{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:41:44Z","timestamp":1768340504428,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.micpath.2021.105256","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T18:10:16Z","timestamp":1634926216000},"page":"105256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"PA","title":["Whole genome global insight of antibiotic resistance gene repertoire and virulome of high - risk multidrug-resistant Uropathogenic Escherichia coli"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-9810","authenticated-orcid":false,"given":"Susweta Das","family":"Mitra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-742X","authenticated-orcid":false,"given":"Pir","family":"Irshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anusree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-8078","authenticated-orcid":false,"given":"Injeti","family":"Rekha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shailaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janshi","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Aishwarya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smeeta","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibek Ranjan","family":"Shome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2021.105256_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12879-020-4844-z","article-title":"Distribution of virulence genes and phylogenetics of uropathogenic Escherichia coli among urinary tract infection patients in Addis Ababa, Ethiopia","volume":"20","author":"Dadi","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105256_bib2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrurol.2010.190","article-title":"The epidemiology of urinary tract infection","volume":"7","author":"Foxman","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.micpath.2021.105256_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Flores-Mireles","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib4","doi-asserted-by":"crossref","DOI":"10.7860\/JCDR\/2016\/21379.9009","article-title":"Genotypic characterization of virulence factors in Escherichia coli isolated from patients with acute cystitis, pyelonephritis and asymptomatic bacteriuria","author":"Tabasi","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.micpath.2021.105256_bib5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/CMR.00116-14","article-title":"The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant enterobacteriaceae","volume":"28","author":"Mathers","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2021.105256_bib6","article-title":"Whole Genomic analysis of a clinical isolate of Uropathogenic Escherichia coli strain of Sequence Type - 101 carrying the drug resistance NDM-7 in IncX3 plasmid","volume":"17","author":"Ramakrishnan","year":"2021","journal-title":"Bioinformation"},{"key":"10.1016\/j.micpath.2021.105256_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/antibiotics9040186","article-title":"The current burden of carbapenemases: review of significant properties and dissemination among gram-negative bacteria","volume":"9","author":"Hammoudi Halat","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.micpath.2021.105256_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.32607\/20758251-2018-10-4-33-48","article-title":"Rubtsova, bacterial enzymes and antibiotic resistance","volume":"10","author":"Egorov","year":"2018","journal-title":"Acta Naturae"},{"key":"10.1016\/j.micpath.2021.105256_bib9","doi-asserted-by":"crossref","first-page":"100880","DOI":"10.1016\/j.genrep.2020.100880","article-title":"Molecular detection of the New Delhi metallo-\u03b2-lactamase clinical variant with double mutation- V88L and M154L in Escherichia coli isolates from South India","volume":"21","author":"Mitra","year":"2020","journal-title":"Gene Rep."},{"key":"10.1016\/j.micpath.2021.105256_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220265","article-title":"The burden of antimicrobial resistance among urinary tract isolates of Escherichia coli in the United States in 2017","volume":"14","author":"Critchley","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105256_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/nyas.12830","article-title":"Mechanisms of drug resistance: quinolone resistance: mechanisms of quinolone resistance","volume":"1354","author":"Hooper","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.micpath.2021.105256_bib12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jgar.2017.12.013","article-title":"High frequency of aac(6 \u2032 )-Ib -cr gene associated with double mutations in gyrA and parC in Escherichia coli isolates from patients with urinary tract infections","volume":"13","author":"Volc\u00e3o","year":"2018","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.micpath.2021.105256_bib13","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1128\/AAC.01707-08","article-title":"Resistance plasmid families in enterobacteriaceae","volume":"53","author":"Carattoli","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib14","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.3389\/fmicb.2019.02913","article-title":"Characterization and bio-typing of multidrug resistance plasmids from uropathogenic Escherichia coli isolated from clinical setting","volume":"10","author":"Mukherjee","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/jac\/dkx488","article-title":"Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae","volume":"73","author":"Rozwandowicz","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01130-19","article-title":"Advantage of the F2:A1:B- IncF pandemic plasmid over IncC plasmids in in vitro acquisition and evolution of bla CTX-M gene-bearing plasmids in Escherichia coli","volume":"63","author":"Mah\u00e9rault","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0924-8579(03)00236-X","article-title":"Virulence factors of uropathogenic Escherichia coli","volume":"22","author":"Emdy","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2021.105256_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232710","article-title":"Plasmid-mediated antibiotic resistance among uropathogens in primigravid women\u2014Hyderabad, India","volume":"15","author":"Kammili","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2021.105256_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/20477724.2018.1547542","article-title":"Multiple antibiotic resistances and virulence markers of uropathogenic Escherichia coli from Mexico","volume":"112","author":"Paniagua-Contreras","year":"2018","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.micpath.2021.105256_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01405-18","article-title":"Genome-based prediction of bacterial antibiotic resistance","volume":"57","author":"Su","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fpubh.2019.00242","article-title":"Using genomics to track global antimicrobial resistance","volume":"7","author":"Hendriksen","year":"2019","journal-title":"Front. Public Health"},{"key":"10.1016\/j.micpath.2021.105256_bib22","series-title":"The Galaxy Platform for Accessible, Reproducible and Collaborative Biomedical Analyses: 2018 Update","first-page":"8","author":"Afgan","year":"2018"},{"key":"10.1016\/j.micpath.2021.105256_bib23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/bioinformatics\/16.10.944","article-title":"Artemis: sequence visualization and