{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:40:04Z","timestamp":1790732404186,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.micpath.2020.104500","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T11:44:03Z","timestamp":1599824643000},"page":"104500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Antibacterial and anti-quorum sensing activities of a substituted thiazole derivative against methicillin-resistant Staphylococcus aureus and other multidrug-resistant bacteria"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-4876","authenticated-orcid":false,"given":"Yasser Musa","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-8628","authenticated-orcid":false,"given":"Ahmed Megahed","family":"Abouwarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-9765","authenticated-orcid":false,"given":"Tamer","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-8011","authenticated-orcid":false,"given":"Farghaly Abdelhamid","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Bondock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2020.104500_bib1","article-title":"An update on clinical burden, diagnostic tools, and therapeutic options of Staphylococcus aureus","volume":"10","author":"Reddy","year":"2017","journal-title":"Inf. Disp."},{"key":"10.1016\/j.micpath.2020.104500_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13065-020-00669-3","article-title":"A review on quinoline derivatives as anti-methicillin resistant Staphylococcus aureus (MRSA) agents","volume":"14","author":"Kumar","year":"2020","journal-title":"BMC Chem"},{"key":"10.1016\/j.micpath.2020.104500_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13059-017-1252-9","article-title":"Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice","volume":"18","author":"Harkins","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.micpath.2020.104500_bib4","series-title":"Antimicrobial Resistance","year":"2018"},{"key":"10.1016\/j.micpath.2020.104500_bib5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus bacteremia","volume":"25","author":"van Hal","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2020.104500_bib6","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.3390\/s120302519","article-title":"Quorum sensing and bacterial social interactions in biofilms","volume":"12","author":"Li","year":"2012","journal-title":"Sensors"},{"key":"10.1016\/j.micpath.2020.104500_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s00284-010-9812-1","article-title":"Cross-species induction of antimicrobial compounds, biosurfactants and quorum-sensing inhibitors in tropical marine epibiotic bacteria by pathogens and biofouling microorganisms","volume":"62","author":"Dusane","year":"2011","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib8","first-page":"67","article-title":"Quorum sensing inhibition, relevance to periodontics","volume":"7","author":"Yada","year":"2015","journal-title":"J. Int. Oral Health"},{"key":"10.1016\/j.micpath.2020.104500_bib9","first-page":"637","article-title":"Inhibition of bacterial quorum sensing by vanilla extract","volume":"42","author":"Choo","year":"2006","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib10","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1099\/00221287-143-12-3703","article-title":"Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones","volume":"143","author":"McClean","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2020.104500_bib11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/17415990500322792","article-title":"Synthesis and biological activity of natural thiazoles: an important class of heterocyclic compounds","volume":"26","author":"de Souza","year":"2005","journal-title":"J. Sulfur Chem."},{"key":"10.1016\/j.micpath.2020.104500_bib12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ejmech.2012.12.050","article-title":"Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents","volume":"62","author":"Bondock","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104500_bib13","first-page":"1","article-title":"Evaluation of fosfomycin combined with vancomycin against vancomycin-resistant coagulase negative staphylococci","author":"Ibrahim","year":"2020","journal-title":"J. Chemother."},{"key":"10.1016\/j.micpath.2020.104500_bib14","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2018"},{"key":"10.1016\/j.micpath.2020.104500_bib15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.micpath.2020.104500_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1128\/AAC.1.4.283","article-title":"Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate","volume":"1","author":"O'Callaghan","year":"1972","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2020.104500_bib17","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1128\/jcm.29.10.2240-2244.1991","article-title":"Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction","volume":"29","author":"Murakami","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/infdis\/153.2.332","article-title":"Usefulness of a test for slime production as a marker for clinically significant infections with coagulase-negative staphylococci","volume":"153","author":"Davenport","year":"1986","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104500_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10482-015-0503-6","article-title":"Isoprenyl caffeate, a major compound in manuka propolis, is a quorum-sensing inhibitor in Chromobacterium violaceum","volume":"108","author":"Gemiarto","year":"2015","journal-title":"Antonie Van Leeuwenhoek"},{"key":"10.1016\/j.micpath.2020.104500_bib20","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3389\/fmicb.2017.01767","article-title":"Antimicrobial and antibiofilm potential of acyclic amines and diamines against multi-drug resistant Staphylococcus aureus","volume":"8","author":"Kaur","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093414","article-title":"The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations","volume":"9","author":"Burt","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2020.104500_bib22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.str.2008.02.011","article-title":"Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding","volume":"16","author":"Sidote","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.micpath.2020.104500_bib23","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.0510439103","article-title":"Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus","volume":"103","author":"Liu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micpath.2020.104500_bib24","article-title":"Antibacterial characterization of novel synthetic thiazole compounds against methicillin-resistant Staphylococcus pseudintermedius","volume":"10","author":"Mohammad","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2020.104500_bib25","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/acs.jmedchem.7b00392","article-title":"Investigating the antibacterial activity of biphenylthiazoles against methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA)","volume":"60","author":"Hagras","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.micpath.2020.104500_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4155\/fmc-2017-0159","article-title":"Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of Staphylococcus aureus","volume":"10","author":"Zheng","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.micpath.2020.104500_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3947\/ic.2016.48.4.267","article-title":"Treatment of methicillin-resistant Staphylococcus aureus bacteremia","volume":"48","author":"Choo","year":"2016","journal-title":"Infect. Chemother."