{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:40:23Z","timestamp":1792035623462,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011760","name":"Chettinad Academy of Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.micpath.2020.104415","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T03:25:05Z","timestamp":1595993105000},"page":"104415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Temporal changes of NF-\u03baB signaling pathway genes in bacterial stimulated whole blood- a host mechanism associated with sepsis"],"prefix":"10.1016","volume":"147","author":[{"given":"Athira","family":"Anirudhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabu","family":"Paramasivam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Murugesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiek S.S.J.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.micpath.2020.104415_bib1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/jth.13061","article-title":"New paradigms in sepsis: from prevention to protection of failing microcirculation","volume":"13","author":"Hawiger","year":"2015","journal-title":"J. Thromb. Haemostasis"},{"issue":"4","key":"10.1016\/j.micpath.2020.104415_bib2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nrg3905","article-title":"Evolutionary insights into host-pathogen interactions from mammalian sequence data","volume":"16","author":"Sironi","year":"2015","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.micpath.2020.104415_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ccm.2016.01.002","article-title":"The changing epidemiology and definitions of sepsis","volume":"37","author":"Kempker","year":"2016","journal-title":"Clin. Chest Med."},{"issue":"4","key":"10.1016\/j.micpath.2020.104415_bib4","article-title":"Does Celiac disease influence survival in sepsis? A nationwide longitudinal study","volume":"28","author":"Tjernberg","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.micpath.2020.104415_bib5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1513\/AnnalsATS.201411-498BC","article-title":"Trends in sepsis and infection sources in the United States.A population-based study","volume":"12","author":"Walkey","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"5","key":"10.1016\/j.micpath.2020.104415_bib6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect. Dis."},{"issue":"8","key":"10.1016\/j.micpath.2020.104415_bib7","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","article-title":"Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program","volume":"42","author":"Ferrer","year":"2014","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.micpath.2020.104415_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0885066611408690","article-title":"Early diagnosis and evidence-based care of surgical sepsis","volume":"28","author":"Moore","year":"2013","journal-title":"J. Intensive Care Med."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12916-015-0335-2","article-title":"Recognizing and managing sepsis: what needs to be done?","volume":"27","author":"Yealy","year":"2015","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"issue":"6","key":"10.1016\/j.micpath.2020.104415_bib11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/apa.12201","article-title":"Toll\u2010like receptors in neonatal sepsis","volume":"102","author":"O'Hare","year":"2013","journal-title":"Acta. Paediatr."},{"issue":"7","key":"10.1016\/j.micpath.2020.104415_bib12","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1073\/pnas.0808146106","article-title":"Protection from lethal gram-negative bacterial sepsis by targeting Toll- like receptor 4","volume":"106","author":"Roger","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/jmg.2006.044446","article-title":"IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease","volume":"44","author":"Ku","year":"2007","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2010.177","article-title":"Non-canonical NF-\u03baB signaling pathway","volume":"21","author":"Sun","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.micpath.2020.104415_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.micpath.2020.104415_bib16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/2211068214567345","article-title":"Sepsis pathogen identification","volume":"20","author":"Chun","year":"2015","journal-title":"J. Lab. Autom."},{"issue":"4","key":"10.1016\/j.micpath.2020.104415_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/CS20050086","article-title":"Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis","volume":"109","author":"Bustin","year":"2005","journal-title":"Clin. Sci."},{"issue":"1\u20132","key":"10.1016\/j.micpath.2020.104415_bib18","first-page":"82","article-title":"Espinoand Francheska Rivera, Quantitation of cytokine mRNA by real-time RT-PCR during a vaccination trial in a rabbit model of fascioliasis","volume":"169","author":"Ana","year":"2010","journal-title":"Vet. Parasitol."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib19","first-page":"55","article-title":"Comparative analysis of inflammatory markers produced by macrophages inoculated with invasive and colonizing strains of Streptococcus Agalactiae (group B Streptococcus) and evaluation of patients' clinical data","volume":"13","author":"Hosseini","year":"2017","journal-title":"Malaysian Journal of Medicine and Health Sciences"},{"issue":"11","key":"10.1016\/j.micpath.2020.104415_bib20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1177\/009127009803801101","article-title":"Nuclear factor kappa B: important transcription factor and therapeutic target","volume":"38","author":"Lee","year":"1998","journal-title":"J. Clin. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.micpath.2020.104415_bib21","first-page":"131","article-title":"Causative bacteria and antibiotic resistance in neonatal sepsis","volume":"24","author":"Najeeb","year":"2012","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"10.1016\/j.micpath.2020.104415_bib22","article-title":"Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis","volume":"20","author":"Sivanandan","year":"2011","journal-title":"Int. J. Pediatr."},{"issue":"8","key":"10.1016\/j.micpath.2020.104415_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/1753425915606525","article-title":"Vascular endothelial cell Toll-like receptor pathways in sepsis","volume":"21","author":"Khakpour","year":"2015","journal-title":"Innate Immun."},{"issue":"4","key":"10.1016\/j.micpath.2020.104415_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting Toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-065X.2011.01088.x","article-title":"The noncanonical NF\u2010\u03baB pathway","volume":"246","author":"Sun","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2020.104415_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1875041901104010031","article-title":"Pathogen associated molecular patterns, pattern recognition receptors and pediatric sepsis","volume":"4","author":"Doughty","year":"2011","journal-title":"Open Inflamm. J."},{"issue":"10","key":"10.1016\/j.micpath.2020.104415_bib27","doi-asserted-by":"crossref","first-page":"4502","DOI":"10.1128\/MCB.24.10.4502-4512.2004","article-title":"TRAF family proteins link PKR with NF-\u03baB activation","volume":"24","author":"Gil","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/cr.2010.161","article-title":"A single NF\u03baB system for both canonical and non- canonical signaling","volume":"21","author":"Shih","year":"2011","journal-title":"Cell Res."},{"issue":"32","key":"10.1016\/j.micpath.2020.104415_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.coi.2015.01.007","article-title":"Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity","volume":"28","author":"Yang","year":"2015","journal-title":"Curr. Opin. Immunol."},{"issue":"4","key":"10.1016\/j.micpath.2020.104415_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.micpath.2020.104415_bib31","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.placenta.2007.05.003","article-title":"Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection","volume":"28","author":"Ma","year":"2007","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.micpath.2020.104415_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrd2781","article-title":"Is NF-\u03baB a good target for cancer therapy? Hopes and pitfalls","volume":"8","author":"Baud","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.micpath.2020.104415_bib33","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1128\/CVI.00009-10","article-title":"HIV-1 reactivation induced by the periodontal pathogens Fusobacteriumnucleatum and Porphyromonasgingivalis involves toll- like receptor 4 and 9 activation in monocytes\/macrophages","volume":"17","author":"Gonz\u00e1lez","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"issue":"3","key":"10.1016\/j.micpath.2020.104415_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/intimm\/dxh052","article-title":"Toll\u2010like receptor 4 plays a protective role in pulmonary tuberculosis in mice","volume":"16","author":"Branger","year":"2004","journal-title":"Int. Immunol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020307816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020307816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:38:45Z","timestamp":1760110725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020307816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":34,"alternative-id":["S0882401020307816"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104415","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal changes of NF-\u03baB signaling pathway genes in bacterial stimulated whole blood- a host mechanism associated with sepsis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104415"}}