{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:20:41Z","timestamp":1790072441730,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2023\/01\/27516"],"award-info":[{"award-number":["PSAU\/2023\/01\/27516"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.micpath.2025.107378","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T12:14:05Z","timestamp":1740744845000},"page":"107378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The effect of quaternary ammonium compounds (QACs) on quorum sensing and resistance of P. aeruginosa in clinical settings"],"prefix":"10.1016","volume":"202","author":[{"given":"Khawla E.","family":"Alsamhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107378_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhin.2024.04.017","article-title":"Effect of prolonged exposure to disinfectants in the antimicrobial resistance profile of relevant microorganisms: a systematic review","author":"Fernandes","year":"2024","journal-title":"J. Hosp. Infect."},{"issue":"7","key":"10.1016\/j.micpath.2025.107378_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1021\/acsinfecdis.5b00047","article-title":"Quaternary ammonium compounds: an antimicrobial Mainstay and Platform for innovation to Address bacterial resistance","volume":"1","author":"Jennings","year":"2015","journal-title":"ACS Infect. Dis."},{"issue":"7","key":"10.1016\/j.micpath.2025.107378_bib3","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1128\/AAC.47.7.2093-2099.2003","article-title":"Correlation between Resistance of Pseudomonas aeruginosa to quaternary ammonium Compounds and Expression of outer membrane protein OprR","volume":"47","author":"Tabata","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.micpath.2025.107378_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1424038","article-title":"Two cinnamoyl hydroxamates as potential quorum sensing inhibitors against Pseudomonas aeruginosa","volume":"14","author":"Pan","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2025.107378_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.micpath.2017.08.017","article-title":"Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors","volume":"111","author":"Kalaiarasan","year":"2017","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.micpath.2025.107378_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nchembio.1225","article-title":"A cell-cell communication signal integrates quorum sensing and stress response","volume":"9","author":"Lee","year":"2013","journal-title":"Nat. Chem. Biol."},{"issue":"13","key":"10.1016\/j.micpath.2025.107378_bib7","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1128\/JB.187.13.4372-4380.2005","article-title":"Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa","volume":"187","author":"Wade","year":"2005","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.micpath.2025.107378_bib8","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3390\/microorganisms10061239","article-title":"Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria","volume":"10","author":"Sionov","year":"2022","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.micpath.2025.107378_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/pathogens11030300","article-title":"Pathogenesis of the Pseudomonas aeruginosa biofilm: a review","volume":"11","author":"Tuon","year":"2022","journal-title":"Pathogens"},{"issue":"22","key":"10.1016\/j.micpath.2025.107378_bib10","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.3390\/ijms21228671","article-title":"Pseudomonas aeruginosa biofilms","volume":"21","author":"Thi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2025.107378_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.addr.2014.11.017","article-title":"Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients","volume":"85","author":"Ciofu","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.micpath.2025.107378_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00248-013-0297-x","article-title":"Pseudomonas aeruginosa biofilms in disease","volume":"68","author":"Mulcahy","year":"2014","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.micpath.2025.107378_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s12016-008-8079-9","article-title":"P. aeruginosa biofilms in CF infection","volume":"35","author":"Wagner","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.micpath.2025.107378_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22111","article-title":"Bile effects on the Pseudomonas aeruginosa pathogenesis in cystic fibrosis patients with gastroesophageal reflux","author":"Bayat","year":"2023","journal-title":"Helyon"},{"issue":"4","key":"10.1016\/j.micpath.2025.107378_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00031-19","article-title":"Epidemiology and treatment of Multidrug-resistant and Extensively Drug-resistant Pseudomonas aeruginosa infections","volume":"32","author":"Horcajada","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.micpath.2025.107378_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2023.100129","article-title":"Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms","author":"Fern\u00e1ndez-Bill\u00f3n","year":"2023","journal-title":"Biofilm"},{"issue":"3","key":"10.1016\/j.micpath.2025.107378_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/pathogens6030036","article-title":"Hospital Drains as Reservoirs of Pseudomonas aeruginosa: Multiple-Locus Variable-number of Tandem Repeats analysis Genotypes recovered from Faucets, Sink surfaces and patients","volume":"6","author":"Lalancette","year":"2017","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.micpath.2025.107378_bib18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1128\/jcm.16.4.663-667.1982","article-title":"Broth microdilution testing of Pseudomonas aeruginosa and aminoglycosides: need for employing dilutions differing by small arithmetic increments","volume":"16","author":"Woolfrey","year":"1982","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2025.107378_bib19","series-title":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing","year":"2023"},{"key":"10.1016\/j.micpath.2025.107378_bib20","author":"Humphries"},{"issue":"1","key":"10.1016\/j.micpath.2025.107378_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/srep29768","article-title":"Bile signalling promotes chronic respiratory infections and antibiotic tolerance","volume":"6","author":"Reen","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.micpath.2025.107378_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/j.2050-0416.2011.tb00458.x","article-title":"Acyl homoserine lactone production of brewery process surface bacteria","volume":"117","author":"Priha","year":"2011","journal-title":"J. Inst. Brew."},{"key":"10.1016\/j.micpath.2025.107378_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125489","article-title":"N-acyl-homoserine-lactones as a critical factor for biofilm formation during the initial adhesion stage in drinking water distribution systems","volume":"366","author":"Chen","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.micpath.2025.107378_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127861","article-title":"A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa","volume":"254","author":"Vadakkan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.micpath.2025.107378_bib25","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.jiph.2020.10.002","article-title":"Effects of disinfectants and ciprofloxacin on quorum sensing genes and biofilm of clinical Pseudomonas aeruginosa isolates","volume":"13","author":"Uzunbayir-Akel","year":"2020","journal-title":"J Infect Public Health."},{"issue":"2","key":"10.1016\/j.micpath.2025.107378_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tim.2023.11.005","article-title":"Pseudomonas aeruginosa","volume":"32","author":"Krell","year":"2024","journal-title":"Trends Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2025.107378_bib27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biotechadv.2012.10.004","article-title":"Quorum sensing inhibitors: an overview","volume":"31","author":"Kalia","year":"2013","journal-title":"Biotechnol. Adv."},{"issue":"8","key":"10.1016\/j.micpath.2025.107378_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/md20080488","article-title":"The molecular architecture of Pseudomonas aeruginosa quorum-sensing inhibitors","volume":"20","author":"Li","year":"2022","journal-title":"Mar. Drugs"},{"issue":"2","key":"10.1016\/j.micpath.2025.107378_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00111-15","article-title":"Effect of human burn wound exudate on Pseudomonas aeruginosa virulence","volume":"1","author":"Gonzalez","year":"2016","journal-title":"mSphere"},{"issue":"1","key":"10.1016\/j.micpath.2025.107378_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13568-022-01444-4","article-title":"The frequency of efflux pump genes expression in Acinetobacter baumannii isolates from pulmonary secretions","volume":"12","author":"Rafiei","year":"2022","journal-title":"AMB Express"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025001032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025001032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:16:15Z","timestamp":1741922175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025001032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S0882401025001032"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107378","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of quaternary ammonium compounds (QACs) on quorum sensing and resistance of P. aeruginosa in clinical settings","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107378"}}