{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:48:19Z","timestamp":1790725699211,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"FUNCAP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.micpath.2020.104453","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T11:42:17Z","timestamp":1597923737000},"page":"104453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Potentiation of antibiotic activity by chalcone (E)-1-(4\u2032-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one against gram-positive and gram-negative MDR strains"],"prefix":"10.1016","volume":"148","author":[{"given":"Carlos A.N.","family":"Ferraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo R.","family":"Tintino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-2076","authenticated-orcid":false,"given":"Alexandre M.R.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo N.","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lcio S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz G.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.S.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talysson F.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-7120","authenticated-orcid":false,"given":"Raimundo L.S.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Diniz M.","family":"Sena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-4715","authenticated-orcid":false,"given":"Thiago S.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina E.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104453_bib1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1517\/13543776.14.12.1669","article-title":"Recent advances in therapeutic chalcones","volume":"14","author":"Ni","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.micpath.2020.104453_bib2","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1021\/acs.chemrev.7b00020","article-title":"Chalcone: a privileged structure in medicinal chemistry","volume":"117","author":"Zhuang","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.micpath.2020.104453_bib3","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.bmc.2009.12.077","article-title":"Synthesis and biological screening of a combinatorial library of \u03b2-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents","volume":"18","author":"Bandgar","year":"2010","journal-title":"Biorg Med Chem"},{"key":"10.1016\/j.micpath.2020.104453_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejmech.2015.05.004","article-title":"Anti-cancer chalcones: structural and molecular target perspectives","volume":"98","author":"Mahapatra","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib5","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-04-3803","article-title":"A novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice","volume":"65","author":"Zi","year":"2005","journal-title":"Canc. Res."},{"key":"10.1016\/j.micpath.2020.104453_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejmech.2005.05.008","article-title":"New syntheses and potential antimalarial activities of new \u2018retinoid-like chalcones\u2019","volume":"41","author":"Valla","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib7","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bmcl.2009.12.062","article-title":"Synthesis, antimalarial and antitubercular activity of acetylenic chalcones","volume":"20","author":"Hans","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.micpath.2020.104453_bib8","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.bmc.2016.04.045","article-title":"Synthesis and bioevaluation of substituted chalcones, coumaranones and other flavonoids as anti-HIV agents","volume":"24","author":"Cole","year":"2016","journal-title":"Biorg Med Chem"},{"key":"10.1016\/j.micpath.2020.104453_bib9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/cbdv.200900027","article-title":"Screening of biological activities of a series of chalcone derivatives against human pathogenic microorganisms","volume":"7","author":"Karaman","year":"2010","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.micpath.2020.104453_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ardp.200400929","article-title":"Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones","volume":"338","author":"Boeck","year":"2005","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.micpath.2020.104453_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1747-0285.2009.00793.x","article-title":"Synthesis, biological evaluation, mechanism of action and quantitative structure\u2013activity relationship studies of chalcones as antibacterial agents","volume":"73","author":"Sivakumar","year":"2009","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.micpath.2020.104453_bib12","first-page":"38","article-title":"Synthesis and Antimicrobial screening of Chalcones containing imidazo [1,2-a] pyridine nucleus","volume":"3","author":"Bhale","year":"2013","journal-title":"Res. J. Chem. Sci."},{"key":"10.1016\/j.micpath.2020.104453_bib13","series-title":"Staphylococcus aureus: Microbiology, Pathology, Immunology, Therapy and Prophylaxis","first-page":"263","article-title":"Bacteremia, sepsis, and infective endocarditis associated with Staphylococcus aureus","author":"Bergin","year":"2017"},{"key":"10.1016\/j.micpath.2020.104453_bib14","first-page":"82","article-title":"Synthesis and antimicrobial activity of 1-(2'',4''-dichlorophenyl)-3-(substituted aryl)-2-propene-1-ones","volume":"2","author":"Mohammad","year":"2012","journal-title":"Int. J. Life Sci. Biotechnol. Pharma Res."