{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:28:43Z","timestamp":1783711723512,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.micpath.2024.107072","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T18:34:29Z","timestamp":1729622069000},"page":"107072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Mycoplasma pneumoniae regulates the expression of GP130 in lung epithelial cells through apoptosis and TLR4\/ NF-\u03baB pathway during infection"],"prefix":"10.1016","volume":"197","author":[{"given":"Zhikun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3055-6072","authenticated-orcid":false,"given":"Deli","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170253","article-title":"Changes in molecular characteristics of Mycoplasma pneumoniae in clinical specimens from children in Beijing between 2003 and 2015","volume":"12","author":"Sun","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.micpath.2024.107072_bib2","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.3892\/mmr.2016.5765","article-title":"Insights into the pathogenesis of Mycoplasma pneumoniae","volume":"14","author":"He","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.micpath.2024.107072_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijid.2014.07.020","article-title":"Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children","volume":"29","author":"Wang","year":"2014","journal-title":"Int. J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.micpath.2024.107072_bib4","first-page":"188","article-title":"Th1\/Th2 immune response in bronchoalveolar lavage fluid in children with severe Mycoplasma pneumoniae pneumonia","volume":"13","author":"Kang","year":"2011","journal-title":"Chin. J. Contemp. Pediatr."},{"key":"10.1016\/j.micpath.2024.107072_bib5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2147\/TCRM.S121928","article-title":"Relationships between Th1\/Th2 cytokine profiles and chest radiographic manifestations in childhood Mycoplasma pneumoniae pneumonia","volume":"12","author":"Zhao","year":"2016","journal-title":"Therapeut. Clin. Risk Manag."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-017-0101-y","article-title":"Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency","volume":"11","author":"Wang","year":"2017","journal-title":"Hum. Genom."},{"key":"10.1016\/j.micpath.2024.107072_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1088725","article-title":"Serum cytokine profiling reveals different immune response patterns during general and severe Mycoplasma pneumoniae pneumonia","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.micpath.2024.107072_bib8","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1084\/jem.20161810","article-title":"A biallelic mutation in IL-6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis","volume":"214","author":"Schwerd","year":"2017","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cyto.2014.05.024","article-title":"Interleukin-6 and its receptors: a highly regulated and dynamic system","volume":"70","author":"Wolf","year":"2014","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.micpath.2024.107072_bib10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI23640","article-title":"The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury","volume":"115","author":"Klein","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1046\/j.1432-1327.2001.01867.x","article-title":"Soluble gp130 is the natural inhibitor of soluble interleukin\u20106 receptor transsignaling responses","volume":"268","author":"Jostock","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.micpath.2024.107072_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/S0161-5890(02)00210-9","article-title":"The two faces of IL-6 on Th1\/Th2 differentiation","volume":"39","author":"Diehl","year":"2002","journal-title":"Mol. Immunol."},{"issue":"18","key":"10.1016\/j.micpath.2024.107072_bib13","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1074\/jbc.RA117.001163","article-title":"The balance of interleukin (IL)-6, IL-6\u00b7soluble IL-6 receptor (sIL-6R), and IL-6\u00b7sIL-6R\u00b7sgp130 complexes allows simultaneous classic and trans-signaling","volume":"293","author":"Baran","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.micpath.2024.107072_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.20120260","article-title":"Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia","volume":"210","author":"Choi","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.micpath.2024.107072_bib15","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.163.8.4583","article-title":"Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor","volume":"163","author":"Klouche","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2024.107072_bib16","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1074\/jbc.272.23.15003","article-title":"Isolation and characterization of the human gp130 promoter","volume":"272","author":"O'Brien","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.micpath.2024.107072_bib17","doi-asserted-by":"crossref","DOI":"10.15761\/CMI.1000211","article-title":"Drastically elevated levels of Interleukin-6 and its soluble receptor complex in COVID-19 patients with acute respiratory distress","volume":"5","author":"Di Spigna","year":"2020","journal-title":"Clinical and Medical Investigations"},{"issue":"6","key":"10.1016\/j.micpath.2024.107072_bib18","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1158\/1535-7163.MCT-12-1082","article-title":"Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer","volume":"12","author":"Xu","year":"2013","journal-title":"Mol. Cancer Therapeut."},{"issue":"17","key":"10.1016\/j.micpath.2024.107072_bib19","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1038\/onc.2013.159","article-title":"Control of gp130 expression by the mitogen-activated protein kinase ERK2","volume":"33","author":"Bonito","year":"2014","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.micpath.2024.107072_bib20","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/MCB.01784-07","article-title":"c-Cbl-Dependent monoubiquitination and lysosomal degradation of gp130","volume":"28","author":"Tanaka","year":"2023","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.micpath.2024.107072_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112366","article-title":"Mechanism of infantile feire kechuan oral solution against Mycoplasma pneumoniae infection of A549 cells","volume":"145","author":"Wan","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.micpath.2024.107072_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2144\/000112401","article-title":"Isolation and solubilization of proteins after TRIzol\u00ae extraction of RNA and DNA from patient material following prolonged storage","volume":"42","author":"Hummon","year":"2007","journal-title":"Biotechniques"},{"issue":"7","key":"10.1016\/j.micpath.2024.107072_bib23","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1128\/IAI.70.7.3649-3655.2002","article-title":"Regulation of proinflammatory cytokines in human lung epithelial cells infected with Mycoplasma pneumoniae","volume":"70","author":"Yang","year":"2002","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.micpath.2024.107072_bib24","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.175.7.4641","article-title":"A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-\u03baB through TLR1, TLR2, and TLR6","volume":"175","author":"Shimizu","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2024.107072_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fmicb.2016.00414","article-title":"Inflammation-inducing factors of Mycoplasma pneumoniae","volume":"7","author":"Shimizu","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.107072_bib26","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2741\/2093","article-title":"Adhesion proteins of Mycoplasma pneumoniae","volume":"12","author":"Chaudhry","year":"2007","journal-title":"Front. Biosci."