annotation","volume":"16","author":"Rutherford","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2021.105256_bib24","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib25","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib26","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1038\/s41467-019-13118-0","article-title":"Characterization of antibiotic resistance genes in the species of the rumen microbiota","volume":"10","author":"Sabino","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2021.105256_bib27","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1128\/JCM.03617-13","article-title":"Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli","volume":"52","author":"Joensen","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1128\/JCM.06094-11","article-title":"Multilocus sequence typing of total-genome-sequenced bacteria","volume":"50","author":"Larsen","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib29","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1101\/gr.2289704","article-title":"Mauve: multiple alignment of conserved genomic sequence with rearrangements","volume":"14","author":"Darling","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.micpath.2021.105256_bib30","doi-asserted-by":"crossref","first-page":"FSO438","DOI":"10.2144\/fsoa-2019-0098","article-title":"A review on bacterial resistance to carbapenems: epidemiology, detection and treatment options","volume":"6","author":"Elshamy","year":"2020","journal-title":"Future Sci. OA."},{"key":"10.1016\/j.micpath.2021.105256_bib31","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1128\/AAC.00475-12","article-title":"Characterization of globally spread Escherichia coli ST131 isolates (1991 to 2010)","volume":"56","author":"Novais","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2021.105256_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41598-019-56763-7","article-title":"Meta-analysis of pandemic Escherichia coli ST131 plasmidome proves restricted plasmid-clade associations","volume":"10","author":"Kondratyeva","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2021.105256_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/sojmid\/7\/1\/00199","article-title":"Identification of novel plasmid replicons harboring \u03b2-lactamase resistant genes in ampicillin-resistant uropathogenic Escherichia coli","volume":"7","author":"Nawaz","year":"2019","journal-title":"SOJ Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2021.105256_bib34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jmii.2018.12.013","article-title":"The new perspective of old antibiotic: in vitro antibacterial activity of TMP-SMZ against Klebsiella pneumoniae","volume":"53","author":"Li","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.micpath.2021.105256_bib35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jiph.2019.06.011","article-title":"Genomic and antimicrobial resistance genes diversity in multidrug-resistant CTX-M-positive isolates of Escherichia coli at a health care facility in Jeddah","volume":"13","author":"Yasir","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.micpath.2021.105256_bib36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.33073\/pjm-2019-048","article-title":"Antibiotic resistance among uropathogenic Escherichia coli","volume":"68","author":"Kot","year":"2019","journal-title":"Pol. J. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib37","doi-asserted-by":"crossref","unstructured":"Foley Steven L., Kaldhone Pravin R., Ricke Steven C., Han Jing, Incompatibility group I1 (IncI1) plasmids: their genetics, biology, and public health relevance, Microbiol. Mol. Biol. Rev. 85 (n.d.) e00031-20. https:\/\/doi.org\/10.1128\/MMBR.00031-20.","DOI":"10.1128\/MMBR.00031-20"},{"key":"10.1016\/j.micpath.2021.105256_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijantimicag.2014.04.016","article-title":"Expansive spread of IncI1 plasmids carrying blaCMY-2 amongst Escherichia coli","volume":"44","author":"Sidjabat","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2021.105256_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mib.2017.10.026","article-title":"Inhibitors of metallo-\u03b2-lactamases","volume":"39","author":"Rotondo","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib40","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.jmb.2019.04.002","article-title":"\u03b2-Lactamases and \u03b2-lactamase inhibitors in the 21st century","volume":"431","author":"Tooke","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micpath.2021.105256_bib41","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00467-019-04316-5","article-title":"Multidrug-resistant organisms in urinary tract infections in children","volume":"35","author":"Mahony","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.micpath.2021.105256_bib42","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1038\/s41598-020-64346-0","article-title":"Discovery of seven novel mutations of gyrB, parC and parE in Salmonella Typhi and Paratyphi strains from Jiangsu Province of China","volume":"10","author":"Qian","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2021.105256_bib43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/IDR.S240013","article-title":"Detection of chromosomal and plasmid-mediated quinolone resistance among Escherichia coli isolated from urinary tract infection cases; Zagazig University Hospitals, Egypt","volume":"13","author":"Esmaeel","year":"2020","journal-title":"Infect. Drug Res."},{"key":"10.1016\/j.micpath.2021.105256_bib44","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1128\/IAI.69.10.6209-6216.2001","article-title":"Identification of a new iron-regulated virulence gene, ireA , in an extraintestinal pathogenic isolate of Escherichia coli","volume":"69","author":"Russo","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2021.105256_bib45","first-page":"359","article-title":"Frequency evaluation of genes encoding siderophores and the effects of different concentrations of Fe ions on growth rate of uropathogenic Escherichia coli","volume":"8","author":"Khasheii","year":"2016","journal-title":"Iran. J. Microbiol."},{"key":"10.1016\/j.micpath.2021.105256_bib46","doi-asserted-by":"crossref","first-page":"14549","DOI":"10.1038\/s41598-020-71213-5","article-title":"Genotype\u2013phenotype correlation of \u03b2-lactamase-producing uropathogenic Escherichia coli (UPEC) strains from Bangladesh","volume":"10","author":"Hossain","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2021.105256_bib47","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3389\/fmicb.2020.00761","article-title":"Targeting plasmids to limit acquisition and transmission of antimicrobial resistance","volume":"11","author":"Vrancianu","year":"2020","journal-title":"Front. Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021005301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401021005301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:53:13Z","timestamp":1760111593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401021005301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":47,"alternative-id":["S0882401021005301"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105256","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole genome global insight of antibiotic resistance gene repertoire and virulome of high - risk multidrug-resistant Uropathogenic Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2021.105256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105256"}}