{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:43:13Z","timestamp":1788252193140,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.micpath.2025.107370","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T23:15:18Z","timestamp":1739056518000},"page":"107370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Berberine disrupts the high-affinity iron transport system to reverse the fluconazole-resistance in Candida albicans"],"prefix":"10.1016","volume":"200","author":[{"given":"Daifan","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4813-8389","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107370_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8060857","article-title":"Candida and candidiasis-opportunism versus pathogenicity: a review of the virulence traits","volume":"8","author":"Ciurea","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2025.107370_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2023.101215","article-title":"The changing epidemiology of fungal infections","volume":"94","author":"Lass-Fl\u00f6rl","year":"2023","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.micpath.2025.107370_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00203-023-03824-1","article-title":"Mechanisms of antifungal resistance and developments in alternative strategies to combat Candida albicans infection","volume":"206","author":"Sharma","year":"2024","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.micpath.2025.107370_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jgar.2023.10.019","article-title":"Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections","volume":"35","author":"Feng","year":"2023","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.micpath.2025.107370_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2023.102351","article-title":"Roles of Hsp90 in Candida albicans morphogenesis and virulence","volume":"75","author":"Robbins","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.micpath.2025.107370_bib6","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2019-0027","article-title":"Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis","volume":"6","author":"Ahmad Khan","year":"2020","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.micpath.2025.107370_bib7","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1142\/S0192415X23500945","article-title":"Coptis chinensis and berberine ameliorate chronic ulcerative colitis: an integrated microbiome-metabolomics study","volume":"51","author":"Zhou","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.micpath.2025.107370_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106817","article-title":"Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites","volume":"193","author":"Sun","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.micpath.2025.107370_bib9","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1097\/CM9.0000000000002696","article-title":"Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: a randomized controlled trial","volume":"136","author":"Chen","year":"2023","journal-title":"Chin Med J (Engl)."},{"key":"10.1016\/j.micpath.2025.107370_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/DDDT.S230857","article-title":"In vitro antifungal effects of berberine against Candida spp. in planktonic and biofilm conditions","volume":"14","author":"Xie","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.micpath.2025.107370_bib11","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1111\/1751-7915.14346","article-title":"Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi","volume":"16","author":"Pijuan","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.micpath.2025.107370_bib12","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.271.5255.1552","article-title":"A permease-oxidase complex involved in high-affinity iron uptake in yeast","volume":"271","author":"Stearman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.micpath.2025.107370_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fcimb.2018.00185","article-title":"Iron at the centre of Candida albicans interactions","volume":"8","author":"Fourie","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2025.107370_bib14","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1111\/febs.16977","article-title":"The intricate link between iron, mitochondria and azoles in Candida species","volume":"291","author":"Van Genechten","year":"2023","journal-title":"FEBS J."},{"key":"10.1016\/j.micpath.2025.107370_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13059-019-1716-1","article-title":"A practical guide to methods controlling false discoveries in computational biology","volume":"20","author":"Korthauer","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.micpath.2025.107370_bib16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.micpath.2025.107370_bib17","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.micpath.2025.107370_bib18","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3389\/fmicb.2017.01055","article-title":"The fungal pathogen Candida glabrata does not depend on surface ferric reductases for iron acquisition","volume":"8","author":"Gerwien","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.micpath.2025.107370_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01951-21","article-title":"Selective metal chelation by a thiosemicarbazone derivative interferes with mitochondrial respiration and ribosome biogenesis in Candida albicans","volume":"10","author":"Duan","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.micpath.2025.107370_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000957","article-title":"An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans","volume":"19","author":"Mamouei","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.micpath.2025.107370_bib21","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.scib.2020.12.035","article-title":"Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p","volume":"66","author":"Tong","year":"2021","journal-title":"Sci. Bull. (Beijing)."},{"key":"10.1016\/j.micpath.2025.107370_bib22","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.288.5468.1062","article-title":"A high-affinity iron permease essential for Candida albicans virulence","volume":"288","author":"Ramanan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.micpath.2025.107370_bib23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbamcr.2013.12.009","article-title":"Cellular iron homeostasis mediated by the Mrs4-Ccc1-Smf3 pathway is essential for mitochondrial function, morphogenesis and virulence in Candida albicans","volume":"1843","author":"Xu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.micpath.2025.107370_bib24","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ptr.8148","article-title":"Insights into the anti-Candida albicans properties of natural phytochemicals: an in vitro and in vivo investigation","volume":"38","author":"Yue","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.micpath.2025.107370_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12906-017-1773-5","article-title":"Membrane of Candida albicans as a target of berberine","volume":"17","author":"Zori\u0107","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.micpath.2025.107370_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126786","article-title":"Calcium-calcineurin