{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:38:21Z","timestamp":1784003901235,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.837841\/2023-00"],"award-info":[{"award-number":["88887.837841\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["16\/2022"],"award-info":[{"award-number":["16\/2022"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310413\/2023-0"],"award-info":[{"award-number":["310413\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403194\/2023-7"],"award-info":[{"award-number":["403194\/2023-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306733\/2023-4"],"award-info":[{"award-number":["306733\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311105\/2020-3"],"award-info":[{"award-number":["311105\/2020-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04164-22"],"award-info":[{"award-number":["APQ-04164-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03519-22"],"award-info":[{"award-number":["APQ-03519-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00126-18"],"award-info":[{"award-number":["APQ-00126-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.micpath.2024.107264","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T02:19:48Z","timestamp":1735179588000},"page":"107264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Pharmacological blockade of infection chronification modulates oxy-inflammation and prevents the activation of stress-induced premature senescence markers in schistosomiasis"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-5328","authenticated-orcid":false,"given":"R\u00f4mulo D.","family":"Novaes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda G.","family":"Souza-e-Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago D.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Edson","family":"Caetano-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo S.","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel L.M.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos J.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reggiani V.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.micpath.2024.107264_bib1","first-page":"89","article-title":"The schistosoma granuloma: friend or foe?","volume":"15","author":"Hams","year":"2013","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.micpath.2024.107264_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/cld.495","article-title":"Schistosomiasis: clinical management of liver disease","volume":"29","author":"Guimar\u00e3es Cavalcanti","year":"2015","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.micpath.2024.107264_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3109\/08820139209069384","article-title":"The pathogenesis of granulomatous inflammation and organ injury in schistosomiasis: interactions between the schistosome ova and the host","volume":"21","author":"Weinstock","year":"1992","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.micpath.2024.107264_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/pim.12087","article-title":"Immunology of human schistosomiasis","volume":"36","author":"Colley","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.micpath.2024.107264_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1157\/13070382","article-title":"Schistosomiasis mansoni -- clinical features","volume":"28","author":"Da Silva","year":"2005","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2024.107264_bib6","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.pt.2012.09.005","article-title":"Role of resident liver cells in the pathogenesis of schistosomiasis","volume":"28","author":"Anthony","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib7","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.3390\/ijms22137216","article-title":"Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis","volume":"22","author":"Masamba","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2024.107264_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpara.2012.12.006","article-title":"Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation end product (RAGE) and tau levels in multiple organs in mice","volume":"43","author":"de Oliveira","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib9","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3390\/cells10081982","article-title":"Does schistosoma mansoni facilitate carcinogenesis?","volume":"10","author":"von B\u00fclow","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.micpath.2024.107264_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jcmgh.2023.08.014","article-title":"Schistosoma mansoni-induced oxidative stress triggers hepatocellular proliferation","volume":"17","author":"von B\u00fclow","year":"2024","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2024.107264_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2478\/s11686-012-0026-5","article-title":"Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis","volume":"57","author":"Cunha","year":"2012","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib12","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/s13287-021-02589-y","article-title":"Hepatic progenitor cells promote the repair of schistosomiasis liver injury by inhibiting IL-33 secretion in mice","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.micpath.2024.107264_bib13","article-title":"Metabolic reprogramming of hepatocytes by Schistosoma mansoni eggs","volume":"5","author":"von B\u00fclow","year":"2022","journal-title":"JHEP Rep."},{"key":"10.1016\/j.micpath.2024.107264_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mayocp.2013.10.009","article-title":"Liver renewal: detecting misrepair and optimizing regeneration","volume":"89","author":"Machado","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.micpath.2024.107264_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.micpath.2024.107264_bib16","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3390\/cells10112974","article-title":"The role of immune cells in oxi-inflamm-aging","volume":"10","author":"Mart\u00ednez de Toda","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.micpath.2024.107264_bib17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1186\/s12864-016-3352-4","article-title":"Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence","volume":"17","author":"Kural","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.micpath.2024.107264_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41419-019-1670-6","article-title":"Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction","volume":"10","author":"Luo","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.micpath.2024.107264_bib19","first-page":"129","article-title":"Cellular stress and senescence induction during Trypanosoma cruzi infection","volume":"7","author":"Guimar\u00e3es-Pinto","year":"2022","journal-title":"Trav. Med. Infect. Dis."