{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:48:08Z","timestamp":1791557288285,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.micpath.2025.107364","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T07:14:28Z","timestamp":1738566868000},"page":"107364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["NAT10 induces mitochondrial dysfunction in lung epithelial cells by acetylating HMGB1 to exacerbate Pseudomonas aeruginosa-induced acute lung injury"],"prefix":"10.1016","volume":"200","author":[{"given":"Miaoyi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-8942","authenticated-orcid":false,"given":"Jiru","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107364_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2020.01.014","article-title":"Pseudomonas aeruginosa polymicrobial interactions during lung infection","volume":"53","author":"Bisht","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2052-0492-2-10","article-title":"The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response","volume":"2","author":"Sawa","year":"2014","journal-title":"Journal of intensive care"},{"issue":"2","key":"10.1016\/j.micpath.2025.107364_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1165\/rcmb.2014-0405OC","article-title":"Airway epithelial cell integrity protects from cytotoxicity of Pseudomonas aeruginosa quorum-sensing signals","volume":"53","author":"Losa","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.micpath.2025.107364_bib4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s13054-014-0668-9","article-title":"Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review","volume":"18","author":"Sawa","year":"2014","journal-title":"Critical care (London, England)"},{"key":"10.1016\/j.micpath.2025.107364_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.omtn.2023.03.023","article-title":"Mechanisms of NAT10 as ac4C writer in diseases","volume":"32","author":"Xie","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.micpath.2025.107364_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.omtn.2020.01.037","article-title":"The processing, gene regulation, biological functions, and clinical relevance of N4-acetylcytidine on RNA: a systematic review","volume":"20","author":"Jin","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"537","key":"10.1016\/j.micpath.2025.107364_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aar5401","article-title":"Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway","volume":"11","author":"Larrieu","year":"2018","journal-title":"Sci. Signal."},{"issue":"18","key":"10.1016\/j.micpath.2025.107364_bib8","doi-asserted-by":"crossref","first-page":"9601","DOI":"10.1093\/nar\/gky777","article-title":"Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress","volume":"46","author":"Liu","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.micpath.2025.107364_bib9","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1158\/0008-5472.CAN-22-2233","article-title":"NAT10 Drives Cisplatin chemoresistance by enhancing ac4C-associated DNA Repair in bladder cancer","volume":"83","author":"Xie","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.micpath.2025.107364_bib10","article-title":"N-acetyltransferase 10 enhances Doxorubicin resistance in human hepatocellular carcinoma cell lines by promoting the epithelial-to-mesenchymal transition","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.micpath.2025.107364_bib11","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.apsb.2022.01.015","article-title":"NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma","volume":"12","author":"Wei","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13075-023-03250-0","article-title":"Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance","volume":"26","author":"Luo","year":"2024","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.micpath.2025.107364_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.chom.2020.05.011","article-title":"Acetylation of cytidine Residues Boosts HIV-1 gene expression by increasing viral RNA stability","volume":"28","author":"Tsai","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"12","key":"10.1016\/j.micpath.2025.107364_bib14","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41577-023-00894-6","article-title":"The multifunctional protein HMGB1: 50 years of discovery","volume":"23","author":"Tang","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.micpath.2025.107364_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.micpath.2025.107364_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","article-title":"Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury","volume":"43","author":"Deng","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"10","key":"10.1016\/j.micpath.2025.107364_bib17","article-title":"Targeting inflammation driven by HMGB1 in bacterial keratitis-A review","volume":"10","author":"Hazlett","year":"2021","journal-title":"Pathogens (Basel, Switzerland)"},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13577-017-0182-x","article-title":"HMGB proteins and arthritis","volume":"31","author":"Taniguchi","year":"2018","journal-title":"Hum. Cell"},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2119\/molmed.2012.00024","article-title":"Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis","volume":"18","author":"Entezari","year":"2012","journal-title":"Mol. Med. (Cambridge, Mass)"},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s12931-022-02253-w","article-title":"Activation of cannabinoid-2 receptor protects against Pseudomonas aeruginosa induced acute lung injury and inflammation","volume":"23","author":"Nagre","year":"2022","journal-title":"Respir. Res."