{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:54:44Z","timestamp":1777874084549,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018551","name":"Science and Technology Innovation Talents in Universities of Henan Province","doi-asserted-by":"publisher","award":["2025L036"],"award-info":[{"award-number":["2025L036"]}],"id":[{"id":"10.13039\/501100018551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microbial Pathogenesis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.micpath.2025.108145","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:25:24Z","timestamp":1761672324000},"page":"108145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Near-infrared activated Fosfomycin\u2013Silver nanoparticles against multidrug-resistant bacteria: Microbiological and molecular insights into resistance modulation"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2606-803X","authenticated-orcid":false,"given":"Lili","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4632-1211","authenticated-orcid":false,"given":"Yiran","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.micpath.2025.108145_bib1","series-title":"Evaluation of Antibiotic Resistance Mechanisms in gram-negative Bacteria","author":"Gauba","year":"2023"},{"key":"10.1016\/j.micpath.2025.108145_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5419874","article-title":"Multidrug-resistant bacteria: their mechanism of action and prophylaxis","volume":"2022","author":"Bharadwaj","year":"2022","journal-title":"BioMed Res. Int."},{"issue":"11","key":"10.1016\/j.micpath.2025.108145_bib3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrmicro.2017.103","article-title":"Diagnosing antimicrobial resistance","volume":"15","author":"Burnham","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"issue":"April","key":"10.1016\/j.micpath.2025.108145_bib4","first-page":"1","article-title":"A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli","volume":"14","author":"Nasrollahian","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.micpath.2025.108145_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1142\/9789813209558_0015","article-title":"Antibiotic resistance mechanisms","author":"Smith","year":"2017","journal-title":"Journeys Med. Res. Three Cont. Over 50 Years"},{"issue":"October","key":"10.1016\/j.micpath.2025.108145_bib6","first-page":"1","article-title":"Nanoparticles in the treatment of infections caused by multidrug-resistant organisms","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/jnt6020009","article-title":"Advanced nanoparticles in combating antibiotic resistance: current innovations and future directions","volume":"6","author":"AlQurashi","year":"2025","journal-title":"J. Nanotheranostics"},{"key":"10.1016\/j.micpath.2025.108145_bib8","series-title":"Silver Nanoparticles as next- Generation Antimicrobial Agents : Mechanisms , Challenges , and Innovations Against multidrug-resistant Bacteria","author":"Khalifa","year":"2025"},{"issue":"6","key":"10.1016\/j.micpath.2025.108145_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11061489","article-title":"Nanotechnology\u2014A light of hope for combating antibiotic resistance","volume":"11","author":"Muteeb","year":"2023","journal-title":"Microorganisms"},{"issue":"23","key":"10.1016\/j.micpath.2025.108145_bib10","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1039\/D3NA00530E","article-title":"Recent advances in nanoantibiotics against multidrug-resistant bacteria","volume":"5","author":"Li","year":"2023","journal-title":"Nanoscale Adv."},{"issue":"6","key":"10.1016\/j.micpath.2025.108145_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s11274-021-03070-x","article-title":"Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects","volume":"37","author":"Mba","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics13020121","article-title":"Nanotechnology in the diagnosis and treatment of antibiotic-resistant infections","volume":"13","author":"Ioannou","year":"2024","journal-title":"Antibiotics"},{"issue":"7","key":"10.1016\/j.micpath.2025.108145_bib13","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1039\/D2NA00934J","article-title":"Self-assembled supramolecular artificial light-harvesting nanosystems: construction, modulation, and applications","volume":"5","author":"Chen","year":"2022","journal-title":"Nanoscale Adv."},{"issue":"1","key":"10.1016\/j.micpath.2025.108145_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics14010005","article-title":"Green silver nanoparticles: an antibacterial mechanism","volume":"14","author":"Mikhailova","year":"2025","journal-title":"Antibiotics"},{"issue":"9","key":"10.1016\/j.micpath.2025.108145_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/pr11092617","article-title":"Synthesis of silver nanoparticles: from conventional to \u2018modern\u2019 Methods\u2014A review","volume":"11","author":"Nguyen","year":"2023","journal-title":"Processes"},{"issue":"3","key":"10.1016\/j.micpath.2025.108145_bib16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/10408398.2021.1947772","article-title":"Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review","volume":"63","author":"Teng","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"27","key":"10.1016\/j.micpath.2025.108145_bib17","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1039\/C8NR02278J","article-title":"Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties","volume":"10","author":"Mourdikoudis","year":"2018","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib18","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1039\/D3TB03004K","article-title":"Review