{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:31:02Z","timestamp":1786537862860,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.micpath.2020.104417","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T13:27:24Z","timestamp":1595856444000},"page":"104417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Bovine leukemia virus relation to human breast cancer: Meta-analysis"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0046","authenticated-orcid":false,"given":"Andrew","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-7027","authenticated-orcid":false,"given":"Valentina L.","family":"Kouznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-8947","authenticated-orcid":false,"given":"Igor F.","family":"Tsigelny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104417_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2013.00328","article-title":"Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus","volume":"4","author":"Aida","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104417_bib2","series-title":"Veterinary Services Centers for Epidemiology and Animal Health","author":"Usda","year":"2008"},{"key":"10.1016\/j.micpath.2020.104417_bib3","series-title":"Field Studies on the Control of Bovine Leukemia Virus in Dairy Cows - ProQuest, search.proquest.Com","author":"Ruggiero","year":"2019"},{"key":"10.1016\/j.micpath.2020.104417_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1742-4690-4-18","article-title":"Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human","volume":"4","author":"Gillet","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.micpath.2020.104417_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1460-2075.1989.tb03403.x","article-title":"Bovine leukemia virus trans-activator p38tax activates heterologous promoters with a common sequence known as a cAMP-responsive element or the binding site of a cellular transcription factor ATF","volume":"8","author":"Katoh","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.micpath.2020.104417_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-4690-1-20","article-title":"Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity","volume":"1","author":"Azran","year":"2004","journal-title":"Retrovirology"},{"key":"10.1016\/j.micpath.2020.104417_bib7","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/sj.onc.1201765","article-title":"Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation","volume":"16","author":"Willems","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.micpath.2020.104417_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15264","article-title":"Cis-perturbation of cancer drivers by the HTLV-1\/BLV proviruses is an early determinant of leukemogenesis","volume":"8","author":"Rosewick","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2020.104417_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14312\/2052-4994.2019-1","article-title":"HTLV-1 can be involved in acceleration of different nonhematological cancers","volume":"7","author":"Kouznetsova","year":"2019","journal-title":"Journal of Cancer Research & Therapy"},{"key":"10.1016\/j.micpath.2020.104417_bib10","first-page":"155","volume":"vol. 33","author":"Mori","year":"1994"},{"key":"10.1016\/j.micpath.2020.104417_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/088922202753472829","article-title":"Short communication: monoclonally integrated HTLV type 1 in epithelial cancers from rabbits infected with an HTLV type 1 molecular clone","volume":"18","author":"Zhao","year":"2002","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.micpath.2020.104417_bib12","first-page":"2365","article-title":"Pathology of lymphosarcoma in sheep induced with bovine leukemia virus","volume":"36","author":"Olson","year":"1976","journal-title":"Canc. Res."},{"key":"10.1016\/j.micpath.2020.104417_bib13","first-page":"521","article-title":"Pathobiology of bovine leukemia virus","volume":"25","author":"Schwartz","year":"1994","journal-title":"Vet. Res."},{"key":"10.1016\/j.micpath.2020.104417_bib14","first-page":"691","article-title":"Human cells of neural origin are permissive for bovine leukemia virus","volume":"36","author":"Altaner","year":"1989","journal-title":"Neoplasma"},{"key":"10.1016\/j.micpath.2020.104417_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134304","article-title":"Exposure to bovine leukemia virus is associated with breast cancer: a case-control study","volume":"10","author":"Buehring","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104417_bib16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1089\/088922203771881202","article-title":"Humans have antibodies reactive with Bovine leukemia virus","volume":"19","author":"Buehring","year":"2003","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.micpath.2020.104417_bib17","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/cncr.31169","article-title":"Bovine leukemia virus linked to breast cancer but not coinfection with human papillomavirus: case-control study of women in Texas","volume":"124","author":"Baltzell","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.micpath.2020.104417_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-019-3891-9","article-title":"Bovine leukemia virus discovered in human blood","volume":"19","author":"Buehring","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104417_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/bjc.2016.213","article-title":"Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung","volume":"115","author":"Robinson","year":"2016","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.micpath.2020.104417_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-39834-7","article-title":"Bovine leukemia virus DNA associated with breast cancer in women from South Brazil","volume":"9","author":"Schwingel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2020.104417_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-016-0763-8","article-title":"Lack of association between bovine leukemia virus and breast cancer in Chinese patients","volume":"18","author":"Zhang","year":"2016","journal-title":"Breast Canc. Res."