{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:16:36Z","timestamp":1774934196235,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"am","delay-in-days":296,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602080"],"award-info":[{"award-number":["31602080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31860691"],"award-info":[{"award-number":["31860691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0500304"],"award-info":[{"award-number":["2017YFD0500304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.micpath.2020.104201","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T02:15:16Z","timestamp":1587348916000},"page":"104201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Functional analysis of Bucella reveals transcriptional regulation of MarR"],"prefix":"10.1016","volume":"144","author":[{"given":"Xingmei","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104201_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007366","article-title":"Brucellosis awareness and knowledge in communities worldwide: a systematic review and meta-analysis of 79 observational studies","volume":"13","author":"Zhang","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2020.104201_bib2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.vetmic.2019.04.025","article-title":"Phylogeography and epidemiology of Brucella suis biovar 2 in wildlife and domestic swine","volume":"233","author":"Munoz","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2020.104201_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.actatropica.2018.10.002","article-title":"Brucellosis seroprevalence in dairy cattle in China during 2008-2018: a systematic review and meta-analysis","volume":"189","author":"Ran","year":"2019","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2020.104201_bib4","first-page":"1","article-title":"The intracellular life cycle of Brucella spp","volume":"7","author":"Jean","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.micpath.2020.104201_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2020.104201_bib6","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1016\/j.cub.2013.01.013","article-title":"MarR family transcription factors","volume":"23","author":"Grove","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.micpath.2020.104201_bib7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.csbj.2017.06.001","article-title":"Regulation of metabolic pathways by MarR family transcription factors","volume":"15","author":"Grove","year":"2017","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.micpath.2020.104201_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1574-6976.2012.00334.x","article-title":"Internal affairs: investigating the Brucella intracellular lifestyle","volume":"36","author":"Von Bargen","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.micpath.2020.104201_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s002390010207","article-title":"Common history at the origin of the position-function correlation in transcriptional regulators in archaea and bacteria","volume":"53","author":"P-R","year":"2001","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.micpath.2020.104201_bib10","doi-asserted-by":"crossref","first-page":"19237","DOI":"10.1002\/jcp.28720","article-title":"Biology of MarR family transcription factors and implications for targets of antibiotics against tuberculosis","volume":"234","author":"Gong","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.micpath.2020.104201_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00039-18","article-title":"MarR family transcription factors from Burkholderia species: hidden clues to control of virulence-associated genes","volume":"83","author":"Gupta","year":"2019","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micpath.2020.104201_bib12","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.3389\/fmicb.2018.01358","article-title":"SAV4189, a MarR-family regulator in Streptomyces avermitilis, activates avermectin biosynthesis","volume":"9","author":"Guo","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104201_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11274-017-2230-9","article-title":"Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages","volume":"33","author":"Li","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2020.104201_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071933","article-title":"Impact of Hfq on global gene expression and intracellular survival in Brucella melitensis","volume":"8","author":"Cui","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104201_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.micpath.2018.08.052","article-title":"Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant","volume":"124","author":"Li","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2020.104201_bib16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11274-016-2015-6","article-title":"The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB\/c mice","volume":"32","author":"Zhang","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2020.104201_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jobm.201900458","article-title":"ChIP-seq analysis of Brucella reveals transcriptional regulation of GntR","volume":"60","author":"Li","year":"2020","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.micpath.2020.104201_bib18","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1093\/nar\/gkx165","article-title":"ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network","volume":"45","author":"Kleinman","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2020.104201_bib19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2020.104201_bib20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2020.104201_bib21","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2020.104201_bib22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2020.104201_bib23","doi-asserted-by":"crossref","first-page":"W369","DOI":"10.1093\/nar\/gkl198","article-title":"MEME: discovering and analyzing DNA and protein sequence motifs","volume":"34","author":"Bailey","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2020.104201_bib24","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2020.104201_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micpath.2020.104201_bib26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12859-018-2472-z","article-title":"Automated generation of genome-scale metabolic draft reconstructions based on KEGG","volume":"19","author":"Karlsen","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.micpath.2020.104201_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212 \u0394\u0394CT) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2020.104201_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12223-019-00691-6","article-title":"Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen","volume":"65","author":"Avila-Calderon","year":"2020","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.micpath.2020.104201_bib29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.resmic.2005.10.002","article-title":"Surviving inside a macrophage: the many ways of Brucella","volume":"157","author":"Celli","year":"2006","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.micpath.2020.104201_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.phrs.2009.01.009","article-title":"Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: pivotal roles of NF-kappaB and MAPK","volume":"59","author":"Kang","year":"2009","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.micpath.2020.104201_bib31","doi-asserted-by":"crossref","first-page":"E8460","DOI":"10.1073\/pnas.1800431115","article-title":"Circadian clock protein BMAL1 regulates IL-1 beta in macrophages via NRF2","volume":"115","author":"Early","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micpath.2020.104201_bib32","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.3389\/fimmu.2019.03049","article-title":"Complement receptor-mediated phagocytosis induces proinflammatory cytokine production in murine macrophages","volume":"10","author":"Acharya","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2020.104201_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2020.104201_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000210","article-title":"Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models","volume":"8","author":"Zhang","year":"2020","journal-title":"Journal for ImmunoTherapy of Cancer"},{"key":"10.1016\/j.micpath.2020.104201_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/589494","article-title":"Host susceptibility to Brucella abortus infection is more pronounced in IFN-\u00e3 knockout than IL-12\/\u00e22-microglobulin double-deficient mice","author":"Brand\u00e3o","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.micpath.2020.104201_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.13041\/jpvm.2019.43.1.1","article-title":"Resistance to Brucella abortus 544 challenge in BALB\/c mice by inoculation of highly immunogenic multiple B. abortus antigens","volume":"43","author":"Arayan","year":"2019","journal-title":"Journal of Preventive Veterinary Medicine"},{"key":"10.1016\/j.micpath.2020.104201_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005893","article-title":"The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens","volume":"4","author":"Barquero-Calvo","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104201_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(03)00963-7","article-title":"Brucella pathogenesis, genes identified from random large-scale screens","volume":"231","author":"Delrue","year":"2004","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"key":"10.1016\/j.micpath.2020.104201_bib39","first-page":"533","article-title":"Internal affairs: investigating the Brucella intracellular lifestyle","volume":"36","author":"Von Bargen","year":"2012","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Rev."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020304885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020304885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:43:40Z","timestamp":1774928620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020304885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":39,"alternative-id":["S0882401020304885"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104201","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional analysis of Bucella reveals transcriptional regulation of MarR","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104201"}}