of NIR-responsive \u2018\u201csmart\u201d\u2019 carriers for photothermal chemotherapy","volume":"12","author":"Karmakar","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1556\/1886.2024.00035","article-title":"Methods for screening and evaluation of antimicrobial activity: a review of protocols, advantages, and limitations","volume":"14","author":"Hossain","year":"2024","journal-title":"Eur. J. Microbiol. Immunol"},{"key":"10.1016\/j.micpath.2025.108145_bib20","first-page":"1","article-title":"Kirby-bauer disk diffusion susceptibility test protocol author information","author":"Hudzicki","year":"2012","journal-title":"Am. Soc. Microbiol., no. December 2009"},{"issue":"8","key":"10.1016\/j.micpath.2025.108145_bib21","doi-asserted-by":"crossref","first-page":"ix","DOI":"10.1046\/j.1469-0691.2003.00790.x","article-title":"Determination of minimum inhibitory concentrations (MICs) of antibacterial agents by broth dilution","volume":"9","author":"Committee","year":"2003","journal-title":"Clin. Microbiol. Infect."},{"issue":"Mic","key":"10.1016\/j.micpath.2025.108145_bib22","first-page":"46","article-title":"Bactericidal concentration (MBC) for twelve antimicrobials","volume":"11","author":"Rodr","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.micpath.2025.108145_bib23","first-page":"237","article-title":"Cancer cell culture","volume":"731","author":"Langdon","year":"2003","journal-title":"Cancer Cell Cult"},{"issue":"1\u20132","key":"10.1016\/j.micpath.2025.108145_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"38","key":"10.1016\/j.micpath.2025.108145_bib25","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1039\/C8AY01339J","article-title":"Methods for the detection of reactive oxygen species","volume":"10","author":"Zhang","year":"2018","journal-title":"Anal. Methods"},{"issue":"October","key":"10.1016\/j.micpath.2025.108145_bib26","first-page":"1","article-title":"Oxidative stress: fundamentals and advances in quantification techniques","volume":"12","author":"Krishnamurthy","year":"2024","journal-title":"Front. Chem."},{"issue":"1","key":"10.1016\/j.micpath.2025.108145_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-43309-0","article-title":"Ampicillin silver nanoformulations against multidrug resistant bacteria","volume":"9","author":"Khatoon","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib28","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/AAC.00996-10","article-title":"Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance","volume":"55","author":"Swick","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.micpath.2025.108145_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-022-01972-5","article-title":"Expression and purification of soluble recombinant \u03b2-lactamases using Escherichia coli as expression host and pET-28a as cloning vector","volume":"21","author":"Li","year":"2022","journal-title":"Microb. Cell Fact."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.20885\/ijca.vol6.iss2.art4","article-title":"Synthesis and characterization of silver nanoparticles (AgNPs) using chemico-physical methods","volume":"6","author":"Siddiqui","year":"2023","journal-title":"IJCA (Indonesian J. Chem. Anal."},{"issue":"1","key":"10.1016\/j.micpath.2025.108145_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-60542-0","article-title":"Phosphate adsorption by silver nanoparticles-loaded activated carbon derived from tea residue","volume":"10","author":"Trinh","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.micpath.2025.108145_bib32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13204-015-0449-z","article-title":"Characterization of silver nanoparticles by green synthesis method using pedalium murex leaf extract and their antibacterial activity","volume":"6","author":"Anandalakshmi","year":"2016","journal-title":"Appl. Nanosci."},{"issue":"5","key":"10.1016\/j.micpath.2025.108145_bib33","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-021-05220-6","article-title":"Dynamic light scattering distributions by any means","volume":"23","author":"Farkas","year":"2021","journal-title":"J. Nanoparticle Res."},{"issue":"4","key":"10.1016\/j.micpath.2025.108145_bib34","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00253-009-2159-5","article-title":"Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli","volume":"85","author":"Li","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.micpath.2025.108145_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/mps6040063","article-title":"Precise analysis of nanoparticle size distribution in TEM image","volume":"6","author":"Zhang","year":"2023","journal-title":"Methods Protoc."