{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:36:50Z","timestamp":1768898210413,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2015\u20132263"],"award-info":[{"award-number":["PICT 2015\u20132263"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.micpath.2022.105645","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T02:19:44Z","timestamp":1655345984000},"page":"105645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Study of the dynamics of in vitro infection with bovine gammaherpesvirus type 4 and apoptosis markers in susceptible cells"],"prefix":"10.1016","volume":"169","author":[{"given":"Florencia","family":"Romeo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique Louge","family":"Uriarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Storani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Mart\u00ednez","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Gonz\u00e1lez","family":"Altamiranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anselmo","family":"Ode\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Verna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.micpath.2022.105645_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.micpath.2022.105645_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology","volume":"104","author":"Locksley","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2022.105645_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","article-title":"Mitochondria as the central control point of apoptosis","volume":"10","author":"Desagher","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.micpath.2022.105645_bib4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/42867","article-title":"Double identity for proteins of the Bcl-2 family","volume":"387","author":"Reed","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2022.105645_bib5","doi-asserted-by":"crossref","first-page":"647 656","DOI":"10.1038\/nrc883","article-title":"The BCL2 family: regulators of the cellular life or death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"336","key":"10.1016\/j.micpath.2022.105645_bib6","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/348334a0","article-title":"Bcl 2 is an inner mitochondrial membrane protein that blocks programmed cell death","volume":"348","author":"Hockenbery","year":"1990","journal-title":"Nature"},{"issue":"332","key":"10.1016\/j.micpath.2022.105645_bib7","first-page":"327","article-title":"Oltvai: bcl 2\/BAX: a rheostat that regulates an anti oxidant pathway and cell death","volume":"4","author":"Korsmeyer","year":"1993","journal-title":"Semin. Cancer Biol."},{"issue":"2","key":"10.1016\/j.micpath.2022.105645_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2613.2001.iep195.x","article-title":"Viruses and apoptosis","volume":"82","author":"Thomson","year":"2001","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micpath.2022.105645_bib9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev.micro.53.1.577","article-title":"Viruses and apoptosis","volume":"53","author":"Roulston","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2022.105645_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104170","article-title":"Analysis of the anti-apoptotic v-Bcl2 and v-Flip genes and effect on in vitro programmed cell death of Argentinean isolates of bovine gammaherpesvirus 4 (BoHV-4)","volume":"144","author":"Mor\u00e1n","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2022.105645_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0065-3527(06)69002-7","article-title":"Apoptosis during herpes simplex virus infection","volume":"69","author":"Nguyen","year":"2007","journal-title":"Adv. Virus Res."},{"issue":"3","key":"10.1016\/j.micpath.2022.105645_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/tbed.12155","article-title":"Impact of bovine herpesvirus 4 (BoHV-4) on reproduction","volume":"62","author":"Chastant-Maillard","year":"2015","journal-title":"Transbound Emerg Dis"},{"key":"10.1016\/j.micpath.2022.105645_bib13","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/104063870101300608","article-title":"Endometritis in postparturient cattle associated with bovine herpesvirus-4 infection: 15 cases","volume":"13","author":"Frazier","year":"2001","journal-title":"J. Vet. Diagn. Invest."},{"issue":"1","key":"10.1016\/j.micpath.2022.105645_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/REP-07-0065","article-title":"Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function","volume":"134","author":"Donofrio","year":"2007","journal-title":"Reproduction"},{"issue":"3","key":"10.1016\/j.micpath.2022.105645_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/REP-08-0171","article-title":"Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease","volume":"136","author":"Donofrio","year":"2008","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.micpath.2022.105645_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/viro.2000.0575","article-title":"The gamma-2-herpesvirus bovine herpesvirus 4 causes apoptotic infection in permissive cell lines","volume":"277","author":"Sciortino","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2022.105645_bib17","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2741\/1320","article-title":"The involvement of oxidative stress in bovine herpesvirus type 4-mediated apoptosis","volume":"9","author":"Pagnini","year":"2004","journal-title":"Front. Biosci."