{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:52:20Z","timestamp":1780066340806,"version":"3.54.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800587"],"award-info":[{"award-number":["81800587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.micpath.2025.107683","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T21:17:02Z","timestamp":1746739022000},"page":"107683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Association between the gut microbiota and cystitis: A two-sample mendelian randomization study combined with the GEO database"],"prefix":"10.1016","volume":"205","author":[{"given":"Zeyu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12879-023-08207-x","article-title":"Unmet needs in uncomplicated urinary tract infection in the United States and Germany: a physician survey","volume":"23","author":"O'Brien","year":"2023","journal-title":"BMC Infect. Dis."},{"issue":"12","key":"10.1016\/j.micpath.2025.107683_bib2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrurol.2010.190","article-title":"The epidemiology of urinary tract infection","volume":"7","author":"Foxman","year":"2010","journal-title":"Nat. Rev. Urol."},{"issue":"5","key":"10.1016\/j.micpath.2025.107683_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41564-022-01107-x","article-title":"Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women","volume":"7","author":"Worby","year":"2022","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1993583","article-title":"Bacterial membrane vesicles and phages in blood after consumption of lacticaseibacillus rhamnosus JB-1","volume":"13","author":"Champagne-Jorgensen","year":"2021","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.micpath.2025.107683_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051234","article-title":"The role of gut microbiota biomodulators on mucosal immunity and intestinal inflammation","volume":"9","author":"Amoroso","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.micpath.2025.107683_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1416185","article-title":"Metagenomic analysis demonstrates distinct changes in the gut microbiome of Kawasaki diseases children","volume":"15","author":"Han","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41522-024-00538-0","article-title":"Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19","volume":"10","author":"Essex","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.micpath.2025.107683_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1324794","article-title":"Investigations of microbiota composition and neuroactive pathways in association with symptoms of stress and depression in a cohort of healthy women","volume":"14","author":"Bashir","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"14","key":"10.1016\/j.micpath.2025.107683_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143328","article-title":"The urogenital system's role in diseases: a synopsis","volume":"14","author":"Zerdan","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.micpath.2025.107683_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/srep26083","article-title":"Stool-based biomarkers of interstitial cystitis\/bladder pain syndrome","volume":"6","author":"Braundmeier-Fleming","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2025.107683_bib11","article-title":"Role of microbiota-derived short-chain fatty acids in cancer development and prevention","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.micpath.2025.107683_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2016.227","article-title":"Functional urological disorders: a sensitized defence response in the bladder-gut-brain axis","volume":"14","author":"Leue","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"8","key":"10.1016\/j.micpath.2025.107683_bib13","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.chom.2022.07.008","article-title":"Gut-bladder axis enters the stage: implication for recurrent urinary tract infections","volume":"30","author":"Salazar","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.micpath.2025.107683_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41564-022-01113-z","article-title":"Gut-bladder axis in recurrent UTI","volume":"7","author":"Schembri","year":"2022","journal-title":"Nat. Microbiol."},{"issue":"5","key":"10.1016\/j.micpath.2025.107683_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158497","article-title":"Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections","volume":"132","author":"Worby","year":"2022","journal-title":"J. Clin. Investig."},{"issue":"10","key":"10.1016\/j.micpath.2025.107683_bib16","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/cid\/cix618","article-title":"Fecal microbiota transplantation for recurrent Clostridium difficile infection reduces recurrent urinary tract infection frequency","volume":"65","author":"Tariq","year":"2017","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.micpath.2025.107683_bib18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat. Med."},{"issue":"2","key":"10.1016\/j.micpath.2025.107683_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41588-020-00763-1","article-title":"Large-scale association analyses identify host factors influencing human gut microbiome composition","volume":"53","author":"Kurilshikov","year":"2021","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.micpath.2025.107683_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.micpath.2025.107683_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.micpath.2025.107683_bib22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet. Epidemiol."},{"issue":"4","key":"10.1016\/j.micpath.2025.107683_bib23","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"Database issue","key":"10.1016\/j.micpath.2025.107683_bib24","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.micpath.2025.107683_bib25","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40168-022-01269-0","article-title":"Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum beta-lactamase-producing enteroaggregative Escherichia coli infection","volume":"10","author":"He","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.micpath.2025.107683_bib27","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3389\/fmicb.2016.01706","article-title":"Mucosal prevalence and interactions with the epithelium indicate commensalism of Sutterella spp","volume":"7","author":"Hiippala","year":"2016","journal-title":"Front. Microbiol."