},{"key":"10.1016\/j.micpath.2025.108145_bib36","first-page":"4","article-title":"Zeta potential measurement of nanoparticles by nanoparticle tracking analysis (NTA)","volume":"1","author":"Griffiths","year":"2011","journal-title":"Tech. Proc. 2011 NSTI Nanotechnol. Conf. Expo, NSTI-Nanotech 2011"},{"issue":"9","key":"10.1016\/j.micpath.2025.108145_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091534","article-title":"Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"53","key":"10.1016\/j.micpath.2025.108145_bib38","doi-asserted-by":"crossref","first-page":"31961","DOI":"10.1039\/D0RA05793B","article-title":"Quercetin loaded folate targeted plasmonic silver nanoparticles for light activated chemo-photothermal therapy of DMBA induced breast cancer in sprague dawley rats","volume":"10","author":"Bose","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.micpath.2025.108145_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4939-7352-1_6","article-title":"Quantitation of surface coating on nanoparticles using thermogravimetric analysis","volume":"1682","author":"Dongargaonkar","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.micpath.2025.108145_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10103-007-0470-x","article-title":"Plasmonic photothermal therapy (PPTT) using gold nanoparticles","volume":"23","author":"Huang","year":"2008","journal-title":"Laser Med. Sci."},{"issue":"6","key":"10.1016\/j.micpath.2025.108145_bib41","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s11696-020-01465-y","article-title":"Efficient Au nanostructures for NIR-responsive controlled drug delivery systems","volume":"75","author":"Zafar","year":"2021","journal-title":"Chem. Pap."},{"key":"10.1016\/j.micpath.2025.108145_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/B978-0-12-823426-6.00030-9","article-title":"Antiviral potential of green-synthesized silver nanoparticles","author":"Barabadi","year":"2022","journal-title":"Handb. Microb. Nanotechnol."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/bios11020030","article-title":"Detection technologies for reactive oxygen species: fluorescence and electrochemical methods and their applications","volume":"11","author":"Duanghathaipornsuk","year":"2021","journal-title":"Biosensors"},{"key":"10.1016\/j.micpath.2025.108145_bib44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/978-3-319-06068-2_23","article-title":"Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends","volume":"806","author":"Marrakchi","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.micpath.2025.108145_bib45","unstructured":"X. Lu and B. Song, \u201cSelective Magnetic Resonance Imaging of antibiotic- Resistant Bacteria Leveraging ATP-Binding Cassette Sugar transporter-responsive Probes,\u201d pp. 1\u201331."},{"issue":"December","key":"10.1016\/j.micpath.2025.108145_bib46","first-page":"1","article-title":"Function and inhibitory mechanisms of multidrug efflux pumps","volume":"12","author":"Nishino","year":"2021","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.micpath.2025.108145_bib47","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1128\/AAC.02621-12","article-title":"Redefining the role of the \u03b2-lactamase locus in methicillin-resistant Staphylococcus aureus: \u03b2-lactamase regulators disrupt the mecimediated strong repression on mecA and optimize the phenotypic expression of resistance in strains with constitutive mecA e","volume":"57","author":"Ar\u00eade","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"190","key":"10.1016\/j.micpath.2025.108145_bib48","first-page":"190ra81","article-title":"Silver enhances antibiotic activity against gram-negative bacteria","volume":"5","author":"Ruben Morones-Ramirez","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"20","key":"10.1016\/j.micpath.2025.108145_bib49","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1401876111","article-title":"Antibiotics induce redox-related physi","volume":"111","author":"Dwyer","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"5","key":"10.1016\/j.micpath.2025.108145_bib50","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.micpath.2025.108145_bib51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3420481","article-title":"Repression of gene expression by oxidative stress","volume":"342","author":"Morel","year":"1999","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.micpath.2025.108145_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/msystems.00718-22","article-title":"\u201c Global Transcriptional Response of Escherichia coli Exposed In Situ to Different Low-Dose Ionizing Radiation Sources ,\u201d","volume":"8","author":"Wintenberg","year":"2023","journal-title":"mSystems"}],"container-title":["Microbial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025008708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882401025008708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:58:18Z","timestamp":1777575498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882401025008708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":52,"alternative-id":["S0882401025008708"],"URL":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108145","relation":{},"ISSN":["0882-4010"],"issn-type":[{"value":"0882-4010","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared activated Fosfomycin\u2013Silver nanoparticles against multidrug-resistant bacteria: Microbiological and molecular insights into resistance modulation","name":"articletitle","label":"Article Title"},{"value":"Microbial Pathogenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.micpath.2025.108145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108145"}}