},{"key":"10.1016\/j.micpath.2020.104417_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-017-0808-7","article-title":"Response to \u2018Lack of association between bovine leukemia virus and breast cancer in Chinese patients","volume":"19","author":"Buehring","year":"2017","journal-title":"Breast Canc. Res."},{"key":"10.1016\/j.micpath.2020.104417_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00270566","article-title":"Prevalence of primary adult lactose malabsorption in three populations of northern China","volume":"67","author":"Yongfa","year":"1984","journal-title":"Hum. Genet."},{"key":"10.1016\/j.micpath.2020.104417_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.30699\/acadpub.mci.4.16","article-title":"Bovine leukemia virus presence in breast tissue of Argentinian women. Its association with cell proliferation and prognosis markers","volume":"2","author":"Carolina Ceriani","year":"2018","journal-title":"Multidisciplinary Cancer Investigation"},{"key":"10.1016\/j.micpath.2020.104417_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179367","article-title":"Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development","volume":"12","author":"Buehring","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104417_bib26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4236\/ojmm.2013.31013","article-title":"Bovine leukemia virus gene segment detected in human breast tissue","volume":"3","author":"Giovanna","year":"2013","journal-title":"Open J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2020.104417_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00705-019-04474-9","article-title":"Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines","volume":"165","author":"Saito","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2020.104417_bib28","series-title":"Bolivia, a Country Study","author":"Hudson","year":"1950"},{"key":"10.1016\/j.micpath.2020.104417_bib29","first-page":"1047","article-title":"Breast cancer incidence in Mongolia","volume":"23","author":"Troisi","year":"2012","journal-title":"Cancer Causes Control: CCC (Cancer Causes Control)"},{"key":"10.1016\/j.micpath.2020.104417_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/ijc.29466","article-title":"Dairy cattle serum and milk factors contributing to the risk of colon and breast cancers","volume":"137","author":"zur Hausen","year":"2015","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2020.104417_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10911-018-9397-z","article-title":"Can bovine leukemia virus Be related to human breast cancer? A review of the evidence","volume":"23","author":"Martinez Cuesta","year":"2018","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.micpath.2020.104417_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/bjc.2014.544","article-title":"Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden","volume":"112","author":"Ji","year":"2014","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.micpath.2020.104417_bib33","article-title":"Breast cancer gone viral? Review of possible role of bovine leukemia virus in breast cancer, and related opportunities for cancer prevention","volume":"17","author":"Buehring","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.micpath.2020.104417_bib34","first-page":"16","article-title":"Abstract B30: bovine leukemia virus in breast tissue linked to increased cell proliferation and breast cancer risk","author":"Buehring","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.micpath.2020.104417_bib35","article-title":"Bovine leukosis virus (BLV) on U.S","volume":"2008","author":"Nahms","year":"2007","journal-title":"Dairy Operations"},{"key":"10.1016\/j.micpath.2020.104417_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s12977-016-0308-3","article-title":"Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA","volume":"13","author":"Gillet","year":"2016","journal-title":"Retrovirology"},{"key":"10.1016\/j.micpath.2020.104417_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.qai.0000557948.28872.4c","article-title":"A-108 HTLV-1\/BLV genomic approaches to understanding ATL","volume":"81","author":"Van den Broeke","year":"2019","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"},{"key":"10.1016\/j.micpath.2020.104417_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103845","article-title":"Epigenetics evaluation of the oncogenic mechanisms of two closely related bovine and human deltaretroviruses: a system biology study","volume":"139","author":"Ashrafi","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2020.104417_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02615","article-title":"HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases","volume":"8","author":"Baratella","year":"2017","journal-title":"Front. Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102030783X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102030783X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:33:44Z","timestamp":1760110424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102030783X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":39,"alternative-id":["S088240102030783X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104417","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bovine leukemia virus relation to human breast cancer: Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104417"}}