{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T16:15:01Z","timestamp":1777824901864,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2018YFC1602900"],"award-info":[{"award-number":["2018YFC1602900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology innovation Plan of Shanghai","award":["19391902000"],"award-info":[{"award-number":["19391902000"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.micpath.2020.104448","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:45:20Z","timestamp":1597355120000},"page":"104448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Immunological evaluation of virulence-deficient Listeria monocytogenes strains in C57BL\/6 mice"],"prefix":"10.1016","volume":"148","author":[{"given":"Junfei","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongpo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104448_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-019-1656-7","article-title":"Immunization: vital progress, unfinished agenda","volume":"575","author":"Piot","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2020.104448_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s40121-020-00312-7","article-title":"Communicating benefits from vaccines beyond preventing infectious diseases","author":"Chevalier-Cottin","year":"2020","journal-title":"Infect. Dis. Ther.y"},{"key":"10.1016\/j.micpath.2020.104448_bib3","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.aar7112","article-title":"Personalized vaccines for cancer immunotherapy","volume":"359","author":"Sahin","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.micpath.2020.104448_bib4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1586\/14760584.2013.836914","article-title":"Live-attenuated bacteria as a cancer vaccine vector","volume":"12","author":"Toussaint","year":"2013","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.micpath.2020.104448_bib5","article-title":"White paper on microbial anti-cancer therapy and prevention","volume":"6","author":"Forbes","year":"2018","journal-title":"J. Immunother. Canc."},{"key":"10.1016\/j.micpath.2020.104448_bib6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ymthe.2006.06.011","article-title":"Anti-tumor immunotherapy via antigen delivery from a live attenuated genetically engineered Pseudomonas aeruginosa type III secretion system-based vector","volume":"14","author":"Epaulard","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.micpath.2020.104448_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw098","article-title":"Stable expression of Shigella dysenteriae serotype 1 O-antigen genes integrated into the chromosome of live Salmonella oral vaccine vector Ty21a","volume":"74","author":"Dharmasena","year":"2016","journal-title":"Pathogens and Disease"},{"key":"10.1016\/j.micpath.2020.104448_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6750-11-126","article-title":"In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli","volume":"11","author":"Andersen","year":"2011","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.micpath.2020.104448_bib9","first-page":"776","article-title":"Chimpanzee Adenovirus vector Ebola vaccine - preliminary report reply","volume":"373","author":"Ledgerwood","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micpath.2020.104448_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1473-3099(15)70043-5","article-title":"Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial","volume":"15","author":"Ramsauer","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104448_bib11","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1126\/science.1059852","article-title":"A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier","volume":"292","author":"Lecuit","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.micpath.2020.104448_bib12","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1084\/jem.20110560","article-title":"Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin","volume":"208","author":"Nikitas","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micpath.2020.104448_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.micinf.2012.12.005","article-title":"The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier","volume":"15","author":"Gruendler","year":"2013","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2020.104448_bib14","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nature07303","article-title":"Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis","volume":"455","author":"Disson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2020.104448_bib15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2958.2002.03176.x","article-title":"Critical role of the N-terminal residues of listeriolysin O in phagosomal escape and virulence of Listeria monocytogenes","volume":"46","author":"Lety","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2020.104448_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.281.5373.105","article-title":"Interaction of human Arp 2\/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation","volume":"281","author":"Welch","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.micpath.2020.104448_bib17","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.micpath.2020.104448_bib18","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1128\/IAI.69.3.1795-1807.2001","article-title":"Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice","volume":"69","author":"Guleria","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104448_bib19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1053::AID-IMMU1053>3.0.CO;2-N","article-title":"Substantial in vivo proliferation of CD4(+) and CD8(+) T lymphocytes during secondary Listeria monocytogenes infection","volume":"30","author":"Mittrucker","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1586\/erv.13.34","article-title":"Live-attenuated listeria-based immunotherapy","volume":"12","author":"Rothman","year":"2013","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.micpath.2020.104448_bib21","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/CJI.0000000000000000","article-title":"Listeria monocytogenes (Lm)-LLO immunotherapies reduce the immunosuppressive activity of myeloid-derived suppressor cells and regulatory T cells in the tumor microenvironment","volume":"36","author":"Wallecha","year":"2013","journal-title":"J. Immunother."