{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:15:37Z","timestamp":1791508537889,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031289","name":"Universidad CEU Cardenal Herrera","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014750","name":"San Pablo CEU University","doi-asserted-by":"publisher","award":["INDI24-38"],"award-info":[{"award-number":["INDI24-38"]}],"id":[{"id":"10.13039\/501100014750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014750","name":"San Pablo CEU University","doi-asserted-by":"publisher","award":["IDOC24-06"],"award-info":[{"award-number":["IDOC24-06"]}],"id":[{"id":"10.13039\/501100014750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014750","name":"San Pablo CEU University","doi-asserted-by":"publisher","award":["ICLINIC24-01"],"award-info":[{"award-number":["ICLINIC24-01"]}],"id":[{"id":"10.13039\/501100014750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014750","name":"San Pablo CEU University","doi-asserted-by":"publisher","award":["GIR24-30"],"award-info":[{"award-number":["GIR24-30"]}],"id":[{"id":"10.13039\/501100014750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.micpath.2025.108096","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:50:36Z","timestamp":1759791036000},"page":"108096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Breed-specific variation in canine cytokine profiles in a leishmaniosis-endemic region"],"prefix":"10.1016","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9095-1106","authenticated-orcid":false,"given":"Lola","family":"Mart\u00ednez-S\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Jes\u00fas","family":"Mar\u00edn-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Boccuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Tomasello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-9174","authenticated-orcid":false,"given":"Lola","family":"Llobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.108096_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2025.108096_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s11259-023-10171-5","article-title":"Is leishmaniasis the new emerging zoonosis in the world?","author":"Montaner-Angoiti","year":"2023","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.micpath.2025.108096_bib3","first-page":"173","article-title":"Feline leishmaniosis: an emerging public health problem","volume":"8","author":"Ahuir-Baraja","year":"2021","journal-title":"Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib4","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.3390\/ani13182889","article-title":"Prevalence and factors related to Leishmania infantum infection in healthy horses (Equus caballus) from Eastern Spain","volume":"13","author":"Mart\u00ednez-S\u00e1ez","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2025.108096_bib5","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1111\/tbed.14199","article-title":"An epidemiological study in wild carnivores from Spanish mediterranean ecosystems reveals association between Leishmania infantum, Babesia spp. and Hepatozoon spp. infection and new hosts for Hepatozoon martis, Hepatozoon canis and Sarcocystis spp","volume":"69","author":"Ortu\u00f1o","year":"2022","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.micpath.2025.108096_bib6","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.3390\/microorganisms9122616","article-title":"Wild rabbit exposure to Leishmania infantum, Toxoplasma gondii, Anaplasma phagocytophilum and Babesia caballi evidenced by serum and aqueous humor antibody detection","volume":"9","author":"Athanasiou","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.micpath.2025.108096_bib7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actatropica.2009.09.014","article-title":"Experimental and field investigations on the role of birds as hosts of Leishmania infantum, with emphasis on the domestic chicken","volume":"113","author":"Otranto","year":"2010","journal-title":"Acta Trop."},{"key":"10.1016\/j.micpath.2025.108096_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010650","article-title":"Leishmania (Sauroleishmania) tarentolae isolation and sympatric occurrence with Leishmania (Leishmania) infantum in geckoes, dogs and sand flies","volume":"16","author":"Mendoza-Roldan","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.micpath.2025.108096_bib9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/JCM.39.2.560-563.2001","article-title":"Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology","volume":"39","author":"Solano-Gallego","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.micpath.2025.108096_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1756-3305-4-86","article-title":"LeishVet guidelines for the practical management of canine leishmaniosis","volume":"4","author":"Solano-Gallego","year":"2011","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.micpath.2025.108096_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.rvsc.2008.12.009","article-title":"Evidence for a relationship between Leishmania load and clinical manifestations","volume":"87","author":"Manna","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib12","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.cvsm.2022.06.012","article-title":"Leishmaniasis","volume":"52","author":"Baneth","year":"2022","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.micpath.2025.108096_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13071-020-04081-7","article-title":"Latest trends in Leishmania infantum infection in dogs in Spain, Part I: mapped seroprevalence and sand fly distributions","volume":"13","author":"G\u00e1lvez","year":"2020","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.micpath.2025.108096_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13071-022-05226-6","article-title":"Leishmania infantum infection serosurveillance