{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:54:37Z","timestamp":1767891277901,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.micpath.2022.105957","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T16:25:23Z","timestamp":1671812723000},"page":"105957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Cyproheptadine hydrochloride inhibits African swine fever viral replication in vitro"],"prefix":"10.1016","volume":"175","author":[{"given":"Huimei","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DengShuai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingguo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2022.105957_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1099\/jgv.0.001049","article-title":"ICTV virus taxonomy profile: Asfarviridae","volume":"99","author":"Alonso","year":"2018","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micpath.2022.105957_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108832","article-title":"Multifaceted immune responses to african swine fever virus: implications for vaccine development","volume":"249","author":"Wang","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2022.105957_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.virusres.2019.04.002","article-title":"African swine fever virus evasion of host defences","volume":"266","author":"Dixon","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2022.105957_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/v11090864","article-title":"An update on african swine fever virology","volume":"11","author":"Karger","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2022.105957_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.736780","article-title":"Flavonoid library screening reveals kaempferol as a potential antiviral agent against african swine fever virus","volume":"12","author":"Arabyan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2022.105957_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.637487","article-title":"Evidence-based african swine fever policies: do we address virus and host adequately?","volume":"8","author":"Busch","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.micpath.2022.105957_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2011.04.013","article-title":"Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication","volume":"91","author":"Galindo","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.micpath.2022.105957_bib8","article-title":"Approaches and perspectives for development of african swine fever virus","volume":"5","author":"Arias","year":"2017","journal-title":"Vaccines. Vaccines."},{"key":"10.1016\/j.micpath.2022.105957_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.antiviral.2016.08.021","article-title":"In vitro inhibition of African swine fever virus-topoisomerase II disrupts viral replication","volume":"134","author":"Freitas","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.micpath.2022.105957_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev-biochem-060713-035546","article-title":"RNA helicase proteins as chaperones and remodelers","volume":"83","author":"Jarmoskaite","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.micpath.2022.105957_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tibs.2018.02.001","article-title":"Unravelling the mechanisms of RNA helicase regulation","volume":"43","author":"Sloan","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.micpath.2022.105957_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.sbi.2010.03.011","article-title":"SF1 and SF2 helicases: family matters","volume":"20","author":"Fairman-Williams","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.micpath.2022.105957_bib13","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1093\/nar\/gkz150","article-title":"Structural basis for RNA translocation by DEAH-box ATPases","volume":"47","author":"Hamann","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2022.105957_bib14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrm1335","article-title":"DEAD-box proteins: the driving forces behind RNA metabolism","volume":"5","author":"Rocak","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.micpath.2022.105957_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1042\/BST20170095","article-title":"Distinct RNA-unwinding mechanisms of DEAD-box and DEAH-box RNA helicase proteins in remodeling structured RNAs and RNPs","volume":"45","author":"Gilman","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.micpath.2022.105957_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vetmic.2018.02.021","article-title":"Interaction of porcine monocyte-derived dendritic cells with African swine fever viruses of diverse virulence","volume":"216","author":"Franzoni","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2022.105957_bib17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1042\/BST20191108","article-title":"Transcriptome view of a killer: African swine fever virus","volume":"48","author":"Cackett","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.micpath.2022.105957_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000237836","article-title":"Effect of disodium phosphonoacetate and iododeoxyuridine on the multiplication of African swine fever virus in vitro","volume":"25","author":"Gil-Fern\u00e1ndez","year":"1979","journal-title":"Chemotherapy"},{"key":"10.1016\/j.micpath.2022.105957_bib19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1192\/bjp.117.541.681","article-title":"Cyproheptadine hydrochloride (Periactin) and anorexia nervosa: a case report","volume":"117","author":"Benady","year":"1970","journal-title":"Br. J. Psychiatr. : J. Ment. Sci."},{"key":"10.1016\/j.micpath.2022.105957_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1186\/2193-1801-2-573","article-title":"Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine","volume":"2","author":"Okuma","year":"2013","journal-title":"SpringerPlus"},{"key":"10.1016\/j.micpath.2022.105957_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0091-3057(73)90012-9","article-title":"Effects of cyproheptadine on the feeding and satiety centers in the rat","volume":"1","author":"Oomura","year":"1973","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.micpath.2022.105957_bib22","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/BF01945832","article-title":"Effect of cyproheptadine hydrochloride on spermatogenesis","volume":"31","author":"Sarkar","year":"1975","journal-title":"Experientia"},{"key":"10.1016\/j.micpath.2022.105957_bib23","series-title":"CARRASCOSA JFSaEV. PRODUCTION AND TITRATION OF AFRICAN SWINE FEVER VIRUS JN PORCINE ALVEOLAR MACROPHAGES","author":"Angel","year":"1982"},{"key":"10.1016\/j.micpath.2022.105957_bib24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12985-021-01637-6","article-title":"Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN\/GS\/2018 