},{"key":"10.1016\/j.micpath.2020.104453_bib15","doi-asserted-by":"crossref","unstructured":"Rasheed MU, Thajuddin N, Ahamed P, Teklemariam Z, Jamil K. Antimicrobial drug resistance in strains of Escherichia coli isolated from food sources, Rev Inst Med Trop. 56 341-346. https:\/\/doi.org\/10.1590\/S0036-46652014000400012..","DOI":"10.1590\/S0036-46652014000400012"},{"key":"10.1016\/j.micpath.2020.104453_bib16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molstruc.2018.11.075","article-title":"Structural, spectroscopic and microbiological characterization of the chalcone 2E-1-(2\u02b9-hydroxy-3\u02b9,4\u02b9,6\u02b9-trimethoxyphenyl)-3-(phenyl)-prop-2-en-1-one derived from the natural product 2-hydroxy-3,4,6-trimethoxyacetophenone","volume":"1179","author":"Teixeira","year":"2019","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.micpath.2020.104453_bib17","first-page":"25","article-title":"Antibiotics and bacterial resistance in the 21st century","volume":"6","author":"Fair","year":"2014","journal-title":"Perspect. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000151267","article-title":"Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. And chlorpromazine","volume":"54","author":"Coutinho","year":"2008","journal-title":"Chemotherapy"},{"key":"10.1016\/j.micpath.2020.104453_bib19","doi-asserted-by":"crossref","first-page":"24204","DOI":"10.1039\/C7RA01705G","article-title":"Effect of solvent polarity on the photophysical properties of chalcone derivatives","volume":"7","author":"Kumari","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.micpath.2020.104453_bib20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00044-019-02434-1","article-title":"Synthesis, structural characterization, and cytotoxic evaluation of chalcone derivatives","volume":"28","author":"Bandeira","year":"2019","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.micpath.2020.104453_bib21","doi-asserted-by":"crossref","first-page":"103133","DOI":"10.1016\/j.bioorg.2019.103133","article-title":"Chalcone derivatives and their antibacterial activities: current development","volume":"91","author":"Xu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2016.02.041","article-title":"Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities","volume":"113","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","article-title":"Medicinal plants and antimicrobial activity","volume":"100","author":"R\u00edos","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.micpath.2020.104453_bib24","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ejmech.2008.05.010","article-title":"Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted","volume":"44","author":"Batovska","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104453_bib25","doi-asserted-by":"crossref","first-page":"128358","DOI":"10.1016\/j.molstruc.2020.128358","article-title":"Structural, vibrational and electrochemical analysis and antibiotic activity study of chalcone (2E)-1-(3\u02b9,-methoxy-4\u02b9,-hydroxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one","volume":"1216","author":"Garcia","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.micpath.2020.104453_bib26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1089\/mdr.2018.0359","article-title":"Structural and microbiological characterization of 5-hydroxy-3,7,4\u2032-trimethoxyflavone: a flavonoid isolated from vitex gardneriana schauer leaves","volume":"25","author":"Macedo","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.micpath.2020.104453_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jep.2018.12.012","article-title":"Antibacterial and antibiotic modifying activity evaluation of ruminants' body fat used as zootherapeutics in ethnoveterinary practices in Northeast Brazil","volume":"233","author":"de Queiroz Dias","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.micpath.2020.104453_bib28","first-page":"1","article-title":"Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin - resistant Staphylococcus aureus by Turnera ulmifolia L","volume":"9","author":"Coutinho","year":"2009","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.micpath.2020.104453_bib29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.micpath.2020.104453_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.micpath.2019.04.015","article-title":"Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"131","author":"U\u0161jak","year":"2019","journal-title":"Microb. Pathog."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:32:00Z","timestamp":1760110320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020308196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"alternative-id":["S0882401020308196"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104453","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potentiation of antibiotic activity by chalcone (E)-1-(4\u2032-aminophenyl)-3-(furan-2-yl)-prop-2-en-1-one against gram-positive and gram-negative MDR strains","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104453"}}