},{"issue":"4","key":"10.1016\/j.micpath.2024.107072_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.micpath.2005.07.004","article-title":"A role for the Mycoplasma pneumoniae adhesin P1 in interleukin (IL)-4 synthesis and release from rodent mast cells","volume":"39","author":"Hoek","year":"2005","journal-title":"Microb. Pathog."},{"issue":"7","key":"10.1016\/j.micpath.2024.107072_bib28","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1128\/IAI.01961-14","article-title":"Cytadherence of Mycoplasma pneumoniae induces inflammatory responses through autophagy and toll-like receptor 4","volume":"82","author":"Shimizu","year":"2014","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/cei.13510","article-title":"Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response","volume":"203","author":"Luo","year":"2021","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.micpath.2024.107072_bib30","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1074\/jbc.M113.523167","article-title":"CD14 mediates toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo","volume":"289","author":"Roy","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.immuni.2016.11.007","article-title":"Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14, and TLR4-MD2 for efficient LPS recognition and transfer","volume":"46","author":"Ryu","year":"2017","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.micpath.2024.107072_bib32","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.4049\/jimmunol.1701390","article-title":"Intravesicular acidification regulates lipopolysaccharide inflammation and tolerance through TLR4 trafficking","volume":"200","author":"Murase","year":"2018","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.micpath.2024.107072_bib33","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.immuni.2015.10.008","article-title":"Mechanisms of toll-like receptor 4 endocytosis reveal a common immune-evasion strategy used by pathogenic and commensal bacteria","volume":"43","author":"Tan","year":"2015","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.micpath.2024.107072_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014417","article-title":"Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae","volume":"5","author":"Lai","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib35","first-page":"85","article-title":"Small molecule inhibitor of TLR4 inhibits ovarian cancer cell proliferation: new insight into the anticancer effect of TAK-242 (Resatorvid)","author":"Kashani","year":"2020","journal-title":"Castanea"},{"issue":"52","key":"10.1016\/j.micpath.2024.107072_bib36","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.1038\/sj.onc.1207170","article-title":"Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma","volume":"22","author":"Hideshima","year":"2003","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.micpath.2024.107072_bib37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10456-006-9038-9","article-title":"Src activation of Stat3 is an independent requirement from NF-\u03baB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells","volume":"9","author":"Trevino","year":"2006","journal-title":"Angiogenesis"},{"issue":"413","key":"10.1016\/j.micpath.2024.107072_bib38","article-title":"Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells","volume":"14","author":"Hansakul","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"issue":"2","key":"10.1016\/j.micpath.2024.107072_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10020119","article-title":"Mycoplasma pneumoniae infections: pathogenesis and vaccine development","volume":"10","author":"Jiang","year":"2021","journal-title":"Pathogens"},{"issue":"5","key":"10.1016\/j.micpath.2024.107072_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00011-012-0437-7","article-title":"Reactive oxygen species mediate Jak2\/Stat3 activation and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins from Mycoplasma pneumoniae","volume":"61","author":"Choi","year":"2012","journal-title":"Inflamm. Res."},{"issue":"11","key":"10.1016\/j.micpath.2024.107072_bib41","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.bbamcr.2012.06.016","article-title":"Proteasome protease mediated regulation of cytokine induction and inflammation","volume":"1823","author":"Qureshi","year":"2012","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"4","key":"10.1016\/j.micpath.2024.107072_bib42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","article-title":"Mycoplasma pneumoniae and its role as a human pathogen","volume":"17","author":"Waites","year":"2004","journal-title":"J. Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.micpath.2024.107072_bib43","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12879-020-05017-3","article-title":"The clinical significance of IL-6 s and IL-27 s in bronchoalveolar lavage fluids from children with Mycoplasma pneumoniae pneumonia","volume":"20","author":"Zhao","year":"2020","journal-title":"BMC Infect. Dis."},{"issue":"8","key":"10.1016\/j.micpath.2024.107072_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00129-22","article-title":"Mycoplasma pneumoniae compared to Streptococcus pneumoniae avoids induction of proinflammatory epithelial cell responses despite robustly inducing TLR2 signaling","volume":"90","author":"de Groot","year":"2022","journal-title":"Infect. Immun."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024005394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024005394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:50:51Z","timestamp":1733971851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024005394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"alternative-id":["S0882401024005394"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107072","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycoplasma pneumoniae regulates the expression of GP130 in lung epithelial cells through apoptosis and TLR4\/ NF-\u03baB pathway during infection","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107072"}}