{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:02:21Z","timestamp":1768910541211,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.micpath.2023.106172","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T06:06:14Z","timestamp":1684908374000},"page":"106172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Diagnostic investigation of Mycoplasma hyorhinis as a potential pathogen associated with neurological clinical signs and central nervous system lesions in pigs"],"prefix":"10.1016","volume":"180","author":[{"given":"Calvin C.","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Merodio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Spronk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-8663","authenticated-orcid":false,"given":"Huigang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganwu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel J.","family":"Derscheid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-7762","authenticated-orcid":false,"given":"Pablo E.","family":"Pi\u00f1eyro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2023.106172_bib1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.20506\/rst.15.4.983","article-title":"Swine mycoplasmoses","volume":"15","author":"Kobisch","year":"1996","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.micpath.2023.106172_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1354\/vp.36-2-174","article-title":"Intranasally inoculated Mycoplasma hyorhinis causes eustachitis in pigs","volume":"36","author":"Morita","year":"1999","journal-title":"Veterin. Pathol."},{"key":"10.1016\/j.micpath.2023.106172_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2460\/ajvr.1998.59.07.869","article-title":"Induction of temporary otitis media in specific-pathogen-free pigs by intratympanic inoculation of Mycoplasma hyorhinis","volume":"59","author":"Morita","year":"1998","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.micpath.2023.106172_bib4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1177\/1040638719865767","article-title":"Swine conjunctivitis outbreaks associated with Mycoplasma hyorhinis","volume":"31","author":"Resende","year":"2019","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.micpath.2023.106172_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1292\/jvms.65.501","article-title":"Identification and characterization of cytopathogenic Mycoplasma hyorhinis from swine farms with a history of abortions","volume":"65","author":"Shin","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.micpath.2023.106172_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetimm.2017.12.001","article-title":"Reduction of mycoplasmal lesions and clinical signs by vaccination against Mycoplasma hyorhinis","volume":"196","author":"Lee","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.micpath.2023.106172_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40813-020-00178-8","article-title":"Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series","volume":"6","author":"B\u00fcnger","year":"2020","journal-title":"Porcine Health Manag."},{"key":"10.1016\/j.micpath.2023.106172_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/vr.162.9.267","article-title":"Associations between pathogens in healthy pigs and pigs with pneumonia","volume":"162","author":"Palzer","year":"2008","journal-title":"Vet. Rec."},{"key":"10.1016\/j.micpath.2023.106172_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1439-0450.1970.tb01565.x","article-title":"On the occurrence of Mycoplasma hyorhinis in the respiratory organs of pigs, with special reference to enzootic pneumonia","volume":"17","author":"Schulman","year":"1970","journal-title":"Zentralblatt f\u00fcr Veterinarmed. - Reihe B"},{"key":"10.1016\/j.micpath.2023.106172_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jinf.2005.07.005","article-title":"Central nervous system manifestations of Mycoplasma pneumoniae infections","volume":"51","author":"Tsiodras","year":"2005","journal-title":"J. Infect."},{"key":"10.1016\/j.micpath.2023.106172_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1651-2227.1980.tb07103.x","article-title":"Meningitis in a newborn infant caused by Mycoplasma hominis","volume":"69","author":"Hjelm","year":"1980","journal-title":"Acta Paediatr. Scand."},{"key":"10.1016\/j.micpath.2023.106172_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0002-9343(90)90338-E","article-title":"Extragenital Mycoplasma hominis infections in adults","volume":"89","author":"McMahon","year":"1990","journal-title":"Am. J. Med."},{"key":"10.1016\/j.micpath.2023.106172_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcpa.2021.08.001","article-title":"Mycoplasma bovis may travel along the eustachian tube to cause meningitis in Japanese black cattle","volume":"188","author":"Suwanruengsri","year":"2021","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.micpath.2023.106172_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ijmm.2014.07.011","article-title":"In vitro and in vivo cell invasion and systemic spreading of Mycoplasma agalactiae in the sheep infection model","volume":"304","author":"Hegde","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/1040638711403413","article-title":"Meningitis caused by Mycoplasma mycoides subspecies capri in a goat","volume":"23","author":"Schumacher","year":"2011","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.micpath.2023.106172_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcpa.2012.06.006","article-title":"Retrospective