{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:19Z","timestamp":1792793839152,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009975","name":"Charotar University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.micpath.2021.105149","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T15:06:15Z","timestamp":1629212775000},"page":"105149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis"],"prefix":"10.1016","volume":"159","author":[{"given":"Nilesh","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Raithatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajesh","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesha","family":"Choxi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutul","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-3652","authenticated-orcid":false,"given":"Neeraj","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2021.105149_bib1","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay J","year":"2020"},{"key":"10.1016\/j.micpath.2021.105149_bib2","series-title":"ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 17 June 2019","author":"de","year":"2019"},{"key":"10.1016\/j.micpath.2021.105149_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182854","article-title":"Multiple HPV genotype infection impact on invasive cervical cancer presentation and survival","volume":"12","author":"Nogueira Dias Genta","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2021.105149_bib4","first-page":"263","article-title":"Significance of multiple HPV infection in cervical cancer patients and its impact on treatment response","volume":"34","author":"Munagala","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib5","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/IGC.0b013e3181a83555","article-title":"Human papilloma virus genotyping, variants and viral load in tumors, squamous intraepithelial lesions, and controls in a north indian population subset","volume":"19","author":"Singh","year":"2009","journal-title":"Int. J. Gynecol. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib6","first-page":"531","article-title":"Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer","volume":"139","author":"Shukla","year":"2014","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.micpath.2021.105149_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.bjc.6602436","article-title":"High viral loads of human papillomavirus predict risk of invasive cervical carcinoma","volume":"92","author":"Moberg","year":"2005","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ijc.23940","article-title":"High-risk human papillomavirus DNA load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer","volume":"124","author":"Hesselink","year":"2009","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib9","first-page":"49","article-title":"Cervicitis: a review","volume":"21","author":"Lusk","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105149_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejogrb.2008.03.009","article-title":"Genital tract infections and infertility","volume":"140","author":"Pellati","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.micpath.2021.105149_bib11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3892\/ol.2015.2884","article-title":"Link between chronic inflammation and human papillomavirus-induced carcinogenesis","volume":"9","author":"Fernandes","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.micpath.2021.105149_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2011.00098","article-title":"Chronic inflammation in cancer development","volume":"2","author":"Multhoff","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2021.105149_bib13","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.7314\/APJCP.2013.14.6.3603","article-title":"Human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Hangzhou, China","volume":"14","author":"Shen","year":"2013","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.micpath.2021.105149_bib14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijgo.2012.07.032","article-title":"Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China","volume":"120","author":"Liu","year":"2013","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.micpath.2021.105149_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/ijgc-00009577-200501000-00013","article-title":"Human papillomavirus (HPV) genotyping by HPV DNA chip in cervical cancer and precancerous lesions","volume":"15","author":"Lee","year":"2005","journal-title":"Int. J. Gynecol. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/dc.23301","article-title":"Association between the human papillomavirus, bacterial vaginosis and cervicitis and the detection of abnormalities in cervical smears from teenage girls and young women","volume":"43","author":"Caixeta","year":"2015","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.micpath.2021.105149_bib17","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.9930","article-title":"Detection of human papillomavirus in chronic cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma","volume":"7","author":"Mirzaie-Kashani","year":"2014","journal-title":"Jundishapur J. Microbiol."},{"key":"10.1016\/j.micpath.2021.105149_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12879-016-2136-4","article-title":"HPV Genotypes distribution in Indian women with and without cervical carcinoma: implication for HPV vaccination program in Odisha, Eastern India","volume":"17","author":"Senapati","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105149_bib19","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1056\/NEJM199210293271804","article-title":"A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection","volume":"327","author":"Koutsky","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.micpath.2021.105149_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1699-0463.1995.tb01106.x","article-title":"Significance of inflammatory cervical smears","volume":"103","author":"Parashari","year":"1995","journal-title":"APMIS"},{"key":"10.1016\/j.micpath.2021.105149_bib21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/CEJ.0000000000000023","article-title":"Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention","volume":"23","author":"Parida","year":"2014","journal-title":"Eur. J. Canc. Prev."