},{"issue":"24","key":"10.1016\/j.micpath.2025.107683_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/nu14245233","article-title":"Heat-killed bifidobacterium bifidum B1628 may alleviate dextran sulfate sodium-induced colitis in mice, and the anti-inflammatory effect is associated with gut microbiota modulation","volume":"14","author":"Feng","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.micpath.2025.107683_bib29","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ijbiomac.2019.05.171","article-title":"In vivo and in vitro anti-inflammatory effects of water-soluble polysaccharide from Arctium lappa","volume":"135","author":"Zhang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.107683_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijbiomac.2021.03.137","article-title":"Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism","volume":"181","author":"Guo","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.micpath.2025.107683_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113830","article-title":"Next-generation prebiotics: maillard-conjugates of 2'-fucosyllactose and lactoferrin hydrolysates beneficially modulate gut microbiome composition and health promoting activity in a murine model","volume":"177","author":"Peled","year":"2024","journal-title":"Food Res. Int."},{"issue":"5","key":"10.1016\/j.micpath.2025.107683_bib32","doi-asserted-by":"crossref","first-page":"G1104","DOI":"10.1152\/ajpgi.90374.2008","article-title":"Regulatory mechanisms underlying agmatine homeostasis in humans","volume":"295","author":"Haenisch","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib33","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2348441","article-title":"Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis","volume":"16","author":"Lu","year":"2024","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.micpath.2025.107683_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/nu10122009","article-title":"Gut microbiota and endothelial dysfunction markers in obese Mexican children and adolescents","volume":"10","author":"Nirmalkar","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.micpath.2025.107683_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.944027","article-title":"Gut dysbiosis and intestinal barrier dysfunction promotes IgA nephropathy by increasing the production of Gd-IgA1","volume":"9","author":"Tang","year":"2022","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13195-023-01218-5","article-title":"A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers","volume":"15","author":"Marizzoni","year":"2023","journal-title":"Alzheimers Res. Ther."},{"issue":"3","key":"10.1016\/j.micpath.2025.107683_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059276","article-title":"Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.micpath.2025.107683_bib38","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1096\/fasebj.8.8.8181668","article-title":"Adhesion molecules and inflammatory injury","volume":"8","author":"Albelda","year":"1994","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.micpath.2025.107683_bib39","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/sj.jid.5700670","article-title":"Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations","volume":"127","author":"Clark","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.micpath.2025.107683_bib40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.urology.2003.11.022","article-title":"Expression of intercellular adhesion molecules in the bladder of patients with interstitial cystitis","volume":"63","author":"Green","year":"2004","journal-title":"Urology"},{"issue":"3","key":"10.1016\/j.micpath.2025.107683_bib41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00345-012-0839-8","article-title":"Reduction of intercellular adhesion molecule 1 may play a role in anti-inflammatory effect of hyaluronic acid in a rat model of severe non-bacterial cystitis","volume":"31","author":"Shao","year":"2013","journal-title":"World J. Urol."},{"key":"10.1016\/j.micpath.2025.107683_bib42","article-title":"Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micpath.2025.107683_bib43","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","article-title":"Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis","volume":"11","author":"Tajik","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.micpath.2025.107683_bib44","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/annrheumdis-2016-210000","article-title":"Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis","volume":"76","author":"Ciccia","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.micpath.2025.107683_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.plabm.2017.09.001","article-title":"Fecal zonulin is elevated in Crohn's disease and in cigarette smokers","volume":"9","author":"Malickova","year":"2017","journal-title":"Pract. Lab. Med."},{"issue":"9","key":"10.1016\/j.micpath.2025.107683_bib46","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ni.3512","article-title":"Apoptosis in response to microbial infection induces autoreactive TH17 cells","volume":"17","author":"Campisi","year":"2016","journal-title":"Nat. Immunol."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T02:36:52Z","timestamp":1749177412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025004085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":46,"alternative-id":["S0882401025004085"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107683","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between the gut microbiota and cystitis: A two-sample mendelian randomization study combined with the GEO database","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107683","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107683"}}