{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:12:50Z","timestamp":1780585970512,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222181"],"award-info":[{"award-number":["7222181"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172109"],"award-info":[{"award-number":["82172109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.micpath.2024.107009","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T02:31:00Z","timestamp":1728613860000},"page":"107009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Repetitive Acinetobacter baumannii pneumonia induces infection tolerance in mice"],"prefix":"10.1016","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-8052","authenticated-orcid":false,"given":"Jianqiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.micpath.2024.107009_bib1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1164\/rccm.201206-1063PP","article-title":"Respiratory infection and the impact of pulmonary immunity on lung health and disease","volume":"186","author":"Mizgerd","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.micpath.2024.107009_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41572-021-00259-0","article-title":"Pneumonia","volume":"7","author":"Torres","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.micpath.2024.107009_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.coi.2017.12.003","article-title":"Disease tolerance: concept and mechanisms","volume":"50","author":"McCarville","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1037850","article-title":"Disease tolerance: a protective mechanism of lung infections","volume":"13","author":"Xu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.micpath.2024.107009_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.imbio.2012.05.029","article-title":"Neutrophil--CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance","volume":"218","author":"Lewkowicz","year":"2013","journal-title":"Immunobiology"},{"issue":"11","key":"10.1016\/j.micpath.2024.107009_bib6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41590-019-0494-y","article-title":"CD103(hi) T(reg) cells constrain lung fibrosis induced by CD103(lo)tissue-resident pathogenic CD4 T cells","volume":"20","author":"Ichikawa","year":"2019","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.micpath.2024.107009_bib7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.micpath.2024.107009_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"issue":"7508","key":"10.1016\/j.micpath.2024.107009_bib9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature13323","article-title":"Aryl hydrocarbon receptor control of a disease tolerance defence pathway","volume":"511","author":"Bessede","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2024.107009_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-immunol-020711-075030","article-title":"Tolerance of infections","volume":"30","author":"Ayres","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib11","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3389\/fimmu.2018.02976","article-title":"Beyond killing Mycobacterium tuberculosis: disease tolerance","volume":"9","author":"Divangahi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63838","article-title":"Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria","volume":"10","author":"Nahrendorf","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.micpath.2024.107009_bib13","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3389\/fimmu.2018.02135","article-title":"Helminth infections induce tissue tolerance mitigating immunopathology but","volume":"9","author":"Yap","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2024.107009_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1128\/CMR.00058-16","article-title":"Clinical and pathophysiological overview of acinetobacter infections: a century of challenges","volume":"30","author":"Wong","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"issue":"12","key":"10.1016\/j.micpath.2024.107009_bib15","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1097\/01.CCM.0000288122.24212.40","article-title":"Inducible nitric oxide synthase and heme oxygenase-1 in the lung during","volume":"35","author":"Koch","year":"2007","journal-title":"Crit. Care Med."},{"issue":"12","key":"10.1016\/j.micpath.2024.107009_bib16","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.4049\/jimmunol.181.12.8402","article-title":"Acute pulmonary lipopolysaccharide tolerance decreases TNF-alpha without reducing neutrophil recruitment","volume":"181","author":"Natarajan","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3389\/fimmu.2019.01416","article-title":"Natural killer cells in the lungs","volume":"10","author":"Cong","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.micpath.2024.107009_bib18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/eji.201242620","article-title":"NK cells exacerbate the pathology of influenza virus infection in mice","volume":"43","author":"Zhou","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.micpath.2024.107009_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12833","article-title":"NK cells inhibit anti-Mycobacterium bovis BCG T cell responses and aggravate pulmonary inflammation in a direct lung infection mouse model","volume":"20","author":"Wang","year":"2018","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.micpath.2024.107009_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106095","article-title":"Pulmonary macrophages and their different roles in health and disease","volume":"141","author":"Melo","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.micpath.2024.107009_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and human disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.micpath.2024.107009_bib23","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.immuni.2021.04.002","article-title":"Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections","volume":"54","author":"Harb","year":"2021","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.micpath.2024.107009_bib24","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.micpath.2024.107009_bib25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41423-018-0004-4","article-title":"When worlds collide: Th17 and Treg cells in cancer and autoimmunity","volume":"15","author":"Knochelmann","year":"2018","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.micpath.2024.107009_bib26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jaci.2021.11.020","article-title":"The new quest in CTLA-4 insufficiency: how to immune modulate effectively?","volume":"149","author":"Westermann-Clark","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.micpath.2024.107009_bib27","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.3389\/fimmu.2017.01522","article-title":"Disease tolerance mediated by phosphorylated indoleamine-2,3 dioxygenase confers resistance to a primary fungal pathogen","volume":"8","author":"de Ara\u00fajo","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2024.107009_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.it.2016.10.002","article-title":"TIGIT: a key inhibitor of the cancer immunity cycle","volume":"38","author":"Manieri","year":"2017","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.micpath.2024.107009_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41423-018-0191-z","article-title":"Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages","volume":"17","author":"Zeng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.micpath.2024.107009_bib30","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.immuni.2015.02.007","article-title":"ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity","volume":"42","author":"Maazi","year":"2015","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.micpath.2024.107009_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2018.09.003","article-title":"The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.micpath.2024.107009_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/JLB.3A0317-106RRR","article-title":"Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia","volume":"104","author":"Kim","year":"2018","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.micpath.2024.107009_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/JLB.5HI0119-018R","article-title":"Frontline Science: endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst","volume":"106","author":"Grondman","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.micpath.2024.107009_bib34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S2213-2600(23)00468-X","article-title":"Reframing sepsis immunobiology for translation: towards informative subtyping and","volume":"12","author":"Shankar-Har","year":"2024","journal-title":"Lancet Respir. Med."},{"issue":"10","key":"10.1016\/j.micpath.2024.107009_bib35","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00134-023-07130-8","article-title":"What's new in intensive care: disease tolerance","volume":"49","author":"Powell","year":"2023","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.micpath.2024.107009_bib36","first-page":"170","article-title":"The deadly burden of drug-resistant bacteria","volume":"vol. 21","author":"Mullard","year":"2022"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024004765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024004765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:48:39Z","timestamp":1733971719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024004765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":36,"alternative-id":["S0882401024004765"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107009","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repetitive Acinetobacter baumannii pneumonia induces infection tolerance in mice","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107009"}}