{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:48:56Z","timestamp":1787312936760,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.micpath.2024.106682","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:56:03Z","timestamp":1715565363000},"page":"106682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Lineage 1 PRRSVs infection induces hemorrhagic injury in intestines of piglets: Effects on complement and coagulation cascades"],"prefix":"10.1016","volume":"192","author":[{"given":"Yongxin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junda","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riteng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basit","family":"Zeshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2024.106682_bib1","article-title":"Recent advances in porcine reproductive and respiratory syndrome virus NADC30-like research in China: molecular characterization, pathogenicity, and control","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib2","article-title":"Recent advances in the study of NADC34-like porcine reproductive and respiratory syndrome virus in China","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12985-021-01675-0","article-title":"Porcine reproductive and respiratory syndrome virus genetic variability a management and diagnostic dilemma","volume":"18","author":"Risser","year":"2021","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2024.106682_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/v15071528","article-title":"Recent progress in studies of porcine reproductive and respiratory syndrome virus 1 in China","volume":"15","author":"Sun","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.106682_bib5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.virol.2017.10.002","article-title":"Porcine reproductive and respiratory disease virus: evolution and recombination yields distinct ORF5 RFLP 1-7-4 viruses with individual pathogenicity","volume":"513","author":"van Geelen","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2024.106682_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00705-023-05822-6","article-title":"Genetic and pathogenic characterization of an NADC-34-like isolate of porcine reproductive and respiratory syndrome virus","volume":"168","author":"Zhao","year":"2023","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2024.106682_bib7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vetmic.2017.09.002","article-title":"Phenotypic characterization of a highly pathogenic Italian porcine reproductive and respiratory syndrome virus (PRRSV) type 1 subtype 1 isolate in experimentally infected pigs","volume":"210","author":"Canelli","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1865-1682.2008.01020.x","article-title":"Highly virulent porcine reproductive and respiratory syndrome virus emerged in China","volume":"55","author":"Zhou","year":"2008","journal-title":"Transbound Emerg. Dis."},{"key":"10.1016\/j.micpath.2024.106682_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.virusres.2012.07.030","article-title":"Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains","volume":"169","author":"Brockmeier","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2024.106682_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/s11259-024-10319-x","article-title":"Characterization of a novel recombinant NADC30-like porcine reproductive and respiratory syndrome virus in Shanxi Province, China","author":"Ren","year":"2024","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.micpath.2024.106682_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.vetmic.2018.06.017","article-title":"Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China","volume":"222","author":"Zhang","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01436-19","article-title":"The nsp2 hypervariable region of porcine reproductive and respiratory syndrome virus strain JXwn06 is associated with viral cellular tropism to primary porcine alveolar macrophages","volume":"93","author":"Song","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2024.106682_bib13","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.virol.2006.05.036","article-title":"Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus","volume":"353","author":"de Lima","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2024.106682_bib14","article-title":"Genetic variability and recombination of the NSP2 gene of PRRSV-2 strains in China from 1996 to 2021","volume":"10","author":"Zhang","year":"2023","journal-title":"Vet. Sci."},{"key":"10.1016\/j.micpath.2024.106682_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109397","article-title":"A NADC30-like PRRSV causes serious intestinal infections and tropism in piglets","volume":"268","author":"Ma","year":"2022","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1743-422X-9-203","article-title":"Chinese highly pathogenic porcine reproductive and respiratory syndrome virus exhibits more extensive tissue tropism for pigs","volume":"9","author":"Li","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.micpath.2024.106682_bib17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00284-018-1613-y","article-title":"Illumina MiSeq sequencing investigation of microbiota in bronchoalveolar lavage fluid and cecum of the swine infected with PRRSV","volume":"76","author":"Jiang","year":"2019","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.micpath.2024.106682_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13567-021-00965-3","article-title":"Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection","volume":"52","author":"Zhao","year":"2021","journal-title":"Vet. Res."},{"key":"10.1016\/j.micpath.2024.106682_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004216","article-title":"Nsp9 and Nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China","volume":"10","author":"Li","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2024.106682_bib20","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/030098589503200606","article-title":"Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus","volume":"32","author":"Halbur","year":"1995","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.micpath.2024.106682_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181256","article-title":"Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli","volume":"12","author":"Miller","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2024.106682_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/imr.13150","article-title":"The complement alternative pathway and hemostasis","volume":"313","author":"Noris","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.micpath.2024.106682_bib23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.kint.2020.05.013","article-title":"The case of complement activation in COVID-19 multiorgan impact","volume":"98","author":"Noris","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.micpath.2024.106682_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1160\/TH13-10-0812","article-title":"New players in haemostasis and thrombosis","volume":"111","author":"Geddings","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.micpath.2024.106682_bib25","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.immuni.2022.04.007","article-title":"Immunity to enteric viruses","volume":"55","author":"Lockhart","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.micpath.2024.106682_bib26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.virs.2024.01.005","article-title":"PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity","volume":"39","author":"Sun","year":"2024","journal-title":"Virol. Sin."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024001499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024001499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T01:48:07Z","timestamp":1718329687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024001499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":26,"alternative-id":["S0882401024001499"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106682","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lineage 1 PRRSVs infection induces hemorrhagic injury in intestines of piglets: Effects on complement and coagulation cascades","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106682","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106682"}}