{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:41:34Z","timestamp":1784842894382,"version":"3.55.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.micpath.2025.107380","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:09:36Z","timestamp":1739549376000},"page":"107380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dydrogesterone alleviates periodontitis in perimenopausal women undergoing periodontal therapy by decreasing inflammation and mediating oral microbiota"],"prefix":"10.1016","volume":"201","author":[{"given":"Ying","family":"Man","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.micpath.2025.107380_bib1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/jcpe.13769","article-title":"Prevalence of periodontitis in dentate people between 2011 and 2020: a systematic review and meta-analysis of epidemiological studies","volume":"50","author":"Trindade","year":"2023","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12047","article-title":"Modifiable risk factors in periodontitis: at the intersection of aging and disease","volume":"64","author":"Reynolds","year":"2014","journal-title":"Periodontol. 2000"},{"issue":"Suppl 2","key":"10.1016\/j.micpath.2025.107380_bib3","doi-asserted-by":"crossref","first-page":"S997","DOI":"10.4103\/jpbs.jpbs_145_21","article-title":"Assessment of periodontal Status in pre- and postmenopausal women with chronic periodontitis: a cross-sectional study","volume":"13","author":"Agrawal","year":"2021","journal-title":"J. Pharm. BioAllied Sci."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12447","article-title":"Risk factors for periodontitis & peri-implantitis","volume":"90","author":"Darby","year":"2022","journal-title":"Periodontol. 2000"},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/10408363.2021.1907298","article-title":"The potential impact of salivary peptides in periodontitis","volume":"58","author":"Hirtz","year":"2021","journal-title":"Crit. Rev. Clin. Lab Sci."},{"issue":"6","key":"10.1016\/j.micpath.2025.107380_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells8060537","article-title":"Periodontal bone-ligament-cementum regeneration via scaffolds and stem cells","volume":"8","author":"Liu","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib7","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1515\/biol-2022-0474","article-title":"Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments","volume":"17","author":"Jin","year":"2022","journal-title":"Open Life Sci."},{"issue":"6","key":"10.1016\/j.micpath.2025.107380_bib8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"issue":"9","key":"10.1016\/j.micpath.2025.107380_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095142","article-title":"Impact of oral microbiome in periodontal health and periodontitis: a critical review on prevention and treatment","volume":"23","author":"Di Stefano","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12250","article-title":"Cellular therapy in periodontal regeneration","volume":"79","author":"Nunez","year":"2019","journal-title":"Periodontol. 2000"},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040647","article-title":"Progesterone actions and resistance in gynecological disorders","volume":"11","author":"MacLean","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/13697137.2018.1446932","article-title":"Progesterone, progestins and the endometrium in perimenopause and in menopausal hormone therapy","volume":"21","author":"Gompel","year":"2018","journal-title":"Climacteric"},{"key":"10.1016\/j.micpath.2025.107380_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2147\/IJWH.S7155","article-title":"Optimal management of perimenopausal depression","volume":"2","author":"Parry","year":"2010","journal-title":"Int J Womens Health"},{"issue":"2","key":"10.1016\/j.micpath.2025.107380_bib15","first-page":"101","article-title":"Management of endometrial modifications in perimenopausal women","volume":"88","author":"Nicula","year":"2015","journal-title":"Clujul Med."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib16","first-page":"74","article-title":"Histopathological pattern of abnormal uterine bleeding in endometrial biopsies","volume":"15","author":"Vaidya","year":"2013","journal-title":"Nepal Med Coll J"},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1210\/edrv.19.4.0341","article-title":"Perimenopause: the complex endocrinology of the menopausal transition","volume":"19","author":"Prior","year":"1998","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/13697137.2018.1463982","article-title":"Non-clinical studies of progesterone","volume":"21","author":"Sitruk-Ware","year":"2018","journal-title":"Climacteric"},{"issue":"2","key":"10.1016\/j.micpath.2025.107380_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1001\/jamapsychiatry.2017.3998","article-title":"Efficacy of transdermal estradiol and micronized progesterone in the prevention of depressive symptoms in the menopause transition: a randomized clinical trial","volume":"75","author":"Gordon","year":"2018","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib20","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1038\/s41598-023-35826-w","article-title":"Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial","volume":"13","author":"Prior","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/03630242.2020.1824956","article-title":"Micronized progesterone, progestins, and