{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:24:36Z","timestamp":1790508276558,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7212104"],"award-info":[{"award-number":["7212104"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014993","name":"Central Military Commission of the People's Republic of China Logistic Support Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.micpath.2023.106132","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:20:17Z","timestamp":1684293617000},"page":"106132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Zinc oxide nanoparticles have biphasic roles on Mycobacterium-induced inflammation by activating autophagy and ferroptosis mechanisms in infected macrophages"],"prefix":"10.1016","volume":"180","author":[{"given":"SiJia","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PengFei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengtao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.micpath.2023.106132_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijantimicag.2012.06.012","article-title":"Evaluation of the in vitro and intracellular efficacy of new monosubstituted sulfonylureas against extensively drug-resistant tuberculosis","volume":"40","author":"Wang","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"3","key":"10.1016\/j.micpath.2023.106132_bib2","first-page":"536","article-title":"Serum zinc concentrations in patients with pulmonary tuberculosis","volume":"27","author":"Mazumder","year":"2018","journal-title":"Mymensingh Med. J."},{"key":"10.1016\/j.micpath.2023.106132_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jtemb.2018.07.008","article-title":"Serum selenium levels in tuberculosis patients: a systematic review and meta-analysis","volume":"50","author":"Muzembo","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"13","key":"10.1016\/j.micpath.2023.106132_bib5","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1074\/jbc.M609974200","article-title":"Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis","volume":"282","author":"Lucarelli","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.micpath.2023.106132_bib4","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.3390\/nu12092491","article-title":"Association of dietary micronutrient intake with pulmonary tuberculosis treatment failure rate: ACohort study","volume":"12","author":"Xiong","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.micpath.2023.106132_bib6","article-title":"A novel zinc exporter CtpG enhances resistance to zinc toxicity and survival in Mycobacterium bovis","author":"Chen","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"4","key":"10.1016\/j.micpath.2023.106132_bib7","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10895-021-02750-z","article-title":"A luminescent Zn(II)-Containing complex: selective sensing of Cr(VI) anion and application values on tuberculosis care through increasing the antibacterial response of macrophages","volume":"31","author":"Mao","year":"2021","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.micpath.2023.106132_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118175","article-title":"A new mononuclear zinc(II) complex: crystal structure, DNA- and BSA-binding, and molecular modeling; in vitro cytotoxicity of the Zn(II) complex and its nanocomplex","volume":"233","author":"Daryanavard","year":"2020","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.micpath.2023.106132_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/0929867328666210614122109","article-title":"An overview of zinc oxide nanoparticles produced by plant extracts for anti-tuberculosis treatments","volume":"29","author":"Behzad","year":"2022","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.micpath.2023.106132_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijtb.2020.07.032","article-title":"Evaluation of magnesium oxide and zinc oxide nanoparticles against multi-drug-resistance Mycobacterium tuberculosis","volume":"68","author":"Yaghubi Kalurazi","year":"2021","journal-title":"Indian J. Tubercul."},{"issue":"2","key":"10.1016\/j.micpath.2023.106132_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijmyco.2016.03.004","article-title":"Limonia acidissima L. leaf mediated synthesis of zinc oxide nanoparticles: a potent tool against Mycobacterium tuberculosis","volume":"5","author":"Taranath","year":"2016","journal-title":"Int J Mycobacteriol"},{"issue":"11","key":"10.1016\/j.micpath.2023.106132_bib12","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3390\/nano9111631","article-title":"Metal oxide nanoparticles in therapeutic regulation of macrophage functions","volume":"9","author":"Dukhinova","year":"2019","journal-title":"Nanomaterials"},{"key":"10.1016\/j.micpath.2023.106132_bib13","series-title":"Nanotechnological Approaches in Food Microbiology","author":"Dhull","year":"2020"},{"key":"10.1016\/j.micpath.2023.106132_bib14","series-title":"Biogenic Metal Nanoparticles and Their Antimicrobial Properties","author":"Srinivasan","year":"2020"},{"issue":"2","key":"10.1016\/j.micpath.2023.106132_bib15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/ci3004545","article-title":"Discovery of novel acetohydroxyacid synthase inhibitors as active agents against Mycobacterium tuberculosis by virtual screening and bioassay","volume":"53","author":"Wang","year":"2013","journal-title":"J. Chem. Inf. Model."