{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:41:15Z","timestamp":1782322875594,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600861"],"award-info":[{"award-number":["81600861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3050064"],"award-info":[{"award-number":["3050064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.micpath.2023.106404","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T23:22:36Z","timestamp":1698448956000},"page":"106404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["LiaSR two-component system modulates the oxidative stress response in Streptococcus mutans"],"prefix":"10.1016","volume":"185","author":[{"given":"Shan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-8532","authenticated-orcid":false,"given":"Xiaojing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41368-022-00167-3","article-title":"Expert consensus on dental caries management","volume":"14","author":"Cheng","year":"2022","journal-title":"Int. J. Oral Sci."},{"issue":"10159","key":"10.1016\/j.micpath.2023.106404_bib48","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.micpath.2023.106404_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/omi.12162","article-title":"Acid-adaptive mechanisms of Streptococcus mutans-the more we know, the more we don't","volume":"32","author":"Baker","year":"2017","journal-title":"Mol Oral Microbiol"},{"issue":"12","key":"10.1016\/j.micpath.2023.106404_bib3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"22","key":"10.1016\/j.micpath.2023.106404_bib4","doi-asserted-by":"crossref","first-page":"12375","DOI":"10.1073\/pnas.1919099117","article-title":"Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries","volume":"117","author":"Kim","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micpath.2023.106404_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102691","article-title":"Hydrogen peroxide potentiates antimicrobial photodynamic therapy in eliminating Candida albicans and Streptococcus mutans dual-species biofilm from denture base","volume":"37","author":"Li","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"4","key":"10.1016\/j.micpath.2023.106404_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/omi.12344","article-title":"Role of D-alanylation of Streptococcus mutans lipoteichoic acid in interspecies competitiveness","volume":"36","author":"Wu","year":"2021","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.micpath.2023.106404_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00257-22","article-title":"Oral commensal Streptococci: gatekeepers of the oral cavity","author":"Baty","year":"2022","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2023.106404_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.693858","article-title":"The role and regulatory network of the CiaRH two-component system in streptococcal species","volume":"12","author":"He","year":"2021","journal-title":"Front. Microbiol."},{"issue":"9","key":"10.1016\/j.micpath.2023.106404_bib9","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1128\/JB.01563-08","article-title":"The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans","volume":"191","author":"Suntharalingam","year":"2009","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.micpath.2023.106404_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1472-765X.2008.02455.x","article-title":"Involvement of Streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence","volume":"47","author":"Perry","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"issue":"22","key":"10.1016\/j.micpath.2023.106404_bib11","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1128\/JB.184.22.6333-6342.2002","article-title":"Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans","volume":"184","author":"Li","year":"2002","journal-title":"J. Bacteriol."},{"issue":"Pt 1","key":"10.1016\/j.micpath.2023.106404_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1099\/mic.0.023077-0","article-title":"A phenotypic microarray analysis of a Streptococcus mutans liaS mutant","volume":"155","author":"Zhang","year":"2009","journal-title":"Microbiology (Read.)"},{"issue":"9","key":"10.1016\/j.micpath.2023.106404_bib13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/0022034519855348","article-title":"Dietary nitrite drives disease outcomes in oral polymicrobial infections","volume":"98","author":"Scoffield","year":"2019","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/omi.12388","article-title":"Molecular and regulatory mechanisms of oxidative stress adaptation in Streptococcus mutans","volume":"38","author":"Yu","year":"2022","journal-title":"Mol. Oral Microbiol."