menopause hormone therapy","volume":"61","author":"Hipolito Rodrigues","year":"2021","journal-title":"Women Health"},{"key":"10.1016\/j.micpath.2025.107380_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bpobgyn.2020.05.004","article-title":"Progesterone and abnormal uterine bleeding\/menstrual disorders","volume":"69","author":"Jewson","year":"2020","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/13697137.2018.1467400","article-title":"Progesterone for the prevention and treatment of osteoporosis in women","volume":"21","author":"Prior","year":"2018","journal-title":"Climacteric"},{"issue":"Suppl 1","key":"10.1016\/j.micpath.2025.107380_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/13697137.2012.669530","article-title":"Progesterone and bone: a closer link than previously realized","volume":"15","author":"Seifert-Klauss","year":"2012","journal-title":"Climacteric"},{"key":"10.1016\/j.micpath.2025.107380_bib25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molimm.2017.02.006","article-title":"Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone","volume":"85","author":"Fei","year":"2017","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107380_bib26","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s10753-020-01390-y","article-title":"Progesterone attenuates brain inflammatory response and inflammation-induced increase in immature myeloid cells in a mouse model","volume":"44","author":"Gutzeit","year":"2021","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.micpath.2025.107380_bib27","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/infdis\/jiaa722","article-title":"Administration of exogenous progesterone protects against Brucella abortus infection-induced inflammation in pregnant mice","volume":"224","author":"Ren","year":"2021","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15285-w","article-title":"Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-kappaB pathway in ovariectomized rats","volume":"7","author":"Xue","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.micpath.2025.107380_bib29","first-page":"1048","article-title":"Progesterone modulates cadmium-induced oxidative stress and inflammation in hepatic tissues of Wistar rats","volume":"14","author":"Alese","year":"2021","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"9","key":"10.1016\/j.micpath.2025.107380_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091299","article-title":"Progesterone as an anti-inflammatory drug and immunomodulator: new aspects in hormonal regulation of the inflammation","volume":"12","author":"Fedotcheva","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jds.2024.05.020","article-title":"Progesterone affects periodontitis in perimenopausal women and in an experimental rat model","volume":"20","author":"Man","year":"2024","journal-title":"J. Dental Sci."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0757.2011.00398.x","article-title":"Sex and the subgingival microbiome: do female sex steroids affect periodontal bacteria?","volume":"61","author":"Kumar","year":"2013","journal-title":"Periodontol. 2000"},{"issue":"10","key":"10.1016\/j.micpath.2025.107380_bib33","article-title":"Relationship between gingival inflammation and pregnancy","author":"Wu","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"Suppl 1","key":"10.1016\/j.micpath.2025.107380_bib34","first-page":"S159","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107380_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jcpe.13400","article-title":"Clinical, inflammatory and microbiological outcomes of full-mouth scaling with adjunctive glycine powder air-polishing: a randomized trial","volume":"48","author":"Zhang","year":"2021","journal-title":"J. Clin. Periodontol."},{"issue":"1224763","key":"10.1016\/j.micpath.2025.107380_bib36","article-title":"The \"double-edged\" role of progesterone in periodontitis among perimenopausal women undergoing or not undergoing scaling and root planing","volume":"14","author":"Yan","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/JPER.18-0412","article-title":"Gingival crevicular fluid and salivary HIF-1\u03b1, VEGF, and TNF-\u03b1 levels in periodontal health and disease","volume":"90","author":"Afacan","year":"2019","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12967-021-03152-2","article-title":"Effect of fecal microbiota transplantation in patients with slow transit constipation and the relative mechanisms based on the protein digestion and absorption pathway","volume":"19","author":"Xie","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.micpath.2025.107380_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-4939-8728-3_8","article-title":"16S rRNA gene analysis with QIIME2","volume":"1849","author":"Hall","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.micpath.2025.107380_bib40","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"issue":"21","key":"10.1016\/j.micpath.2025.107380_bib41","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.micpath.2025.107380_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/biom12081029","article-title":"Progesterone suppresses uterine contraction by reducing odontogenic Porphyromonas gingivalis induced chronic inflammation in mice","volume":"12","author":"Teraoka","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","article-title":"Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases","volume":"130","author":"Cardoso","year":"2018","journal-title":"Postgrad. Med. J."