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Microb. Antimicrob."},{"key":"10.1016\/j.micpath.2025.107691_bib115","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11081912","article-title":"The challenge of overcoming antibiotic resistance in carbapenem-resistant gram-negative bacteria: \"attack on titan\"","volume":"11","author":"Mancuso","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2025.107691_bib116","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13017-023-00518-3","article-title":"Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action","volume":"18","author":"Sartelli","year":"2023","journal-title":"World J. Emerg. Surg."},{"key":"10.1016\/j.micpath.2025.107691_bib117","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/phar.2781","article-title":"Antimicrobial susceptibility testing: an updated primer for clinicians in the era of antimicrobial resistance: insights from the Society of Infectious Diseases Pharmacists","volume":"43","author":"Wenzler","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.micpath.2025.107691_bib118","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","article-title":"Molecular mechanisms of antibiotic resistance","volume":"13","author":"Blair","year":"2015","journal-title":"Nat. Rev. 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J. Mol. Sci."},{"key":"10.1016\/j.micpath.2025.107691_bib184","first-page":"1","article-title":"Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers","author":"Yin","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.micpath.2025.107691_bib185","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1128\/IAI.68.12.6744-6749.2000","article-title":"Capsule impedes adhesion to and invasion of epithelial cells by Klebsiella pneumoniae","volume":"68","author":"Sahly","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.micpath.2025.107691_bib186","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/IAI.00864-09","article-title":"Roles of capsule and lipopolysaccharide O antigen in interactions of human monocyte-derived dendritic cells and Klebsiella pneumoniae","volume":"78","author":"Evrard","year":"2010","journal-title":"Infect. 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