{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:41:20Z","timestamp":1790692880361,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["111,056,934,589"],"award-info":[{"award-number":["111,056,934,589"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016837","name":"Universidad del Quind\u00edo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017923","name":"Alliance Fran\u00e7aise contre les Maladies Parasitaires","doi-asserted-by":"publisher","award":["070304"],"award-info":[{"award-number":["070304"]}],"id":[{"id":"10.13039\/100017923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017923","name":"Alliance Fran\u00e7aise contre les Maladies Parasitaires","doi-asserted-by":"publisher","award":["ANR-11-LABX-0024"],"award-info":[{"award-number":["ANR-11-LABX-0024"]}],"id":[{"id":"10.13039\/100017923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013367","name":"Universidad Tecnol\u00f3gica de Pereira","doi-asserted-by":"publisher","award":["5-11-3"],"award-info":[{"award-number":["5-11-3"]}],"id":[{"id":"10.13039\/501100013367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013367","name":"Universidad Tecnol\u00f3gica de Pereira","doi-asserted-by":"publisher","award":["5-14-1"],"award-info":[{"award-number":["5-14-1"]}],"id":[{"id":"10.13039\/501100013367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013409","name":"Sistema General de Regal\u00edas de Colombia","doi-asserted-by":"publisher","award":["BPIN 2012000100050"],"award-info":[{"award-number":["BPIN 2012000100050"]}],"id":[{"id":"10.13039\/501100013409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.micpath.2020.104465","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T02:26:51Z","timestamp":1598495211000},"page":"104465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Serotyping, host genes and cytokines response in human ocular toxoplasmosis"],"prefix":"10.1016","volume":"148","author":[{"given":"Luz Eliana","family":"Mantilla-Muriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Hern\u00e1ndez-de-los-R\u00edos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"de-la-Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Murillo-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie France","family":"Cesbron-Delauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-1904","authenticated-orcid":false,"given":"Corinne","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Sep\u00falveda-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Enrique","family":"Gomez-Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104465_bib1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/apha.12458","article-title":"Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases","volume":"213","author":"Xiao","year":"2015","journal-title":"Acta Physiol."},{"key":"10.1016\/j.micpath.2020.104465_bib2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1093\/infdis\/jit313","article-title":"Toxoplasma serotype is associated with development of ocular toxoplasmosis","volume":"208","author":"Shobab","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/322800","article-title":"Unusual abundance of atypical strains associated with human ocular toxoplasmosis","volume":"184","author":"Grigg","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.micinf.2008.04.001","article-title":"Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America","volume":"10","author":"Morisset","year":"2008","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2020.104465_bib5","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1128\/CVI.00092-09","article-title":"Selection of polymorphic peptides from GRA6 and GRA7 sequences of Toxoplasma gondii strains to be used in serotyping","volume":"16","author":"Sousa","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.micpath.2020.104465_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fcimb.2019.00368","article-title":"Testing new peptides from Toxoplasma gondii SAG1, GRA6, and GRA7 for serotyping: better definition using GRA6 in mother\/newborns pairs with risk of congenital transmission in Mexico","volume":"9","author":"Xicot\u00e9ncatl-Garc\u00eda","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2020.104465_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.actatropica.2018.01.013","article-title":"Polymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American setting","volume":"184","author":"G\u00f3mez Mar\u00edn","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2020.104465_bib8","doi-asserted-by":"crossref","first-page":"e00597","DOI":"10.1128\/IAI.00597-17","article-title":"Genetic polymorphisms in cytokine genes in Colombian patients with ocular toxoplasmosis","volume":"86","author":"Naranjo-Galvis","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104465_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S0074-02762009000300009","article-title":"The IFN-gamma +874T\/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility","volume":"104","author":"de Albuquerque","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.micpath.2020.104465_bib10","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1167\/iovs.07-1393","article-title":"Interleukin-10 gene polymorphism (-1082G\/A) is associated with toxoplasmic retinochoroiditis","volume":"49","author":"Cordeiro","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.micpath.2020.104465_bib11","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1136\/bjo.2008.140590","article-title":"TNF-alpha gene polymorphism (-308G\/A) and toxoplasmic retinochoroiditis","volume":"92","author":"Cordeiro","year":"2008","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.micpath.2020.104465_bib12","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1111\/aos.12046","article-title":"Interleukin-6 gene polymorphism (-174 G\/C) is associated with toxoplasmic retinochoroiditis","volume":"91","author":"Cordeiro","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.micpath.2020.104465_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijpara.2013.09.007","article-title":"New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis","volume":"44","author":"Pfaff","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2020.104465_bib14","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.micinf.2006.03.023","article-title":"Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)","volume":"8","author":"Peyron","year":"2006","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2020.104465_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12879-018-3613-8","article-title":"Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin","volume":"19","author":"de-la-Torre","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4303\/jnp\/N110402","article-title":"Detection of Toxoplasma DNA in the peripheral blood of HIV-positive patients with neuro-opportunistic infections by a real-time PCR assay","volume":"2","author":"Cardona N","year":"2011","journal-title":"J. Neuroparasitol."},{"key":"10.1016\/j.micpath.2020.104465_bib17","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1128\/JCM.41.8.3537-3541.2003","article-title":"Comparison of enzyme-linked immunosorbent assay, immunoblotting, and PCR for diagnosis of toxoplasmic chorioretinitis","volume":"41","author":"Villard","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2020.104465_bib18","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1128\/CVI.00186-08","article-title":"Use of GRA6-derived synthetic polymorphic peptides in an immunoenzymatic assay to serotype Toxoplasma gondii in human serum samples collected from three continents","volume":"15","author":"Sousa","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.micpath.2020.104465_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002541","article-title":"Severe South American ocular toxoplasmosis is associated with decreased Ifn-\u03b3\/Il-17a and increased Il-6\/Il-13 intraocular levels","volume":"7","author":"de-la-Torre","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00430-014-0339-0","article-title":"Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis","volume":"203","author":"Torres-Morales","year":"2014","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.micpath.2020.104465_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cyto.2014.03.005","article-title":"Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis","volume":"68","author":"de-la-Torre","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.micpath.2020.104465_bib22","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.parint.2013.10.012","article-title":"Characterization of ROP18 alleles in human toxoplasmosis","volume":"63","author":"S\u00e1nchez","year":"2014","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.micpath.2020.104465_bib23","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1133690","article-title":"Polymorphic secreted kinases are key virulence factors in toxoplasmosis","volume":"314","author":"Saeij","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.micpath.2020.104465_bib24","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1101\/gr.5318106","article-title":"Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii","volume":"16","author":"Khan","year":"2006","journal-title":"Genome Res."},{"issue":"9","key":"10.1016\/j.micpath.2020.104465_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003182","article-title":"Geographic separation of domestic and wild strains of Toxoplasma gondii in French guiana correlates with a monomorphic version of Chromosome1a","volume":"8","author":"Khan","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib26","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1371\/journal.pntd.0000277","article-title":"Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe","volume":"2","author":"Gilbert","year":"2008","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2020.104465_bib27","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/infdis\/jiu189","article-title":"Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines","volume":"210","author":"Pernas","year":"2014","journal-title":"J. Infect. Dis."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:34:04Z","timestamp":1760110444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020308317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":27,"alternative-id":["S0882401020308317"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104465","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotyping, host genes and cytokines response in human ocular toxoplasmosis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104465"}}