{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:04:00Z","timestamp":1784865840011,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006766","name":"Iran University of Science and Technology","doi-asserted-by":"publisher","award":["192122"],"award-info":[{"award-number":["192122"]}],"id":[{"id":"10.13039\/501100006766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.micpath.2023.106280","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:00:27Z","timestamp":1690977627000},"page":"106280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Antibacterial potential of Thymus linearis essential oil collected from Wasturwan mountain: A combination of experimental and theoretical studies involving in silico molecular docking simulation of the major compounds against Novobiocin-resistant mutant of DNA Gyrase-B"],"prefix":"10.1016","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8555-314X","authenticated-orcid":false,"given":"Sameera","family":"Firdous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Showkat H.","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5412-1864","authenticated-orcid":false,"given":"Safeena","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2340-5472","authenticated-orcid":false,"given":"Muneeza","family":"Jehangir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobiya","family":"Syeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Iqra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abrar","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Rasool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-2180","authenticated-orcid":false,"given":"Aadil","family":"Khursheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aabid Hussain","family":"Shalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsheed A.","family":"Ganaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-5482","authenticated-orcid":false,"given":"Manzoor A.","family":"Rather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2023.106280_bib1","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.2147\/IDR.S234610","article-title":"Antimicrobial resistance: implications and costs","volume":"12","author":"Dadgostar","year":"2019","journal-title":"Infect. Drug Resist."},{"issue":"11","key":"10.1016\/j.micpath.2023.106280_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002184","article-title":"Will 10 million people die a year due to antimicrobial resistance by 2050?","volume":"13","author":"de Kraker","year":"2016","journal-title":"PLoS Med."},{"issue":"12","key":"10.1016\/j.micpath.2023.106280_bib3","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3390\/molecules22122223","article-title":"Calli essential oils synergize with lawsone against multidrug resistant pathogens","volume":"22","author":"Soliman","year":"2017","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.micpath.2023.106280_bib4","article-title":"Plant essential oil: an alternative to emerging multidrug resistant pathogens","volume":"5","author":"Taiwo","year":"2017","journal-title":"J Microbiol Exp"},{"issue":"8","key":"10.1016\/j.micpath.2023.106280_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201835","article-title":"Antimicrobial activity of essential oils against multidrug-resistant clinical isolates of the Burkholderia cepacia complex","volume":"13","author":"Vasireddy","year":"2018","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.micpath.2023.106280_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.foodcont.2003.10.005","article-title":"\u2015The in vitro antimicrobial and antioxidant activities of the essential oils and methanol extracts of endemic Thymus spathulifolius","volume":"15","author":"Sokmen","year":"2004","journal-title":"Food Control"},{"issue":"26","key":"10.1016\/j.micpath.2023.106280_bib7","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.1021\/jf049113i","article-title":"Essential oils of Satureja, Origanum, and Thymus species: chemical composition and antibacterial activities against foodborne pathogens","volume":"52","author":"Chorianopoulos","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.micpath.2023.106280_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2478\/10004-1254-63-2012-2309","article-title":"The effects of wild thyme (Thymus linearis L.) Essential oil components against ochratoxinproducing Aspergilli","volume":"63","author":"Sokolic-Mihalak","year":"2013","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"10.1016\/j.micpath.2023.106280_bib9","unstructured":"World Checklist of Selected Plant Families, http:\/\/apps.kew.org\/wcsp\/incfamilies.do."},{"key":"10.1016\/j.micpath.2023.106280_bib10","first-page":"167","volume":"vol. 6","author":"Harley","year":"2004"},{"issue":"5","key":"10.1016\/j.micpath.2023.106280_bib11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/jf950508z","article-title":"\u2015Influence of harvesting time on yield and composition of the essential oil of thyme (Thymus pulegioides L.) Growing wild in Campania (Southern Italy)","volume":"44","author":"Senatore","year":"1996","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.micpath.2023.106280_bib12","series-title":"PDR for Herbal Medicines","author":"Thomson","year":"2004"},{"key":"10.1016\/j.micpath.2023.106280_bib13","series-title":"Herbal Drugs and Phytopharmaceuticals","author":"Wichtl","year":"1994"},{"key":"10.1016\/j.micpath.2023.106280_bib14","series-title":"1-Dukic, and B. Laku\u0161i\u0107, Aromatic Plants of Serbia, NIP Decije Novine","author":"Jan\u010di\u0107","year":"1995"},{"key":"10.1016\/j.micpath.2023.106280_bib15","series-title":"Trease and Evans \u2018Pharmacognosy","author":"Evans","year":"2000"},{"key":"10.1016\/j.micpath.2023.106280_bib16","series-title":"Identification of Essential Oil Components by Gas Chromatography\/mass Spectrometry","author":"Adams","year":"2007"},{"key":"10.1016\/j.micpath.2023.106280_bib17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/fpd.2018.2459","article-title":"Antimicrobial resistance profle of Salmonella isolates in chicken carcasses in dakar, Senegal","volume":"16","author":"Fall-Niang","year":"2019","journal-title":"Foodb. Pathog. Dis."},{"issue":"33","key":"10.1016\/j.micpath.2023.106280_bib18","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1021\/acs.jpcb.6b01991","article-title":"Rapid characterization of allosteric networks with ensemble normal mode analysis","volume":"120","author":"Yao","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.micpath.2023.106280_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.indcrop.2013.10.006","article-title":"Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils","volume":"52","author":"Nikoli\u0107","year":"2014","journal-title":"Ind. Crop. Prod."