{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:13:14Z","timestamp":1783721594408,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20250584KJ"],"award-info":[{"award-number":["JJKH20250584KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.micpath.2025.107681","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:15:35Z","timestamp":1747077335000},"page":"107681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effect of vmeB gene deletion on biofilm formation and enrofloxacin resistance in Vibrio parahaemolyticus"],"prefix":"10.1016","volume":"205","author":[{"given":"Xinru","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5848-2273","authenticated-orcid":false,"given":"Xin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107681_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127744","article-title":"Virulence phenotypes differ between toxigenic Vibrio parahaemolyticus isolated from western coasts of Europe","volume":"285","author":"Sor\u00e9e","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.micpath.2025.107681_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121379","article-title":"Assessing biofilm formation and resistance of Vibrio parahaemolyticus on UV-aged microplastics in aquatic environments","volume":"254","author":"Lim","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.micpath.2025.107681_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2024.110732","article-title":"RT-RPA and RPA-LFA assay for rapid and ultrasensitive detection of Vibrio parahaemolyticus","volume":"166","author":"Hu","year":"2024","journal-title":"Food Control"},{"key":"10.1016\/j.micpath.2025.107681_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104283","article-title":"Antimicrobial mechanism of linalool against Vibrio parahaemolyticus and its application in black tiger shrimp (Penaeus monodon)","volume":"60","author":"Ren","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.micpath.2025.107681_bib5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jgar.2019.05.006","article-title":"Genome-facilitated discovery of RND efflux pump-mediated resistance to cephalosporins in Vibrio spp. isolated from the mummichog fish gut","volume":"19","author":"Lloyd","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.micpath.2025.107681_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2024.103116","article-title":"Required criteria of drug efflux pump inhibitors to disrupt the function of AcrB subunit protein from AcrAB-TolC multidrug efflux pump from Escherichia coli","author":"Alenazy","year":"2024","journal-title":"J. King Saud Univ. Sci."},{"issue":"3","key":"10.1016\/j.micpath.2025.107681_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00659-23","article-title":"Cryo-EM structures of the Klebsiella pneumoniae AcrB multidrug efflux pump","volume":"14","author":"Zhang","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2025.107681_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104697","article-title":"Inhibition effect of marine active peptides SF on dual-species biofilms of Vibrio parahaemolyticus and Aeromonas sobria","volume":"61","author":"Lv","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.micpath.2025.107681_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104037","article-title":"Insight into the antibacterial properties of terpinen-4-ol on planktonic growth and biofilm-formation of Vibrio parahaemolyticus","volume":"59","author":"Lv","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.micpath.2025.107681_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.110021","article-title":"Antimicrobial and biofilm inhibition effects of p-anisaldehyde against Vibrio parahaemolyticus","volume":"154","author":"Xin","year":"2023","journal-title":"Food Control"},{"key":"10.1016\/j.micpath.2025.107681_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2023.105540","article-title":"Whole-genome sequencing and transcriptome-characterized mechanism of streptomycin resistance in Vibrio parahaemolyticus O10: K4","volume":"117","author":"Zhang","year":"2024","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.micpath.2025.107681_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105573","article-title":"Characterization of ampicillin-resistant genes in Vibrio parahaemolyticus","volume":"168","author":"Tan","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.micpath.2025.107681_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.105260","article-title":"Global metabolic regulation in Vibrio parahaemolyticus under polymyxin B stimulation","volume":"161","author":"Tan","year":"2021","journal-title":"Microb. Pathog."},{"issue":"10","key":"10.1016\/j.micpath.2025.107681_bib14","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/jac\/dks228","article-title":"Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm","volume":"67","author":"Baugh","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"issue":"7","key":"10.1016\/j.micpath.2025.107681_bib15","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/jac\/dku078","article-title":"Impact of quinolone-resistance acquisition on biofilm production and fitness in Salmonella enterica","volume":"69","author":"Fabrega","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.micpath.2025.107681_bib16","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3389\/fmicb.2020.01695","article-title":"Flagellar motility is critical for Salmonella enterica serovar Typhimurium biofilm development","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"issue":"13","key":"10.1016\/j.micpath.2025.107681_bib17","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1128\/JB.00363-09","article-title":"The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host","volume":"191","author":"Webber","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2025.107681_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154738","article-title":"Mechanism of enrofloxacin-induced multidrug resistance in the pathogenic Vibrio harveyi from diseased abalones","volume":"830","author":"Wang","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.micpath.2025.107681_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/mdr.2016.0207","article-title":"Upregulation of AcrEF in quinolone resistance development in Escherichia coli when AcrAB-TolC function is impaired","volume":"24","author":"Zhang","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"10.1016\/j.micpath.2025.107681_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.112418","article-title":"Effects and molecular mechanism of flagellar gene flgK on the motility, adhesion\/invasion, and desiccation resistance of Cronobacter sakazakii","volume":"164","author":"Li","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.micpath.2025.107681_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2021.108033","article-title":"Identification of a phosphoethanolamine transferase for lipid A modification in Vibrio parahaemolyticus","volume":"125","author":"Tan","year":"2021","journal-title":"Food Control"},{"key":"10.1016\/j.micpath.2025.107681_bib22","article-title":"Transcriptomic analysis of sub-MIC Eugenol exposition on antibiotic resistance profile in Multidrug Resistant Enterococcus faecalis E9","volume":"8","author":"G\u00f3mez","year":"2025"},{"key":"10.1016\/j.micpath.2025.107681_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2023.127423","article-title":"BolA affects the biofilm formation ability, outer membrane permeability and virulence, thus is required for the adaptability of Salmonella enterica serotype Typhimurium to the harsh survival environment","volume":"274","author":"Chen","year":"2023","journal-title":"Microbiol. Res."