{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:31:53Z","timestamp":1788982313378,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KYXJ202005"],"award-info":[{"award-number":["KYXJ202005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872528"],"award-info":[{"award-number":["31872528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172933"],"award-info":[{"award-number":["32172933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172933,31872528"],"award-info":[{"award-number":["32172933,31872528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.micpath.2023.106135","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T16:16:43Z","timestamp":1683735403000},"page":"106135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["High-concentrate diet elevates histone lactylation mediated by p300\/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows"],"prefix":"10.1016","volume":"180","author":[{"given":"Lairong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2023.106135_bib1","first-page":"1483","article-title":"The economic importance of the losses of cow milk due to mastitis: a meta-analysis","volume":"6","author":"Kvapilik","year":"2014","journal-title":"Bulgarian Journal of Agricultural Science"},{"key":"10.1016\/j.micpath.2023.106135_bib2","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3168\/jds.S0022-0302(00)75002-8","article-title":"Effects of brown midrib 3 mutation in corn silage on productivity of dairy cows fed two concentrations of dietary neutral detergent fiber: 3. Digestibility and microbial efficiency","volume":"83","author":"Oba","year":"2000","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib3","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3168\/jds.S0022-0302(99)75340-3","article-title":"Diagnostic methods for the detection of subacute ruminal acidosis in dairy cows","volume":"82","author":"Garrett","year":"1999","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib4","doi-asserted-by":"crossref","first-page":"38578","DOI":"10.18632\/oncotarget.6161","article-title":"Hepatic tlr4 signaling is activated by lps from digestive tract during sara, and epigenetic mechanisms contribute to enforced tlr4 expression","volume":"6","author":"Chang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.micpath.2023.106135_bib5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jsfa.10734","article-title":"Sodium butyrate attenuated ie-dap induced inflammatory response in the mammary glands of dairy goats fed high-concentrate diet","volume":"101","author":"Wang","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.micpath.2023.106135_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12917-018-1491-3","article-title":"Histamine activates inflammatory response and depresses casein synthesis in mammary gland of dairy cows during sara","volume":"14","author":"Chang","year":"2018","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.micpath.2023.106135_bib7","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3168\/jds.S0022-0302(05)72807-1","article-title":"Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response","volume":"88","author":"Gozho","year":"2005","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib8","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jsfa.10734","article-title":"Sodium butyrate attenuated ie-dap induced inflammatory response in the mammary glands of dairy goats fed high-concentrate diet","volume":"101","author":"Wang","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.micpath.2023.106135_bib9","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.18632\/oncotarget.7371","article-title":"Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits casein synthesis in the mammary glands of lactating dairy cows","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.micpath.2023.106135_bib10","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2527\/2004.8272033x","article-title":"Splanchnic metabolism of volatile fatty acids absorbed from the washed reticulorumen of steers","volume":"82","author":"Kristensen","year":"2004","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2180-12-142","article-title":"Rumen microbial and fermentation characteristics are affected differently by bacterial probiotic supplementation during induced lactic and subacute acidosis in sheep","volume":"12","author":"Lettat","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2023.106135_bib12","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3168\/jds.S0022-0302(03)73641-8","article-title":"Effects of particle size of alfalfa-based dairy cow diets on chewing activity, ruminal fermentation, and milk production","volume":"86","author":"Beauchemin","year":"2003","journal-title":"J. Dairy Sci."},{"issue":"Pt 2","key":"10.1016\/j.micpath.2023.106135_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3430281","article-title":"The proton-linked monocarboxylate transporter (mct) family: structure, function and regulation","volume":"343","author":"Halestrap","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.micpath.2023.106135_bib14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/pr.119.018762","article-title":"Monocarboxylate transporters (slc16): function, regulation, and role in health and disease","volume":"72","author":"Felmlee","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.micpath.2023.106135_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-12-394316-3.00009-0","article-title":"The slc16a family of monocarboxylate transporters (mcts)--physiology and function in cellular metabolism, ph homeostasis, and fluid transport","volume":"70","author":"Adijanto","year":"2012","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.micpath.2023.106135_bib16","doi-asserted-by":"crossref","first-page":"G1139","DOI":"10.1152\/ajpgi.00268.2001","article-title":"Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1","volume":"283","author":"Muller","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.micpath.2023.106135_bib17","doi-asserted-by":"crossref","first-page":"R997","DOI":"10.1152\/ajpregu.00343.2006","article-title":"Expression and localization of monocarboxylate transporters and sodium\/proton exchangers in bovine rumen epithelium","volume":"292","author":"Graham","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.micpath.2023.106135_bib18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/d41586-019-03122-1","article-title":"Lactate links metabolism to