{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:53:54Z","timestamp":1789674834261,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.micpath.2024.106763","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:59:28Z","timestamp":1719284368000},"page":"106763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Tyrosol-gold nanoparticle functionalized acacia gum-PVA nanofibers for mitigation of Candida biofilm"],"prefix":"10.1016","volume":"193","author":[{"given":"Jinan","family":"Alhariry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-1946","authenticated-orcid":false,"given":"Tara Chand","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emansi","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasare","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Mohan","family":"Poluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-1752","authenticated-orcid":false,"given":"Payal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2024.106763_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002585","article-title":"Fungal biofilms","volume":"8","author":"Fanning","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2024.106763_bib2","series-title":"Introd. To Biofilm Eng.","first-page":"17","article-title":"Role of exopolysaccharides in biofilm formation","author":"Gupta","year":"2019"},{"key":"10.1016\/j.micpath.2024.106763_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm matrixome: extracellular components in structured microbial communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.micpath.2024.106763_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1186\/s12879-022-07848-8","article-title":"Epidemiologic features, clinical characteristics, and predictors of mortality in patients with candidemia in Alameda County, California; a 2017\u20132020 retrospective analysis","volume":"22","author":"Meyahnwi","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.micpath.2024.106763_bib5","article-title":"Retrospective analysis on distribution and antifungal susceptibility profile of Candida in clinical samples: a study from Southern India","volume":"11","author":"Sumana","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.micpath.2024.106763_bib6","series-title":"WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action","author":"Organization","year":"2023"},{"key":"10.1016\/j.micpath.2024.106763_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2015978","article-title":"Quorum sensing: a prospective therapeutic target for bacterial diseases","volume":"2019","author":"Jiang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.micpath.2024.106763_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof3020022","article-title":"Fungal biofilms and polymicrobial diseases","volume":"3","author":"Costa-Orlandi","year":"2017","journal-title":"J. Fungi"},{"key":"10.1016\/j.micpath.2024.106763_bib9","article-title":"Fungal quorum-sensing molecules and antiseptics: a promising strategy for biofilm modulation?","author":"Marcomini","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.micpath.2024.106763_bib10","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/jam.13070","article-title":"Activity of tyrosol against single and mixed\u2010species oral biofilms","volume":"120","author":"Arias","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.micpath.2024.106763_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/456463","article-title":"Effect of tyrosol and farnesol on virulence and antibiotic resistance of clinical isolates of Pseudomonas aeruginosa","volume":"2015","author":"Hassan Abdel-Rhman","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.micpath.2024.106763_bib12","doi-asserted-by":"crossref","first-page":"fov012","DOI":"10.1093\/femsyr\/fov012","article-title":"Exogenous tyrosol inhibits planktonic cells and biofilms of Candida species and enhances their susceptibility to antifungals","volume":"15","author":"Cordeiro","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.micpath.2024.106763_bib13","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/08927014.2020.1828373","article-title":"Exogenous fungal quorum sensing molecules inhibit planktonic cell growth and modulate filamentation and biofilm formation in the Sporothrix schenckii complex","volume":"36","author":"Brilhante","year":"2020","journal-title":"Biofouling"},{"key":"10.1016\/j.micpath.2024.106763_bib14","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1021\/acsomega.1c05822","article-title":"Plausible mechanistic insights in biofilm eradication potential against Candida spp. using in situ-synthesized tyrosol-functionalized chitosan gold nanoparticles as a versatile antifouling coating on implant surfaces","volume":"7","author":"Yadav","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.micpath.2024.106763_bib15","series-title":"Chapter 1 - Chitosan: Source, Chemistry, and Properties","first-page":"1","author":"Chatterjee","year":"2022"},{"key":"10.1016\/j.micpath.2024.106763_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2023.105634","article-title":"Chitosan: a review on properties, biological activities and recent progress in biomedical