{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:38:02Z","timestamp":1784396282753,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.micpath.2025.107695","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:05:48Z","timestamp":1747148748000},"page":"107695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Novel hepcidin genes in gilthead seabream: Implications for immune response and iron metabolism"],"prefix":"10.1016","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6678-8426","authenticated-orcid":false,"given":"Laura","family":"Garc\u00eda-Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon A.","family":"Serna-Duque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0906-7995","authenticated-orcid":false,"given":"Alberto","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-1458","authenticated-orcid":false,"given":"M. \u00c1ngeles","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107695_bib1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.18388\/abp.2003_3698","article-title":"Novel properties of antimicrobial peptides","volume":"50","author":"Kamysz","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.micpath.2025.107695_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/antibiotics10060621","article-title":"An overview of antimicrobial compounds from african edible insects and their associated microbiota","volume":"10","author":"Mudalungu","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.micpath.2025.107695_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10989-020-10068-w","article-title":"Piscidin, fish antimicrobial peptide: structure, classification, properties, mechanism, gene regulation and therapeutical importance","volume":"27","author":"Raju","year":"2021","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.micpath.2025.107695_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.pharep.2016.03.015","article-title":"LL-37: cathelicidin-related antimicrobial peptide with pleiotropic activity","volume":"68","author":"Fabisiak","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.micpath.2025.107695_bib5","series-title":"Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies","author":"Wang","year":"2017"},{"key":"10.1016\/j.micpath.2025.107695_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2025.107695_bib7","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/ph6121543","article-title":"Antimicrobial peptides","volume":"6","author":"Bahar","year":"2013","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.micpath.2025.107695_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.26444\/aaem\/74471","article-title":"Utilisation of peptides against microbial infections - a review","volume":"25","author":"Mirski","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.micpath.2025.107695_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/138920309789630589","article-title":"Anionic antimicrobial peptides from eukaryotic organisms","volume":"10","author":"Harris","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.micpath.2025.107695_bib10","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1021\/acs.jcim.1c00175","article-title":"Computational methods and tools in antimicrobial peptide research","volume":"61","author":"Aronica","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.micpath.2025.107695_bib11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3390\/v11080704","article-title":"Human antimicrobial peptides as therapeutics for viral infections","volume":"11","author":"Ahmed","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.micpath.2025.107695_bib12","first-page":"3919","article-title":"The antimicrobial peptides and their potential clinical applications","volume":"11","author":"Lei","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.micpath.2025.107695_bib13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1517\/14712598.4.4.543","article-title":"Antimicrobial peptides and the skin","volume":"4","author":"Bardan","year":"2004","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.micpath.2025.107695_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/biology4040607","article-title":"Antimicrobial peptides as mediators of innate immunity in teleosts","volume":"4","author":"Katzenback","year":"2015","journal-title":"Biology"},{"key":"10.1016\/j.micpath.2025.107695_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/ph7030265","article-title":"Antimicrobial peptides from fish","volume":"7","author":"Masso-Silva","year":"2014","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.micpath.2025.107695_bib16","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.molimm.2007.11.007","article-title":"The antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish gilthead seabream","volume":"45","author":"Cuesta","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib17","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.dci.2005.10.009","article-title":"Hepcidins in amphibians and fishes: antimicrobial peptides or iron-regulatory hormones?","volume":"30","author":"Shi","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fsi.2019.01.020","article-title":"Identification and expression of the hepcidin gene from brown trout (Salmo trutta) and functional analysis of its synthetic peptide","volume":"87","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(00)01920-7","article-title":"LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity","volume":"480","author":"Krause","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.micpath.2025.107695_bib20","doi-asserted-by":"crossref","first-page":"37597","DOI":"10.1074\/jbc.M205305200","article-title":"The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis","volume":"277","author":"Hunter","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2025.107695_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10930-013-9530-1","article-title":"Characterization and structural analysis of hepcidin like antimicrobial peptide from Schizothorax richardsonii (Gray)","volume":"33","author":"Chaturvedi","year":"2014","journal-title":"Protein J."