genes","volume":"574","author":"Izzo","year":"2019","journal-title":"Nature (London)"},{"key":"10.1016\/j.micpath.2023.106135_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2023.106135_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m(6)a reader protein ythdf2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.micpath.2023.106135_bib21","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"Tlr signaling adapter bcap regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"Irizarry-Caro","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2023.106135_bib22","article-title":"A novel metabolic reprogramming code: current status and prospects","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2023.106135_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101456","article-title":"A proteomic atlas of ligand-receptor interactions at the ovine maternal-fetal interface reveals the role of histone lactylation in uterine remodeling","volume":"298","author":"Yang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2023.106135_bib24","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41591-019-0485-4","article-title":"Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism","volume":"25","author":"Scheiman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.micpath.2023.106135_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41576-018-0072-4","article-title":"The many lives of kats - detectors, integrators and modulators of the cellular environment","volume":"20","author":"Sheikh","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.micpath.2023.106135_bib26","series-title":"A Passing Fad or the Future of Posttranslational Modification","author":"Xin","year":"2022"},{"key":"10.1016\/j.micpath.2023.106135_bib27","first-page":"1826","article-title":"Transcription coactivator p300 promotes inflammation by enhancing p65 subunit activation in type 2 diabetes nephropathy","volume":"12","author":"Lan","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.micpath.2023.106135_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage hmgb1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.micpath.2023.106135_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1165\/rcmb.2020-0360OC","article-title":"Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation","volume":"64","author":"Cui","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.micpath.2023.106135_bib30","doi-asserted-by":"crossref","DOI":"10.3168\/jds.2021-21066","article-title":"A high-concentrate diet induces an inflammatory response and oxidative stress and depresses milk fat synthesis in the mammary gland of dairy cows","author":"Ma","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib31","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.3168\/jds.2021-21187","article-title":"A high-concentrate diet provokes inflammation, endoplasmic reticulum stress, and apoptosis in mammary tissue of dairy cows through the upregulation of stim1\/orai1","volume":"105","author":"Meng","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib32","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The science and translation of lactate shuttle theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.micpath.2023.106135_bib33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The cbp co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2023.106135_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3233\/CBM-160336","article-title":"Elevated lactate dehydrogenase (ldh) can be a marker of immune suppression in cancer: interplay between hematologic and solid neoplastic clones and their microenvironments","volume":"19","author":"Ding","year":"2017","journal-title":"Cancer Biomarkers"},{"key":"10.1016\/j.micpath.2023.106135_bib35","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.3168\/jds.2021-20395","article-title":"Genetic parameters of differential somatic cell count, milk composition, and cheese-making traits measured and predicted using spectral data in holstein cows","volume":"104","author":"Pegolo","year":"2021","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib36","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.3168\/jds.2021-21267","article-title":"Quarter-level analyses of the associations among subclinical intramammary infection and milk quality, udder health, and cheesemaking traits in holstein cows","volume":"105","author":"Pegolo","year":"2022","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1439-0442.2003.00569.x","article-title":"Subacute ruminal acidosis (sara): a review","volume":"50","author":"Kleen","year":"2003","journal-title":"J Vet Med A Physiol Pathol Clin Med"},{"key":"10.1016\/j.micpath.2023.106135_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2007.12.016","article-title":"Subacute ruminal acidosis in dairy cows: the physiological causes, incidence and consequences","volume":"176","author":"Plaizier","year":"2008","journal-title":"Vet. J."},{"key":"10.1016\/j.micpath.2023.106135_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.anifeedsci.2005.08.004","article-title":"Understanding and preventing subacute ruminal acidosis in dairy herds: a review","volume":"126","author":"Krause","year":"2006","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.micpath.2023.106135_bib40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2180-12-142","article-title":"Rumen microbial and fermentation characteristics are affected differently by bacterial probiotic supplementation during induced lactic and subacute acidosis in sheep","volume":"12","author":"Lettat","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2023.106135_bib41","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/aem.38.3.422-430.1979","article-title":"Changes in lactate-producing and lactate-utilizing bacteria in relation to ph in the rumen of sheep during stepwise adaptation to a high-concentrate diet","volume":"38","author":"Mackie","year":"1979","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.micpath.2023.106135_bib42","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3168\/jds.S0022-0302(85)81017-1","article-title":"Regulation of lactate production in streptococcus bovis: a spiraling effect that contributes to rumen acidosis","volume":"68","author":"Russell","year":"1985","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib43","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2527\/jas1979.4961569x","article-title":"Effect of dietary lactic acid on rumen lactate metabolism and blood acid-base