{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:38:19Z","timestamp":1783114699029,"version":"3.54.6"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.micpath.2024.107060","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T06:48:11Z","timestamp":1730270891000},"page":"107060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Targeting PI3K\u03b3 Pathway for Treating Dengue virus Infection"],"prefix":"10.1016","volume":"197","author":[{"given":"Felipe R. da S.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah F.","family":"Valad\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana L.","family":"Bambirra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaiane P.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla D.F.","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8066-8093","authenticated-orcid":false,"given":"Ingredy B.S.","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso M.","family":"Queiroz-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-5233","authenticated-orcid":false,"given":"Caio T.","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian V.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele G.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1 2","key":"10.1016\/j.micpath.2024.107060_bib1","first-page":"1","article-title":"Dengue infection","volume":"2","author":"Guzman","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.micpath.2024.107060_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Wilder-Smith","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.micpath.2024.107060_bib3","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1080\/22221751.2021.1935327","article-title":"Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis","volume":"10","author":"Htun","year":"2021","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.micpath.2024.107060_bib4","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.4254\/wjh.v13.i12.1968","article-title":"Dengue hemorrhagic fever and the liver","volume":"13","author":"Leowattana","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.micpath.2024.107060_bib5","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1080\/14787210.2021.1949983","article-title":"Dengue vaccine: an update","volume":"19","author":"Huang","year":"2021","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.micpath.2024.107060_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/imm.12748","article-title":"Pathogenesis of vascular leak in dengue virus infection","volume":"151","author":"Malavige","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.micpath.2024.107060_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199306","article-title":"Temporal cytokine storm dynamics in dengue infection predicts severity","volume":"341","author":"Bhatt","year":"2024","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2024.107060_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biom9090427","article-title":"Function, regulation and biological roles of PI3K\u03b3 variants","volume":"9","author":"N\u00fcrnberg","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.micpath.2024.107060_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41577-022-00701-8","article-title":"The role of PI3K\u03b3 in the immune system: new insights and translational implications","volume":"22","author":"Lanahan","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107060_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-9-12","article-title":"Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS\/c-Src\/PDGFR\/PI3K\/Akt\/MAPKs-dependent AP-1 pathway in rat brain astrocytes","volume":"9","author":"Yang","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.micpath.2024.107060_bib11","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1128\/JVI.79.13.8388-8399.2005","article-title":"Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection","volume":"79","author":"Lee","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2024.107060_bib12","doi-asserted-by":"crossref","DOI":"10.4161\/cib.23360","article-title":"PI3K-\u03b3 inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens","volume":"6","author":"Oghumu","year":"2013","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.micpath.2024.107060_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.virusres.2018.08.013","article-title":"Disentangling the role of PI3K\/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection","volume":"256","author":"Cuartas-L\u00f3pez","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2024.107060_bib14","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.3390\/v5123192","article-title":"Make yourself at home: viral hijacking of the PI3K\/Akt signaling pathway","volume":"5","author":"Diehl","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.107060_bib15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s13577-021-00484-5","article-title":"PI3K\/AKT signaling pathway: a possible target for adjuvant therapy in COVID-19","volume":"34","author":"Khezri","year":"2021","journal-title":"Hum. Cell"},{"key":"10.1016\/j.micpath.2024.107060_bib16","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41577-022-00701-8","article-title":"The role of PI3K\u03b3 in the immune system: new insights and translational implications","volume":"22","author":"Lanahan","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107060_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005508","article-title":"PI3K\u03b3 is critical for dendritic cell-mediated CD8+ T cell priming and viral clearance during Influenza virus infection","volume":"12","author":"Nobs","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2024.107060_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/v12101190","article-title":"Phosphoinositide 3\u2019-kinase \u03b3 facilitates Polyomavirus