{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:20:33Z","timestamp":1778127633259,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.micpath.2021.105243","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T03:08:55Z","timestamp":1634267335000},"page":"105243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"PA","title":["KDR polymorphism (1192G\/A, 1719A\/T) and modulation of ARV drug-induced hepatotoxicity"],"prefix":"10.1016","volume":"161","author":[{"given":"HariOm","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmesh","family":"Samani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-7017","authenticated-orcid":false,"given":"Sushama","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2021.105243_bib1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1359-6446(02)02211-0","article-title":"Toxicoproteomics -- a new preclinical tool","volume":"7","author":"Bandara","year":"2002","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.micpath.2021.105243_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-2002-30100","article-title":"Biochemical and cellular mechanisms of toxic liver injury","volume":"22","author":"Kaplowitz","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.micpath.2021.105243_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cbi.2008.10.028","article-title":"Th1\/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury","volume":"79","author":"Masubuchi","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.micpath.2021.105243_bib4","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1002\/hep.21060","article-title":"The liver as an immunological organ","volume":"43","author":"Racanelli","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.micpath.2021.105243_bib5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1086\/593022","article-title":"For the pediatric ACTGCT. Toxicities associated with dual nucleoside reverse-transcriptase inhibitor regimens in HIV-infected children","volume":"198","author":"Van Dyke","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105243_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jtbi.2011.08.009","article-title":"In vitro transcriptomic prediction of hepatotoxicity for early drug discovery","volume":"290","author":"Cheng","year":"2011","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.micpath.2021.105243_bib7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0140-6736(04)15997-7","article-title":"Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study","volume":"363","author":"van Leth","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.micpath.2021.105243_bib8","series-title":"Incidence of Hepatotoxicity and Mortality in 21 Adult Antiretroviral Treatment Trials. The 1st IAS Conference on HIV Pathogenesis and Treatment","year":"2010"},{"issue":"6","key":"10.1016\/j.micpath.2021.105243_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/0019-5359.99597","article-title":"Adverse drug reactions to antiretroviral therapy in AIDS patients at a tertiary care hospital in India: a prospective observational study","volume":"64","author":"Nagpal","year":"2010","journal-title":"Indian J. Med. Sci."},{"key":"10.1016\/j.micpath.2021.105243_bib10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jmri.10108","article-title":"Streamlined flow in the portal vein: demonstration with MR angiography","volume":"15","author":"Gallix","year":"2002","journal-title":"J. Magn. Reson. Imag."},{"key":"10.1016\/j.micpath.2021.105243_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-5926-10-8","article-title":"Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver","volume":"10","author":"Fuentealba","year":"2011","journal-title":"Comp. Hepatol."},{"issue":"9","key":"10.1016\/j.micpath.2021.105243_bib12","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1136\/gut.52.9.1347","article-title":"Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis","volume":"52","author":"Yoshiji","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.micpath.2021.105243_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0958-1669(00)00153-1","article-title":"VEGF.An update on biological and therapeutic aspects","volume":"11","author":"Ferrara","year":"2000","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.micpath.2021.105243_bib14","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1478-3231.2009.02015.x","article-title":"Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes","volume":"29","author":"Copple","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.micpath.2021.105243_bib15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.toxlet.2009.04.013","article-title":"Hepatocyte growth factor, vascular endothelial growth factor, glial cell-derived neurotrophic factor and nerve growth factor are differentially affected by early chronic ethanol or red wine intake","volume":"188","author":"Fiore","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.micpath.2021.105243_bib16","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.90368.2008","article-title":"Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice","volume":"296","author":"Moon","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.micpath.2021.105243_bib17","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jacc.2007.04.074","article-title":"Polymorphisms of KDR gene are associated with coronary heart disease","volume":"50","author":"Wang","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.micpath.2021.105243_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047158","article-title":"The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization","volume":"7","author":"Park","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105243_bib19","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.fertnstert.2012.10.038","article-title":"Association of kinase insert domain-containing receptor (KDR) gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women","volume":"99","author":"Rah","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2021.105243_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2407-9-144","article-title":"The -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer","volume":"9","author":"An","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.micpath.2021.105243_bib21","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1203\/01.PDR.0000145280.26284.B9","article-title":"Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease","volume":"56","author":"Kariyazono","year":"2004","journal-title":"Pediatr. Res."