in stray dogs inhabiting the Madrid community: 2007-2018","volume":"15","author":"M\u00fcller","year":"2022","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.micpath.2025.108096_bib15","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.3390\/ani11092579","article-title":"Is the prevalence of Leishmania infantum linked to breeds in dogs? Characterization of seropositive dogs in ibiza","volume":"11","author":"Edo","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2025.108096_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13071-020-3992-8","article-title":"Exploring the relationship between susceptibility to canine leishmaniosis and anti-Phlebotomus perniciosus saliva antibodies in Ibizan hounds and dogs of other breeds in Mallorca, Spain","volume":"13","author":"Burnham","year":"2020","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.micpath.2025.108096_bib17","article-title":"Immunological profile of two canine breeds in an endemic region of Leishmania infantum","volume":"40","author":"Maci\u00e0","year":"2023","journal-title":"Vet. Parasitol. Reg. Stud. Rep."},{"key":"10.1016\/j.micpath.2025.108096_bib18","first-page":"305","article-title":"Canine cytokines profile in an endemic region of L. infantum: related factors","volume":"9","author":"Mar\u00edn-Garc\u00eda","year":"2022","journal-title":"Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-4017(00)00223-5","article-title":"The Ibizian hound presents a predominantly cellular immune response against natural Leishmania infection","volume":"90","author":"Solano-Gallego","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.micpath.2025.108096_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40249-023-01058-3","article-title":"Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region","volume":"12","author":"\u00c1lvarez","year":"2023","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.micpath.2025.108096_bib21","article-title":"Serum levels and genetic variations of cytokines in two canine breeds (Ibizan hound and boxer) in the Mediterranean region, in terms of Leishmania infantum infection","volume":"90\u201391","author":"\u00c1lvarez","year":"2022","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2025.108096_bib22","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3390\/ani14111516","article-title":"Effect of breed on hematological and biochemical parameters of apparently healthy dogs infected with zoonotic pathogens endemic to the Mediterranean Basin","volume":"14","author":"Amato","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2025.108096_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.rvsc.2023.01.010","article-title":"Phylogeographic and population genetic structure of hound-like native dogs of the Mediterranean Basin","volume":"155","author":"Perini","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5326\/JAAHA-MS-6999","article-title":"2019 AAHA Canine life stage guidelines","volume":"55","author":"Creevy","year":"2019","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"10.1016\/j.micpath.2025.108096_bib25","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/pathogens10070865","article-title":"Molecular diagnosis of leishmaniasis: quantification of parasite load by a real-time PCR assay with high sensitivity","volume":"10","author":"Castelli","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.micpath.2025.108096_bib26","series-title":"PLS Modeling with Latent Variables in Two or More Dimensions","author":"Wold","year":"1987"},{"key":"10.1016\/j.micpath.2025.108096_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chemolab.2012.12.005","article-title":"Comparison of sparse and Jack-knife partial least squares regression methods for variable selection","volume":"122","author":"Karaman","year":"2013","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"10.1016\/j.micpath.2025.108096_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11306-014-0698-y","article-title":"Sparse multi-block PLSR for biomarker discovery when integrating data from LC\u2013MS and NMR metabolomics","volume":"11","author":"Karaman","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.micpath.2025.108096_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-3164.2006.00534.x","article-title":"Evaluation of Th1-like, Th2-like and immunomodulatory cytokine mRNA expression in the skin of dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis","volume":"17","author":"Breathnach","year":"2006","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.micpath.2025.108096_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/s-0038-1632931","article-title":"Cytokine profile in canine immune-mediated polyarthritis and osteoarthritis","volume":"18","author":"Hegemann","year":"2005","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"10.1016\/j.micpath.2025.108096_bib31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1046\/j.1365-2222.2002.01356.x","article-title":"Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis","volume":"32","author":"Nuttall","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.micpath.2025.108096_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78451-x","article-title":"Expression of key cytokines in dog macrophages infected by Leishmania tarentolae opening new avenues for the protection against Leishmania infantum","volume":"14","author":"Louzada-Flores","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.micpath.2025.108096_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-2427(02)00134-4","article-title":"Cytokine expression during the outcome of canine experimental infection by Leishmania infantum","volume":"88","author":"Santos-Gomes","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.micpath.2025.108096_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s13071-022-05504-3","article-title":"Immunological and genomic characterization of ibizan hound dogs in an endemic Leishmania infantum region","volume":"15","author":"\u00c1lvarez","year":"2022","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.micpath.2025.108096_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2024.102232","article-title":"Adaptive and innate immune response of Leishmania infantum infection in Cirneco dell'Etna dog breed","volume":"113","author":"Mart\u00ednez-S\u00e1ez","year":"2024","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.micpath.2025.108096_bib36","unstructured":"FCI, n.d. Perros tipo spitz y tipo primitivo [WWW Document]. URL http:\/\/www.fci.be\/es\/nomenclature\/5-Perros-tipo-spitz-y-tipo-primitivo.html#s7 (accessed 10.March.19)."