{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:56:52Z","timestamp":1767992212813,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.micpath.2024.106871","type":"journal-article","created":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T13:51:33Z","timestamp":1723989093000},"page":"106871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Improved cellular immune response induced by intranasal boost immunization with chitosan coated DNA vaccine against H9N2 influenza virus challenge"],"prefix":"10.1016","volume":"195","author":[{"given":"Tongyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingkai","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhannan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3662-9955","authenticated-orcid":false,"given":"Yanlong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2024.106871_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102021","article-title":"The relationship among avian influenza, gut microbiota and chicken immunity: an updated overview","volume":"101","author":"Abd El-Hack","year":"2022","journal-title":"Poultry Sci."},{"key":"10.1016\/j.micpath.2024.106871_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102639","article-title":"Molecular detection of highly pathogenic avian influenza H5N8 in commercial broiler chicken farms from 2019 to 2022","volume":"102","author":"Setta","year":"2023","journal-title":"Poultry Sci."},{"key":"10.1016\/j.micpath.2024.106871_bib3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jbiotec.2017.08.011","article-title":"Molecular mechanisms underlying protection against H9N2 influenza virus challenge in mice by recombinant Lactobacillus plantarum with surface displayed HA2-LTB","volume":"259","author":"Jiang","year":"2017","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.micpath.2024.106871_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.drudis.2012.06.002","article-title":"Recent progress in structure-based anti-influenza drug design","volume":"17","author":"Du","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.micpath.2024.106871_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2307\/1588472","article-title":"Avian influenza virus infections. III. Antibody response by turkeys to influenza A\/Turkey\/Wisconsin\/1966 virus","author":"Homme","year":"1970","journal-title":"Avian Dis."},{"key":"10.1016\/j.micpath.2024.106871_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/v11070620","article-title":"A global perspective on H9N2 avian influenza virus","volume":"11","author":"Peacock","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.106871_bib7","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1038\/s41467-020-19671-3","article-title":"Dominant subtype switch in avian influenza viruses during 2016-2019 in China","volume":"11","author":"Bi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2024.106871_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.105983","article-title":"The role of transforming growth factor beta-1 protein in Escherichia coli secondary infection induced by H9N2 avian influenza virus in chickens","volume":"175","author":"Wang","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2024.106871_bib9","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12512","article-title":"Sequence characteristics and phylogenetic analysis of H9N2 subtype avian influenza A viruses detected from poultry and the environment in China, 2018","volume":"9","author":"Gao","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.micpath.2024.106871_bib10","article-title":"The multifaceted zoonotic risk of H9N2 avian influenza","volume":"5","author":"Pusch","year":"2018","journal-title":"Vet Sci"},{"key":"10.1016\/j.micpath.2024.106871_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109624","article-title":"Field efficacy of HVT-H9 vaccination after natural infection of H9N2 avian influenza virus in broilers","volume":"276","author":"Chen","year":"2023","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2024.106871_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3390\/vaccines3020373","article-title":"Influenza vaccination strategies: comparing inactivated and live attenuated influenza vaccines","volume":"3","author":"Sridhar","year":"2015","journal-title":"Vaccines (Basel)."},{"key":"10.1016\/j.micpath.2024.106871_bib13","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1080\/22221751.2020.1812436","article-title":"Protein transduction domain-mediated influenza NP subunit vaccine generates a potent immune response and protection against influenza virus in mice","volume":"9","author":"Yin","year":"2020","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.micpath.2024.106871_bib14","article-title":"Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection","volume":"102","author":"Zhang","year":"2023","journal-title":"Poultry Sci."},{"key":"10.1016\/j.micpath.2024.106871_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102925","article-title":"Enhance immune response to H9 AIV DNA vaccine based on polygene expression and DGL nanoparticle encapsulation","volume":"102","author":"Xu","year":"2023","journal-title":"Poultry Sci."},{"key":"10.1016\/j.micpath.2024.106871_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/03079457.2022.2148516","article-title":"Live recombinant Newcastle disease virus vectored vaccine expressing the haemagglutinin of H9N2 avian influenza virus suppresses viral replication in chickens","volume":"52","author":"Lee","year":"2023","journal-title":"Avian Pathol."},{"key":"10.1016\/j.micpath.2024.106871_bib17","article-title":"Self\u2010assembled virus\u2010like particle vaccines via fluorophilic interactions enable infection mimicry and immune protection","author":"Xia","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.micpath.2024.106871_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0958-1669(97)80041-9","article-title":"Plasmid DNA expression systems for the purpose of immunization","volume":"8","author":"Davis","year":"1997","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.micpath.2024.106871_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1517\/17425247.2016.1121990","article-title":"Clinical potential of electroporation for gene therapy and DNA vaccine delivery","volume":"13","author":"Lambricht","year":"2016","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.micpath.2024.106871_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126286","article-title":"An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice","volume":"251","author":"Xu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106871_bib21","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1016\/j.vaccine.2015.07.101","article-title":"Chitosan-based mucosal adjuvants: sunrise on the ocean","volume":"33","author":"Xia","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2024.106871_bib22","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines","volume":"11","author":"Holmgren","year":"2005","journal-title":"Nat Med."