},{"issue":"20","key":"10.1016\/j.micpath.2022.105645_bib18","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-05-1076","article-title":"Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo","volume":"65","author":"Gillet","year":"2005","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.micpath.2022.105645_bib19","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/JVI.78.5.2336-2347.2004","article-title":"Investigation of the susceptibility of human cell lines to bovine herpesvirus 4 infection: demonstration that human cells can support a nonpermissive persistent infection which protects them against tumor necrosis factor alpha-induced apoptosis","volume":"78","author":"Gillet","year":"2004","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.micpath.2022.105645_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1095\/biolreprod.116.139097","article-title":"Virusmediated metalloproteinase 1 induction revealed by transcriptome profiling of bovine herpesvirus 4-infected bovine endometrial stromal cells","volume":"95","author":"Tebaldi","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.micpath.2022.105645_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2021.114097","article-title":"Effect of bovine viral diarrhea virus on subsequent infectivity of bovine gammaherpesvirus 4 in endometrial cells in primary culture: an in vitro model of viral co-infection","volume":"291","author":"Romeo","year":"2021","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.micpath.2022.105645_bib22","article-title":"Characterization of the first bovine gammaherpesvirus 4 strain isolated from an aborted bovine fetus in Argentina","author":"Romeo","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2022.105645_bib23","article-title":"Frequency of bovine viral diarrhea virus (BVDV) in Argentinean bovine herds and comparison of diagnostic tests for BVDV detection in bovine serum samples: a preliminary study","volume":"2020","author":"Spetter","year":"2020","journal-title":"Braz. J. Microbiol."},{"issue":"1\u20132","key":"10.1016\/j.micpath.2022.105645_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2012.04.039","article-title":"Genomic analysis of bovine herpesvirus type 4 (BoHV-4) from Argentina: high genetic variability and novel phylogenetic groups","volume":"160","author":"Verna","year":"2012","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2022.105645_bib25","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.4142\/jvs.2020.21.e5","article-title":"Analysis of the transcripts encoding for antigenic proteins of bovine gammaherpesvirus 4","volume":"21","author":"Romeo","year":"2020","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.micpath.2022.105645_bib26","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"issue":"No 6","key":"10.1016\/j.micpath.2022.105645_bib27","doi-asserted-by":"crossref","DOI":"10.1262\/jrd.2018-063","article-title":"Involvement of interferon-tau in the induction of apoptotic, pyroptotic, and autophagic cell death-related signaling pathways in the bovine uterine endometrium during early pregnancy","volume":"64","author":"Suzuki","year":"2018","journal-title":"J. Reprod. Dev."},{"issue":"6","key":"10.1016\/j.micpath.2022.105645_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micpath.2022.105645_bib29","series-title":"R: a Language and Environment for Statistical Computing","author":"Core Team","year":"2020"},{"key":"10.1016\/j.micpath.2022.105645_bib30","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/bj3180749","article-title":"Chromatin condensation during apoptosis requires ATP","volume":"318","author":"Kass","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.micpath.2022.105645_bib31","article-title":"Mitochondrial membrane dynamics, cristae remodeling and apoptosis","volume":"1763","author":"Heath-Engel","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micpath.2022.105645_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-291X(03)00615-6","article-title":"Mechanisms of cytochrome c release by proapoptotic BCL-2 family members","volume":"304","author":"Scorrano","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.micpath.2022.105645_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5483\/BMBRep.2008.41.1.011","article-title":"The role of mitochondria in apoptosis","volume":"41","author":"Seon-Yong","year":"2008","journal-title":"BMB Rep"},{"key":"10.1016\/j.micpath.2022.105645_bib34","doi-asserted-by":"crossref","unstructured":"A. Autret, S.J. Martin, 2009. Emerging role for members of the Bcl-2 family of mitochondrial morphogenesis. Mol. Cell 36:355\u2013363.","DOI":"10.1016\/j.molcel.2009.10.011"},{"key":"10.1016\/j.micpath.2022.105645_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cimid.2019.01.014","article-title":"Comparative analysis of replicative properties of phylogenetically divergent, Argentinean BoHV-4 strains in cell lines from different origins","volume":"63","author":"Mor\u00e1n","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2022.105645_bib36","article-title":"Gene expression and in vitro replication of bovine gammaherpesvirus type 4","author":"Romeo","year":"2020","journal-title":"Arch. Virol."},{"issue":"7","key":"10.1016\/j.micpath.2022.105645_bib37","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/jcb.24494","article-title":"Bovine herpesvirus type 4 infection modulates autophagy in a permissive cell line","volume":"114","author":"Montagnaro","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.micpath.2022.105645_bib38","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/jvi.71.3.1739-1746.1997","article-title":"Regulation of apoptosis by viral gene products","volume":"71","author":"Teodoro","year":"1997","journal-title":"J. Virol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022002583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022002583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:42:06Z","timestamp":1760110926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401022002583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":38,"alternative-id":["S0882401022002583"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105645","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study of the dynamics of in vitro infection with bovine gammaherpesvirus type 4 and apoptosis markers in susceptible cells","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105645"}}