{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:54:46Z","timestamp":1780494886875,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"publisher","award":["2022\\u20132023"],"award-info":[{"award-number":["2022\\u20132023"]}],"id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013776","name":"Assam Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR46409\/AAQ\/1\/852\/2022"],"award-info":[{"award-number":["BT\/PR46409\/AAQ\/1\/852\/2022"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.micpath.2025.107744","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:57:53Z","timestamp":1748260673000},"page":"107744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs"],"prefix":"10.1016","volume":"206","author":[{"given":"S","family":"Arutkumaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajib","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmathi","family":"S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumendu","family":"Chakravarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-1628","authenticated-orcid":false,"given":"Pranab Jyoti","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra Singh","family":"Sengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema Rani","family":"Pegu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaraj","family":"Rajkhowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.107744_bib1","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00115-15","article-title":"Faustovirus, an asfarvirus-related new lineage of giant viruses infecting amoebae","volume":"89","author":"Reteno","year":"2015","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.micpath.2025.107744_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/v8110278","article-title":"Kaumoebavirus, a new virus that clusters with faustoviruses and Asfarviridae","volume":"8","author":"Bajrai","year":"2016","journal-title":"Viruses"},{"issue":"14","key":"10.1016\/j.micpath.2025.107744_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00212-17","article-title":"Pacmanvirus, a new giant icosahedral virus at the crossroads between Asfarviridae and faustoviruses","volume":"91","author":"Andreani","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.micpath.2025.107744_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0368-1742(21)80031-4","article-title":"On a form of swine fever occurring in British East Africa (Kenya colony)","volume":"34","author":"Montgomery","year":"1921","journal-title":"J. Comp. Pathol. Ther."},{"key":"10.1016\/j.micpath.2025.107744_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.00282","article-title":"Comparative Pathology and pathogenesis of African swine fever infection in swine","volume":"7","author":"Salguero","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.micpath.2025.107744_bib6","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1111\/tbed.14318","article-title":"Consequences of African swine fever in India: beyond economic implications","volume":"68","author":"Mohan","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2025.107744_bib7","series-title":"Agricultural and Processed Food Products Export Development Authority","article-title":"Export of other meat","year":"2021"},{"issue":"12","key":"10.1016\/j.micpath.2025.107744_bib8","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.3201\/eid1712.110430","article-title":"Characterization of African swine fever virus Caucasus isolate in European wild boars","volume":"17","author":"Gabriel","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.micpath.2025.107744_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.virusres.2012.10.026","article-title":"Pathogenesis of African swine fever in domestic pigs and European wild boar","volume":"173","author":"Blome","year":"2013","journal-title":"Virus Res."},{"issue":"6","key":"10.1016\/j.micpath.2025.107744_bib10","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/tbed.12614","article-title":"Biological characterization of African swine fever virus genotype II strains from north-eastern Estonia in European wild boar","volume":"64","author":"Nurmoja","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2025.107744_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.aivir.2017.10.002","article-title":"African swine fever virus biology and vaccine approaches","author":"Revilla","year":"2018","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.micpath.2025.107744_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fgene.2019.00402","article-title":"The genetics of life and death: virus-host interactions underpinning resistance to african swine fever, a viral hemorrhagic disease","volume":"10","author":"Netherton","year":"2019","journal-title":"Front. Genet."},{"issue":"12","key":"10.1016\/j.micpath.2025.107744_bib13","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1128\/JVI.00331-11","article-title":"Species-specific variation in RELA underlies differences in NF-\u03baB activity: a potential role in african swine fever pathogenesis","volume":"85","author":"Palgrave","year":"2011","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/srep21645","article-title":"Mammalian interspecies substitution of immune modulatory alleles by genome editing","volume":"6","author":"Lillico","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12985-024-02351-9","article-title":"Resistance to African swine fever virus among African domestic pigs appears to be associated with a distinct polymorphic signature in the RelA gene and upregulation of RelA transcription","volume":"21","author":"Bisimwa","year":"2024","journal-title":"Virol. J."