},{"issue":"1","key":"10.1016\/j.micpath.2023.106280_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3329\/bjp.v10i1.20639","article-title":"In vitro phytochemical and antimicrobial screening of Thymus linearis","volume":"10","author":"Naz","year":"2015","journal-title":"Bangladesh J. Pharmacol."},{"issue":"4","key":"10.1016\/j.micpath.2023.106280_bib21","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/0972060X.2014.935071","article-title":"Chemical composition and antimicrobial activity of the essential oils isolated from the herbage and aqueous distillates of two Thymus species","volume":"19","author":"Verma","year":"2016","journal-title":"Journal of Essential Oil Bearing Plants"},{"key":"10.1016\/j.micpath.2023.106280_bib22","first-page":"12560","article-title":"Chemical composition and biological (antioxidant, antimicrobial and haemolyitc) activities of essential oils of an endemic plant (Thymus linearis subsp. hedgei Jalas)","volume":"22","author":"Rashid","year":"2017","journal-title":"Biotechnol. Lett."},{"issue":"2","key":"10.1016\/j.micpath.2023.106280_bib23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1099-1026(199803\/04)13:2<98::AID-FFJ705>3.0.CO;2-B","article-title":"Relationship between bioactivity and chemical composition of commercial essential oils","volume":"13","author":"Lis-Balchin","year":"1998","journal-title":"Flavour Fragrance J."},{"key":"10.1016\/j.micpath.2023.106280_bib24","series-title":"Natural Food Antimicrobial Systems. Edit.","first-page":"265","article-title":"Phyto-phenol","author":"Davidson","year":"2000"},{"issue":"11","key":"10.1016\/j.micpath.2023.106280_bib25","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.3390\/molecules15117532","article-title":"Antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model","volume":"15","author":"Sokovi\u0107","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2023.106280_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.indcrop.2012.07.063","article-title":"Chemical composition, antioxidant and antimicrobial activities of essential oils obtained from wild and cultivated Moroccan Thymus species","volume":"43","author":"El Bouzidi","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.micpath.2023.106280_bib27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.indcrop.2014.07.024","article-title":"Antioxidative activity and synergistic effect of Thymus saturejoides Coss. essential oils with cefixime against selected food-borne bacteria","volume":"61","author":"Kasrati","year":"2014","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.micpath.2023.106280_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jgar.2020.12.025","article-title":"Exploring the future of infectious disease treatment in a post-antibiotic era: a comparative review of alternative therapeutics","volume":"24","author":"Streicher","year":"2021","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.micpath.2023.106280_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-58259-3_2","article-title":"Dietary management by probiotics, prebiotics and synbiotics for the prevention of antimicrobial resistance","volume":"49","author":"Elshaghabee","year":"2021","journal-title":"Sustainable Agriculture Reviews"},{"key":"10.1016\/j.micpath.2023.106280_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaim.2017.05.004","article-title":"Development of botanicals to combat antibiotic resistance","volume":"8","author":"Gupta","year":"2017","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.micpath.2023.106280_bib31","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2023.106280_bib32","article-title":"Transcriptome-based drug repositioning for coronavirus disease 2019 (COVID-19)","volume":"78","author":"Jia","year":"2020","journal-title":"Pathogens Dis"},{"issue":"6","key":"10.1016\/j.micpath.2023.106280_bib33","doi-asserted-by":"crossref","first-page":"11357","DOI":"10.3390\/molecules200611357","article-title":"Individual constituents from essential oils inhibit biofilm mass production by multi-drug resistant Staphylococcus aureus","volume":"20","author":"Espina","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.micpath.2023.106280_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12906-023-03928-7","article-title":"Six Spain Thymus essential oils composition analysis and their in vitro and in silico study against Streptococcus mutans","volume":"23","author":"Park","year":"2023","journal-title":"BMC Complementary Medicine and Therapies"},{"key":"10.1016\/j.micpath.2023.106280_bib35","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10989-020-10157-w","article-title":"A novel multi-epitopic peptide vaccine candidate against Helicobacter pylori: in-silico identification, design, cloning and validation through molecular dynamics","volume":"27","author":"Ghosh","year":"2021","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.micpath.2023.106280_bib36","doi-asserted-by":"crossref","first-page":"W271","DOI":"10.1093\/nar\/gku339","article-title":"Internal coordinates normal mode analysis server","volume":"42","author":"L\u00f3pez-Blanco","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2023.106280_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/prot.20151","article-title":"Predictions of protein flexibility: first-order measures","volume":"56","author":"Kovacs","year":"2004","journal-title":"Proteins"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023003133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023003133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:58:52Z","timestamp":1760111932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401023003133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":37,"alternative-id":["S0882401023003133"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106280","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibacterial potential of Thymus linearis essential oil collected from Wasturwan mountain: A combination of experimental and theoretical studies involving in silico molecular docking simulation of the major compounds against Novobiocin-resistant mutant of DNA Gyrase-B","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106280"}}