{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:03:10Z","timestamp":1784599390147,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21771199"],"award-info":[{"award-number":["21771199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.micpath.2023.106303","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T11:34:48Z","timestamp":1692185688000},"page":"106303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The mechanisms of metronidazole resistance of Helicobacter pylori: A transcriptomic and biochemical study"],"prefix":"10.1016","volume":"183","author":[{"given":"Zeyuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9223-0323","authenticated-orcid":false,"given":"Yulin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4105-5421","authenticated-orcid":false,"given":"Xinhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-3091","authenticated-orcid":false,"given":"Ruiguang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8390","key":"10.1016\/j.micpath.2023.106303_bib1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall","year":"1984","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/clind\/15.3.386","article-title":"Helicobacter pylori: its role in disease","volume":"15","author":"Blaser","year":"1992","journal-title":"Clin. Infect. Dis."},{"issue":"15","key":"10.1016\/j.micpath.2023.106303_bib3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/hel.12266","article-title":"Comparison of iron-binding ability between Thr70-NapA and Ser70-NapA of Helicobacter pylori","volume":"21","author":"Shan","year":"2016","journal-title":"Helicobacter"},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10534-011-9512-8","article-title":"Iron trafficking system in Helicobacter pylori","volume":"25","author":"Ge","year":"2012","journal-title":"Biometals"},{"issue":"Suppl 1","key":"10.1016\/j.micpath.2023.106303_bib6","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1111\/j.1523-5378.1997.06b05.x","article-title":"Autoantibodies to gastric mucosa in Helicobacter pylori infection","volume":"2","author":"Negrini","year":"1997","journal-title":"Helicobacter"},{"issue":"41","key":"10.1016\/j.micpath.2023.106303_bib7","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.3748\/wjg.v16.i41.5181","article-title":"Consequences of Helicobacter pylori infection in children","volume":"16","author":"Pacifico","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.micpath.2023.106303_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ejim.2004.05.008","article-title":"Helicobacter pylori and Alzheimer's disease: a possible link","volume":"15","author":"Malaguarnera","year":"2004","journal-title":"Eur. J. Intern. Med."},{"issue":"5","key":"10.1016\/j.micpath.2023.106303_bib9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.mehy.2011.07.038","article-title":"The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer's diseases together?","volume":"77","author":"Ge","year":"2011","journal-title":"Med. Hypotheses"},{"issue":"Suppl 1","key":"10.1016\/j.micpath.2023.106303_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2036.11.s1.13.x","article-title":"The actions of bismuth in the treatment of Helicobacter pylori infection","volume":"11","author":"Lambert","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1039\/c2mt00180b","article-title":"The actions of bismuth in the treatment of Helicobacter pylori infections: an update","volume":"4","author":"Ge","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.micpath.2023.106303_bib12","first-page":"59","article-title":"Molecular mechanisms of bismuth-containing drugs against Helicobacter pylori: a further update","volume":"8","author":"Liu","year":"2023","journal-title":"Current Pharmacology Reports"},{"issue":"9","key":"10.1016\/j.micpath.2023.106303_bib13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1517\/14656566.3.9.1301","article-title":"Alternative and rescue treatment regimens for Helicobacter pylori eradication","volume":"3","author":"Xia","year":"2002","journal-title":"Expet Opin. Pharmacother."},{"issue":"10","key":"10.1016\/j.micpath.2023.106303_bib14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nrgastro.2010.131","article-title":"Infection: bismuth improves PPI-based triple therapy for H. pylori eradication","volume":"7","author":"Malfertheiner","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2023.106303_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fphar.2019.00316","article-title":"Vonoprazan and Helicobacter pylori treatment: a lesson from Japan or a limited geographic phenomenon?","volume":"10","author":"Abadi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.micpath.2023.106303_bib16","article-title":"The efficacy and mechanism of vonoprazan-containing triple therapy in the eradication of Helicobacter pylori","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1756283X11432492","article-title":"The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy","volume":"5","author":"Megraud","year":"2012","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.micpath.2023.106303_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.anaerobe.2018.10.004","article-title":"Metronidazole resistance and nim genes in anaerobes: a