},{"key":"10.1016\/j.micpath.2024.106871_bib23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1517\/17425247.2012.697455","article-title":"Chitosan-based delivery systems for mucosal vaccines","volume":"9","author":"Jabbal-Gill","year":"2012","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.micpath.2024.106871_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053314","article-title":"Preparation and efficacy of a live newcastle disease virus vaccine encapsulated in chitosan nanoparticles","volume":"7","author":"Zhao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2024.106871_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/vim.2021.0207","article-title":"A combination of recombinant HA1-and nucleoprotein-based chitosan nanoparticles induces early and potent immune responses against the H9N2 influenza virus","volume":"35","author":"Shahsavandi","year":"2022","journal-title":"Viral Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib26","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0264-410X(98)00077-2","article-title":"Stimulation of mucosal and systemic antibody responses against Bordetella pertussis filamentous haemagglutinin and recombinant pertussis toxin after nasal administration with chitosan in mice","volume":"16","author":"Jabbal-Gill","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2024.106871_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12951-020-00618-1","article-title":"Effect of the cagW-based gene vaccine on the immunologic properties of BALB\/c mouse: an efficient candidate for Helicobacter pylori DNA vaccine","volume":"18","author":"Chehelgerdi","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.micpath.2024.106871_bib28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4161\/hv.27449","article-title":"Chitosan: a promising safe and immune-enhancing adjuvant for intranasal vaccines","volume":"10","author":"Smith","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.micpath.2024.106871_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2021.104884","article-title":"Intranasal immunization with chitosan microparticles enhances LACK-DNA vaccine protection and induces specific long-lasting immunity against visceral leishmaniasis","volume":"24","author":"Gomes","year":"2022","journal-title":"Microb. Infect."},{"key":"10.1016\/j.micpath.2024.106871_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijbiomac.2022.08.073","article-title":"Immune enhancement of N-2-Hydroxypropyl trimethyl ammonium chloride chitosan\/carboxymethyl chitosan nanoparticles vaccine","volume":"220","author":"Gao","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2024.106871_bib31","doi-asserted-by":"crossref","first-page":"19414","DOI":"10.1073\/pnas.1217554109","article-title":"3rd. Turning self-destructing Salmonella into a universal DNA vaccine delivery platform","volume":"109","author":"Kong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.micpath.2024.106871_bib32","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1073\/pnas.0803801105","article-title":"Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment","volume":"105","author":"Kong","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.micpath.2024.106871_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13568-020-01036-0","article-title":"Effect of the selection pressure of vaccine antibodies on evolution of H9N2 avian influenza virus in chickens","volume":"10","author":"Su","year":"2020","journal-title":"Amb. Express"},{"key":"10.1016\/j.micpath.2024.106871_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102957","article-title":"Evolution of prevalent H9N2 subtype of avian influenza virus during 2019-2022 for the development of a control strategy in China","author":"Xia","year":"2023","journal-title":"Poultry Sci."},{"key":"10.1016\/j.micpath.2024.106871_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/life12091326","article-title":"Status and challenges for vaccination against avian H9N2 influenza virus in China","volume":"12","author":"Dong","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.micpath.2024.106871_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13567-017-0453-2","article-title":"Current situation of H9N2 subtype avian influenza in China","volume":"48","author":"Gu","year":"2017","journal-title":"Vet Res"},{"key":"10.1016\/j.micpath.2024.106871_bib37","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1358\/dot.2018.54.5.2807864","article-title":"Plasmid DNA vaccines: where are we now?","volume":"54","author":"Ghaffarifar","year":"2018","journal-title":"Drugs Today"},{"key":"10.1016\/j.micpath.2024.106871_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2020.102209","article-title":"Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickens","volume":"27","author":"Zhao","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.micpath.2024.106871_bib39","article-title":"A DNA prime and MVA boost strategy provides a robust immunity against infectious bronchitis virus in chickens","volume":"11","author":"Chandrasekar","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.micpath.2024.106871_bib40","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.drudis.2021.06.008","article-title":"Methods to improve the immunogenicity of plasmid DNA vaccines","volume":"26","author":"Eus\u00e9bio","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.micpath.2024.106871_bib41","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.foodchem.2015.06.076","article-title":"Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides","volume":"190","author":"Zou","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.micpath.2024.106871_bib42","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.immuni.2016.03.002","article-title":"Chitosan: an adjuvant with an unanticipated STING","volume":"44","author":"Riteau","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.micpath.2024.106871_bib43","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.4049\/jimmunol.2100909","article-title":"Development of a nanoparticle multiepitope DNA vaccine against virulent infectious bronchitis virus challenge","volume":"208","author":"Qin","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tvjl.2017.11.006","article-title":"Construction of a ptfA chitosan nanoparticle DNA vaccine against Pasteurella multocida and the immune response in chickens","volume":"231","author":"Gong","year":"2018","journal-title":"Vet. J."