study of Mycoplasma gallisepticum meningoencephalitis in six Turkey flocks in western France","volume":"148","author":"Wyrzykowski","year":"2013","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.micpath.2023.106172_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.vetmic.2016.08.007","article-title":"Two strains of Mycoplasma synoviae from chicken flocks on the same layer farm differ in their ability to produce eggshell apex abnormality","volume":"193","author":"Catania","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1099\/00207713-41-1-39","article-title":"Mycoplasma phocarhinis sp. nov. and Mycoplasma phocacerebrale sp. nov., two new species from harbor seals (Phoca vitulina L.)","volume":"41","author":"Giebel","year":"1991","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.micpath.2023.106172_bib19","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1111\/tbed.13645","article-title":"Genetic characterization of Streptococcus equi subspecies zooepidemicus associated with high swine mortality in the United States","volume":"67","author":"Chen","year":"2020","journal-title":"Transb. Emerg. Dis."},{"key":"10.1016\/j.micpath.2023.106172_bib20","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/1462-2920.15721","article-title":"Whole-genome analysis of Klebsiella pneumoniae from bovine mastitis milk in the U.S","volume":"24","author":"Zheng","year":"2022","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib21","doi-asserted-by":"crossref","first-page":"D687","DOI":"10.1093\/nar\/gky1080","article-title":"VFDB 2019: a comparative pathogenomic platform with an interactive web interface","volume":"47","author":"Liu","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2023.106172_bib22","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1128\/IAI.73.5.2828-2834.2005","article-title":"Identification and characterization of human surfactant protein A binding protein of Mycoplasma pneumoniae","volume":"73","author":"Kannan","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2023.106172_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/art.1780140202","article-title":"Mycoplasma hyorhinis swine arthritis. I. Clinical and microbiologic features","volume":"14","author":"Barden","year":"1971","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.micpath.2023.106172_bib24","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1073\/pnas.0510644103","article-title":"ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens","volume":"103","author":"Kannan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micpath.2023.106172_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.rvsc.2017.09.006","article-title":"Mycoplasmas: brain invaders?","volume":"113","author":"Rosales","year":"2017","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.micpath.2023.106172_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9891673","article-title":"Capsular polysaccharide is a main component of Mycoplasma ovipneumoniae in the pathogen-induced toll-like receptor-mediated inflammatory responses in sheep airway epithelial cells","volume":"2017","author":"Jiang","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.micpath.2023.106172_bib27","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/iai.36.2.830-833.1982","article-title":"Capsular material of Mycoplasma gallisepticum and its possible relevance to the pathogenic process","volume":"36","author":"Tajima","year":"1982","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2023.106172_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/vr.147.1.20","article-title":"Comparison of the virulence of European and African isolates of Mycoplasma mycoides subspecies mycoides small colony type","volume":"147","author":"March","year":"2000","journal-title":"Vet. Rec."},{"key":"10.1016\/j.micpath.2023.106172_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ygeno.2019.04.013","article-title":"Comparative genomics analysis of Mycoplasma capricolum subsp. capripneumoniae 87001","volume":"112","author":"Li","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.micpath.2023.106172_bib30","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2105-10-S6-S7","article-title":"The Mycoplasma conjunctivae genome sequencing, annotation and analysis","volume":"10","author":"Calderon-Copete","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.micpath.2023.106172_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1574-6968.1994.tb06682.x","article-title":"Membrane-associated hemolysin activities in mycoplasmas","volume":"116","author":"Chris Minion","year":"1994","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"key":"10.1016\/j.micpath.2023.106172_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.vetmic.2011.08.026","article-title":"Demonstration of neuraminidase activity in Mycoplasma neurolyticum and of neuraminidase proteins in three canine Mycoplasma species","volume":"155","author":"Ber\u010di\u010d","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib33","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1939-1676.2012.00954.x","article-title":"Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis","volume":"26","author":"Barber","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.micpath.2023.106172_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.vetmic.2008.02.004","article-title":"A survey of avian Mycoplasma species for neuraminidase enzymatic