},{"key":"10.1016\/j.micpath.2025.107695_bib22","doi-asserted-by":"crossref","first-page":"48671","DOI":"10.1074\/jbc.M404690200","article-title":"Structure-activity relationships in defensin dimers: a novel link between \u03b2-DEFENSIN tertiary structure and antimicrobial activity","volume":"279","author":"Campopiano","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2025.107695_bib23","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1074\/jbc.M411154200","article-title":"Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections","volume":"280","author":"Lauth","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.micpath.2025.107695_bib24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gene.2008.02.016","article-title":"Molecular evolution and characterization of hepcidin gene products in vertebrates","volume":"415","author":"Hilton","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.micpath.2025.107695_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.dci.2017.04.014","article-title":"Antimicrobial peptides within the yellowtail kingfish (Seriola lalandi)","volume":"80","author":"Muncaster","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib26","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1111\/j.1742-4658.2005.04922.x","article-title":"Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus","volume":"272","author":"Hirono","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.micpath.2025.107695_bib27","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.molimm.2006.09.031","article-title":"Three different hepcidins from tilapia, Oreochromis mossambicus: analysis of their expressions and biological functions","volume":"44","author":"Huang","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dci.2008.07.009","article-title":"Gene structure and differential modulation of multiple rockbream (Oplegnathus fasciatus) hepcidin isoforms resulting from different biological stimulations","volume":"33","author":"Cho","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.fsi.2010.11.021","article-title":"Molecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus cocoides","volume":"30","author":"Zhou","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.fsi.2012.11.052","article-title":"Expression profile of immune-related genes in Lates calcarifer infected by Cryptocaryon irritans","volume":"34","author":"Mohd-Shaharuddin","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cmet.2012.03.018","article-title":"Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination","volume":"15","author":"Qiao","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.micpath.2025.107695_bib32","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cmet.2012.03.017","article-title":"Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT","volume":"15","author":"Ross","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.micpath.2025.107695_bib33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3324\/haematol.2009.014399","article-title":"Hepcidin targets ferroportin for degradation in hepatocytes","volume":"95","author":"Ramey","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.micpath.2025.107695_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.fsi.2022.04.032","article-title":"Massive gene expansion of hepcidin, a host defense peptide, in gilthead seabream (Sparus aurata)","volume":"124","author":"Serna-Duque","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/md22020086","article-title":"Synthetic antimicrobial peptides fail to induce leucocyte innate immune functions but elicit opposing transcriptomic profiles in European sea bass and gilthead seabream","volume":"22","author":"Cervera","year":"2024","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.micpath.2025.107695_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108899","article-title":"Hepcidin and piscidin modulation and antibacterial response in gilthead seabream (Sparus aurata) infected with Vibrio harveyi","volume":"139","author":"Serna-Duque","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib37","doi-asserted-by":"crossref","DOI":"10.1007\/s10126-024-10293-0","article-title":"Participation of hepcidins in the inflammatory response triggered by \u03bb-carrageenin in gilthead seabream (Sparus aurata)","author":"Campos-S\u00e1nchez","year":"2024","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.micpath.2025.107695_bib38","doi-asserted-by":"crossref","first-page":"D1025","DOI":"10.1093\/nar\/gkab1091","article-title":"Genomicus in 2022: comparative tools for thousands of genomes and reconstructed ancestors","volume":"50","author":"Nguyen","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2025.107695_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-2836(78)90297-8","article-title":"Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins","volume":"120","author":"Garnier","year":"1978","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.micpath.2025.107695_bib40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2025.107695_bib41","article-title":"Predict protein structures with AlphaFold","year":"2023","journal-title":"Benchling"},{"key":"10.1016\/j.micpath.2025.107695_bib42","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1093\/bioinformatics\/btac358","article-title":"mebipred: identifying metal-binding potential in protein sequence","volume":"38","author":"Aptekmann","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2025.107695_bib43","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/microorganisms9050964","article-title":"Alteration of the immune response and the microbiota of the skin during a natural infection by