},{"key":"10.1016\/j.micpath.2024.107264_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2023.106950","article-title":"Oxidative stress, cardiomyocytes premature senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease","volume":"244","author":"Nogueira","year":"2023","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2024.107264_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151108","article-title":"Aging of the cells: insight into cellular senescence and detection Methods","volume":"99","author":"Mohamad Kamal","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.micpath.2024.107264_bib22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41594-022-00790-y","article-title":"Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening","volume":"29","author":"Barnes","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.micpath.2024.107264_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.intimp.2019.02.032","article-title":"Doxycycline hyclate: a schistosomicidal agent in vitro with immunomodulatory potential on granulomatous inflammation in vivo","volume":"70","author":"Dias","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2024.107141","article-title":"Dietary glycemic and energy load differentially modulates Schistosoma mansoni-induced granulomatous inflammation and response to antiparasitic chemotherapy","volume":"252","author":"Reis","year":"2024","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2024.107264_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1590\/S0074-02762001000300020","article-title":"Lower faecal egg excretion in chemically-induced diabetic mice infected with Schistosoma mansoni due to impaired egg maturation","volume":"96","author":"Hulstijn","year":"2001","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.micpath.2024.107264_bib26","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.micpath.2024.107264_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/S0074-02762006000900045","article-title":"Comparison between morphological and staining characteristics of live and dead eggs of Schistosoma mansoni","volume":"101","author":"Sarvel","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.micpath.2024.107264_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110416","article-title":"Pharmacological potential of new metronidazole\/eugenol\/dihydroeugenol hybrids against Trypanosoma cruzi in vitro and in vivo","volume":"121","author":"Gon\u00e7alves-Santos","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.niox.2017.02.013","article-title":"mansoni-T. cruzi co-infection modulates arginase-1\/iNOS expression, liver and heart disease in mice","volume":"66","author":"Rodrigues","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.micpath.2024.107264_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00441-013-1562-5","article-title":"The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine","volume":"352","author":"Sequetto","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.micpath.2024.107264_bib31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.fct.2013.11.032","article-title":"Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis","volume":"64","author":"Sequetto","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.micpath.2024.107264_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107462","article-title":"Doxycycline aggravates granulomatous inflammation and lung microstructural remodeling induced by Schistosoma mansoni infection","volume":"94","author":"Santos","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106611","article-title":"Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice","volume":"85","author":"Mendon\u00e7a","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2018.09.031","article-title":"Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice","volume":"129","author":"Felizardo","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.micpath.2024.107264_bib35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2613.2011.00781.x","article-title":"Effects of Trypanosoma cruzi infection on myocardial morphology, single cardiomyocyte contractile function and exercise tolerance in rats","volume":"92","author":"Novaes","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micpath.2024.107264_bib36","first-page":"328","article-title":"Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues","volume":"39","author":"Cheever","year":"1968","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.micpath.2024.107264_bib37","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1111\/liv.15710","article-title":"Bsep\/Abcb11 knockout ameliorates Schistosoma mansoni liver pathology by reducing parasite fecundity","volume":"43","author":"Mach\u00e1\u010dek","year":"2023","journal-title":"Liver Int."},{"key":"10.1016\/j.micpath.2024.107264_bib38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.micpath.2024.107264_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fimmu.2020.00061","article-title":"T lymphocyte-mediated liver immunopathology of schistosomiasis","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2024.107264_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116603","article-title":"Trans-fatty acids aggravate anabolic steroid-induced metabolic disturbances and differential gene expression in muscle, pancreas and adipose tissue","volume":"232","author":"Gon\u00e7alves","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2024.107264_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112917","article-title":"From waste to the gut: can blackcurrant press cake be a new functional ingredient? Insights on in vivo microbiota modulation, oxidative stress, and inflammation","volume":"170","author":"Dos Santos Lima","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.micpath.2024.107264_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/iep.12063","article-title":"The energy density of laser light differentially modulates the skin morphological reorganization in a murine model of healing by secondary intention","volume":"95","author":"Novaes","year":"2014","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micpath.2024.107264_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111353","article-title":"Matrix metalloproteinases inhibition reveals the association between inflammation, collagen accumulation and intestinal translocation of Schistosoma mansoni eggs in vivo","volume":"127","author":"Silva","year":"2024","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib44","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/jphp.12451","article-title":"Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice","volume":"67","author":"Santos","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.micpath.2024.107264_bib45","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1017\/S1431927615015366","article-title":"Time-dependent resolution of collagen deposition during skin repair in rats: a correlative morphological and biochemical study","volume":"2","author":"Novaes","year":"2015","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.micpath.2024.107264_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100086","article-title":"Protocol for primary mouse hepatocyte