},{"key":"10.1016\/j.micpath.2020.104500_bib28","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.3389\/fmicb.2018.02723","article-title":"Factors contributing to the evolution of mecA-mediated beta-lactam resistance in staphylococci: update and new insights from whole genome sequencing (WGS)","volume":"9","author":"Miragaia","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib29","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1007\/s00018-005-5148-6","article-title":"Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome","volume":"62","author":"Fuda","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.micpath.2020.104500_bib30","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jac\/dkl393","article-title":"Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin","volume":"58","author":"French","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2020.104500_bib31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1086\/381972","article-title":"Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections","volume":"38","author":"Pankey","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104500_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum sensing in bacteria","volume":"55","author":"Miller","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/BA20090072","article-title":"Microbial quorum sensing: a tool or a target for antimicrobial therapy?","volume":"54","author":"Raina","year":"2009","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.micpath.2020.104500_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tim.2017.10.005","article-title":"Quorum-sensing systems as targets for antivirulence therapy","volume":"26","author":"Defoirdt","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib35","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.3390\/s130506217","article-title":"Plant-derived natural products as sources of anti-quorum sensing compounds","volume":"13","author":"Koh","year":"2013","journal-title":"Sensors"},{"key":"10.1016\/j.micpath.2020.104500_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/md17020080","article-title":"Quorum sensing inhibitors from marine microorganisms and their synthetic derivatives","volume":"17","author":"Chen","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.micpath.2020.104500_bib37","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.apjtm.2017.07.022","article-title":"Recent research advances on Chromobacterium violaceum","volume":"10","author":"Kothari","year":"2017","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.micpath.2020.104500_bib38","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1128\/IAI.00046-11","article-title":"Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis","volume":"79","author":"Cheung","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104500_bib39","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1086\/533591","article-title":"Pathogenesis of methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Gordon","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104500_bib40","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00253-020-10349-w","article-title":"Prevention of biofilm formation by quorum quenching","volume":"104","author":"Paluch","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2020.104500_bib41","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1038\/s41598-018-26483-5","article-title":"Antimicrobial and anti-biofilm activity of hexadentated macrocyclic complex of copper (II) derived from thiosemicarbazide against Staphylococcus aureus","volume":"8","author":"Brahma","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2020.104500_bib42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/acsinfecdis.9b00211","article-title":"Balancing physicochemical properties of phenylthiazole compounds with antibacterial potency by modifying the lipophilic side chain","volume":"6","author":"Mancy","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.micpath.2020.104500_bib43","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1128\/IAI.00131-10","article-title":"Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence","volume":"78","author":"Zhao","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104500_bib44","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1590\/S1415-47572009000300031","article-title":"Computational analysis suggests that virulence of Chromobacterium violaceum might be linked to biofilm formation and poly-NAG biosynthesis","volume":"32","author":"Becker","year":"2009","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.micpath.2020.104500_bib45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tim.2013.09.006","article-title":"Quorum sensing inhibitors: how strong is the evidence?","volume":"21","author":"Defoirdt","year":"2013","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib46","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1128\/IAI.71.7.4206-4211.2003","article-title":"Mutation of sarA in Staphylococcus aureus limits biofilm formation","volume":"71","author":"Beenken","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2020.104500_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrmicro2695","article-title":"Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal","volume":"10","author":"McDougald","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib48","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3389\/fmicb.2017.02409","article-title":"Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms","volume":"8","author":"Grassi","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2020.104500_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231583","article-title":"Potential combinations of endocannabinoid\/endocannabinoid-like compounds and antibiotics against methicillin-resistant Staphylococcus aureus","volume":"15","author":"Feldman","year":"2020","journal-title":"PloS One"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401020308664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:35:18Z","timestamp":1760110518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401020308664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":49,"alternative-id":["S0882401020308664"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104500","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibacterial and anti-quorum sensing activities of a substituted thiazole derivative against methicillin-resistant Staphylococcus aureus and other multidrug-resistant bacteria","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2020.104500","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104500"}}