micpath.2020.104038_bib19","first-page":"1679","article-title":"[Studies on the choleretic action of 1-phenylpropanol]","volume":"81","author":"Brugel","year":"1956","journal-title":"DMW (Dtsch. Med. Wochenschr.)"},{"key":"10.1016\/j.micpath.2020.104038_bib20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.numecd.2018.06.013","article-title":"Thiamine deficiency and cardiovascular disorders","volume":"28","author":"Eshak","year":"2018","journal-title":"Nutr. Metabol. Cardiovasc. Dis. : Nutr. Metabol. Cardiovasc. Dis."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019317255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401019317255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:26:58Z","timestamp":1760110018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401019317255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":20,"alternative-id":["S0882401019317255"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104038","relation":{},"ISSN":["0882-4010"],"issn-type":[{"type":"print","value":"0882-4010"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degeneration of the intestinal microbial community in PI3K\u03b3-knockout mice","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104038"}}