isolation","volume":"1","author":"Charni-Natan","year":"2020","journal-title":"STAR Protoc"},{"key":"10.1016\/j.micpath.2024.107264_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111467","article-title":"Schistosoma mansoni co-infection modulates Chagas disease development but does not impair the effect of benznidazole-based chemotherapy","volume":"128","author":"Lozano","year":"2024","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.micpath.2024.107264_bib48","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/iep.12183","article-title":"Acute paraquat exposure determines dose-dependent oxidative injury of multiple organs and metabolic dysfunction in rats: impact on exercise tolerance","volume":"97","author":"Novaes","year":"2016","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.micpath.2024.107264_bib49","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2337\/diabetes.51.5.1588","article-title":"Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats","volume":"51","author":"Kakimoto","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.micpath.2024.107264_bib50","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1017\/S0031182016002675","article-title":"Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative\/nitrosative stress and heart disease in T. cruzi-infected mice","volume":"144","author":"Novaes","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.micpath.2024.107264_bib51","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/cells11030541","article-title":"Dynamic spatiotemporal expression pattern of the senescence-associated factor p16Ink4a in development and aging","volume":"11","author":"Safwan-Zaiter","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.micpath.2024.107264_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122408","article-title":"Prolonged testosterone 17\u03b2-cyclopentylpropionate exposition induces behavioral, ovarian, oviductal, uterine and reproductive disturbances in female mice","volume":"338","author":"Barcelos","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.micpath.2024.107264_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jgr.2021.04.002","article-title":"High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture","volume":"46","author":"Hou","year":"2022","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.micpath.2024.107264_bib54","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/MCB.26.2.654-667.2006","article-title":"Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation","volume":"26","author":"Ju","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.micpath.2024.107264_bib55","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bj.2021.12.007","article-title":"Doxycycline hyclate stimulates inducible nitric oxide synthase and arginase imbalance, potentiating inflammatory and oxidative lung damage in schistosomiasis","volume":"45","author":"Souza","year":"2022","journal-title":"Biomed. J."},{"key":"10.1016\/j.micpath.2024.107264_bib56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.exppara.2017.05.004","article-title":"Lipopolysaccharide-induced acute lung injury in mice chronically infected by Schistosoma mansoni","volume":"178","author":"Rocha Pereira","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib57","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1128\/IAI.72.6.3391-3397.2004","article-title":"Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection","volume":"72","author":"de Jesus","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2024.107264_bib58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40249-017-0324-0","article-title":"Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study","volume":"6","author":"Lamberton","year":"2017","journal-title":"Infect Dis. Poverty"},{"key":"10.1016\/j.micpath.2024.107264_bib59","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.ijpara.2006.03.007","article-title":"Effect of artemether administered alone or in combination with praziquantel to mice infected with Plasmodium berghei or Schistosoma mansoni or both","volume":"36","author":"Shu-Hua","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib60","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1179\/136485906X118530","article-title":"Differential expression of collagen, MMP, TIMP and fibrogenic-cytokine genes in the granulomatous colon of Schistosoma mansoni-infected mice","volume":"100","author":"Singh","year":"2006","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.micpath.2024.107264_bib61","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1590\/S0036-46651999000400010","article-title":"Hepatic regeneration after partial hepatectomy in mice infected with Schistosoma mansoni, at the acute and chronic phases of the disease","volume":"41","author":"Costa","year":"1999","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.micpath.2024.107264_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010382","article-title":"Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection","volume":"16","author":"Membe Femoe","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2024.107264_bib63","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41598-017-00326-1","article-title":"Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2\/P27 signaling pathway","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107264_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-47646-z","article-title":"Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice","volume":"13","author":"H\u00e4rle","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2024.107264_bib65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1101\/gad.13.5.607","article-title":"Control of cell cycle progression by c-Jun is p53 dependent","volume":"13","author":"Schreiber","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.micpath.2024.107264_bib66","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.dnarep.2004.03.002","article-title":"DNA damage responses to oxidative stress","volume":"3","author":"Barzilai","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.micpath.2024.107264_bib67","series-title":"Cellular Ageing and Replicative Senescence. Healthy Ageing and Longevity","article-title":"Stress-induced (premature) senescence","author":"Debacq-Chainiaux","year":"2016"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024007319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401024007319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:53:42Z","timestamp":1777575222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401024007319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":67,"alternative-id":["S0882401024007319"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107264","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological blockade of infection chronification modulates oxy-inflammation and prevents the activation of stress-induced premature senescence markers in schistosomiasis","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2024.107264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107264"}}