{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:47:06Z","timestamp":1790128026349,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/11042-0"],"award-info":[{"award-number":["2019\/11042-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/10279-1"],"award-info":[{"award-number":["2022\/10279-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.micpath.2024.107244","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T17:43:10Z","timestamp":1734630190000},"page":"107244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Peritoneal fluid microbiota profile of patients with deep endometriosis"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-6116","authenticated-orcid":false,"given":"Helena","family":"Malvezzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Azevedo","family":"Cestari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Hernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Podgaec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2024.107244_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13669-017-0187-1","article-title":"Endometriosis: epidemiology, diagnosis and clinical management","volume":"6","author":"Parasar","year":"2017","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"10.1016\/j.micpath.2024.107244_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bpobgyn.2018.01.010","article-title":"Immunology of endometriosis","volume":"50","author":"Riccio","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.micpath.2024.107244_bib3","first-page":"1","article-title":"Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1590\/S0104-42302010000100022","article-title":"Th1 and Th2 immune responses related to pelvic endometriosis","volume":"56","author":"Podgaec","year":"2010","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.micpath.2024.107244_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0897.2012.01173.x","article-title":"CD4+CD25highFoxp3+ cells increased in the peritoneal fluid of patients with endometriosis","volume":"68","author":"Podgaec","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052476","article-title":"Altered p16Ink4a, IL-1\u03b2, and lamin b1 protein expression suggest cellular senescence in deep endometriotic lesions","volume":"23","author":"Malvezzi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2024.107244_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jri.2018.02.003","article-title":"Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease","volume":"126","author":"Gueuvoghlanian-Silva","year":"2018","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib8","first-page":"411","article-title":"Measurement of serum and peritoneal levels of amyloid protein A and their importance in the diagnosis of pelvic endometriosis","volume":"58","author":"Ejzenberg","year":"2013","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.micpath.2024.107244_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/rmb2.12083","article-title":"Bacterial contamination hypothesis: a new concept in endometriosis","volume":"17","author":"Khan","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.micpath.2024.107244_bib10","doi-asserted-by":"crossref","DOI":"10.31744\/einstein_journal\/2020AO5294","article-title":"Regulatory T cells isolated from endometriotic peritoneal fluid express a different number of Toll-like receptors","volume":"18","author":"Hernandes","year":"2020","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.micpath.2024.107244_bib11","article-title":"Microbiome profile of deep endometriosis patients: comparison of vaginal fluid, endometrium and lesion","volume":"10","author":"Hernandes","year":"2020","journal-title":"Diagn."},{"key":"10.1016\/j.micpath.2024.107244_bib12","first-page":"1","article-title":"Comparison of microbial abundance and diversity in uterine and peritoneal fluid in infertile patients with or without endometriosis","volume":"24","author":"Zhu","year":"2024","journal-title":"BMC Wom. Health"},{"key":"10.1016\/j.micpath.2024.107244_bib13","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00404-021-06338-7","article-title":"The colonized microbiota composition in the peritoneal fluid in women with endometriosis","volume":"305","author":"Yuan","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.micpath.2024.107244_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2021.788836","article-title":"Gut microbiota exceeds cervical microbiota for early diagnosis of endometriosis","volume":"11","author":"Huang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2024.107244_bib15","article-title":"Altered composition of microbiota in women with ovarian endometrioma: microbiome analyses of extracellular vesicles in the peritoneal fluid","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2024.107244_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12941-020-00356-0","article-title":"Microbiota composition and distribution along the female reproductive tract of women with endometriosis","volume":"19","author":"Wei","year":"2020","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.micpath.2024.107244_bib17","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2024.107244_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmb2.12441","article-title":"Microbiome analysis in women with endometriosis: does a microbiome exist in peritoneal fluid and ovarian cystic fluid?","volume":"21","author":"Oishi","year":"2022","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.micpath.2024.107244_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-82311-3","article-title":"Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country","volume":"11","author":"Dwiyanto","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107244_bib20","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41591-018-0210-8","article-title":"The influence of ethnicity and geography on human gut microbiome composition","volume":"24","author":"Gaulke","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.micpath.2024.107244_bib21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.fertnstert.2018.06.028","article-title":"NLRC5 and autophagy combined as possible predictors in patients with endometriosis","volume":"110","author":"Zhan","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2024.107244_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007401","article-title":"Conservative fragments in bacterial 16S rRNA genes and primer design for 16S ribosomal DNA amplicons in metagenomic studies","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2024.107244_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2021.638231","article-title":"Equivolumetric protocol generates library sizes proportional to total microbial load in 16S amplicon sequencing","volume":"12","author":"Cruz","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.107244_bib24","article-title":"KatharoSeq enables high-throughput microbiome analysis from low-biomass samples","volume":"3","author":"Minich","year":"2018","journal-title":"mSyst."