review","volume":"55","author":"Alauzet","year":"2019","journal-title":"Anaerobe"},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jac\/dkx351","article-title":"Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms","volume":"73","author":"Dingsdag","year":"2018","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03903-22","article-title":"RdxA diversity and mutations associated with metronidazole resistance of Helicobacter pylori","volume":"11","author":"Gong","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"8","key":"10.1016\/j.micpath.2023.106303_bib21","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.14309\/ajg.0000000000001828","article-title":"Helicobacter pylori antibiotic resistance in the United States between 2011 and 2021: a Systematic review and meta-analysis","volume":"117","author":"Ho","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.micpath.2023.106303_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104075","article-title":"Proton-pump inhibitor and amoxicillin-based triple therapy containing clarithromycin versus metronidazole for Helicobacter pylori: a meta-analysis","volume":"142","author":"Li","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2023.106303_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/2277-9175.128469","article-title":"The mutation of the rdxA gene in metronidazole-resistant Helicobacter pylori clinical isolates","volume":"3","author":"Mirzaei","year":"2014","journal-title":"Adv. Biomed. Res."},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib24","first-page":"346","article-title":"Evaluation of frxA and rdxA gene mutations in clinical metronidazole resistance Helicobacter pylori isolates","volume":"34","author":"Somi","year":"2017","journal-title":"Trop. Biomed."},{"issue":"8","key":"10.1016\/j.micpath.2023.106303_bib25","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1128\/AAC.44.8.2133-2142.2000","article-title":"Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori","volume":"44","author":"Kwon","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.micpath.2023.106303_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/AAC.7.1.15","article-title":"Broth-dilution method for determining the antibiotic susceptibility of anaerobic bacteria","volume":"7","author":"Stalons","year":"1975","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/vms3.404","article-title":"Effects of in vitro-induced drug resistance on the virulence of Streptococcus","volume":"7","author":"Ding","year":"2021","journal-title":"Vet. Med. Sci."},{"issue":"10","key":"10.1016\/j.micpath.2023.106303_bib28","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1099\/jmm.0.001070","article-title":"Improved quadruplex real-time PCR assay for the diagnosis of diphtheria","volume":"68","author":"Badell","year":"2019","journal-title":"J. Med. Microbiol."},{"issue":"4","key":"10.1016\/j.micpath.2023.106303_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"10.1016\/j.micpath.2023.106303_bib30","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00775-007-0237-7","article-title":"A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori","volume":"12","author":"Ge","year":"2007","journal-title":"J. Biol. Inorg. Chem."},{"issue":"8","key":"10.1016\/j.micpath.2023.106303_bib31","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.bbamcr.2011.04.005","article-title":"Histidine-rich protein Hpn from Helicobacter pylori formas amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells","volume":"1813","author":"Ge","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.micpath.2023.106303_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1413-8670(11)70197-0","article-title":"Evaluation of different detection methods of biofilm formation in the clinical isolates","volume":"15","author":"Hassan","year":"2011","journal-title":"Braz. J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.micpath.2023.106303_bib33","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1021\/acs.jproteome.1c00077","article-title":"Ciprofloxacin-resistant Staphylococcus aureus displays enhanced resistance and virulence in iron-restricted conditions","volume":"20","author":"Dong","year":"2021","journal-title":"J. Proteome Res."},{"issue":"45","key":"10.1016\/j.micpath.2023.106303_bib34","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.3748\/wjg.v19.i45.8211","article-title":"Nickel trafficking system responsible for urease maturation in Helicobacter pylori","volume":"19","author":"Ge","year":"2013","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.micpath.2023.106303_bib35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/apt.14561","article-title":"Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection","volume":"47","author":"Zamani","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.25122\/jml-2018-0035","article-title":"MALT lymphoma: epidemiology, clinical diagnosis and treatment","volume":"11","author":"Violeta Filip","year":"2018","journal-title":"J Med Life"},{"issue":"9","key":"10.1016\/j.micpath.2023.106303_bib37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41575-021-00449-x","article-title":"Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications","volume":"18","author":"Tshibangu-Kabamba","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.micpath.2023.106303_bib38","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1053\/j.gastro.2018.07.007","article-title":"Prevalence of antibiotic