{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:07:21Z","timestamp":1762312041615,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["302142\/2022-3","308991\/2023-0"],"award-info":[{"award-number":["302142\/2022-3","308991\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.micpath.2025.107541","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:09:17Z","timestamp":1744171757000},"page":"107541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Variation in SeM genotype is associated with virulence of Streptococcus equi subspecies equi in mice"],"prefix":"10.1016","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-2089","authenticated-orcid":false,"given":"Marlane Geribone","family":"Seeger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Cristiano","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2428-8397","authenticated-orcid":false,"given":"Roberto Ant\u00f4nio Delgado","family":"Barcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia","family":"Werle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Kenji","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Ilha","family":"Bordin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Silveira Flores","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-3643","authenticated-orcid":false,"given":"Juliana Felipetto","family":"Cargnelutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.micpath.2025.107541_bib1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2460\/javma.1991.198.010.1745","article-title":"Medical problems of adult horses, as ranked by equine practitioners","volume":"198","author":"Traub-Dargatz","year":"1991","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.micpath.2025.107541_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2046-0481-63-1-37","article-title":"Causes of disease and death from birth to 12 months of age in the Thoroughbred horse in Ireland","volume":"63","author":"Galvin","year":"2009","journal-title":"Ir. Vet. J."},{"key":"10.1016\/j.micpath.2025.107541_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tvjl.2019.02.003","article-title":"Long-term silent carriers of Streptococcus equi ssp. equi following strangles; carrier detection related to sampling site of collection and culture versus qPCR","volume":"246","author":"Pringle","year":"2019","journal-title":"Vet. J."},{"key":"10.1016\/j.micpath.2025.107541_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0368-1742(10)80038-4","article-title":"Strangles","volume":"23","author":"Todd","year":"1910","journal-title":"J. Comp. Pathol. Ther."},{"key":"10.1016\/j.micpath.2025.107541_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108638","article-title":"Comparison of whole genome sequences of Streptococcus equi subsp. equi from an outbreak in Texas with isolates from within the region, Kentucky, USA, and other countries","volume":"243","author":"Morris","year":"2020","journal-title":"Vet. Microbiol."},{"issue":"7","key":"10.1016\/j.micpath.2025.107541_bib6","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.14202\/vetworld.2021.1808-1814","article-title":"Vancomycin resistant Streptococcus equi subsp. equi isolated from equines suffering from respiratory manifestation in Egypt","volume":"14","author":"Arafa","year":"2021","journal-title":"Vet. World"},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jvim.15043","article-title":"Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles-revised consensus statement","volume":"32","author":"Boyle","year":"2018","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.micpath.2025.107541_bib8","article-title":"Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses","volume":"7","author":"Mitchell","year":"2021","journal-title":"Microb. Genom."},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib9","first-page":"78","article-title":"Voluntary biosurveillance of Streptococcus equi subsp. equi in nasal secretions of 9409 equids with upper airway infection in the USA","volume":"10","author":"Jaramillo-Morales","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.micpath.2025.107541_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cveq.2022.11.006","article-title":"Streptococcus equi subspecies equi","volume":"39","author":"Boyle","year":"2023","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0749-0739(17)30403-0","article-title":"Strangles","volume":"9","author":"Timoney","year":"1993","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"issue":"3","key":"10.1016\/j.micpath.2025.107541_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/eve.12451","article-title":"Lessons learned from a strangles outbreak on a large Standardbred farm","volume":"29","author":"Christmann","year":"2017","journal-title":"Equine Vet. Educ."},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/JCM.44.2.480-486.2006","article-title":"Sequence variation of the SeM gene of Streptococcus equi allows discrimination of the source of strangles outbreaks","volume":"44","author":"Kelly","year":"2006","journal-title":"J. Clin. Microbiol."},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/jvim.16368","article-title":"Repeated nasopharyngeal lavage predicts freedom from silent carriage of Streptococcus equi after a strangles outbreak","volume":"36","author":"Pringle","year":"2022","journal-title":"J. Vet. Intern. Med."},{"issue":"6","key":"10.1016\/j.micpath.2025.107541_bib15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2746\/042516400777584721","article-title":"Control of strangles outbreaks by isolation of guttural pouch carriers identified using PCR and culture of Streptococcus equi","volume":"32","author":"Newton","year":"2000","journal-title":"Equine Vet. J."},{"issue":"9","key":"10.1016\/j.micpath.2025.107541_bib16","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1128\/iai.65.9.3600-3605.1997","article-title":"Comparison of the sequences and functions of Streptococcus equi M-like proteins SeM and SzPSe","volume":"65","author":"Timoney","year":"1997","journal-title":"Infect. Immun."