},{"issue":"14","key":"10.1016\/j.micpath.2023.106404_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00062-18","article-title":"Disruption of a novel iron transport system reverses oxidative stress phenotypes of a dpr mutant strain of Streptococcus mutans","volume":"200","author":"Ganguly","year":"2018","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.micpath.2023.106404_bib16","first-page":"281","article-title":"Typing of Streptococcus mutans (serotype C) by arbitrarily primed polymerase chain reaction","volume":"36","author":"Huang","year":"2001","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.micpath.2023.106404_bib17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/ijms18040713","article-title":"Effect of the biofilm age and starvation on acid tolerance of biofilm formed by Streptococcus mutans isolated from caries-active and caries-free adults","volume":"18","author":"Jiang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/1758-2229.12600","article-title":"Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model","volume":"10","author":"Liu","year":"2018","journal-title":"Environ Microbiol Rep"},{"issue":"6","key":"10.1016\/j.micpath.2023.106404_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/omi.12147","article-title":"The SloR metalloregulator is involved in the Streptococcus mutans oxidative stress response","volume":"31","author":"Crepps","year":"2016","journal-title":"Mol Oral Microbiol"},{"issue":"11","key":"10.1016\/j.micpath.2023.106404_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00678-20","article-title":"Regulatory involvement of the PerR and SloR metalloregulators in the Streptococcus mutans oxidative stress response","volume":"203","author":"Ruxin","year":"2021","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2023.106404_bib19","first-page":"169","article-title":"D-alanylation of lipoteichoic acid contributes to biofilm formation and acidogenesis capacity of Streptococcus mutans","author":"Wu","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2023.106404_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2022.106540","article-title":"The dlt operon contributes to the resistance to chlorhexidine in Streptococcus mutans","author":"Huang","year":"2022","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2019.1607505","article-title":"Inactivation of Streptococcus mutans genes lytST and dltAD impairs its pathogenicity in vivo","volume":"11","author":"Castillo Pedraza","year":"2019","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.micpath.2023.106404_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2180-12-187","article-title":"Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance","volume":"12","author":"Ahn","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.micpath.2023.106404_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.656471","article-title":"Anti-bacterial properties of cannabigerol toward Streptococcus mutans","volume":"12","author":"Aqawi","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2023.106404_bib23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/978-1-0716-2099-1_39","article-title":"Optimal use of 2',7'-dichlorofluorescein diacetate in cultured hepatocytes","volume":"2451","author":"Reiniers","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"10","key":"10.1016\/j.micpath.2023.106404_bib24","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.3390\/ijms22105353","article-title":"Antimicrobial and anti-biofilm peptide octominin for controlling multidrug-resistant acinetobacter baumannii","volume":"22","author":"Jayathilaka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.micpath.2023.106404_bib25","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1007\/s00284-021-02615-5","article-title":"dinF elicits nitric oxide signaling induced by periplanetasin-4 from American cockroach in Escherichia coli","volume":"78","author":"Lee","year":"2021","journal-title":"Curr. Microbiol."},{"issue":"5","key":"10.1016\/j.micpath.2023.106404_bib26","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/AEM.03306-12","article-title":"Dpr and sod in Streptococcus mutans are involved in coexistence with S. sanguinis, and PerR is associated with resistance to H2O2","volume":"79","author":"Fujishima","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"issue":"9","key":"10.1016\/j.micpath.2023.106404_bib28","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1093\/nar\/gkz198","article-title":"New insights into the structures and interactions of bacterial Y-family DNA polymerases","volume":"47","author":"Timinskas","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/mmi.14499","article-title":"Regulatory circuits controlling Spx levels in Streptococcus mutans","volume":"114","author":"Ganguly","year":"2020","journal-title":"Mol. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/JB.00990-07","article-title":"Involvement of sensor kinases in the stress tolerance response of Streptococcus mutans","volume":"190","author":"Biswas","year":"2008","journal-title":"J. Bacteriol."},{"issue":"11","key":"10.1016\/j.micpath.2023.106404_bib30","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1128\/JB.184.11.2931-2939.2002","article-title":"An iron-binding protein, dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro","volume":"184","author":"Yamamoto","year":"2002","journal-title":"J. Bacteriol."},{"issue":"23","key":"10.1016\/j.micpath.2023.106404_bib31","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1128\/JB.00383-15","article-title":"Loss of NADH oxidase activity in Streptococcus mutans leads to rex-mediated overcompensation in NAD+ regeneration by lactate dehydrogenase","volume":"197","author":"Baker","year":"2015","journal-title":"J. Bacteriol."