},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib44","first-page":"ZE21","article-title":"C-reactive protein (CRP) and its association with periodontal disease: a brief review","volume":"8","author":"Bansal","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.micpath.2025.107380_bib45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molimm.2017.02.006","article-title":"Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone","volume":"85","author":"Fei","year":"2017","journal-title":"Mol. Immunol."},{"issue":"8","key":"10.1016\/j.micpath.2025.107380_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biom12081029","article-title":"Progesterone suppresses uterine contraction by reducing odontogenic Porphyromonas gingivalis induced chronic inflammation in mice","volume":"12","author":"Teraoka","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.micpath.2025.107380_bib47","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ajpa.20785","article-title":"C-reactive protein across the menstrual cycle","volume":"136","author":"Wander","year":"2008","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.micpath.2025.107380_bib48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-319-31248-4_4","article-title":"The oral microbiota","volume":"902","author":"Arweiler","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.micpath.2025.107380_bib49","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/jre.13173","article-title":"New putative periodontopathogens and periodontal health-associated species: a systematic review and meta-analysis","volume":"58","author":"Antezack","year":"2023","journal-title":"J. Periodontal. Res."},{"issue":"1121399","key":"10.1016\/j.micpath.2025.107380_bib50","article-title":"Oral microbial dysbiosis in patients with periodontitis and chronic obstructive pulmonary disease","volume":"13","author":"Liu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib51","first-page":"17","article-title":"Variations in oral microbiota associated with oral cancer","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib52","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/jcpe.13793","article-title":"Subgingival microbiome in periodontal health, gingivitis and different stages of periodontitis","volume":"50","author":"Iniesta","year":"2023","journal-title":"J. Clin. Periodontol."},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib53","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/jcpe.13815","article-title":"Parents with periodontitis drive the early acquisition of dysbiotic microbiomes in their offspring","volume":"50","author":"Reis","year":"2023","journal-title":"J. Clin. Periodontol."},{"issue":"2","key":"10.1016\/j.micpath.2025.107380_bib54","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.joen.2022.11.015","article-title":"Endodontic microbial communities in apical periodontitis","volume":"49","author":"Buonavoglia","year":"2023","journal-title":"J. Endod."},{"key":"10.1016\/j.micpath.2025.107380_bib55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jdsr.2020.12.001","article-title":"Etiology of aggressive periodontitis in individuals of African descent","volume":"57","author":"Yoshida","year":"2021","journal-title":"Jpn Dent Sci Rev"},{"issue":"663756","key":"10.1016\/j.micpath.2025.107380_bib56","article-title":"Structure and function of oral microbial community in periodontitis based on integrated data","volume":"11","author":"Cai","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"10","key":"10.1016\/j.micpath.2025.107380_bib57","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1902\/jop.2012.110566","article-title":"Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray","volume":"83","author":"Colombo","year":"2012","journal-title":"J. Periodontol."},{"issue":"5","key":"10.1016\/j.micpath.2025.107380_bib58","first-page":"1539","article-title":"Porphyromonas gingivalis in the development of periodontitis: impact on dysbiosis and inflammation","volume":"77","author":"Gasmi Benahmed","year":"2022","journal-title":"Arch Razi Inst"},{"key":"10.1016\/j.micpath.2025.107380_bib59","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010231","article-title":"Curcumin supplementation (Meriva(\u00ae)) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease","volume":"14","author":"Pivari","year":"2022","journal-title":"Nutrients"},{"issue":"105694","key":"10.1016\/j.micpath.2025.107380_bib61","first-page":"2","article-title":"Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner","volume":"170","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.micpath.2025.107380_bib62","article-title":"Alteration of the oral and gut microbiota in patients with Kawasaki disease","volume":"10","author":"Zeng","year":"2023","journal-title":"PeerJ"},{"issue":"652837","key":"10.1016\/j.micpath.2025.107380_bib63","article-title":"Potential roles of oral microbiota in the pathogenesis of immunoglobin A nephropathy","volume":"11","author":"He","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107380_bib64","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1142\/S0192415X2250032X","article-title":"A clinical study on the relationship among insomnia, tongue diagnosis, and oral microbiome","volume":"50","author":"Park","year":"2022","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib65","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41598-020-61912-4","article-title":"Effects of Chlorhexidine mouthwash on the oral microbiome","volume":"10","author":"Bescos","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib66","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2023.2185962","article-title":"A mouthwash formulated with o-cymen-5-ol and zinc chloride specifically targets potential pathogens without impairing the native oral microbiome in healthy individuals","volume":"15","author":"Pascual","year":"2023","journal-title":"J. Oral Microbiol."