},{"key":"10.1016\/j.micpath.2021.105149_bib22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ygyno.2012.03.047","article-title":"Susceptibility to cervical cancer: an overview","volume":"126","author":"De Freitas","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0002-9378(95)90279-1","article-title":"Determinants of cervical ectopia and of cervicitis: age, oral contraception, specific cervical infection, smoking, and douching","volume":"173","author":"Critchlow","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.micpath.2021.105149_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/CS20070214","article-title":"Toll-like receptor polymorphisms and susceptibility to human disease","volume":"114","author":"Misch","year":"2008","journal-title":"Clin. Sci."},{"key":"10.1016\/j.micpath.2021.105149_bib25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2021.105149_bib26","article-title":"The role of TLRs in cervical cancer with HPV infection: a review","volume":"2","author":"Yang","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.micpath.2021.105149_bib27","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/j.1582-4934.2010.01127.x","article-title":"Endogenous toll-like receptor ligands and their biological significance","volume":"14","author":"Yu","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.micpath.2021.105149_bib28","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/IAI.71.6.3496-3502.2003","article-title":"Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells","volume":"71","author":"Su","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2021.105149_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.164.2.558","article-title":"Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex","volume":"164","author":"Ohashi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2021.105149_bib30","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0966-842X(00)01845-X","article-title":"The Toll receptor family and microbial recognition","volume":"8","author":"Medzhitov","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2021.105149_bib31","doi-asserted-by":"crossref","first-page":"7912","DOI":"10.4049\/jimmunol.174.12.7912","article-title":"B lymphocyte activation by human papillomavirus-like particles directly induces ig class switch recombination via TLR4-MyD88","volume":"174","author":"Yang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2021.105149_bib32","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.178.5.3186","article-title":"TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16","volume":"178","author":"Hasan","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2021.105149_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/sj.onc.1210912","article-title":"Polymorphisms in Toll-like receptor genes and risk of cancer","volume":"27","author":"El-Omar","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.micpath.2021.105149_bib34","first-page":"11","article-title":"The associations between toll-like receptor 9 gene polymorphisms and cervical cancer susceptibility","author":"Tian","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.micpath.2021.105149_bib35","first-page":"1","article-title":"Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility","volume":"9","author":"Pandey","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2021.105149_bib36","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00335-017-9691-x","article-title":"Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population","volume":"28","author":"Jin","year":"2017","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.micpath.2021.105149_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ygyno.2009.05.032","article-title":"Impact of Toll-like receptors [TLR] 2 (-196 to -174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women","volume":"114","author":"Pandey","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12253-015-0009-6","article-title":"Evaluation of toll-like receptors 2\/3\/4\/9 gene polymorphisms in cervical cancer evolution","volume":"22","author":"Zidi","year":"2016","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.micpath.2021.105149_bib39","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1089\/dna.2011.1427","article-title":"A genetic variant in the promoter region of toll-like receptor 9 and cervical cancer susceptibility","volume":"31","author":"Chen","year":"2012","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.micpath.2021.105149_bib40","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1007\/s11033-010-0607-z","article-title":"Evaluation of Toll-like receptors 3 (c.1377C\/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility","volume":"38","author":"Pandey","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.micpath.2021.105149_bib41","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1007\/s11033-012-1695-8","article-title":"Involvement of toll-like receptor 9 polymorphism in cervical cancer development","volume":"39","author":"Roszak","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.micpath.2021.105149_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220330","article-title":"Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility","volume":"14","author":"Chauhan","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2021.105149_bib43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jcv.2005.09.001","article-title":"Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions","volume":"35","author":"Monnier-Benoit","year":"2006","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.micpath.2021.105149_bib44","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1086\/344207","article-title":"Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms [5]","volume":"71","author":"Qin","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.micpath.2021.105149_bib45","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0140-6736(02)08151-5","article-title":"Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study","volume":"359","author":"Mu\u00f1oz","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.micpath.2021.105149_bib46","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0959-8049(96)00089-5","article-title":"Human papilloma virus has no prognostic significance in cervical carcinoma","volume":"32","author":"Kristensen","year":"1996","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12038-008-0023-x","article-title":"Human papillomavirus genotyping by multiplex pyrosequencing in cervical cancer patients from India","volume":"33","author":"Travasso","year":"2008","journal-title":"J. Biosci."