},{"key":"10.1016\/j.micpath.2024.106871_bib45","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1016\/j.vaccine.2018.05.093","article-title":"Examination of the effects of virus inactivation methods on the induction of antibody- and cell-mediated immune responses against whole inactivated H9N2 avian influenza virus vaccines in chickens","volume":"36","author":"Astill","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2024.106871_bib46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/vim.2021.0207","article-title":"A combination of recombinant HA1-and nucleoprotein-based chitosan nanoparticles induces early and potent immune responses against the H9N2 influenza virus","volume":"35","author":"Shahsavandi","year":"2022","journal-title":"Viral Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib47","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1016\/j.vaccine.2010.09.019","article-title":"Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant","volume":"28","author":"Sui","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2024.106871_bib48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00705-010-0621-4","article-title":"Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant","volume":"155","author":"Sui","year":"2010","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2024.106871_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clim.2008.11.003","article-title":"Analysis of in vitro lymphocyte proliferation as a screening tool for cellular immunodeficiency","volume":"131","author":"Stone","year":"2009","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib50","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.immunol.18.1.561","article-title":"Accessing complexity: the dynamics of virus-specific T cell responses","volume":"18","author":"Doherty","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib51","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.it.2014.06.004","article-title":"T cell mediated immunity to influenza: mechanisms of viral control","volume":"35","author":"La Gruta","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib52","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/acsnano.5b06750","article-title":"Graphene oxides decorated with carnosine as an adjuvant to modulate innate immune and improve adaptive immunity in vivo","volume":"10","author":"Meng","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.micpath.2024.106871_bib53","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1002\/adfm.201401358","article-title":"Ultrasmall graphene oxide supported gold nanoparticles as adjuvants improve humoral and cellular immunity in mice","volume":"24","author":"Cao","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.micpath.2024.106871_bib54","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1016\/j.biomaterials.2009.04.001","article-title":"The effect of Gd@C82(OH)22 nanoparticles on the release of Th1\/Th2 cytokines and induction of TNF-alpha mediated cellular immunity","volume":"30","author":"Liu","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.micpath.2024.106871_bib55","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1365-2249.2001.01638.x","article-title":"The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome","volume":"125","author":"Van Damme","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biomaterials.2017.05.001","article-title":"Tailoring nanostructured lipid carriers for the delivery of protein antigens: physicochemical properties versus immunogenicity studies","volume":"136","author":"Courant","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.micpath.2024.106871_bib57","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jconrel.2017.06.026","article-title":"Pathogen-mimicking vaccine delivery system designed with a bioactive polymer (inulin acetate) for robust humoral and cellular immune responses","volume":"261","author":"Kumar","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.micpath.2024.106871_bib58","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2024.106871_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106092","article-title":"Immunological evaluation of a recombinant vaccine delivered with an analogous hyaluronic acid chitosan nanoparticle-hydrogel against Toxoplasma gondii in mice","volume":"179","author":"Li","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2024.106871_bib60","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijpharm.2014.07.005","article-title":"Intranasal chitosan-DNA vaccines that protect across influenza virus subtypes","volume":"473","author":"Sawaengsak","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.micpath.2024.106871_bib61","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.vaccine.2023.03.067","article-title":"Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens","volume":"41","author":"Liu","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.micpath.2024.106871_bib62","article-title":"Recombinant hemagglutinin protein and DNA-RNA-combined nucleic acid vaccines harbored by yeast elicit protective immunity against H9N2 avian influenza infection","volume":"102","author":"Zhang","year":"2023","journal-title":"Poultry Sci."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024003383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024003383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T11:07:07Z","timestamp":1726312027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024003383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":62,"alternative-id":["S0882401024003383"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106871","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved cellular immune response induced by intranasal boost immunization with chitosan coated DNA vaccine against H9N2 influenza virus challenge","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.106871","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106871"}}