},{"issue":"691216","key":"10.1016\/j.micpath.2025.107380_bib67","article-title":"Subgingival microbiome and specialized pro-resolving lipid mediator pathway profiles are correlated in periodontal inflammation","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.micpath.2025.107380_bib68","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/jre.12922","article-title":"Cross-sectional comparisons of subgingival microbiome and gingival fluid inflammatory cytokines in periodontally healthy vegetarians versus non-vegetarians","volume":"56","author":"Khocht","year":"2021","journal-title":"J. Periodontal. Res."},{"issue":"110276","key":"10.1016\/j.micpath.2025.107380_bib69","first-page":"7","article-title":"Probiotic characteristics of Lactobacillus gasseri TF08-1: a cholesterol-lowering bacterium, isolated from human gut","volume":"169","author":"Wang","year":"2023","journal-title":"Enzyme Microb Technol"},{"issue":"3","key":"10.1016\/j.micpath.2025.107380_bib70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/microbiolspec.BAD-0010-2016","article-title":"Bifidobacteria and their health-promoting effects","volume":"5","author":"Hidalgo-Cantabrana","year":"2017","journal-title":"Microbiol. Spectr."},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib71","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12275-022-1514-4","article-title":"The rationale and potential for using Lactobacillus in the management of periodontitis","volume":"60","author":"Wang","year":"2022","journal-title":"J. Microbiol."},{"issue":"806463","key":"10.1016\/j.micpath.2025.107380_bib72","article-title":"Probiotic species in the management of periodontal diseases: an overview","volume":"12","author":"Zhang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7","key":"10.1016\/j.micpath.2025.107380_bib73","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/14787210.2016.1194198","article-title":"The role of probiotic bacteria in managing periodontal disease: a systematic review","volume":"14","author":"Matsubara","year":"2016","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib74","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/prd.12382","article-title":"Probiotics for periodontal health-Current molecular findings","volume":"87","author":"Nguyen","year":"2000","journal-title":"Periodontol"},{"issue":"10","key":"10.1016\/j.micpath.2025.107380_bib75","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/jcpe.12995","article-title":"Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial","volume":"45","author":"Invernici","year":"2018","journal-title":"J. Clin. Periodontol."},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib76","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s11325-022-02732-w","article-title":"Whole-genome metagenomic analysis of the oral microbiota in patients with obstructive sleep apnea","volume":"27","author":"Gao","year":"2023","journal-title":"Sleep Breath."},{"issue":"1","key":"10.1016\/j.micpath.2025.107380_bib77","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1324725","article-title":"16S rDNA analysis of periodontal plaque in chronic obstructive pulmonary disease and periodontitis patients","volume":"9","author":"Wu","year":"2017","journal-title":"J. Oral Microbiol."},{"issue":"6","key":"10.1016\/j.micpath.2025.107380_bib78","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1111\/odi.14829","article-title":"Ozonized gels vs chlorhexidine in non-surgical periodontal treatment: a randomized clinical trial","volume":"30","author":"Scribante","year":"2024","journal-title":"Oral Dis."},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib79","first-page":"54","article-title":"Effects of photobiomodulation with different application parameters on injection pain in children: a randomized clinical trial","volume":"47","author":"Elbay","year":"2023","journal-title":"J. Clin. Pediatr. Dent"},{"issue":"4","key":"10.1016\/j.micpath.2025.107380_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/dj12040116","article-title":"Clinical use of paraprobiotics for pregnant women with periodontitis: randomized clinical trial","volume":"12","author":"Butera","year":"2024","journal-title":"Dent. J."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025001056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025001056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:58:45Z","timestamp":1762311525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025001056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":80,"alternative-id":["S0882401025001056"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107380","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dydrogesterone alleviates periodontitis in perimenopausal women undergoing periodontal therapy by decreasing inflammation and mediating oral microbiota","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107380"}}