},{"issue":"18","key":"10.1016\/j.micpath.2025.107364_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.156613","article-title":"CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury","volume":"7","author":"Sung","year":"2022","journal-title":"JCI insight"},{"issue":"2","key":"10.1016\/j.micpath.2025.107364_bib22","doi-asserted-by":"crossref","first-page":"L314","DOI":"10.1152\/ajplung.00309.2019","article-title":"Serum amyloid A3 confers protection against acute lung injury in Pseudomonas aeruginosa-infected mice","volume":"318","author":"Fan","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"11","key":"10.1016\/j.micpath.2025.107364_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006737","article-title":"Interleukin-36\u03b3 and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: role of prostaglandin E2","volume":"13","author":"Aoyagi","year":"2017","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/mi.2017.71","article-title":"Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense","volume":"11","author":"Leiva-Ju\u00e1rez","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.micpath.2025.107364_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mito.2019.06.002","article-title":"Mitochondrial dynamics and their potential as a therapeutic target","volume":"49","author":"Whitley","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.micpath.2025.107364_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev-physiol-022516-034322","article-title":"Mitochondrial dysfunction in lung pathogenesis","volume":"79","author":"Piantadosi","year":"2017","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47457-1","article-title":"Pseudomonas aeruginosa induced host epithelial cell mitochondrial dysfunction","volume":"9","author":"Maurice","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micpath.2025.107364_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s10020-024-00912-w","article-title":"NAT10-mediated ac(4)C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis","volume":"30","author":"Xing","year":"2024","journal-title":"Mol. Med. (Cambridge, Mass)"},{"issue":"4","key":"10.1016\/j.micpath.2025.107364_bib29","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s10565-022-09743-z","article-title":"Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions","volume":"39","author":"Zheng","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107364_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00202-21","article-title":"Potent killing of Pseudomonas aeruginosa by an antibody-antibiotic conjugate","volume":"12","author":"Kajihara","year":"2021","journal-title":"mBio"},{"issue":"9","key":"10.1016\/j.micpath.2025.107364_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011612","article-title":"Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections","volume":"19","author":"Johnson","year":"2023","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.micpath.2025.107364_bib32","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.cell.2018.10.030","article-title":"Acetylation of cytidine in mRNA promotes translation efficiency","volume":"175","author":"Arango","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.micpath.2025.107364_bib33","article-title":"Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease","volume":"13","author":"Mao","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107364_bib34","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1681\/ASN.0000000000000024","article-title":"Tubular epithelial cell HMGB1 promotes AKI-CKD transition by sensitizing cycling tubular cells to oxidative stress: a Rationale for targeting HMGB1 during AKI Recovery","volume":"34","author":"Zhao","year":"2023","journal-title":"J. Am. Soc. Nephrol. : JASN"},{"issue":"4","key":"10.1016\/j.micpath.2025.107364_bib35","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4049\/jimmunol.1401684","article-title":"High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis","volume":"194","author":"McClellan","year":"1950","journal-title":"J. Immunol. (Baltimore, Md :"},{"issue":"3","key":"10.1016\/j.micpath.2025.107364_bib36","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/1547691X.2013.839587","article-title":"Partially-desulfated heparin improves survival in Pseudomonas pneumonia by enhancing bacterial clearance and ameliorating lung injury","volume":"11","author":"Sharma","year":"2014","journal-title":"J. Immunot."},{"issue":"3","key":"10.1016\/j.micpath.2025.107364_bib37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1165\/rcmb.2012-0279OC","article-title":"High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice","volume":"48","author":"Patel","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"Pt B","key":"10.1016\/j.micpath.2025.107364_bib38","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.freeradbiomed.2015.05.004","article-title":"Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism","volume":"88","author":"Dong","year":"2015","journal-title":"Free Radic. Biol. Med."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025000890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025000890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T22:49:21Z","timestamp":1740696561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025000890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":38,"alternative-id":["S0882401025000890"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107364","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAT10 induces mitochondrial dysfunction in lung epithelial cells by acetylating HMGB1 to exacerbate Pseudomonas aeruginosa-induced acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107364"}}