{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:41:16Z","timestamp":1792302076077,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.micpath.2021.105206","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T20:40:09Z","timestamp":1633380009000},"page":"105206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"PA","title":["Strict relationship between class 1 integrons and resistance to sulfamethoxazole in Escherichia coli"],"prefix":"10.1016","volume":"161","author":[{"given":"Eliana","family":"de los Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magela","family":"Lavi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elo\u00edsa","family":"Poey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2021.105206_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1574-6968.2007.00757.x","article-title":"Evolution and ecology of antibiotic resistance genes","volume":"271","author":"Aminov","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2021.105206_bib2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/AAC.49.2.836-839.2005","article-title":"Dissemination of sulfonamide resistance genes (sul1, sul2, and sul3) in Portuguese Salmonella enterica strains and relation with integrons","volume":"49","author":"Antunes","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105206_bib3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.micpath.2009.09.003","article-title":"Microcins and urovirulence in Escherichia coli","volume":"47","author":"Azpiroz","year":"2009","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2021.105206_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034953","article-title":"Antibiotic resistance is prevalent in an isolated cave microbiome","volume":"7","author":"Bhullar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105206_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-genet-102209-163504","volume":"44","author":"Cambray","year":"2010","journal-title":"Integrons. Annu. Rev. Genet."},{"key":"10.1016\/j.micpath.2021.105206_bib6","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1093\/nar\/gkw319","article-title":"Identification and analysis of integrons and cassette arrays in bacterial genomes","volume":"44","author":"Cury","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2021.105206_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012754","article-title":"Distribution of class 1 integrons with IS26-mediated deletions in their 3'-conserved segments in Escherichia coli of human and animal origin","volume":"5","author":"Dawes","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105206_bib8","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1099\/mic.0.000099","article-title":"Global dissemination patterns of common gene cassette arrays in class 1 integrons","volume":"161","author":"Domingues","year":"2015","journal-title":"Microbiol."},{"key":"10.1016\/j.micpath.2021.105206_bib9","article-title":"Antibiotic resistance: what is so special about multidrug-resistant Gram-negative bacteria?","volume":"12","author":"Exner","year":"2017","journal-title":"GMS Hyg. Infect. Contr."},{"key":"10.1016\/j.micpath.2021.105206_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-60327-853-9_6","article-title":"The integron\/gene cassette system: an active player in bacterial adaptation","volume":"532","author":"Labbate","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.micpath.2021.105206_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1086\/345880","article-title":"Multidrug resistance among Enterobacteriaceae is strongly associated with the presence of integrons and is independent of species or isolate origin","volume":"187","author":"Leverstein-Van Hall","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105206_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03447-x","article-title":"Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole","volume":"9","author":"Minato","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2021.105206_bib13","series-title":"Escherichia coli and Salmonella: Cellular and Molecular Biology","author":"Neidhardt","year":"1996"},{"key":"10.1016\/j.micpath.2021.105206_bib14","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1007\/s00253-020-10982-5","article-title":"Living with sulfonamides: a diverse range of mechanisms observed in bacteria","volume":"104","author":"Nunes","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2021.105206_bib15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1574-6976.2011.00277.x","article-title":"Analysis of antibiotic resistance regions in Gram-negative bacteria","volume":"35","author":"Partridge","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.micpath.2021.105206_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.micpath.2018.02.006","article-title":"Horizontal transfer of class 1 integrons from uropathogenic Escherichia coli to E. coli K12","volume":"117","author":"Poey","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2021.105206_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.micpath.2014.11.002","article-title":"Integrons in uropathogenic Escherichia coli and their relationship with phylogeny and virulence","volume":"77","author":"Poey","year":"2014","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2021.105206_bib18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.micpath.2012.02.006","article-title":"Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities","volume":"52","author":"Poey","year":"2012","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2021.105206_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103611","article-title":"On sulfonamide resistance, sul genes, class 1 integrons and their horizontal transfer in Escherichia coli","volume":"135","author":"Poey","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2021.105206_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-017-0379-y","article-title":"Discovery of the fourth mobile sulfonamide resistance gene","volume":"5","author":"Razavi","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.micpath.2021.105206_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.03332","article-title":"Origin of the mobile di-hydro-pteroate synthase gene determining sulfonamide resistance in clinical isolates","volume":"9","author":"S\u00e1nchez-Osuna","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2021.105206_bib22","article-title":"Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim","volume":"6","author":"S\u00e1nchez-Osuna","year":"2020","journal-title":"Microb. Genom."},{"key":"10.1016\/j.micpath.2021.105206_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128797","article-title":"Integron, plasmid and host strain characteristics of Escherichia coli from humans and food included in the Norwegian Antimicrobial Resistance Monitoring Programs","volume":"10","author":"Sunde","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105206_bib24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/AAC.42.1.88","article-title":"Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli","volume":"42","author":"Vedantam","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105206_bib25","series-title":"WHO Model List of Essential Medicines (20th List)","author":"World Health Organization","year":"2017"},{"key":"10.1016\/j.micpath.2021.105206_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-018-0516-2","article-title":"Conserved phylogenetic distribution and limited antibiotic resistance of class 1 integrons revealed by assessing the bacterial genome and plasmid collection","volume":"6","author":"Zhang","year":"2018","journal-title":"Microbiome"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021004800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021004800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:49:33Z","timestamp":1760111373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401021004800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":26,"alternative-id":["S0882401021004800"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105206","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strict relationship between class 1 integrons and resistance to sulfamethoxazole in Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105206"}}