status of lambs switched from low to high concentrate diets","volume":"49","author":"Huntington","year":"1979","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib44","article-title":"D-lactate increases cytokine production in bovine fibroblast-like synoviocytes via mct1 uptake and the mapk, pi3k\/akt, and nfkappab pathways","volume":"10","author":"Manosalva","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2023.106135_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.12701\/yujm.2020.00892","article-title":"A multifunctional signaling molecule","volume":"38","author":"Lactate","year":"2021","journal-title":"Yeungnam Univ J Med"},{"key":"10.1016\/j.micpath.2023.106135_bib46","first-page":"E677","article-title":"Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans","volume":"259","author":"Consoli","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.micpath.2023.106135_bib47","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1113\/jphysiol.2002.027128","article-title":"Lactate and glucose interactions during rest and exercise in men: effect of exogenous lactate infusion","volume":"544","author":"Miller","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.micpath.2023.106135_bib48","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cmet.2019.10.004","article-title":"Lactate buildup at the site of chronic inflammation promotes disease by inducing cd4(+) t cell metabolic rewiring","volume":"30","author":"Pucino","year":"2019","journal-title":"Cell Metabol."},{"key":"10.1016\/j.micpath.2023.106135_bib49","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cbin.10975","article-title":"Trem2 inhibits inflammatory responses in mouse microglia by suppressing the pi3k\/nf-kappab signaling","volume":"43","author":"Li","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.micpath.2023.106135_bib50","first-page":"976","article-title":"Propofol relieves inflammation in miri rats by inhibiting rho\/rock signaling pathway","volume":"25","author":"Liu","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib51","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.3168\/jds.2019-17444","article-title":"Staphylococcal enterotoxin m induced inflammation and impairment of bovine mammary epithelial cells","volume":"103","author":"Zhao","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib52","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.3168\/jds.2019-17458","article-title":"Klebsiella pneumoniae isolated from bovine mastitis is cytopathogenic for bovine mammary epithelial cells","volume":"103","author":"Cheng","year":"2020","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejps.2016.09.014","article-title":"Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells","volume":"96","author":"Manerba","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.micpath.2023.106135_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/iub.573","article-title":"The monocarboxylate transporter family--structure and functional characterization","volume":"64","author":"Halestrap","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.micpath.2023.106135_bib55","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mam.2012.05.003","article-title":"The slc16 gene family - structure, role and regulation in health and disease","volume":"34","author":"Halestrap","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.micpath.2023.106135_bib56","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jsfa.10734","article-title":"Sodium butyrate attenuated ie-dap induced inflammatory response in the mammary glands of dairy goats fed high-concentrate diet","volume":"101","author":"Wang","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.micpath.2023.106135_bib57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12917-021-02797-x","article-title":"Metformin activated ampk signaling contributes to the alleviation of lps-induced inflammatory responses in bovine mammary epithelial cells","volume":"17","author":"Xu","year":"2021","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.micpath.2023.106135_bib58","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.94.7.2927","article-title":"Creb-binding protein\/p300 are transcriptional coactivators of p65","volume":"94","author":"Gerritsen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2023.106135_bib59","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1074\/jbc.M209572200","article-title":"Post-activation turn-off of nf-kappa b-dependent transcription is regulated by acetylation of p65","volume":"278","author":"Kiernan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2023.106135_bib60","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bcp.2015.12.010","article-title":"The histone acetyltransferase p300 inhibitor c646 reduces pro-inflammatory gene expression and inhibits histone deacetylases","volume":"102","author":"van den Bosch","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.micpath.2023.106135_bib61","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/cbin.11662","article-title":"Uchl1 regulates inflammation via mapk and nf-kappab pathways in lps-activated macrophages","volume":"45","author":"Zhang","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.micpath.2023.106135_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.micpath.2017.03.011","article-title":"Sodium houttuyfonate inhibits lps-induced inflammatory response via suppressing tlr4\/nf-kb signaling pathway in bovine mammary epithelial cells","volume":"107","author":"Wang","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2023.106135_bib63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage hmgb1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.micpath.2023.106135_bib64","article-title":"Lactylated histone h3k18 as a potential biomarker for the diagnosis and predicting the severity of septic shock","volume":"12","author":"Chu","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023001687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023001687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:32:46Z","timestamp":1736404366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401023001687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":64,"alternative-id":["S0882401023001687"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106135","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-concentrate diet elevates histone lactylation mediated by p300\/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106135"}}