{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:54:48Z","timestamp":1788990888341,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305036\/2017-3"],"award-info":[{"award-number":["305036\/2017-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.micpath.2020.104123","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T12:37:18Z","timestamp":1583843838000},"page":"104123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Cryptococcus neoformans\/Cryptococcus gattii species complex melanized by epinephrine: Increased yeast survival after amphotericin B exposure"],"prefix":"10.1016","volume":"143","author":[{"given":"Raimunda S\u00e2mia Norgueira","family":"Brilhante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gleiciane da","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathas Sales de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemiro Aquino","family":"Pereira-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Morgana de Melo","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana de Aguiar","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J\u00falio Costa","family":"Sidrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos F\u00e1bio Gadelha","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora de Souza Collares Maia","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104123_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2016.167","article-title":"Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy","volume":"13","author":"Williamson","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.micpath.2020.104123_bib2","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760180057","article-title":"Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain","volume":"113","author":"Esher","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.micpath.2020.104123_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fgb.2014.09.004","article-title":"Virulence mechanisms and Cryptococcus neoformans pathogenesis","volume":"919","author":"Alspaugh","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.micpath.2020.104123_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.01463","article-title":"Fungal melanin: what do we know about structure?","volume":"6","author":"Nosanchuk","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104123_bib5","first-page":"9","article-title":"Melanin production at 37 C is linked to the high virulent Cryptococcus gattii Vancouver Island outbreak genotype VGIIa","volume":"28","author":"Ngamskulrungroj","year":"2009","journal-title":"Australas. Mycologist"},{"key":"10.1016\/j.micpath.2020.104123_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02267-19","article-title":"Unraveling melanin biosynthesis and signaling networks in Cryptococcus neoformans","volume":"10","author":"Lee","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2020.104123_bib7","doi-asserted-by":"crossref","first-page":"10471","DOI":"10.1074\/jbc.RA119.008684","article-title":"The structural unit of melanin in the cell wall of the fungal pathogen Cryptococcus neoformans","volume":"294","author":"Camacho","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2020.104123_bib8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00253-011-3777-2","article-title":"Synthesis and assembly of fungal melanin","volume":"93","author":"Eisenman","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2020.104123_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrmicro.2015.6","article-title":"Cryptococcus: from environmental saprophyte to global pathogen","volume":"14","author":"May","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2020.104123_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.FUNK-0037-2016","article-title":"Melanin, radiation, and energy transduction in fungi","volume":"5","author":"Casadevall","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.micpath.2020.104123_bib11","series-title":"Atlas of Clinical Fungi","author":"De Hoog","year":"2008"},{"key":"10.1016\/j.micpath.2020.104123_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3201\/eid0902.020246","article-title":"Molecular typing of Ibero American Cryptococcus neoformans isolates","volume":"9","author":"Meyer","year":"2003","journal-title":"Emerg. Infect. Dis. J."},{"key":"10.1016\/j.micpath.2020.104123_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/myc.12650","article-title":"An alternative method for the analysis of melanin production in Cryptococcus neoformans sensu lato and Cryptococcus gattii sensu lato","volume":"60","author":"Brilhante","year":"2017","journal-title":"Mycoses"},{"key":"10.1016\/j.micpath.2020.104123_bib14","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing ofYeasts: Approved Standard. CLSI Document M27-A3","author":"CLSI","year":"2008"},{"key":"10.1016\/j.micpath.2020.104123_bib15","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1128\/AAC.48.7.2477-2482.2004","article-title":"Patterns of amphotericin B killing kinetics against seven Candida species","volume":"48","author":"Cant\u00f3n","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2020.104123_bib16","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.fgb.2005.09.003","article-title":"Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates","volume":"42","author":"Garcia-Rivera","year":"2005","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.micpath.2020.104123_bib17","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1021\/bi300325m","article-title":"Using solid-state NMR to monitor the molecular consequences of Cryptococcus neoformans melanization with different catecholamine precursors","volume":"51","author":"Chatterjee","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.micpath.2020.104123_bib18","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1128\/AAC.38.11.2648","article-title":"Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B","volume":"38","author":"Wang","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2020.104123_bib19","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1128\/AAC.46.11.3394-3400.2002","article-title":"Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin","volume":"46","author":"Van Duin","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2020.104123_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1348-0421.2003.tb03395.x","article-title":"Effects of melanin upon susceptibility of Cryptococcus to antifungals","volume":"47","author":"Ikeda","year":"2003","journal-title":"Microbiol. Immunol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020304101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020304101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:29:29Z","timestamp":1778542169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020304101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":20,"alternative-id":["S0882401020304101"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104123","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptococcus neoformans\/Cryptococcus gattii species complex melanized by epinephrine: Increased yeast survival after amphotericin B exposure","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104123"}}