},{"issue":"2","key":"10.1016\/j.micpath.2025.107681_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.107066","article-title":"Combining with domiphen bromide restores colistin efficacy against colistin-resistant Gram-negative bacteria in vitro and in vivo","volume":"63","author":"Chen","year":"2024","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2025.107681_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118334","article-title":"Therapeutic effect and immune mechanism of chitosan-gentamicin conjugate on Pacific white shrimp (Litopenaeus vannamei) infected with Vibrio parahaemolyticus","volume":"269","author":"Liang","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.micpath.2025.107681_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijantimicag.2018.05.002","article-title":"Transcriptional analysis reveals the critical role of RNA polymerase-binding transcription factor, DksA, in regulating multi-drug resistance of Escherichia coli","volume":"52","author":"Wang","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2025.107681_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107221","article-title":"Bacteriophage-resistant carbapenem-resistant Klebsiella pneumoniae shows reduced antibiotic resistance and virulence","author":"Chen","year":"2024","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.micpath.2025.107681_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115878","article-title":"Benzopyrone-mediated quinolones as potential multitargeting antibacterial agents","volume":"262","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.micpath.2025.107681_bib29","doi-asserted-by":"crossref","DOI":"10.46989\/001c.84647","article-title":"Transcriptome analysis reveals the important roles of a two-component system, flagellar assembly, active efflux system and outer membrane proteins in the anti-quinolone ability of Vibrio harveyi from orange-spotted grouper (Epinephelus coioides)","author":"Tang","year":"2023","journal-title":"Isr. J. Aquacult. Bamidgeh"},{"issue":"3","key":"10.1016\/j.micpath.2025.107681_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4161\/viru.23724","article-title":"Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm","volume":"4","author":"Soto","year":"2013","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.micpath.2025.107681_bib31","first-page":"51","article-title":"Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria","volume":"737","author":"Lugtenberg","year":"1983","journal-title":"Bba-Biomembranes"},{"issue":"4","key":"10.1016\/j.micpath.2025.107681_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00968-17","article-title":"Lack of AcrB efflux function confers loss of virulence on Salmonella enterica serovar Typhimurium","volume":"8","author":"Wang-Kan","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.micpath.2025.107681_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2024.110031","article-title":"Effect of chitooligosaccharides in inhibiting textural deterioration of chicken myofibril protein gel induced by high temperature","volume":"153","author":"Wang","year":"2024","journal-title":"Food Hydrocoll."},{"issue":"20","key":"10.1016\/j.micpath.2025.107681_bib34","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1128\/JB.00684-06","article-title":"Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway","volume":"188","author":"Su","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.micpath.2025.107681_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvrad.2024.107396","article-title":"Effect of RSN1 gene knockout on the adsorption of strontium ions by irradiated Saccharomyces cerevisiae","volume":"273","author":"Feng","year":"2024","journal-title":"J. Environ. Radioact."},{"issue":"12","key":"10.1016\/j.micpath.2025.107681_bib36","article-title":"Study on the inhibition of dexmedetomidine (DEX) on malignant development of breast cancer by synchrotron radiation infrared spectroscopy","volume":"51","author":"Chao","year":"2023","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.micpath.2025.107681_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2022.108166","article-title":"Probing the biotoxicity of starch nanoparticles in vivo and their mechanism to desensitize \u03b2-lactoglobulin","volume":"135","author":"Zhang","year":"2023","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.micpath.2025.107681_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2021.107269","article-title":"Influence of konjac glucomannan on the emulsion-filled\/non-filled chicken gel: study on intermolecular forces, microstructure and gelling properties","volume":"124","author":"Xu","year":"2022","journal-title":"Food Hydrocoll."},{"issue":"6","key":"10.1016\/j.micpath.2025.107681_bib39","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.bbadis.2017.02.025","article-title":"Conformational and thermal characterization of left ventricle remodeling post-myocardial infarction","volume":"1863","author":"Samouillan","year":"2017","journal-title":"Bba-Mol Basis Dis"},{"key":"10.1016\/j.micpath.2025.107681_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2022.102304","article-title":"Analyzing the roles of cyclic dimeric guanosine monophosphate (c-di-GMP) on the formation of autotrophic granules and autotrophic biofilm in integrated fixed-film activated sludge (IFAS) reactor","volume":"26","author":"Zhang","year":"2022","journal-title":"Environ. Technol. Innov."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:40:14Z","timestamp":1778694014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025004061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":40,"alternative-id":["S0882401025004061"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107681","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of vmeB gene deletion on biofilm formation and enrofloxacin resistance in Vibrio parahaemolyticus","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107681"}}