signaling pathway in Candida albicans: a potential drug target","volume":"249","author":"Li","year":"2021","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2025.107370_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000532","article-title":"Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin","volume":"5","author":"Singh","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2025.107370_bib28","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1111\/1462-2920.16157","article-title":"Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency","volume":"24","author":"Jord\u00e1","year":"2022","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.micpath.2025.107370_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1101553","article-title":"Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.micpath.2025.107370_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018684","article-title":"Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans","volume":"6","author":"Hameed","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2025.107370_bib31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbrc.2021.05.039","article-title":"Candida albicans requires iron to sustain hyphal growth","volume":"561","author":"Luo","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micpath.2025.107370_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000217","article-title":"The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin","volume":"4","author":"Almeida","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2025.107370_bib33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.micpath.2016.07.004","article-title":"Mechanistic insights into the mode of action of anticandidal sesamol","volume":"98","author":"Ansari","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2025.107370_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jare.2021.06.016","article-title":"Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration","volume":"34","author":"Jin","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.micpath.2025.107370_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04095-23","article-title":"A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen Candida albicans","volume":"12","author":"Fallah","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.micpath.2025.107370_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010390","article-title":"Regulation of heme utilization and homeostasis in Candida albicans","volume":"18","author":"Andrawes","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.micpath.2025.107370_bib37","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1038\/s41467-019-13298-9","article-title":"Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion","volume":"10","author":"Pradhan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.micpath.2025.107370_bib38","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1080\/17435390.2017.1398357","article-title":"Graphene oxide significantly inhibits cell growth at sublethal concentrations by causing extracellular iron deficiency","volume":"11","author":"Yu","year":"2017","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.micpath.2025.107370_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/yea.3531","article-title":"Modulation of antioxidant defence system in response to berberine in Candida albicans","volume":"38","author":"Poopedi","year":"2021","journal-title":"Yeast"},{"key":"10.1016\/j.micpath.2025.107370_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006405","article-title":"Elevated catalase expression in a fungal pathogen is a double-edged sword of iron","volume":"13","author":"Pradhan","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.micpath.2025.107370_bib41","article-title":"Vacuole and mitochondria patch (vCLAMP) protein Vam6 is involved in maintenance of mitochondrial and vacuolar functions under oxidative stress in Candida albicans","volume":"10","author":"Mao","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.micpath.2025.107370_bib42","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/15548627.2016.1183080","article-title":"Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeast Candida glabrata","volume":"12","author":"Nagi","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.micpath.2025.107370_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2017.01.021","article-title":"Loss of Ssq1 leads to mitochondrial dysfunction, activation of autophagy and cell cycle arrest due to iron overload triggered by mitochondrial iron-sulfur cluster assembly defects in Candida albicans","volume":"85","author":"Dong","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.micpath.2025.107370_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/796306","article-title":"Effects of berberine on cell cycle, DNA, reactive oxygen species, and apoptosis in L929 murine fibroblast cells","volume":"2015","author":"Gu","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.micpath.2025.107370_bib45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.bbrc.2014.06.039","article-title":"Mitochondrial protein cyclophilin-D-mediated programmed necrosis attributes to berberine-induced cytotoxicity in cultured prostate cancer cells","volume":"450","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.micpath.2025.107370_bib46","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.canlet.2005.08.024","article-title":"Berberine-antiproliferative activity in vitro and induction of apoptosis\/necrosis of the U937 and B16 cells","volume":"239","author":"Letasiov\u00e1","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.micpath.2025.107370_bib47","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1039\/D0TB01260B","article-title":"Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines","volume":"8","author":"Qiao","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.micpath.2025.107370_bib48","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.2147\/IJN.S469350","article-title":"Transforming cancer treatment with nanotechnology: the role of berberine as a star natural compound","volume":"19","author":"Sun","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.micpath.2025.107370_bib49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/s12951-024-02804-x","article-title":"Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures","volume":"22","author":"Xu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.micpath.2025.107370_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104722","article-title":"Berberine pharmacology and the gut microbiota: a hidden therapeutic link","volume":"155","author":"Habtemariam","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025000956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025000956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:12:53Z","timestamp":1740492773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025000956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"alternative-id":["S0882401025000956"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107370","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine disrupts the high-affinity iron transport system to reverse the fluconazole-resistance in Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107370"}}