applications","volume":"191","author":"Harugade","year":"2023","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.micpath.2024.106763_bib17","article-title":"Electrospun nanofibers for wound management","volume":"8","author":"V John","year":"2022","journal-title":"ChemNanoMat"},{"key":"10.1016\/j.micpath.2024.106763_bib18","article-title":"Assessing the eradication potential of fungal biofilms using acacia gum\/PVA nanofibers functionalized with geraniol-\u03b2 cyclodextrin inclusion complex","volume":"91","author":"Gupta","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.micpath.2024.106763_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121163","article-title":"Eucalyptol\/\u03b2-cyclodextrin inclusion complex loaded gellan\/PVA nanofibers as antifungal drug delivery system","volume":"609","author":"Mishra","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.micpath.2024.106763_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111450","article-title":"Cinnamaldehyde incorporated gellan\/PVA electrospun nanofibers for eradicating Candida biofilm","volume":"119","author":"Mishra","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.micpath.2024.106763_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.carbpol.2017.07.043","article-title":"Geraniol grafted chitosan oligosaccharide as a potential antibacterial agent","volume":"176","author":"Yue","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.micpath.2024.106763_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/mmy\/myac042","article-title":"Elucidating the lactic acid tolerance mechanism in vaginal clinical isolates of Candida glabrata","volume":"60","author":"Gupta","year":"2022","journal-title":"Med. Mycol."},{"key":"10.1016\/j.micpath.2024.106763_bib23","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.2217\/nnm-2021-0274","article-title":"Eugenol-acacia gum-based bifunctional nanofibers as a potent antifungal transdermal substitute","volume":"16","author":"Gupta","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.micpath.2024.106763_bib24","article-title":"Elucidating the eradication mechanism of perillyl alcohol against Candida glabrata biofilms: insights into the synergistic effect with azole drugs","author":"Gupta","year":"2021","journal-title":"ACS Bio Med Chem Au"},{"key":"10.1016\/j.micpath.2024.106763_bib25","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1007\/s00253-023-12714-x","article-title":"Biochemical and metabolomic insights into antifungal mechanism of berberine against Candida glabrata","volume":"107","author":"Gupta","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.micpath.2024.106763_bib26","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1021\/acs.molpharmaceut.8b01345","article-title":"Nanofiber dressings topically delivering molecularly engineered human cathelicidin peptides for the treatment of biofilms in chronic wounds","volume":"16","author":"Su","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.micpath.2024.106763_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-73678-w","article-title":"Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics","volume":"11","author":"Fereydouni","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.106763_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijbiomac.2020.03.194","article-title":"Synthesis and characterization of antimicrobial wound dressing material based on silver nanoparticles loaded gum Arabic nanofibers","volume":"155","author":"Eghbalifam","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106763_bib29","first-page":"28","article-title":"Synthesis and characterization of chitosan\/gum Arabic nanoparticles for bone regeneration","volume":"5","author":"Ibekwe","year":"2017","journal-title":"Am. J. Mater. Sci. Eng."},{"key":"10.1016\/j.micpath.2024.106763_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijbiomac.2016.05.064","article-title":"Electrospun fibers based on Arabic, karaya and kondagogu gums","volume":"91","author":"Padil","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106763_bib31","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ijbiomac.2021.08.069","article-title":"Electrospun polyvinyl-alcohol\/gum Arabic nanofibers: biomimetic platform for in vitro cell growth and cancer nanomedicine delivery","volume":"188","author":"Serio","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106763_bib32","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.saa.2010.12.051","article-title":"FTIR studies of plasticized poly (vinyl alcohol)\u2013chitosan blend doped with NH4NO3 polymer electrolyte membrane","volume":"78","author":"Kadir","year":"2011","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.micpath.2024.106763_bib33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.ijbiomac.2022.11.255","article-title":"A nanofiber-hydrogel composite from green synthesized AgNPs embedded to PEBAX\/PVA hydrogel and PA\/Pistacia atlantica gum nanofiber for wound dressing","volume":"226","author":"Rajati","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106763_bib34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s11947-020-02407-y","article-title":"Encapsulation of the antioxidant tyrosol and characterization of loaded microparticles: an integrative approach on the study of the polymer-carriers and loading contents","volume":"13","author":"Paulo","year":"2020","journal-title":"Food Bioprocess Technol."