},{"issue":"3","key":"10.1016\/j.micpath.2023.106404_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/omi.12282","article-title":"Streptococcus mutans SpxA2 relays the signal of cell envelope stress from LiaR to effectors that maintain cell wall and membrane homeostasis","volume":"35","author":"Baker","year":"2020","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"10.1016\/j.micpath.2023.106404_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1574-6968.2012.02603.x","article-title":"Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response","volume":"333","author":"Dengler","year":"2012","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.micpath.2023.106404_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.634438","article-title":"Mini review: bacterial membrane composition and its modulation in response to stress","volume":"8","author":"Willdigg","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"7","key":"10.1016\/j.micpath.2023.106404_bib36","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1128\/JB.01489-09","article-title":"The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics","volume":"192","author":"Eldholm","year":"2010","journal-title":"J. Bacteriol."},{"issue":"13","key":"10.1016\/j.micpath.2023.106404_bib37","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1128\/JB.00118-15","article-title":"Transcription of oxidative stress genes is directly activated by SpxA1 and, to a lesser extent, by SpxA2 in Streptococcus mutans","volume":"197","author":"Kajfasz","year":"2015","journal-title":"J. Bacteriol."},{"issue":"2","key":"10.1016\/j.micpath.2023.106404_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/omi.12160","article-title":"Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model","volume":"32","author":"Galv\u00e3o","year":"2017","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"10.1016\/j.micpath.2023.106404_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16367-5","article-title":"Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx","volume":"7","author":"Kajfasz","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.micpath.2023.106404_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124969","article-title":"Transcriptional and phenotypic characterization of novel spx-regulated genes in Streptococcus mutans","volume":"10","author":"Galv\u00e3o","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2023.106404_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biochi.2019.02.005","article-title":"Cross-talk between the RcsCDB and RstAB systems to control STM1485 gene expression in Salmonella Typhimurium during acid-resistance response","volume":"160","author":"Torrez Lamberti","year":"2019","journal-title":"Biochimie"},{"issue":"7","key":"10.1016\/j.micpath.2023.106404_bib42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/gtc.12251","article-title":"Cross talk in promoter recognition between six NarL-family response regulators of Escherichia coli two-component system","volume":"20","author":"Yoshida","year":"2015","journal-title":"Gene Cell."},{"issue":"Pt 9","key":"10.1016\/j.micpath.2023.106404_bib43","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1099\/mic.0.028456-0","article-title":"Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system","volume":"155","author":"Tremblay","year":"2009","journal-title":"Microbiology (Read.)"},{"issue":"6","key":"10.1016\/j.micpath.2023.106404_bib44","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00294-021-01204-0","article-title":"Contribution of SOS genes to H2O2-induced apoptosis-like death in Escherichia coli","volume":"67","author":"Kim","year":"2021","journal-title":"Curr. Genet."},{"issue":"7","key":"10.1016\/j.micpath.2023.106404_bib45","article-title":"Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli","volume":"13","author":"Burkholder","year":"2017","journal-title":"PLoS Genet."},{"issue":"19","key":"10.1016\/j.micpath.2023.106404_bib46","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1074\/jbc.RA118.006233","article-title":"Residues in the fingers domain of the translesion DNA polymerase DinB enable its unique participation in error-prone double-strand break repair","volume":"294","author":"Tashjian","year":"2019","journal-title":"J. Biol. Chem."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023004370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401023004370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:28:12Z","timestamp":1778545692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401023004370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":49,"alternative-id":["S0882401023004370"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106404","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LiaSR two-component system modulates the oxidative stress response in Streptococcus mutans","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2023.106404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106404"}}