},{"issue":"10","key":"10.1016\/j.micpath.2025.107744_bib16","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/cbic.200400144","article-title":"NF-kappaB: a multifaceted transcription factor regulated at several levels","volume":"5","author":"Schmitz","year":"2004","journal-title":"Chembiochem"},{"key":"10.1016\/j.micpath.2025.107744_bib17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80066-0","article-title":"Phosphorylation of NF-\u03baB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP\/p300","volume":"1","author":"Zhong","year":"1998","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.micpath.2025.107744_bib18","doi-asserted-by":"crossref","DOI":"10.1007\/s00705-023-05959-4","article-title":"Transcriptome signatures of host tissue infected with African swine fever virus reveal differential expression of associated oncogenes","volume":"169","author":"Deb","year":"2024","journal-title":"Arch. Virol."},{"issue":"12","key":"10.1016\/j.micpath.2025.107744_bib19","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1128\/jvi.70.12.8527-8533.1996","article-title":"An IkappaB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages","volume":"70","author":"Powell","year":"1996","journal-title":"J. Virol."},{"issue":"44","key":"10.1016\/j.micpath.2025.107744_bib20","doi-asserted-by":"crossref","first-page":"34656","DOI":"10.1074\/jbc.M000320200","article-title":"Mechanism of inactivation of NF-kappa B by a viral homologue of I kappa b alpha. Signal-induced release of i kappa b alpha results in binding of the viral homologue to NF-kappa B","volume":"275","author":"Tait","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.56093\/ijans.v92i1.120940","article-title":"Performance appraisal and conservation need of Doom pig of Assam","volume":"92","author":"Banik","year":"2022","journal-title":"Indian J. Anim. Sci."},{"issue":"7","key":"10.1016\/j.micpath.2025.107744_bib22","doi-asserted-by":"crossref","DOI":"10.1007\/s00705-024-06062-y","article-title":"Characterization of an African swine fever virus outbreak in India and comparative analysis of immune genes in infected and surviving crossbreed vs. indigenous Doom pigs","volume":"169","author":"Das","year":"2024","journal-title":"Arch. Virol."},{"key":"10.1016\/j.micpath.2025.107744_bib23","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkn860","article-title":"PDBsum new things","volume":"37","author":"Laskowski","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.micpath.2025.107744_bib24","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.micpath.2025.107744_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","article-title":"Assessment of protein models with three-dimensional profiles","volume":"356","author":"Luthy","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.micpath.2025.107744_bib26","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/bioinformatics\/btu097","article-title":"ZDOCK server: interactive docking prediction of protein\u2013protein complexes and symmetric multimers","volume":"30","author":"Pierce","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.micpath.2025.107744_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.micpath.2025.107744_bib28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"Gromacs 4.5: a high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-016-0830-5","article-title":"Evidence for the presence of African swine fever virus in an endemic region of Western Kenya in the absence of any reported outbreak","volume":"12","author":"Thomas","year":"2016","journal-title":"BMC Vet. Res."},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190080","article-title":"Genetic diversity, breed composition and admixture of Kenyan domestic pigs","volume":"13","author":"Mujibi","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.micpath.2025.107744_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0092-8674(02)00822-X","article-title":"Modifying gene expression programs by altering core promoter chromatin architecture","volume":"110","author":"Lomvardas","year":"2002","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.micpath.2025.107744_bib32","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1128\/JVI.02213-10","article-title":"Distinct roles for the NF-\u03baB RelA subunit during antiviral innate immune responses","volume":"85","author":"Basagoudanavar","year":"2011","journal-title":"J. Virol."},{"issue":"21","key":"10.1016\/j.micpath.2025.107744_bib33","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1128\/JB.180.21.5515-5519.1998","article-title":"Functional consequences of changing proline residues in the phenylalanine-specific permease of Escherichia coli","volume":"180","author":"Pi","year":"1998","journal-title":"J. Bacteriol."},{"issue":"3","key":"10.1016\/j.micpath.2025.107744_bib34","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1006\/bbrc.1995.2084","article-title":"A hypothetical structural role for proline residues in the flanking segments of Protein-Protein interaction sites","volume":"212","author":"Kini","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.micpath.2025.107744_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-65808-1","article-title":"Substitution of warthog NF-\u03baB motifs into RELA of domestic pigs is not sufficient to confer resilience to African swine fever virus","volume":"10","author":"McCleary","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025004693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:40:12Z","timestamp":1778694012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025004693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":35,"alternative-id":["S0882401025004693"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107744","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.107744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107744"}}