},{"key":"10.1016\/j.micpath.2021.105149_bib48","article-title":"Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India","volume":"5","author":"Sowjanaya","year":"2005","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105149_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/ijc.11350","article-title":"Human papillomavirus and risk factors for cervical cancer in Chennai, India: a case-control study","volume":"107","author":"Franceschi","year":"2003","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib50","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ijc.25396","article-title":"Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication","volume":"128","author":"Li","year":"2011","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.micpath.2021.105149_bib51","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/0971-5851.144991","article-title":"National cancer control and registration program in India","volume":"35","author":"Rath","year":"2014","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib52","first-page":"166","article-title":"The prevalence of human papilloma virus DNA in women with mucopurulent endocervicitis","volume":"23","author":"Altuglu","year":"2002","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib53","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1128\/JCM.02202-07","article-title":"Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in North India","volume":"46","author":"Pande","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105149_bib54","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1158\/1055-9965.EPI-06-0129","article-title":"Human papillomavirus infections with multiple types and risk of cervical neoplasia","volume":"15","author":"Trottier","year":"2006","journal-title":"Canc. Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.micpath.2021.105149_bib55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ygyno.2007.05.004","article-title":"Viral DNA load, physical status and E2\/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions","volume":"106","author":"Cricca","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.micpath.2021.105149_bib56","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1128\/JCM.01212-08","article-title":"Analysis of human papillomavirus type 16 (HPV16) DNA load and physical state for identification of HPV16-infected women with high-grade lesions or cervical carcinoma","volume":"46","author":"Saunier","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105149_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154100","article-title":"TLR9 -1486T\/C and 2848C\/T SNPs are associated with human cytomegalovirus infection in infants","volume":"11","author":"Paradowska","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2021.105149_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122831","article-title":"TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus","volume":"10","author":"Wujcicka","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.micpath.2021.105149_bib59","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1097\/QAD.0b013e328330b489","article-title":"Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals","volume":"23","author":"Pine","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.micpath.2021.105149_bib60","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/QAI.0b013e318184fb41","article-title":"Influence of the toll-like receptor 9 1635A\/G polymorphism on the CD4 count, HIV viral load, and clinical progression","volume":"49","author":"Soriano-Sarabia","year":"2008","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.micpath.2021.105149_bib61","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/bib\/bbv072","article-title":"Comparison of haplotype-based statistical tests for disease association with rare and common variants","volume":"17","author":"Datta","year":"2016","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.micpath.2021.105149_bib62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/QAD.0000000000001680","article-title":"Toll-like receptor 9 polymorphism is associated with increased Epstein\u2013Barr virus and Cytomegalovirus acquisition in HIV-exposed infants","volume":"32","author":"Beima-Sofie","year":"2018","journal-title":"AIDS"},{"key":"10.1016\/j.micpath.2021.105149_bib63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canep.2019.05.003","article-title":"Genetic variations of TLRs and their association with HPV\/EBV, co-infection along with nicotine exposure in the development of premalignant\/malignant lesions of the oral cavity in Indian population","volume":"61","author":"Sharma","year":"2019","journal-title":"Canc. Epidemiol."},{"key":"10.1016\/j.micpath.2021.105149_bib64","first-page":"1566","article-title":"TLR4 and TLR7 genetic polymorphism in patients with HIV\/HCV-coinfection: prevalence and gender-related features - PubMed","volume":"71","author":"Koval Ti","year":"2018","journal-title":"Wiad. Lek."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102100423X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102100423X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:46:24Z","timestamp":1760111184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102100423X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":64,"alternative-id":["S088240102100423X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105149","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105149"}}