{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:35:02Z","timestamp":1787906102813,"version":"build-2784847793"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.micpath.2024.106774","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T16:44:50Z","timestamp":1720025090000},"page":"106774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Mechanisms of action of berberine hydrochloride in planktonic cells and biofilms of Pseudomonas aeruginosa"],"prefix":"10.1016","volume":"193","author":[{"given":"Qingyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-3283","authenticated-orcid":false,"given":"Yongxue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.micpath.2024.106774_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2022.104950","article-title":"Therapeutic approaches for combating Pseudomonas aeruginosa infections","volume":"24","author":"Jangra","year":"2022","journal-title":"Microb. Infect."},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/antibiotics10010008","article-title":"Carbapenem-resistant Pseudomonas aeruginosa strains-distribution of the essential enzymatic virulence factors genes","volume":"10","author":"Bogiel","year":"2020","journal-title":"Antibiotics. (Basel)"},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/antibiotics10010042","article-title":"It's not easy being green: a narrative review on the microbiology, virulence and therapeutic prospects of multidrug-resistant Pseudomonas aeruginosa","volume":"10","author":"Behzadi","year":"2021","journal-title":"Antibiotics. (Basel)"},{"issue":"2","key":"10.1016\/j.micpath.2024.106774_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jmii.2022.08.017","article-title":"Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: a longitudinal observational study","volume":"56","author":"Huang","year":"2023","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"Suppl 4","key":"10.1016\/j.micpath.2024.106774_bib5","doi-asserted-by":"crossref","first-page":"S386","DOI":"10.1093\/cid\/ciaa1522","article-title":"Risk factors and outcomes of antibiotic-resistant Pseudomonas aeruginosa bloodstream infection in adult patients with acute leukemia","volume":"71","author":"Zhao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.micpath.2024.106774_bib6","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2147\/IDR.S358778","article-title":"Carbapenem resistant Pseudomonas aeruginosa infections in elderly patients: antimicrobial resistance profiles, risk factors and impact on clinical outcomes","volume":"15","author":"Qin","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.micpath.2024.106774_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2147\/IDR.S346313","article-title":"Epidemiology, molecular characteristics, and virulence factors of carbapenem-resistant Pseudomonas aeruginosa isolated from patients with urinary tract infections","volume":"15","author":"Park","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.micpath.2024.106774_bib8","series-title":"Antibiotic Resistant Threats in the United States 2019","year":"2019"},{"key":"10.1016\/j.micpath.2024.106774_bib9","series-title":"Global Priority List of Antibiotic-Resistance Bacteria to Guide Research, Discovery, and Development of New Antibiotics","year":"2017"},{"key":"10.1016\/j.micpath.2024.106774_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105714","article-title":"Biofilm matrix proteome of clinical strain of P. aeruginosa isolated from bronchoalveolar lavage of patient in intensive care unit","volume":"170","author":"Egorova","year":"2022","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/microorganisms10010160","article-title":"Antimicrobial susceptibility of persister biofilm cells of Bacillus cereus and Pseudomonas fluorescens","volume":"10","author":"Fernandes","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2024.106774_bib12","article-title":"Antibiofilm property and multiple action of peptide PEW300 against Pseudomonas aeruginosa","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.106774_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114513","article-title":"Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development","volume":"239","author":"Deng","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.micpath.2024.106774_bib14","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/metabo12111062","article-title":"Antiadhesive and antibiofilm effect of malvidin-3-glucoside and malvidin-3-glucoside\/neochlorogenic acid mixtures upon Staphylococcus","volume":"12","author":"Silva","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.micpath.2024.106774_bib15","article-title":"A new perspective on the antimicrobial mechanism of berberine hydrochloride against Staphylococcus aureus revealed by untargeted metabolomic studies","author":"Wu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.106774_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.micres.2016.03.003","article-title":"The effect of berberine hydrochloride on Enterococcus faecalis biofilm formation and dispersion in vitro","volume":"186\u2013187","author":"Chen","year":"2016","journal-title":"Microbiol. Res."},{"issue":"2","key":"10.1016\/j.micpath.2024.106774_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00203-021-02617-8","article-title":"Mechanism of berberine hydrochloride interfering with biofilm formation of Hafnia alvei","volume":"204","author":"Pang","year":"2022","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.micpath.2024.106774_bib18","article-title":"In situ gelling hydrogel loaded with berberine liposome for the treatment of biofilm-infected wounds","volume":"11","author":"Li","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.micpath.2024.106774_bib19","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fmicb.2016.01223","article-title":"Berberine is a novel type efflux inhibitor which attenuates the MexXY-mediated aminoglycoside resistance in Pseudomonas aeruginosa","volume":"7","author":"Morita","year":"2016","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.micpath.2024.106774_bib20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1021\/acs.jnatprod.0c01151","article-title":"The natural alkaloid berberine can reduce the number of