},{"issue":"6","key":"10.1016\/j.micpath.2025.107541_bib17","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1128\/IAI.72.6.3228-3236.2004","article-title":"Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses","volume":"72","author":"Flock","year":"2004","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.micpath.2025.107541_bib18","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.2460\/ajvr.2005.66.2167","article-title":"Variation in the N-terminal region of an M-like protein of Streptococcus equi and evaluation of its potential as a tool in epidemiologic studies","volume":"66","author":"Anzai","year":"2005","journal-title":"Am. J. Vet. Res."},{"issue":"6","key":"10.1016\/j.micpath.2025.107541_bib19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1099\/00221287-146-6-1361","article-title":"Streptococcus equi with truncated M-proteins isolated from outwardly healthy horses","volume":"146","author":"Chanter","year":"2000","journal-title":"Microbiology"},{"issue":"6","key":"10.1016\/j.micpath.2025.107541_bib20","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.vaccine.2009.11.064","article-title":"Affects of N-terminal variation in the SeM protein of Streptococcus equi on antibody and fibrinogen binding","volume":"28","author":"Timoney","year":"2010","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.micpath.2025.107541_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0165-2427(97)00074-3","article-title":"Serum and mucosal antibody isotype responses to M-like protein (SeM) of Streptococcus equi in convalescent and vaccinated horses","volume":"59","author":"Sheoran","year":"1997","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"2\u20134","key":"10.1016\/j.micpath.2025.107541_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.vetmic.2012.09.010","article-title":"Diversity of seM in Streptococcus equi subsp. equi isolated from strangles outbreaks","volume":"162","author":"Libardoni","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.micpath.2025.107541_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.12688\/wellcomeopenres.14826.1","article-title":"Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications","volume":"3","author":"Jolley","year":"2018","journal-title":"Wellcome Open Res"},{"issue":"2\u20133","key":"10.1016\/j.micpath.2025.107541_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0378-1135(94)00090-J","article-title":"Equine strangles modelled in mice","volume":"43","author":"Chanter","year":"1995","journal-title":"Vet. Microbiol."},{"issue":"22","key":"10.1016\/j.micpath.2025.107541_bib25","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1016\/j.vaccine.2006.02.016","article-title":"Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse","volume":"24","author":"Flock","year":"2006","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.micpath.2025.107541_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0166-0934(95)00024-O","article-title":"A mouse model for testing the pathogenicity of equine herpes virus-1 strains","volume":"54","author":"van Woensel","year":"1995","journal-title":"J. Virol. Methods"},{"issue":"1","key":"10.1016\/j.micpath.2025.107541_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cveq.2014.11.003","article-title":"Update on Streptococcus equi subsp. equi infections","volume":"31","author":"Mallicote","year":"2015","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"10.1016\/j.micpath.2025.107541_bib28","doi-asserted-by":"crossref","DOI":"10.1590\/1678-5150-pvb-6910","article-title":"Immunogenicity of Streptococcus equi subsp. equi recombinant SeM protein and bacterin in mice","volume":"41","author":"Rosa","year":"2021","journal-title":"Pesqui. Vet. Bras."},{"issue":"4","key":"10.1016\/j.micpath.2025.107541_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1051\/vetres:2004025","article-title":"The pathogenic equine streptococci","volume":"35","author":"Timoney","year":"2004","journal-title":"Vet Res"},{"issue":"2","key":"10.1016\/j.micpath.2025.107541_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2746\/042516403776114153","article-title":"Brain abscesses as a metastatic manifestation of strangles: symptomatology and the use of magnetic resonance imaging as a diagnostic aid","volume":"35","author":"Spoormakers","year":"2003","journal-title":"Equine Vet. J."},{"issue":"1","key":"10.1016\/j.micpath.2025.107541_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1939-1676.2005.tb02671.x","article-title":"Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles","volume":"19","author":"Sweeney","year":"2005","journal-title":"J. Vet. Intern. Med."},{"issue":"5","key":"10.1016\/j.micpath.2025.107541_bib32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1892\/0891-6640(2001)015<0494:STOIAI>2.3.CO;2","article-title":"Successful treatment of intracranial abscesses in 2 horses","volume":"15","author":"Cornelisse","year":"2001","journal-title":"J. Vet. Intern. Med."},{"issue":"5","key":"10.1016\/j.micpath.2025.107541_bib33","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.2042-3306.1994.tb04414.x","article-title":"Pituitary abscess and basilar empyema in 4 horses","volume":"26","author":"Reilly","year":"1994","journal-title":"Equine Vet. J."},{"issue":"5","key":"10.1016\/j.micpath.2025.107541_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2460\/javma.229.5.721","article-title":"Streptococcus equi meningoencephalomyelitis in a foal","volume":"229","author":"Finno","year":"2006","journal-title":"J. Am. Vet. Med. Assoc."},{"issue":"Suppl 41","key":"10.1016\/j.micpath.2025.107541_bib35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.2042-3306.2011.00508.x","article-title":"Clinical findings in 10 foals with bacterial meningoencephalitis","volume":"44","author":"Viu","year":"2012","journal-title":"Equine Vet. J."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025002669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025002669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:02:11Z","timestamp":1762311731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025002669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":35,"alternative-id":["S0882401025002669"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107541","relation":{},"ISSN":["0882-4010"],"issn-type":[{"type":"print","value":"0882-4010"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation in SeM genotype is associated with virulence of Streptococcus equi subspecies equi in mice","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107541"}}