infection","volume":"12","author":"Clark","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.107060_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001663","article-title":"A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-\u03b3 in host resistance to infection","volume":"6","author":"Costa","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2024.107060_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73853","article-title":"Targeting the Annexin A1-FPR2\/ALX pathway for host-directed therapy in dengue disease","volume":"11","author":"Costa","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.micpath.2024.107060_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-0270(83)90050-X","article-title":"Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues","volume":"8","author":"Saria","year":"1983","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.micpath.2024.107060_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001663","article-title":"A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-\u03b3 in host resistance to infection","volume":"6","author":"Costa","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2024.107060_bib23","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1016\/S2542-5196(23)00252-8","article-title":"Estimating the potential risk of transmission of arboviruses in the Americas and Europe: a modelling study","volume":"8","author":"Zardini","year":"2024","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.micpath.2024.107060_bib24","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/pathogens12111362","article-title":"Viremia and inflammatory cytokines in dengue: interleukin-2 as a biomarker of infection, and interferon-\u03b1 and -\u03b3 as markers of primary versus secondary infection","volume":"12","author":"de Arruda","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2024.107060_bib25","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12098-023-04514-y","article-title":"IL-6 levels in prediction of severity of dengue fever","volume":"90","author":"Vachher","year":"2023","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.micpath.2024.107060_bib26","article-title":"Plasma levels of tumour necrosis factor a and transforming children with dengue 2 virus infection in French Polynesia growth factor p-1 in","volume":"92","author":"Recherches","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.micpath.2024.107060_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/v15030705","article-title":"Molecular mechanisms of antiviral agents against dengue virus","volume":"15","author":"Lee","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.107060_bib28","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2024.107060_bib29","doi-asserted-by":"crossref","DOI":"10.1515\/hsz-2017-0236","article-title":"Host target-based approaches against arboviral diseases","volume":"399","author":"Rocha","year":"2018","journal-title":"Biol. Chem."},{"key":"10.1016\/j.micpath.2024.107060_bib30","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","article-title":"The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration","volume":"26","author":"Heras-Sandoval","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.micpath.2024.107060_bib31","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/rccm.201001-0088OC","article-title":"Phosphoinositide-3 kinase \u03b3 activity contributes to sepsis and organ damage by altering neutrophil recruitment","volume":"182","author":"Martin","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.micpath.2024.107060_bib32","first-page":"287","article-title":"Function of PI3K\u03b3 in thymocyte development, T cell activation, and neutrophil migration","volume":"2000","author":"Sasaki","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.micpath.2024.107060_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119633","article-title":"Phosphatidylinositol 3-kinase ? is required for the development of experimental cerebral malaria","volume":"10","author":"Lacerda-Queiroz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2024.107060_bib34","doi-asserted-by":"crossref","DOI":"10.4161\/cib.23360","article-title":"PI3K-\u03b3 inhibitors in the therapeutic intervention of diseases caused by obligate intracellular pathogens","volume":"6","author":"Oghumu","year":"2013","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.micpath.2024.107060_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00266","article-title":"Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy","volume":"5","author":"Bl\u00e1zquez","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.107060_bib36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41577-022-00701-8","article-title":"The role of PI3K\u03b3 in the immune system: new insights and translational implications","volume":"22","author":"Lanahan","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107060_bib37","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1128\/JVI.78.4.1697-1705.2004","article-title":"Latent membrane protein 2A inhibits transforming growth factor-\u03b21-induced apoptosis through the phosphatidylinositol 3-kinase\/akt pathway","volume":"78","author":"Fukuda","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2024.107060_bib38","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1128\/JVI.77.12.7106-7112.2003","article-title":"Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human Papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB\/Akt-Dependent pathway","volume":"77","author":"Nair","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2024.107060_bib39","doi-asserted-by":"crossref","first-page":"25858","DOI":"10.1074\/jbc.M003578200","article-title":"Hepatitis B virus X protein inhibits transforming growth