Pseudomonas aeruginosa tolerant cells","volume":"84","author":"Mangiaterra","year":"2021","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.micpath.2024.106774_bib21","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/AAC.46.10.3133-3141.2002","article-title":"Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials","volume":"46","author":"Tegos","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2024.106774_bib22","article-title":"In vitro synergistic inhibitory activity of natural alkaloid berberine combined with azithromycin against alginate production by Pseudomonas aeruginosa PAO1","author":"Zhao","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.micpath.2024.106774_bib23","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2020"},{"issue":"11","key":"10.1016\/j.micpath.2024.106774_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s00018-022-04588-5","article-title":"L007-0069 kills Staphylococcus aureus in high resistant phenotypes","volume":"79","author":"She","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.micpath.2024.106774_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/1389203723666220630162920","article-title":"Overexpression of efflux pumps AcrAB and OqxAB contributes to ciprofloxacin resistance in clinical isolates of K. pneumonia","volume":"23","author":"Albarri","year":"2022","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13568-022-01488-6","article-title":"Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening","volume":"12","author":"Liu","year":"2022","journal-title":"Amb. Express"},{"issue":"11","key":"10.1016\/j.micpath.2024.106774_bib27","article-title":"Effect of imipenem and amikacin combination against multi-drug resistant Pseudomonas aeruginosa","volume":"10","author":"Farhan","year":"2021","journal-title":"Antibiotics. (Basel)"},{"key":"10.1016\/j.micpath.2024.106774_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jgar.2022.04.008","article-title":"Isolation and characterisation of carbapenem-resistant Pseudomonas aeruginosa from hospital environments in tertiary care hospitals in Dhaka, Bangladesh","volume":"30","author":"Saha","year":"2022","journal-title":"J Glob Antimicrob Resist."},{"issue":"7","key":"10.1016\/j.micpath.2024.106774_bib29","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41396-022-01221-y","article-title":"Pseudomonas aeruginosa polysaccharide Psl supports airway microbial community development","volume":"16","author":"Stoner","year":"2022","journal-title":"ISME J."},{"issue":"5","key":"10.1016\/j.micpath.2024.106774_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10051004","article-title":"Evaluation of a novel chromogenic medium for the detection of Pseudomonas aeruginosa in respiratory samples from patients with cystic fibrosis","volume":"10","author":"Truong","year":"2022","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.micpath.2024.106774_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01842-22","article-title":"The effects of antibiotic combination treatments on Pseudomonas aeruginosa tolerance evolution and coexistence with stenotrophomonas maltophilia","volume":"10","author":"Law","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"22","key":"10.1016\/j.micpath.2024.106774_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228671","article-title":"Pseudomonas aeruginosa biofilms","volume":"21","author":"Thi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chom.2019.06.002","article-title":"Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms","volume":"26","author":"Yan","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2175820","article-title":"Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa","volume":"38","author":"Mao","year":"2023","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.micpath.2024.106774_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12941-020-00350-6","article-title":"A rapid and simple method for routine determination of antibiotic sensitivity to biofilm populations of Pseudomonas aeruginosa","volume":"19","author":"Wannigama","year":"2020","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.micpath.2024.106774_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/759348","article-title":"The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms","author":"Rasamiravaka","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.micpath.2024.106774_bib37","first-page":"363","article-title":"Association between biofilm formation and antimicrobial resistance in carbapenem-resistant Pseudomonas aeruginosa","volume":"48","author":"Cho","year":"2018","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.micpath.2024.106774_bib38","first-page":"201","article-title":"Association of biofilm formation with multi drug resistance in clinical isolates of Pseudomonas aeruginosa","volume":"19","author":"Abdulhaq","year":"2020","journal-title":"EXCLI J"},{"key":"10.1016\/j.micpath.2024.106774_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jgar.2017.04.008","article-title":"Affiliations expand deficiency of quorum sensing system inhibits the resistance selection of Pseudomonas aeruginosa to ciprofloxacin and levofloxacin in vitro","volume":"10","author":"Gao","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.micpath.2024.106774_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1035574","article-title":"Bacterial cell membranes and their role in daptomycin resistance: a review","author":"Nguyen","year":"2022","journal-title":"Front. Mol. Biosci."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024002419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024002419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:23:14Z","timestamp":1721953394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024002419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":40,"alternative-id":["S0882401024002419"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106774","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3408372\/v1","asserted-by":"object"}]},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of action of berberine hydrochloride in planktonic cells and biofilms of Pseudomonas aeruginosa","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106774"}}