},{"key":"10.1016\/j.micpath.2024.107244_bib25","first-page":"1","article-title":"Deblur rapidly resolves single nucleotide community sequence patterns","volume":"2","author":"Amir","year":"2017","journal-title":"Am. Soc. Microbiol."},{"key":"10.1016\/j.micpath.2024.107244_bib26","first-page":"1","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"2016","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.micpath.2024.107244_bib27","first-page":"1","article-title":"The regulation and modification of GSDMD signaling in diseases","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1182\/blood.V23.1.18.18","article-title":"On the origin of peritoneal fluid cells","volume":"23","author":"Goodman","year":"1964","journal-title":"Blood"},{"key":"10.1016\/j.micpath.2024.107244_bib29","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1016\/j.fertnstert.2010.04.053","article-title":"Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis","volume":"94","author":"Khan","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.micpath.2024.107244_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01162","article-title":"Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity","volume":"8","author":"Gupta","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2024.107244_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-82311-3","article-title":"Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country","volume":"11","author":"Dwiyanto","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107244_bib32","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-038163","article-title":"Does geographical variation confound the relationship between host factors and the human gut microbiota: a population-based study in China","volume":"10","author":"Sun","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.micpath.2024.107244_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003605","article-title":"Temporal dynamics of the human vaginal microbiota","volume":"4","author":"Gajer","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.micpath.2024.107244_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/aji.13147","article-title":"Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis","volume":"82","author":"Akiyama","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib35","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1007\/s43032-021-00506-5","article-title":"Associations between endometriosis and gut microbiota","volume":"28","author":"Svensson","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.micpath.2024.107244_bib36","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/RAF-21-0113","article-title":"The microbiome and endometriosis","volume":"3","author":"Miyashira","year":"2022","journal-title":"Reprod. Fert."},{"key":"10.1016\/j.micpath.2024.107244_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147450","article-title":"Bioinformatics characteristics and expression analysis of TLR3 and its adaptor protein TRIF in largemouth bass (Micropterus salmoides) upon Flavobacterium columnare infection","volume":"872","author":"Zhao","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.micpath.2024.107244_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jri.2007.04.004","article-title":"TLR2-mediated cell stimulation in bacterial vaginosis","volume":"77","author":"Mares","year":"2008","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.micpath.2024.107244_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2021.102153","article-title":"Evaluation of Toll-like receptor 3 (TLR3) signaling pathway genes and its genetic polymorphisms in ectopic and eutopic endometrium of women with endometriosis","volume":"50","author":"Almasi","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.micpath.2024.107244_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9081813","article-title":"Toll-like receptor 2 expression as a new hallmark of advanced endometriosis","volume":"9","author":"Sobstyl","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.micpath.2024.107244_bib41","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.micpath.2024.107244_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s40168-017-0278-2","article-title":"Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis","volume":"5","author":"Rogier","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.micpath.2024.107244_bib43","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.micpath.2024.107244_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-020-0167-x","article-title":"Inflammasome activation and regulation: toward a better understanding of complex mechanisms","volume":"6","author":"Zheng","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.micpath.2024.107244_bib45","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41586-022-05546-8","article-title":"Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies","volume":"613","author":"Kennedy","year":"2023","journal-title":"Nat."},{"key":"10.1016\/j.micpath.2024.107244_bib46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nat."},{"key":"10.1016\/j.micpath.2024.107244_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-016-0708-5","article-title":"Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study","volume":"16","author":"Odamaki","year":"2016","journal-title":"BMC Microbiol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024007113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024007113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T19:26:39Z","timestamp":1737314799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024007113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":47,"alternative-id":["S0882401024007113"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107244","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peritoneal fluid microbiota profile of patients with deep endometriosis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107244"}}