resistance in Helicobacter pylori: a Systematic review and meta-analysis in world Health organization regions","volume":"155","author":"Savoldi","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.micpath.2023.106303_bib39","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/MMBR.00020-06","article-title":"Stimulus perception in bacterial signal-transducing histidine kinases","volume":"70","author":"Mascher","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"7","key":"10.1016\/j.micpath.2023.106303_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071781","article-title":"Two component regulatory systems and antibiotic resistance in gram-negative pathogens","volume":"20","author":"Bhagirath","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.micpath.2023.106303_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/JB.01219-08","article-title":"The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pylori","volume":"191","author":"Wen","year":"2009","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.micpath.2023.106303_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12715","article-title":"Transporters HP0939, HP0497, and HP0471 participate in intrinsic multidrug resistance and biofilm formation in Helicobacter pylori by enhancing drug efflux","volume":"25","author":"Cai","year":"2020","journal-title":"Helicobacter"},{"issue":"1","key":"10.1016\/j.micpath.2023.106303_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5152\/tjg.2017.17349","article-title":"A proposed role for diffusible signal factors in the biofilm formation and morphological transformation of Helicobacter pylori","volume":"29","author":"Krzyzek","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.micpath.2023.106303_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073301","article-title":"Impact of Helicobacter pylori biofilm formation on clarithromycin susceptibility and generation of resistance mutations","volume":"8","author":"Yonezawa","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jobm.201900537","article-title":"Influence of N-acylhomoserine lactonase silver nanoparticles on the quorum sensing system of Helicobacter pylori: a potential strategy to combat biofilm formation","volume":"60","author":"Gopalakrishnan","year":"2020","journal-title":"J. Basic Microbiol."},{"issue":"9","key":"10.1016\/j.micpath.2023.106303_bib46","doi-asserted-by":"crossref","first-page":"752","DOI":"10.5301\/ijao.5000024","article-title":"Role of antibiofilm-antimicrobial agents in controlling device-related infections","volume":"34","author":"Aslam","year":"2011","journal-title":"Int. J. Artif. Organs"},{"issue":"128","key":"10.1016\/j.micpath.2023.106303_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000724","article-title":"Origins and diversification of a complex signal transduction system in prokaryotes","volume":"3","author":"Wuichet","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.micpath.2023.106303_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mib.2018.01.010","article-title":"Exploring the function of bacterial chemotaxis","volume":"45","author":"Wong-Ng","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"issue":"12","key":"10.1016\/j.micpath.2023.106303_bib49","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nrm1524","article-title":"Making sense of it all: bacterial chemotaxis","volume":"5","author":"Wadhams","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.micpath.2023.106303_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/prot.26430","article-title":"Analysis of CheW-like domains provides insights into organization of prokaryotic chemotaxis systems","volume":"91","author":"Vass","year":"2023","journal-title":"Proteins"},{"issue":"11","key":"10.1016\/j.micpath.2023.106303_bib51","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1073\/pnas.1618227114","article-title":"Cooperation of two distinct coupling proteins creates chemosensory network connections","volume":"114","author":"Abedrabbo","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 9","key":"10.1016\/j.micpath.2023.106303_bib52","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1099\/00221287-147-9-2493","article-title":"Chemotaxis in the human gastric pathogen Helicobacter pylori: different roles for CheW and the three CheV paralogues, and evidence for CheV2 phosphorylation","volume":"147","author":"Pittman","year":"2001","journal-title":"Microbiology (Read.)"},{"issue":"9","key":"10.1016\/j.micpath.2023.106303_bib53","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cgh.2010.05.006","article-title":"Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacter pylori: a clinical trial","volume":"8","author":"Cammarota","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023003364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023003364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:41Z","timestamp":1760111981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401023003364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":53,"alternative-id":["S0882401023003364"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106303","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanisms of metronidazole resistance of Helicobacter pylori: A transcriptomic and biochemical study","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106303"}}