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J."},{"key":"10.1016\/j.micpath.2022.105418_bib145","doi-asserted-by":"crossref","DOI":"10.1038\/emboj.2008.219","article-title":"The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans","author":"Li","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.micpath.2022.105418_bib146","doi-asserted-by":"crossref","DOI":"10.1042\/BJ20120952","article-title":"Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans","author":"Wang","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.micpath.2022.105418_bib147","doi-asserted-by":"crossref","DOI":"10.1111\/mmi.13386","article-title":"CDK phosphorylates the polarisome scaffold Spa2 to maintain its localization at the site of cell growth","author":"Wang","year":"2016","journal-title":"Mol. 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Biol."},{"key":"10.1016\/j.micpath.2022.105418_bib193","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101517","article-title":"Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans","author":"Kamthan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2022.105418_bib194","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000294","article-title":"The protein kinase Tor1 regulates adhesin gene expression in Candida albicans","author":"Bastidas","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2022.105418_bib195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020063","article-title":"Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo","author":"Nobile","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2022.105418_bib196","doi-asserted-by":"crossref","DOI":"10.1128\/EC.00194-06","article-title":"Function of Candida albicans adhesin hwp1 in biofilm formation","author":"Nobile","year":"2006","journal-title":"Eukaryot. 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Bacteriol."},{"key":"10.1016\/j.micpath.2022.105418_bib199","series-title":"TUP1, CPH1 and EFG1 Make Independent Contributions to Filamentation in Candida Albicans, Genetics","author":"Braun","year":"2000"},{"key":"10.1016\/j.micpath.2022.105418_bib200","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M104484200","article-title":"DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans","author":"Lane","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2022.105418_bib201","doi-asserted-by":"crossref","DOI":"10.1046\/j.1365-2958.2002.02873.x","article-title":"Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway","author":"Fu","year":"2002","journal-title":"Mol. 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Microbiol."},{"key":"10.1016\/j.micpath.2022.105418_bib203","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002663","article-title":"A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans","author":"Lu","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2022.105418_bib204","doi-asserted-by":"crossref","DOI":"10.1099\/00221287-144-10-2715","article-title":"The two-component hybrid kinase regulator CaNIK1 of Candida albicans","author":"Srikantha","year":"1998","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2022.105418_bib205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006350","article-title":"Metal chelation as a powerful strategy to probe cellular circuitry governing fungal drug resistance and morphogenesis","author":"Polvi","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.micpath.2022.105418_bib206","doi-asserted-by":"crossref","DOI":"10.1271\/bbb.66.2209","article-title":"Effects of iprodione and fludioxonil on glycerol synthesis and hyphal development in candid","author":"Ochiai","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.micpath.2022.105418_bib207","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1097-0061(199805)14:7<665::AID-YEA246>3.0.CO;2-#","article-title":"Identification of a putative histidine kinase two-component phosphorelay gene (CaHK1) in Candida albicans","author":"Calera","year":"1998","journal-title":"Yeast"},{"key":"10.1016\/j.micpath.2022.105418_bib208","article-title":"The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis","author":"Kruppa","year":"2003","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2022.105418_bib209","doi-asserted-by":"crossref","DOI":"10.1128\/JB.181.23.7243-7247.1999","article-title":"Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans","author":"Yamada-Okabe","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2022.105418_bib210","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.040006-0","article-title":"Deletion of the Candida albicans histidine kinase gene CHK1 improves recognition by phagocytes through an increased exposure of cell wall \u03b2-1,3-glucans","author":"Klippel","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.micpath.2022.105418_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/0966-842X(93)90033-N","article-title":"Recognition between Candida albicans and host cells","author":"Calderone","year":"1993","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2022.105418_bib212","doi-asserted-by":"crossref","DOI":"10.1111\/mmi.13588","article-title":"cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans","author":"Parrino","year":"2017","journal-title":"Mol. 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