},{"key":"10.1016\/j.micpath.2020.104448_bib22","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1073\/pnas.1211287110","article-title":"Nontoxic radioactive Listeria(at) is a highly effective therapy against metastatic pancreatic cancer","volume":"110","author":"Quispe-Tintaya","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2020.104448_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/cmi.2013.64","article-title":"Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells","volume":"11","author":"Yang","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib24","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/bjc.2013.206","article-title":"Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice","volume":"108","author":"Chandra","year":"2013","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.micpath.2020.104448_bib25","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1158\/0008-5472.CAN-08-3160","article-title":"Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection","volume":"69","author":"Stark","year":"2009","journal-title":"Canc. Res."},{"key":"10.1016\/j.micpath.2020.104448_bib26","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.4049\/jimmunol.175.6.3663","article-title":"Fusion to listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2\/neu and reveals subdominant epitopes in the FVB\/N mouse","volume":"175","author":"Singh","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib27","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1158\/0008-5472.CAN-07-0573","article-title":"Live attenuated Listeria Monocytogenes effectively treats hepatic colorectal cancer Metastases and is strongly enhanced by depletion of regulatory T cells","volume":"67","author":"Yoshimura","year":"2007","journal-title":"Canc. Res."},{"key":"10.1016\/j.micpath.2020.104448_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ijc.10759","article-title":"Oral vaccination with recombinant Listeria monocytogenes expressing human papillomavirus type 16 E7 can cause tumor growth in mice to regress","volume":"102","author":"Lin","year":"2002","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2020.104448_bib29","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1158\/1078-0432.CCR-11-2121","article-title":"A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing Mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction","volume":"18","author":"Le","year":"2012","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.micpath.2020.104448_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micpath.2018.04.059","article-title":"Evaluation of Caco-2 cells response to Listeria monocytogenes virulence factors by RT-PCR","volume":"120","author":"Xie","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2020.104448_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micpath.2020.104448_bib32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/IAI.66.2.747-755.1998","article-title":"Comprehensive study of the intestinal stage of listeriosis in a rat ligated ileal loop system","volume":"66","author":"Pron","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104448_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/gene.2011.86","article-title":"CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments","volume":"13","author":"Zinzow-Kramer","year":"2012","journal-title":"Gene Immun."},{"key":"10.1016\/j.micpath.2020.104448_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0021-9975(92)90090-H","article-title":"A microbiological, histopathological and immunohistological study of the intragastric inoculation of Listeria monocytogenes in mice","volume":"107","author":"Marco","year":"1992","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.micpath.2020.104448_bib35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4049\/jimmunol.173.1.420","article-title":"Listerta monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy","volume":"173","author":"Starks","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib36","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/jcs.115.17.3357","article-title":"InIB, a surface protein of Listeria monocytogenes that behaves as an invasin and a growth factor","volume":"115","author":"Bierne","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.micpath.2020.104448_bib37","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0092-8674(00)81070-3","article-title":"E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells","volume":"84","author":"Mengaud","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2020.104448_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.15.1.297","article-title":"Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches","volume":"15","author":"Constant","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2958.1996.tb02494.x","article-title":"Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes","volume":"20","author":"Guzman","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2020.104448_bib40","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1128\/JB.186.18.6265-6276.2004","article-title":"A novel mutation within the central Listeria monocytogenes regulator PrfA that results in constitutive expression of virulence gene products","volume":"186","author":"Wong","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2020.104448_bib41","doi-asserted-by":"crossref","first-page":"13832","DOI":"10.1073\/pnas.0406035101","article-title":"Listeria-based cancer vaccines that segregate immunogenicity from toxicity","volume":"101","author":"Brockstedt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2020.104448_bib42","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.4049\/jimmunol.167.11.6471","volume":"167","author":"Gunn","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2020.104448_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/cgt.2010.48","article-title":"Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her 2\/neu-overexpressing cancers in human","volume":"18","author":"Shahabi","year":"2011","journal-title":"Canc. Gene Ther."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:31:01Z","timestamp":1760110261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020308147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":43,"alternative-id":["S0882401020308147"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104448","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological evaluation of virulence-deficient Listeria monocytogenes strains in C57BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104448"}}