},{"issue":"4","key":"10.1016\/j.micpath.2021.105243_bib22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.fertnstert.2008.11.017","article-title":"Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion","volume":"93","author":"Lee","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2021.105243_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jns.2011.06.012","article-title":"Association between kinase insert domain-containing receptor gene polymorphism and haplotypes and ischemic stroke","volume":"308","author":"Oh","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.micpath.2021.105243_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000099064","article-title":"Association of vascular endothelial growth factor gene polymorphism with myocardial infarction in patients with type 2 diabetes","volume":"107","author":"Petrovic","year":"2007","journal-title":"Cardiology"},{"key":"10.1016\/j.micpath.2021.105243_bib25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/humrep\/deq401","article-title":"Association of polymorphisms\/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss","volume":"26","author":"Su","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.micpath.2021.105243_bib26","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1161\/STROKEAHA.109.554394","article-title":"VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence","volume":"40","author":"Zhang","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.micpath.2021.105243_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jns.2012.03.020","article-title":"Association between kinase insert domain-containing receptor gene polymorphisms and silent brain infarction: a Korean study","volume":"318","author":"Han","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.micpath.2021.105243_bib28","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/gme.0b013e318248f2e8","article-title":"Association between kinase insert domain-containing receptor polymorphisms (-604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women","volume":"19","author":"Rah","year":"2012","journal-title":"Menopause"},{"issue":"12","key":"10.1016\/j.micpath.2021.105243_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.29252\/ijrm.13.12.755","article-title":"Association of kinase insert domain-containing receptor (KDR) gene polymorphism\/haplotypes with recurrent spontaneous abortion and genetic structure","volume":"13","author":"Shahsavari","year":"2015","journal-title":"Int J Reprod Biomed (Yazd)"},{"key":"10.1016\/j.micpath.2021.105243_bib30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/MEG.0000000000000044","article-title":"Genetic polymorphisms of proangiogenic factors seem to favor hepatocellular carcinoma development in alcoholic cirrhosis","volume":"26","author":"Machado","year":"2014","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2021.105243_bib31","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","article-title":"SNPStats: a web tool for the analysis of association studies","volume":"22","author":"Sole","year":"2006","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.micpath.2021.105243_bib32","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1086\/301817","article-title":"An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers","volume":"62","author":"Cox","year":"1998","journal-title":"Am. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.micpath.2021.105243_bib33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.stem.2013.04.026","article-title":"KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development","volume":"12","author":"Goldman","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.micpath.2021.105243_bib34","doi-asserted-by":"crossref","unstructured":"Salles JI, Duarte ME, Guimar\u00e3es JM, Lopes LR, Vilarinho Cardoso J, Aguiar DP, Machado Neto JO, Machado DE, Perini JA. Vascular endothelial growth factor receptor-2 polymorphisms have protective effect against the development of tendinopathy in volleyball athletes. PLoS One. 2016 Dec 8;11(12):e0167717.","DOI":"10.1371\/journal.pone.0167717"},{"key":"10.1016\/j.micpath.2021.105243_bib35","doi-asserted-by":"crossref","unstructured":"Nouri K, Haslinger P, Szabo L, Sator M, Schreiber M, Schneeberger C, Pietrowski D. Polymorphisms of VEGF and VEGF receptors are associated with the occurrence of ovarian hyperstimulation syndrome (OHSS)-a retrospective case-control study. J. Ovarian Res.. 2014 May 13;7:54.","DOI":"10.1186\/1757-2215-7-54"},{"key":"10.1016\/j.micpath.2021.105243_bib36","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(05)67485-5","article-title":"Shaking the tree: mapping complex disease genes with linkage disequilibrium","volume":"366","author":"Palmer","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.micpath.2021.105243_bib37","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.neulet.2004.05.061","article-title":"Case-only study of interactions between genetic polymorphisms of GSTM1, P1, T1 and Z1 and smoking in Parkinson's disease","volume":"366","author":"Deng","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.micpath.2021.105243_bib38","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/carcin\/18.11.2127","article-title":"A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer","volume":"11","author":"Hunter","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.micpath.2021.105243_bib39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/oxfordjournals.aje.a113025","article-title":"The effect of misclassification in the presence of covariates","volume":"112","author":"Greenland","year":"1980","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.micpath.2021.105243_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/QAI.0b013e318142aabb","article-title":"Alcohol consumption and HIV disease progression","volume":"46","author":"Samet","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021005179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021005179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:50:38Z","timestamp":1760111438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401021005179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":40,"alternative-id":["S0882401021005179"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105243","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KDR polymorphism (1192G\/A, 1719A\/T) and modulation of ARV drug-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105243"}}