Vibrio harveyi in European seabass (Dicentrarchus labrax)","volume":"9","author":"C\u00e1mara-Ruiz","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2025.107695_bib44","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.3390\/microorganisms8121990","article-title":"Probiotic shewanella putrefaciens (SpPdp11) as a fish health modulator: a review","volume":"8","author":"C\u00e1mara-Ruiz","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2025.107695_bib45","author":"Braik"},{"key":"10.1016\/j.micpath.2025.107695_bib46","first-page":"880","volume":"vol. 6","author":"Gayathiri","year":"2018"},{"key":"10.1016\/j.micpath.2025.107695_bib47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1001\/jama.1907.25320140022001f","article-title":"The nephelometer: an instrument for estimating the number of bacteria in suspensions used for calculating the opsonic index and for vaccines","volume":"49","author":"McFarland","year":"1907","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.micpath.2025.107695_bib48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: the MTT assay","volume":"731","author":"van Meerloo","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"Pt 9","key":"10.1016\/j.micpath.2025.107695_bib49","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1099\/0022-1317-77-9-2067","article-title":"Cell culture isolation of piscine neuropathy nodavirus from juvenile sea bass, Dicentrarchus labrax","volume":"77","author":"Frerichs","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.micpath.2025.107695_bib50","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.fsi.2012.09.002","article-title":"Nodavirus infection induces a great innate cell-mediated cytotoxic activity in resistant, gilthead seabream, and susceptible, European sea bass, teleost fish","volume":"33","author":"Chaves-Pozo","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib51","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.fsi.2013.09.007","article-title":"Vibrio anguillarum bacterin uptake via the gills of Japanese flounder and subsequent immune responses","volume":"35","author":"Kato","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib52","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.4049\/jimmunol.1501153","article-title":"Multiple hepcidins in a teleost fish, Dicentrarchus labrax: different hepcidins for different roles","volume":"195","author":"Neves","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib53","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1258\/0023677041958909","article-title":"A model for acute iron overload in sea bass (Dicentrarchus labrax L.)","volume":"38","author":"Rodrigues","year":"2004","journal-title":"Lab. Anim"},{"key":"10.1016\/j.micpath.2025.107695_bib54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/jeb.00712","article-title":"Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets","volume":"207","author":"Carriquiriborde","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.micpath.2025.107695_bib55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.micpath.2025.107695_bib56","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/bies.20293","article-title":"From 2R to 3R: evidence for a fish-specific genome duplication (FSGD)","volume":"27","author":"Meyer","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.micpath.2025.107695_bib57","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.micpath.2025.107695_bib58","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.fsi.2007.04.011","article-title":"Genomic organization and tissue-specific expression analysis of hepcidin-like genes from black porgy (Acanthopagrus schlegelii B.)","volume":"23","author":"Yang","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib59","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.peptides.2003.08.017","article-title":"Molecular strategies in biological evolution of antimicrobial peptides","volume":"24","author":"Nicolas","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.micpath.2025.107695_bib60","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1420-9101.2005.00925.x","article-title":"Molecular evolution of animal antimicrobial peptides: widespread moderate positive selection","volume":"18","author":"Tennessen","year":"2005","journal-title":"J. Evol. Biol."},{"key":"10.1016\/j.micpath.2025.107695_bib61","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0145-305X(03)00036-3","article-title":"Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish","volume":"27","author":"Douglas","year":"2003","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib62","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.dci.2003.11.009","article-title":"Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates","volume":"28","author":"Shike","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib63","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.dci.2005.03.006","article-title":"Catfish hepcidin gene is expressed in a wide range of tissues and exhibits tissue-specific upregulation after bacterial infection","volume":"29","author":"Bao","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib64","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.3390\/ijms20225602","article-title":"Expression and functional analysis of hepcidin from Mandarin fish (Siniperca chuatsi)","volume":"20","author":"Shen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.micpath.2025.107695_bib65","volume":"vol. 12","author":"\u00c1lvarez","year":"2022"},{"key":"10.1016\/j.micpath.2025.107695_bib66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s43141-023-00579-6","article-title":"In silico molecular and functional characterization of a dual function antimicrobial peptide, hepcidin (GIFT-Hep), isolated from genetically improved farmed tilapia (GIFT, Oreochromis