strain","volume":"18","author":"Yang","year":"2021","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2022.105957_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02330-21","article-title":"MGF360-9L is a major virulence factor associated with the african swine fever virus by antagonizing the JAK\/STAT signaling pathway","volume":"13","author":"Zhang","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2022.105957_bib26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micpath.2022.105957_bib27","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.31557\/APJCP.2022.23.5.1539","article-title":"Inhibitors of EYA3 protein in ewing sarcoma","volume":"23","author":"Shah","year":"2022","journal-title":"Asian Pac. J. Cancer Prev. APJCP : Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.micpath.2022.105957_bib28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/omi.2022.0067","article-title":"Searching for novel anaplastic lymphoma kinase inhibitors: structure-guided screening of natural compounds for a tyrosine kinase therapeutic target in cancers","volume":"26","author":"Adnan","year":"2022","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.micpath.2022.105957_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2022.108272","article-title":"Pharmacophore modelling, docking and molecular dynamic simulation studies in the discovery of potential human renin inhibitors","volume":"116","author":"Halimi","year":"2022","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.micpath.2022.105957_bib30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jviromet.2005.05.005","article-title":"Rapid human metapneumovirus microneutralization assay based on green fluorescent protein expression","volume":"128","author":"Biacchesi","year":"2005","journal-title":"J. Virol Methods"},{"key":"10.1016\/j.micpath.2022.105957_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb2614s53","article-title":"Methods for growing and titrating African swine fever virus: field and laboratory samples","author":"Carrascosa","year":"2011","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.micpath.2022.105957_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0378-1119(93)90090-P","article-title":"Two putative African swine fever virus helicases similar to yeast 'DEAH' pre-mRNA processing proteins and vaccinia virus ATPases D11L and D6R","volume":"134","author":"Y\u00e1\u00f1ez","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.micpath.2022.105957_bib33","first-page":"135","article-title":"Research advances on the structure and function of African swine fever virus helicases","volume":"51","author":"Zhang","year":"2021","journal-title":"Chinese Veterinary Science"},{"key":"10.1016\/j.micpath.2022.105957_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01293-18","article-title":"A proteomic atlas of the african swine fever virus particle","volume":"92","author":"Alejo","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2022.105957_bib35","first-page":"17","article-title":"The treatment of migraine headaches in children and adolescents","volume":"13","author":"Brenner","year":"2008","journal-title":"J. Pediatr. Pharmacol. Therapeut. : JPPT : the official journal of PPAG"},{"key":"10.1016\/j.micpath.2022.105957_bib36","series-title":"Preventive Effect of Cyproheptadine Hydrochloride in Refractory Patients with Frequent Migraine","author":"Hirohisa Okuma","year":"2013"},{"key":"10.1016\/j.micpath.2022.105957_bib37","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/cen.13594","article-title":"A novel treatment for height growth in patients with growth hormone insensitivity syndrome by cyproheptadine hydrochloride","volume":"88","author":"Razzaghy-Azar","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.micpath.2022.105957_bib38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/MPH.0b013e3181864a5e","article-title":"The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer\/treatment-related cachexia","volume":"30","author":"Couluris","year":"2008","journal-title":"Journal of pediatric hematology\/oncology"},{"key":"10.1016\/j.micpath.2022.105957_bib39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/1871523019666201023111825","article-title":"Silico and in vitro studies of the inhibitory effect of antihistamine drug cyproheptadine hydrochloride on human salivary alpha amylase","volume":"20","author":"Madjda","year":"2021","journal-title":"Anti-Inflammatory Anti-Allergy Agents Med. Chem."},{"key":"10.1016\/j.micpath.2022.105957_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/14756366.2013.766607","article-title":"Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase","volume":"29","author":"Furuta","year":"2014","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.micpath.2022.105957_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/bph.13358","article-title":"Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase","volume":"173","author":"Lee","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.micpath.2022.105957_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/v14010010","article-title":"Evaluation of an ASFV RNA helicase gene A859L for virus replication and swine virulence","volume":"14","author":"Ramirez-Medina","year":"2021","journal-title":"Viruses"},{"issue":"Pt 9","key":"10.1016\/j.micpath.2022.105957_bib43","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1099\/0022-1317-74-9-1969","article-title":"Three African swine fever virus genes encoding proteins with homology to putative helicases of vaccinia virus","volume":"74","author":"Baylis","year":"1993","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micpath.2022.105957_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002754","article-title":"African swine fever virus uses macropinocytosis to enter host cells","volume":"8","author":"S\u00e1nchez","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2022.105957_bib45","first-page":"347","article-title":"Chemical stability of cyproheptadine hydrochloride in an oral liquid dosage form","volume":"11","author":"Gupta","year":"2007","journal-title":"Int. J. Pharm. Compd."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022005708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401022005708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:29:14Z","timestamp":1736404154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401022005708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":45,"alternative-id":["S0882401022005708"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105957","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyproheptadine hydrochloride inhibits African swine fever viral replication in vitro","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2022.105957","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105957"}}