},{"issue":"12","key":"10.1016\/j.micpath.2023.106132_bib16","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"2021","journal-title":"Autophagy"},{"issue":"Pt B","key":"10.1016\/j.micpath.2023.106132_bib17","article-title":"Selenium donor restricts the intracellular growth of Mycobacterium tuberculosis through the induction of c-Jun-mediated both canonical autophagy and LC3-associated phagocytosis of alveolar macrophages","volume":"161","author":"Chen","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2023.106132_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104278","article-title":"SIRP\u03b1 maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis","volume":"85","author":"Wang","year":"2022","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.micpath.2023.106132_bib19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"Acute Lung Injury in Animals Study Group. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.micpath.2023.106132_bib20","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3389\/fimmu.2019.01824","article-title":"The caspase inhibitor Z-VAD-FMK alleviates endotoxic shock via inducing macrophages necroptosis and promoting MDSCs-mediated inhibition of macrophages activation","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2023.106132_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1556-276X-9-117","article-title":"ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes","volume":"9","author":"Wang","year":"2014","journal-title":"Nanoscale Res. Lett."},{"issue":"16","key":"10.1016\/j.micpath.2023.106132_bib22","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.3390\/ijms20164042","article-title":"Role of autophagy in zinc oxide nanoparticles-induced apoptosis of mouse LEYDIG cells","volume":"20","author":"Shen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2023.106132_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.freeradbiomed.2017.05.015","article-title":"Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death","volume":"110","author":"Arakha","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.micpath.2023.106132_bib24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7883\/yoken.67.485","article-title":"Evaluation of the in vivo efficacy of novel monosubstituted sulfonylureas against H37Rv and extensively drug-resistant tuberculosis","volume":"67","author":"Liu","year":"2014","journal-title":"Jpn. J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.micpath.2023.106132_bib25","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/nano11040903","article-title":"Interactive effects of biosynthesized nanocomposites and their antimicrobial and cytotoxic potentials","volume":"11","author":"El-Kahky","year":"2021","journal-title":"Nanomaterials"},{"issue":"2","key":"10.1016\/j.micpath.2023.106132_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijtb.2020.07.032","article-title":"Evaluation of magnesium oxide and zinc oxide nanoparticles against multi-drug-resistance Mycobacterium tuberculosis","volume":"68","author":"Yaghubi Kalurazi","year":"2021","journal-title":"Indian J. Tubercul."},{"issue":"9","key":"10.1016\/j.micpath.2023.106132_bib27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2217\/nnm.14.48","article-title":"Zinc oxide nanoparticles impair bacterial clearance by macrophages","volume":"9","author":"Lin","year":"2014","journal-title":"Nanomedicine"},{"issue":"9","key":"10.1016\/j.micpath.2023.106132_bib28","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1166\/jnn.2015.10319","article-title":"Zinc oxide nanoparticles suppress LPS-induced NF-\u03baB activation by inducing A20, a negative regulator of NF-\u03baB, in RAW 264.7 macrophages","volume":"15","author":"Kim","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"3","key":"10.1016\/j.micpath.2023.106132_bib29","first-page":"1557","article-title":"Zinc oxide nanoparticles promotes liver cancer cell apoptosis through inducing autophagy and promoting p53","volume":"25","author":"Yang","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.micpath.2023.106132_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.micpath.2023.106132_bib31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/15376516.2018.1553221","article-title":"Zinc oxide nanoparticles impacts: cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity","volume":"29","author":"Singh","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.micpath.2023.106132_bib32","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.2147\/IJN.S250367","article-title":"Zinc oxide nanoparticles induce ferroptotic neuronal cell death in vitro and in vivo","volume":"15","author":"Qin","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.micpath.2023.106132_bib33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1084\/jem.20181776","article-title":"A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis","volume":"216","author":"Amaral","year":"2019","journal-title":"J. Exp. Med."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:32:31Z","timestamp":1736404351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401023001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":33,"alternative-id":["S0882401023001651"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106132","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc oxide nanoparticles have biphasic roles on Mycobacterium-induced inflammation by activating autophagy and ferroptosis mechanisms in infected macrophages","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106132"}}