activity","volume":"130","author":"Ber\u010di\u010d","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-2958.1995.mmi_18040649.x","article-title":"Mycoplasma hyorhinis vlp gene transcription: critical role in phase variation and expression of surface lipoproteins","volume":"18","author":"Citti","year":"1995","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib36","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1128\/iai.65.5.1773-1785.1997","article-title":"Elongated versions of Vlp surface lipoproteins protect Mycoplasma hyorhinis escape variants from growth-inhibiting host antibodies","volume":"65","author":"Citti","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2023.106172_bib37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.vetmic.2016.01.017","article-title":"The functions of the variable lipoprotein family of Mycoplasma hyorhinis in adherence to host cells","volume":"186","author":"Xiong","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pediatrneurol.2009.04.012","article-title":"Pathogenesis of neurologic manifestations of Mycoplasma pneumoniae infection","volume":"41","author":"Narita","year":"2009","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.micpath.2023.106172_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/BF03548359","article-title":"Mycoplasma hyorhinis in the etiology of serositis among piglets","volume":"35","author":"Eriis","year":"1994","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.micpath.2023.106172_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/vr.156.12.391-b","article-title":"Mycoplasma bovis isolated from brain tissue of calves","volume":"156","author":"Ayling","year":"2005","journal-title":"Vet. Rec."},{"key":"10.1016\/j.micpath.2023.106172_bib41","series-title":"Evaluation of Immune Response and Direct Detection Diagnostics of Mycoplasma Hyorhinis","author":"Merodio","year":"2021"},{"key":"10.1016\/j.micpath.2023.106172_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/1040638714555175","article-title":"Field evaluation of a quantitative polymerase chain reaction assay for Mycoplasma hyorhinis","volume":"26","author":"Clavijo","year":"2014","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.micpath.2023.106172_bib43","first-page":"285","article-title":"Associations among Haemophilus parasuis, Mycoplasma hyorhinis, and porcine reproductive and respiratory syndrome virus infections in pigs with polyserositis","volume":"56","author":"Palzer","year":"2015","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.micpath.2023.106172_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1439-0442.1997.tb01111.x","article-title":"Microbiology and pathology of fibrinous pericarditis in Danish slaughter pigs","volume":"44","author":"Buttensch\u00f8n","year":"1997","journal-title":"J. Vet. Med. Ser. A"},{"key":"10.1016\/j.micpath.2023.106172_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.vetmic.2015.11.003","article-title":"Synergistic pathogenicity in sequential coinfection with Mycoplasma hyorhinis and porcine circovirus type 2","volume":"182","author":"Chen","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2023.106172_bib46","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetimm.2016.06.008","article-title":"Mycoplasma hyorhinis is a potential pathogen of porcine respiratory disease complex that aggravates pneumonia caused by porcine reproductive and respiratory syndrome virus","volume":"177","author":"Lee","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.micpath.2023.106172_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1439-0450.1995.tb00704.x","article-title":"Pattern of infection with the porcine reproductive and respiratory syndrome virus on swine farms in Belgium","volume":"42","author":"Houben","year":"1995","journal-title":"J. Vet. Med. Ser. B"},{"key":"10.1016\/j.micpath.2023.106172_bib48","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1177\/104063879700900323","article-title":"Immunohistochemical detection of porcine reproductive and respiratory syndrome virus antigen in neurovascular lesions","volume":"9","author":"Thanawongnuwech","year":"1997","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.micpath.2023.106172_bib49","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/vr.144.16.444","article-title":"Porcine reproductive and respiratory syndrome virus infection in neonatal pigs characterised by marked neurovirulence","volume":"144","author":"Rossow","year":"1999","journal-title":"Vet. Rec."},{"key":"10.1016\/j.micpath.2023.106172_bib50","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1128\/JVI.75.10.4889-4895.2001","article-title":"In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II","volume":"75","author":"Feng","year":"2001","journal-title":"J. Virol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102300205X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088240102300205X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:33:50Z","timestamp":1736404430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088240102300205X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":50,"alternative-id":["S088240102300205X"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106172","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic investigation of Mycoplasma hyorhinis as a potential pathogen associated with neurological clinical signs and central nervous system lesions in pigs","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106172"}}