factor-\u03b2-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway","volume":"275","author":"Shih","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2024.107060_bib40","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1128\/JVI.76.18.9207-9217.2002","article-title":"Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase","volume":"76","author":"He","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2024.107060_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.715208","article-title":"Dengue virus dysregulates master transcription factors and PI3K\/AKT\/mTOR signaling pathway in megakaryocytes","volume":"11","author":"Lahon","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2024.107060_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.virol.2013.09.016","article-title":"Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k\/Akt signaling pathway","volume":"448","author":"Liu","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.micpath.2024.107060_bib43","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1146\/annurev-biochem-060208-104626","article-title":"Virus entry by endocytosis","volume":"79","author":"Mercer","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.micpath.2024.107060_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.virusres.2018.08.013","article-title":"Disentangling the role of PI3K\/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection","volume":"256","author":"Cuartas-L\u00f3pez","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2024.107060_bib45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/pathogens10020244","article-title":"Akt interacts with Usutu virus polymerase, and its activity modulates viral replication","volume":"10","author":"Albentosa-Gonz\u00e1lez","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2024.107060_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/v13050896","article-title":"Akt kinase intervenes in flavivirus replication by interacting with viral protein NS5","volume":"13","author":"Albentosa-Gonz\u00e1lez","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2024.107060_bib47","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cyto.2011.01.013","article-title":"Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability","volume":"54","author":"Chuang","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.micpath.2024.107060_bib48","article-title":"Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3K\u03b3 mediated PI3K\/AKT\/mTOR\/p70S6K\/ULK signaling pathway in human breast cancer cells","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107060_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051048","article-title":"Autophagy in zika virus infection: a possible therapeutic target to counteract viral replication","volume":"20","author":"Gratton","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2024.107060_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2024.199422","article-title":"Hijacking autophagy for infection by flaviviruses","volume":"347","author":"Song","year":"2024","journal-title":"Virus Res."},{"key":"10.1016\/j.micpath.2024.107060_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.coviro.2021.12.007","article-title":"Platelets in the pathogenesis of flavivirus disease","volume":"52","author":"Balakrishna Pillai","year":"2022","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.micpath.2024.107060_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3358325","article-title":"Severe thrombocytopenia associated with dengue fever: an evidence-based approach to management of thrombocytopenia","author":"Das","year":"2022","journal-title":"Case Rep. Hematol."},{"key":"10.1016\/j.micpath.2024.107060_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/jth.12178","article-title":"Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases","volume":"11","author":"Hottz","year":"2013","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.micpath.2024.107060_bib54","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1182\/blood-2004-05-2005","article-title":"The relative role of PLCbeta and PI3Kgamma in platelet activation","volume":"106","author":"Lian","year":"2005","journal-title":"Blood"},{"issue":"1 9","key":"10.1016\/j.micpath.2024.107060_bib55","first-page":"1","article-title":"Critical roles for the phosphatidylinositide 3-kinase isoforms p110\u03b2 and p110\u03b3 in thrombopoietin-mediated priming of platelet function","volume":"9","author":"Moore","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107060_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122074","article-title":"Hepatic damage caused by flaviviruses: a systematic review","volume":"331","author":"Pinheiro","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2024.107060_bib57","article-title":"Predictors of mortality in patients with dengue fever: insights from a comparative analysis","author":"Mahmood","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.micpath.2024.107060_bib58","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/rccm.201001-0088OC","article-title":"Phosphoinositide-3 kinase \u03b3 activity contributes to sepsis and organ damage by altering neutrophil recruitment","volume":"182","author":"Martin","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.micpath.2024.107060_bib59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-immunol-101220-023458","article-title":"IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19","volume":"40","author":"Kishimoto","year":"2022","journal-title":"Annu. Rev. Immunol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024005278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024005278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:50:23Z","timestamp":1733971823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024005278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":59,"alternative-id":["S0882401024005278"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107060","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting PI3K\u03b3 Pathway for Treating Dengue virus Infection","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107060"}}