},{"key":"10.1016\/j.micpath.2024.106763_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/polym13010087","article-title":"Encapsulation of the natural product tyrosol in carbohydrate nanosystems and study of their binding with ctdna","volume":"13","author":"Pontillo","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.micpath.2024.106763_bib36","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijbiomac.2020.09.177","article-title":"Synthesis and characterization of nano-chitosan capped gold nanoparticles with multifunctional bioactive properties","volume":"165","author":"Saravanakumar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106763_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41538-019-0034-z","article-title":"Chitosan-capped gold nanoparticles for indicating temperature abuse in frozen stored products","volume":"3","author":"Mohan","year":"2019","journal-title":"Npj Sci. Food."},{"key":"10.1016\/j.micpath.2024.106763_bib38","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1039\/c3tb20795a","article-title":"Designing electrospun nanofiber mats to promote wound healing-a review","volume":"1","author":"Rieger","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.micpath.2024.106763_bib39","doi-asserted-by":"crossref","DOI":"10.1021\/acsabm.3c00047","article-title":"Exploration of antibiofilm and in vivo wound healing activity of p-cymene-loaded gellan\/PVA nanofibers","author":"Mishra","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.micpath.2024.106763_bib40","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/ab8fea","article-title":"Electrospun poly (lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb","volume":"7","author":"Wongkanya","year":"2020","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.micpath.2024.106763_bib41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41579-023-00905-2","article-title":"Drug delivery strategies for antibiofilm therapy","volume":"21","author":"Choi","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.micpath.2024.106763_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.02993","article-title":"The fungal cell wall: Candida, cryptococcus, and Aspergillus species","volume":"10","author":"Garcia-Rubio","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.106763_bib43","doi-asserted-by":"crossref","first-page":"e00310","DOI":"10.1128\/mSphere.00310-20","article-title":"Variation in cell surface hydrophobicity among Cryptococcus neoformans strains influences interactions with amoebas","volume":"5","author":"Vij","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.micpath.2024.106763_bib44","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/mmy\/myu046","article-title":"Synergistic effect of amphotericin B and tyrosol on biofilm formed by Candida krusei and Candida tropicalis from intrauterine device users","volume":"52","author":"Shanmughapriya","year":"2014","journal-title":"Med. Mycol."},{"key":"10.1016\/j.micpath.2024.106763_bib45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12088-019-00797-y","article-title":"Antimicrobial activity of compounds containing silver nanoparticles and calcium glycerophosphate in combination with tyrosol","volume":"59","author":"Souza","year":"2019","journal-title":"Indian J. Microbiol."},{"key":"10.1016\/j.micpath.2024.106763_bib46","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acsomega.2c07740","article-title":"Nanoparticle-based photodynamic inhibition of Candida albicans biofilms with interfering quorum sensing","volume":"8","author":"Tang","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.micpath.2024.106763_bib47","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.0401416101","article-title":"Tyrosol is a quorum-sensing molecule in Candida albicans","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.micpath.2024.106763_bib48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.intimp.2016.12.012","article-title":"Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages","volume":"43","author":"Bigagli","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.106763_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060843","article-title":"Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans","volume":"17","author":"Rigacci","year":"2016","journal-title":"Int. J. Mol. Sci."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024002304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024002304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T21:46:33Z","timestamp":1728251193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024002304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":49,"alternative-id":["S0882401024002304"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106763","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tyrosol-gold nanoparticle functionalized acacia gum-PVA nanofibers for mitigation of Candida biofilm","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106763","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106763"}}