},{"key":"10.1016\/j.micpath.2025.108096_bib37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1534\/genetics.116.192427","article-title":"Commonalities in development of pure breeds and population isolates revealed in the genome of the Sardinian Fonni's dog","volume":"204","author":"Dreger","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.micpath.2025.108096_bib38","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/ece3.3842","article-title":"Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution","volume":"8","author":"Talenti","year":"2018","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.micpath.2025.108096_bib39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3390\/ani13050818","article-title":"Genomic analysis of the endangered Fonni's dog breed: a comparison of genomic and phenotypic evaluation scores","volume":"13","author":"Cortellari","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.micpath.2025.108096_bib40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/1828051X.2021.1873076","article-title":"Genomic variability of cirneco dell'Etna and the genetic distance with other dog breeds","volume":"20","author":"Cortellari","year":"2021","journal-title":"Ital. J. Anim. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","article-title":"T cell exhaustion","volume":"42","author":"Baessler","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.micpath.2025.108096_bib42","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.4049\/jimmunol.1301810","article-title":"Programmed death 1\u2013Mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function","volume":"191","author":"Esch","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.micpath.2025.108096_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rvsc.2020.02.004","article-title":"The balancing act: immunology of leishmaniosis","volume":"130","author":"Toepp","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib44","doi-asserted-by":"crossref","first-page":"13639","DOI":"10.1073\/pnas.1516215112","article-title":"Genetic structure in village dogs reveals a Central Asian domestication origin","volume":"112","author":"Shannon","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib45","series-title":"Immunotherapy","first-page":"33","article-title":"Interleukin-2: old and new approaches to enhance immune-therapeutic efficacy","author":"Dhupkar","year":"2017"},{"issue":"1","key":"10.1016\/j.micpath.2025.108096_bib46","article-title":"Cytokines in canine inflammatory bowel disease","author":"Depta","year":"2013","journal-title":"Pol. J. Vet. Sci."},{"key":"10.1016\/j.micpath.2025.108096_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199506","article-title":"Genetic diversity and population structure of African village dogs based on microsatellite and immunity-related molecular markers","volume":"13","author":"Vychodilova","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.micpath.2025.108096_bib48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10522-023-10037-y","article-title":"Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1\u03b2, and TNF-\u03b1 in serum of healthy dogs of different body sizes and ages","volume":"24","author":"Jim\u00e9nez","year":"2023","journal-title":"Biogerontology"},{"key":"10.1016\/j.micpath.2025.108096_bib49","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1007\/s11357-024-01217-w","article-title":"The companion dog as a model for inflammaging: a cross-sectional pilot study","volume":"46","author":"Schmid","year":"2024","journal-title":"Geroscience"},{"key":"10.1016\/j.micpath.2025.108096_bib50","first-page":"1055","article-title":"Assessment of the circulating inflammatory mediator interleukin-8 in dogs with tracheal collapse","volume":"65","author":"Toone","year":"2024","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.micpath.2025.108096_bib51","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/eji.200636012","article-title":"Interleukin-10 derived from macrophages and\/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA","volume":"36","author":"Siewe","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.micpath.2025.108096_bib52","first-page":"1563","article-title":"Immunology of IL-12: an update on functional activities and implications for disease","volume":"19","author":"Ullrich","year":"2020","journal-title":"EXCLI J"},{"key":"10.1016\/j.micpath.2025.108096_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: an evolving chemokine","volume":"153","author":"Matsushima","year":"2022","journal-title":"Cytokine"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025008216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025008216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:03:25Z","timestamp":1763370205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025008216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":53,"alternative-id":["S0882401025008216"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108096","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breed-specific variation in canine cytokine profiles in a leishmaniosis-endemic region","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108096"}}