{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:06:14Z","timestamp":1760123174797,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.micpath.2022.105413","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:33:43Z","timestamp":1642678423000},"page":"105413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Serial systemic candidiasis alters Candida albicans macromorphology associated with enhancement of virulence attributes"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-7566","authenticated-orcid":false,"given":"Glaucia Sayuri","family":"Arita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-4634","authenticated-orcid":false,"given":"Pollyanna Cristina","family":"Vincenzi Conrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Mayumi","family":"Sakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele Abigail","family":"Vilugron Rodrigues-Vendramini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella Renata","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Seki","family":"Kioshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"de Souza Bonfim-Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-9046","authenticated-orcid":false,"given":"Terezinha Inez","family":"Estivalet Svidzinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2022.105413_bib1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.chom.2017.07.002","article-title":"Commensal fungi in Health and disease","volume":"22","author":"Limon","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.micpath.2022.105413_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuaa060","article-title":"The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives","volume":"45","author":"d'Enfert","year":"2021","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.micpath.2022.105413_bib3","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"year":"2021","author":"Carpio","key":"10.1016\/j.micpath.2022.105413_bib4"},{"key":"10.1016\/j.micpath.2022.105413_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0966-842X(01)02094-7","article-title":"Virulence factors of Candida albicans","volume":"9","author":"Calderone","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"10.1016\/j.micpath.2022.105413_bib7","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3390\/ijms17101643","article-title":"Dissecting Candida albicans infection from the perspective of C. albicans virulence and omics approaches on host-pathogen interaction: a review","volume":"17","author":"Chin","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2022.105413_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/jof7020079","article-title":"Candida albicans- the virulence factors and clinical manifestations of infection","volume":"7","author":"Talapko","year":"2021","journal-title":"J. Fungi (Basel)"},{"key":"10.1016\/j.micpath.2022.105413_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1439-0507.2005.01165.x","article-title":"Hydrolytic enzymes as virulence factors of Candida albicans","volume":"48","author":"Schaller","year":"2005","journal-title":"Mycoses"},{"issue":"Pt 1","key":"10.1016\/j.micpath.2022.105413_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1242\/jeb.088930","article-title":"Stress adaptation in a pathogenic fungus","volume":"217","author":"Brown","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.micpath.2022.105413_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008478","article-title":"Adapting to survive: how Candida overcomes host-imposed constraints during human colonization","volume":"16","author":"Alves","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2022.105413_bib12","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/IAI.66.7.3317-3325.1998","article-title":"The pH of the host niche controls gene expression in and virulence of Candida albicans","volume":"66","author":"De Bernardis","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2022.105413_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fcimb.2019.00230","article-title":"Serial systemic Candida albicans infection highlighted by proteomics","volume":"9","author":"Arita","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2217\/fmb-2019-0342","article-title":"Impact of serial systemic infection on Candida albicans virulence factors","volume":"15","author":"Arita","year":"2020","journal-title":"Future Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064482","article-title":"Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney","volume":"8","author":"L\u00fcttich","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2022.105413_bib16","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1462-5822.2006.00805.x","article-title":"Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue","volume":"9","author":"Cheng","year":"2007","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1186\/s12879-017-2879-6","article-title":"Radiation used for head and neck cancer increases virulence in Candida tropicalis isolated from a cancer patient","volume":"17","author":"da Silva","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2022.105413_bib18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2217\/fmb-2015-0016","article-title":"Propolis: a potential natural product to fight Candida species infections","volume":"11","author":"Tobaldini-Valerio","year":"2016","journal-title":"Future Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib19","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3730","article-title":"Candida albicans agar invasion assays","volume":"10","author":"Naseem","year":"2020","journal-title":"Bio Protoc"},{"key":"10.1016\/j.micpath.2022.105413_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038584","article-title":"Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans","volume":"7","author":"Mayer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2022.105413_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fcimb.2018.00135","article-title":"Non-canonical activities of Hog1 control sensitivity of Candida albicans to killer toxins from Debaryomyces hansenii","volume":"8","author":"Morales-Mench\u00e9n","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib22","doi-asserted-by":"crossref","first-page":"151466","DOI":"10.1016\/j.ijmm.2020.151466","article-title":"The V-ATPase regulates localization of the TRP Ca 2+ channel Yvc1 in response to oxidative stress in Candida albicans","volume":"310","author":"Peng","year":"2020","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001830","article-title":"Discovery of a \"white-gray-opaque\" tristable phenotypic switching system in Candida albicans: roles of non-genetic diversity in host adaptation","volume":"12","author":"Tao","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.micpath.2022.105413_bib24","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3389\/fmicb.2016.00780","article-title":"Phenotypic plasticity regulates Candida albicans interactions and virulence in the vertebrate host","volume":"7","author":"Mallick","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib25","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1093\/jac\/dku198","article-title":"In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy","volume":"69","author":"Jacobsen","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2022.105413_bib26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nrmicro2636","article-title":"Growth of Candida albicans hyphae","volume":"9","author":"Sudbery","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2022.105413_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1586\/eri.11.152","article-title":"Candida albicans dimorphism as a therapeutic target","volume":"10","author":"Jacobsen","year":"2012","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.micpath.2022.105413_bib28","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1534\/g3.117.300224","article-title":"Filamentation involves two overlapping, but distinct, programs of filamentation in the pathogenic fungus Candida albicans","volume":"7","author":"Azadmanesh","year":"2017","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.micpath.2022.105413_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/foaa005","article-title":"Transcriptional control of hyphal morphogenesis in Candida albicans","volume":"20","author":"Villa","year":"2020","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2022.105413_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.femsle.2005.02.031","article-title":"Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance","volume":"245","author":"Fan","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2022.105413_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/physiol.00005.2009","article-title":"Hypertonic stress in the kidney: a necessary evil","volume":"24","author":"Kwon","year":"2009","journal-title":"Physiology"},{"key":"10.1016\/j.micpath.2022.105413_bib32","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/j.1365-2958.2011.07542.x","article-title":"Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans","volume":"79","author":"Leach","year":"2011","journal-title":"Mol. Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022000262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022000262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:47:40Z","timestamp":1760111260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401022000262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":32,"alternative-id":["S0882401022000262"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105413","relation":{},"ISSN":["0882-4010"],"issn-type":[{"type":"print","value":"0882-4010"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serial systemic candidiasis alters Candida albicans macromorphology associated with enhancement of virulence attributes","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105413","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105413"}}