{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:19:22Z","timestamp":1775247562986,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.micpath.2022.105557","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T01:56:27Z","timestamp":1653357387000},"page":"105557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Functional insights into Brucella transcriptional regulator ArsR"],"prefix":"10.1016","volume":"168","author":[{"given":"Chuanxin","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-0006","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2022.105557_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.BAI-0006-2019","article-title":"The intracellular life cycle of Brucella spp","volume":"7","author":"Celli","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.micpath.2022.105557_bib2","first-page":"340","article-title":"Triad of infective endocarditis, splenic abscess, and septicemia caused by Brucella melitensis","volume":"9","author":"Purwar","year":"2017","journal-title":"J. Lab. Phys."},{"key":"10.1016\/j.micpath.2022.105557_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-micro-090110-102905","article-title":"Interactions of the human pathogenic Brucella species with their hosts","volume":"65","author":"Atluri","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005792-199607000-00003","article-title":"Complications associated with Brucella melitensis infection: a study of 530 cases","volume":"75","author":"Colmenero","year":"1996","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.micpath.2022.105557_bib5","first-page":"533","article-title":"Internal affairs: investigating the Brucella intracellular lifestyle","volume":"36","author":"Von Bargen","year":"2012","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Rev."},{"key":"10.1016\/j.micpath.2022.105557_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2022.105557_bib7","doi-asserted-by":"crossref","first-page":"14034","DOI":"10.1073\/pnas.95.24.14034","article-title":"The pir gene of Erwinia chrysanthemi EC16 regulates hyperinduction of pectate lyase virulence genes in response to plant signals","volume":"95","author":"Nomura","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.micpath.2022.105557_bib8","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1128\/IAI.73.9.5578-5586.2005","article-title":"Systematic targeted mutagenesis of Brucella melitensis 16M reveals a major role for GntR regulators in the control of virulence","volume":"73","author":"Haine","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2022.105557_bib9","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/AEM.00262-16","article-title":"Regulatory activities of four ArsR proteins in Agrobacterium tumefaciens 5A","volume":"82","author":"Kang","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib10","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1128\/AEM.00606-16","article-title":"Paralogous regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a basis for arsenic biosensor development","volume":"82","author":"Fernandez","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib11","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1021\/bi050094v","article-title":"Structural and functional characterization of Mycobacterium tuberculosis CmtR, a PbII\/CdII-sensing SmtB\/ArsR metalloregulatory repressor","volume":"44","author":"Wang","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.micpath.2022.105557_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11274-017-2230-9","article-title":"Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages","volume":"33","author":"Li","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2022.105557_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071933","article-title":"Impact of Hfq on global gene expression and intracellular survival in Brucella melitensis","volume":"8","author":"Cui","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2022.105557_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.micpath.2017.01.043","article-title":"Brucella abortus 2308\u0394NodV\u0394NodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB\/c mice","volume":"106","author":"Li","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2022.105557_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.micpath.2018.08.052","article-title":"Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant","volume":"124","author":"Li","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2022.105557_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jobm.201900458","article-title":"ChIP-seq analysis of Brucella reveals transcriptional regulation of GntR","volume":"60","author":"Li","year":"2020","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib17","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1093\/nar\/gkx165","article-title":"ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network","volume":"45","author":"Kleinman","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2022.105557_bib18","doi-asserted-by":"crossref","first-page":"104201","DOI":"10.1016\/j.micpath.2020.104201","article-title":"Functional analysis of Bucella reveals transcriptional regulation of MarR","volume":"144","author":"Deng","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2022.105557_bib19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2022.105557_bib20","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2022.105557_bib21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2022.105557_bib22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2022.105557_bib23","doi-asserted-by":"crossref","first-page":"W369","DOI":"10.1093\/nar\/gkl198","article-title":"MEME: discovering and analyzing DNA and protein sequence motifs","volume":"34","author":"Bailey","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2022.105557_bib24","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"Meme suite: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2022.105557_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micpath.2022.105557_bib26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12859-018-2472-z","article-title":"Automated generation of genome-scale metabolic draft reconstructions based on KEGG","volume":"19","author":"Karlsen","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.micpath.2022.105557_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212 \u0394\u0394CT) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2022.105557_bib28","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.7150\/thno.33800","article-title":"The miR-26a\/AP-2alpha\/Nanog signaling axis mediates stem cell self-renewal and temozolomide resistance in glioma","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.micpath.2022.105557_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pep.2017.12.014","article-title":"Cloning, expression and purification of virB10 protein of Brucella melitensis and evaluation of its role as a serological marker for Brucella infection in experimental and natural host","volume":"145","author":"Pathak","year":"2018","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.micpath.2022.105557_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11274-016-2015-6","article-title":"The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB\/c mice","volume":"32","author":"Zhang","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2022.105557_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/toxsci\/kfj063","article-title":"Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells","volume":"91","author":"Kim","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.micpath.2022.105557_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/mmi.13123","article-title":"A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the alpha-proteobacteria","volume":"98","author":"Sheehan","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib33","first-page":"10","article-title":"Different impacts of MucR binding to the and promoters on gene expression in 2308","author":"Borriello","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.micpath.2022.105557_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00980-20","article-title":"Elucidation of regulatory modes for five two-component Systems in Escherichia coli reveals novel relationships","volume":"5","author":"Choudhary","year":"2020","journal-title":"mSystems"},{"key":"10.1016\/j.micpath.2022.105557_bib35","first-page":"1","article-title":"Ambivalent effects of tumor necrosis factor alpha on apoptosis of malignant and normal human keratinocytes","author":"Kokolakis","year":"2021","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.micpath.2022.105557_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fcimb.2012.00130","article-title":"The role of innate immune signals in immunity to Brucella abortus","volume":"2","author":"Gomes","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2022.105557_bib37","doi-asserted-by":"crossref","first-page":"589494","DOI":"10.1155\/2012\/589494","article-title":"Host susceptibility to Brucella abortus infection is more pronounced in IFN-\u03b3 knockout than IL-12\/\u03b22-microglobulin double-deficient mice","volume":"2012","author":"Brand\u00e3o","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.micpath.2022.105557_bib38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.2001.01258.x","article-title":"Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL\/6 and susceptible BALB\/c mice","volume":"103","author":"Murphy","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.micpath.2022.105557_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/CMR.16.1.65-78.2003","article-title":"Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans","volume":"16","author":"Ko","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2022.105557_bib40","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1128\/iai.64.7.2782-2786.1996","article-title":"Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms","volume":"64","author":"Zhan","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2022.105557_bib41","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1128\/IAI.00761-12","article-title":"Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice","volume":"80","author":"Vitry","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2022.105557_bib42","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00361-18","article-title":"Caspase-1 and Caspase-11 mediate pyroptosis, inflammation, and control of Brucella joint infection","volume":"86","author":"Lacey","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2022.105557_bib43","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1172\/JCI7317","article-title":"A proinflammatory role for IL-18 in rheumatoid arthritis","volume":"104","author":"Gracie","year":"1999","journal-title":"J. Clin. Invest."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102200170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102200170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:48:51Z","timestamp":1760111331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102200170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":43,"alternative-id":["S088240102200170X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105557","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional insights into Brucella transcriptional regulator ArsR","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105557"}}