niloticus)","volume":"21","author":"Lenin","year":"2023","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.micpath.2025.107695_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108872","article-title":"Characterization of hepcidin gene and protection of recombinant hepcidin supplemented in feed against Aeromonas hydrophila infection in Yellow River carp (Cyprinus carpio haematopterus)","volume":"139","author":"Qiao","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103845","article-title":"Sequence analysis of hepcidin in barbel steed (Hemibarbus labeo): QSHLS motif confers hepcidin iron-regulatory activity but limits its antibacterial activity","volume":"114","author":"Chen","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110279","article-title":"A novel antimicrobial peptide Larimicin78-102 from large yellow croaker (Larimichthys crocea) shows potent antibacterial activity in vitro and enhances resistance to Vibrio fluvialis infection in vivo","volume":"161","author":"Zhou","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109406","article-title":"Antibacterial activity and modes of action of a novel hepcidin isoform from the shrimp scad, Alepes djedaba (Forssk\u00e5l, 1775)","volume":"146","author":"Anooja","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib72","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/jfd.13797","article-title":"Identification of antibacterial activity of LEAP2 from Antarctic icefish Chionodraco hamatus","volume":"46","author":"Fei","year":"2023","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.micpath.2025.107695_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2023.108549","article-title":"Electric field charge polarity triggers the organization and promotes the stability of electrosprayed probiotic cells","volume":"139","author":"Dima","year":"2023","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.micpath.2025.107695_bib74","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40779-021-00343-2","article-title":"Antimicrobial peptides: mechanism of action, activity and clinical potential","volume":"8","author":"Zhang","year":"2021","journal-title":"Military Med. Res."},{"key":"10.1016\/j.micpath.2025.107695_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1058862","article-title":"Essential immune functions of fibroblasts in innate host defense","volume":"13","author":"Cavagnero","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib76","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2006.04.004","article-title":"Molecular cloning and expression analysis of a hepcidin antimicrobial peptide gene from turbot (Scophthalmus maximus)","volume":"22","author":"Chen","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib77","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.fsi.2009.01.012","article-title":"Genomic characterization and gene expression analysis of four hepcidin genes in the redbanded seabream (Pagrus auriga)","volume":"26","author":"Martin-Antonio","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/fishes2040020","article-title":"Antimicrobial peptides are expressed during early development of zebrafish (Danio rerio) and are inducible by immune challenge","volume":"2","author":"Caccia","year":"2017","journal-title":"Fishes"},{"key":"10.1016\/j.micpath.2025.107695_bib79","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s13205-019-1874-6","article-title":"Cloning and identification of antimicrobial peptide, hepcidin from freshwater carp, Catla catla on pathogen challenge and PAMPs stimulation","volume":"9","author":"Banerjee","year":"2019","journal-title":"3 Biotech"},{"key":"10.1016\/j.micpath.2025.107695_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14933-5","article-title":"Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types","volume":"7","author":"Neves","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2025.107695_bib81","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.15252\/embr.201541476","article-title":"Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage","volume":"17","author":"Feng","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.micpath.2025.107695_bib82","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molcel.2018.07.017","article-title":"Emerging principles of gene expression programs and their regulation","volume":"71","author":"Pope","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.micpath.2025.107695_bib83","article-title":"The role of lipopolysaccharide-induced cell signalling in chronic inflammation","volume":"6","author":"Page","year":"2022","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.micpath.2025.107695_bib84","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.molimm.2020.03.004","article-title":"Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)","volume":"121","author":"Vats","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dci.2013.04.002","article-title":"Detection of the hepcidin prepropeptide and mature peptide in liver of rainbow trout","volume":"41","author":"\u00c1lvarez","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.micpath.2025.107695_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2022.1073060","article-title":"Immunometabolic involvement of hepcidin genes in iron homeostasis, storage, and regulation in gilthead seabream (Sparus aurata)","volume":"9","author":"Serna-Duque","year":"2022","journal-title":"Front. Mar. Sci."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T02:37:16Z","timestamp":1749177436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025004206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":85,"alternative-id":["S0882401025004206"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107695","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel hepcidin genes in gilthead seabream: Implications for immune response and iron metabolism","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107695"}}